Review
Immunology
Heather Amsden, Olena Kourko, Madison Roth, Katrina Gee
Summary: IL-27 is a cytokine that regulates immune response and has antiviral activities. It can increase interferon production to participate in antiviral immune response and directly interfere with viral infection by modulating immune cell function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Nathanael A. Caveney, Caleb R. Glassman, Kevin M. Jude, Naotaka Tsutsumi, K. Christopher Garcia
Summary: Interleukin 27 (IL-27) is a heterodimeric cytokine that plays an important role in immune homeostasis. This study used cryogenic-electron microscopy to determine the quaternary structure of IL-27 and its receptor complex, providing insights into the receptor assembly mechanism and distinguishing it from related cytokines.
Article
Cardiac & Cardiovascular Systems
Wei-Wen Lim, Jinrui Dong, Benjamin Ng, Anissa A. Widjaja, Chen Xie, Liping Su, Xiu-Yi Kwek, Nicole G. Z. Tee, Chee Jian Pua, Sebastian Schafer, Sivakumar Viswanathan, Stuart A. Cook
Summary: IL11 is upregulated in the aorta of Marfan syndrome patients, leading to aortic dilatation, inflammation, and fibrosis. Therapeutic inhibition of IL11 may be a new approach in treating Marfan syndrome.
CIRCULATION RESEARCH
(2022)
Article
Oncology
Lauryn R. Werner, Katelin A. Gibson, Merit L. Goodman, Dominika E. Helm, Katherine R. Walter, Sean M. Holloran, Gloria M. Trinca, Richard C. Hastings, Howard H. Yang, Ying Hu, Junping Wei, Gangjun Lei, Xiao-Yi Yang, Rashna Madan, Alfredo A. Molinolo, Mary A. Markiewicz, Prabhakar Chalise, Margaret L. Axelrod, Justin M. Balko, Kent W. Hunter, Zachary C. Hartman, Carol A. Lange, Christy R. Hagan
Summary: Clinical studies have linked the use of progestins, synthetic progesterone, to an increased risk of breast cancer. However, the specific role of native progesterone signaling through the progesterone receptor in breast tumor formation remains poorly understood. Research suggests that progesterone can repress certain immune signaling pathways, potentially promoting tumor development in the mammary gland. This study investigated the effects of progesterone on immune cell populations in mouse mammary glands, as well as the impact of progesterone receptor overexpression on tumor formation and immune cell populations. The findings indicate that progesterone treatment and progesterone receptor overexpression are associated with inhibited immune responses, decreased immune cell populations, and an increased risk of mammary gland tumor development in mice.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Fatemeh Ahmadi, Fredrik Junghus, Christian Ashworth, Amanda Lappalainen, Urs Morbe, Knut Kotarsky, William W. Agace
Summary: This study reveals that the post-weaning accumulation of Th1 cells in the intestine, which is microbiota-dependent, requires the expression of MHC-II and IL-27 by cDC1 cells. IL-27 derived from cDC1 cells plays a crucial role in maintaining the balance between Th1 and Th17 cells in the small intestinal lamina propria.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Immunology
Renyi Ding, Anjun Jiao, Baojun Zhang
Summary: This article summarizes the prospects and role of therapeutic methods targeting T cells in patients with hematologic malignancies. Studies have found that Toll-like receptors (TLRs) play an important role in T cell-mediated anti-tumor immunity. The article discusses the potential of combining TLR agonists with other treatment methods.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Jeffrey Downey, Haley E. Randolph, Erwan Pernet, Kim A. Tran, Shabaana A. Khader, Irah L. King, Luis B. Barreiro, Maziar Divangahi
Summary: This study demonstrates the role of mitochondrial cyclophilin D (CypD) in disease tolerance during influenza A virus (IAV) infection. CypD(-/-) mice are more susceptible to IAV infection due to damage to the lung epithelial barrier and reduced IL-22 production by NK cells. Administration of recombinant IL-22 or transfer of wild-type NK cells protects CypD(-/-) mice from pulmonary damage after IAV infection.
Article
Immunology
Jingjing Qi, Jiaqing Liu, Xiangge Zhao, Huina Huang, Yawei Tang, Xia Li
Summary: Our study found that IL-27 can promote B cell dysfunction in rheumatoid arthritis by activating the mTOR signaling pathway. The study aimed to explore the effects of IL-27 on B cell metabolism and clarify the mechanisms by which IL-27 enhances glycolysis to induce B cell hyperactivation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Liang Han, Zhe Chen, Kun Yu, Jiahui Yan, Tingting Li, Xin Ba, Weiji Lin, Yao Huang, Pan Shen, Ying Huang, Kai Qin, Yinhong Geng, Yafei Liu, Yu Wang, Shenghao Tu
Summary: IL-27 plays an important role in regulating inflammatory responses, but its function in rheumatoid arthritis (RA) is still debated. IL-27 can modulate the development of RA through various mechanisms, but its specific role in RA treatment requires further research.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Feiyu Fu, Zhenyu Lin, Yanlin Li, Jie Wang, Yawen Li, Pengcheng Liu, Zhaofei Wang, Jingjiao Ma, Yaxian Yan, Jianhe Sun, Yuqiang Cheng
Summary: This study cloned and analyzed the molecular characteristics of goose STING (GoSTING). The results showed that GoSTING plays a crucial role in the regulation of RNA virus replication and is a key component of the innate immune defense in geese.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Patrick Haider, Julia B. Kral-Pointner, Manuel Salzmann, Florian Moik, Sonja Bleichert, Waltraud C. Schrottmaier, Christoph Kaun, Mira Brekalo, Michael B. Fischer, Walter S. Speidl, Christian Hengstenberg, Bruno K. Podesser, Kurt Huber, Ingrid Pabinger, Sylvia Knapp, Frank Brombacher, Christine Brostjan, Cihan Ay, Johann Wojta, Philipp J. Hohensinner
Summary: IL-4R alpha plays a homeostatic role in regulating the lifespan of monocytes, and its absence leads to a reduction in monocyte numbers and affects the occurrence of inflammatory responses.
Article
Immunology
Emily S. Cribas, Joshua E. Denny, Jeffrey R. Maslanka, Michael C. Abt
Summary: The study reveals that sustained intestinal immune activation can enhance IL-22-dependent host defense mechanisms to limit the pathogenesis of C. difficile.
INFECTION AND IMMUNITY
(2021)
Review
Immunology
Monica Parodi, Simonetta Astigiano, Paolo Carrega, Gabriella Pietra, Chiara Vitale, Laura Damele, Melania Grottoli, Maria de la Luz Guevara Lopez, Riccardo Ferracini, Giulia Bertolini, Ilaria Roato, Massimo Vitale, Paola Orecchia
Summary: Since the first studies, mouse models have played a crucial role in understanding NK cells, their development, function, and behavior in normal and tumor tissues. Initially used to study murine NK cells, more sophisticated human-in-mice models have been developed to investigate human NK cells and minimize murine interference. This review provides an overview of the different models used to study NK cells, with a focus on the popular NOG and NSG models, which are used for human-in-mice tumor models, studying transferred human NK cells, and evaluating enhancers of human NK cell function.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Nicolas Cuburu, Lukasz Bialkowski, Sergio M. Pontejo, Shiv K. Sethi, Alexander T. F. Bell, Rina Kim, Cynthia D. Thompson, Douglas R. Lowy, John T. Schiller
Summary: Tumor infiltration by T cells plays a significant role in cancer progression and immunotherapy. This study explores the use of intratumoral injection of virus-derived peptide epitopes to activate preexisting antiviral T cell responses and promote antitumor responses or antigen spreading. The results show that this approach can act as a standalone therapy to control tumor growth and induce long-term antitumor immunity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Yoichi Takimoto, Po-sung Chu, Nobuhiro Nakamoto, Yuya Hagihara, Yohei Mikami, Kentar Miyamoto, Rei Morikawa, Toshiaki Teratani, Nobuhito Taniki, Sota Fujimori, Takahiro Suzuki, Yuzo Koda, Rino Ishihara, Masataka Ichikawa, Akira Honda, Takanori Kanai
Summary: The resolution process of liver fibrosis after liver injury withdrawal is still not fully understood. In this study, the pro-fibrogenic role of Toll-like receptor 4 (TLR4) signaling in tissue fibroblasts was explored. Interestingly, pharmacological inhibition of TLR4 signaling in vivo in two murine models resulted in a significant delay in fibrosis resolution. Single-cell transcriptome analysis revealed a cluster of Tlr4-expressing myeloid cells that played a restorative role in the resolution process. Further investigation suggested a microbiome-dependent nature of the delayed resolution after gut sterilization. These findings provide insights into the pro-fibrolytic role of myeloid TLR4 signaling and potential targets for anti-fibrotic therapy.
Article
Biochemistry & Molecular Biology
Rushika C. Wirasinha
Summary: With the COVID-19 pandemic shedding light on the crucial role of science in informing policy decisions, Rushika Wirasinha, PhD, discusses the career path of science policy available to academic researchers.
DNA AND CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aina Akmal Mohd Noor, Maryam Azlan, Norhanani Mohd Redzwan
Summary: Psoriasis is an autoimmune disease mediated by disturbed T cells and other immune cells. The use of biologics to target specific immune components is the most advanced therapy for psoriasis. By inhibiting pro-inflammatory cytokines, cellular signaling can be altered to alleviate cellular inflammation.
Correction
Cell Biology
Sarah B. Crist, Travis Nemkov, Ruth F. Dumpit, Jinxiang Dai, Stephen J. Tapscott, Lawrence D. True, Alexander Swarbrick, Lucas B. Sullivan, Peter S. Nelson, Kirk C. Hansen, Cyrus M. Ghajar
NATURE CELL BIOLOGY
(2022)
Article
Cell Biology
Sarah B. Crist, Travis Nemkov, Ruth F. Dumpit, Jinxiang Dai, Stephen J. Tapscott, Lawrence D. True, Alexander Swarbrick, Lucas B. Sullivan, Peter S. Nelson, Kirk C. Hansen, Cyrus M. Ghajar
Summary: This study reveals that skeletal muscle imposes oxidative stress on disseminated tumour cells (DTCs), which inhibits their proliferation and prevents metastatic colonization. The findings suggest new vulnerabilities of DTCs that can be targeted to prevent metastasis in susceptible tissues.
NATURE CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexandra R. Dvorscek, Craig McKenzie, Marcus J. Robinson, Zhoujie Ding, Catherine Pitt, Kristy O'Donnell, Dimitra Zotos, Robert Brink, David M. Tarlinton, Isaak Quast
Summary: IL-21 acts as a key regulator in the initial B cell response, accelerating cell cycle progression and fueling cyclic re-entry of B cells, thereby promoting plasma cell differentiation.
Editorial Material
Genetics & Heredity
Daniel Roden, Alexander Swarbrick
Summary: A new study systematically characterizes the recurrent gene-expression programs controlling neoplastic cell states in various cancers using single-cell and spatial transcriptomics.
Editorial Material
Oncology
Ana C. Anderson, Itai Yanai, Lucy R. Yates, Linghua Wang, Alexander Swarbrick, Peter Sorger, Sandro Santagata, Wolf H. Fridman, Qiang Gao, Livnat Jerby, Benjamin Izar, Lulu Shang, Xiang Zhou
Article
Immunology
Simona Ceglia, Alyssa Berthelette, Kelsey Howley, Yun Li, Benedikt Mortzfeld, Shakti K. Bhattarai, Nicole K. H. Yiew, Ying Xu, Robert Brink, Jason G. Cyster, Lora V. Hooper, Gwendalyn J. Randolph, Vanni Bucci, Andrea Reboldi
Summary: Research shows that high-cholesterol diets can influence IgA secretion. Cholesterol-derived metabolites affect the positioning of IgA(+) plasma cells and suppress antibody responses to intestinal pathogens by acting on GPR183 receptors.
Article
Biochemistry & Molecular Biology
Abigail K. Grootveld, Wunna Kyaw, Veera Panova, Angelica W. Y. Lau, Emily Ashwin, Guillaume Seuzaret, Rama Dhenni, Nayan Deger Bhattacharyya, Weng Hua Khoo, Mate Biro, Tanmay Mitra, Michael Meyer-Hermann, Patrick Bertolino, Masato Tanaka, David A. Hume, Peter I. Croucher, Robert Brink, Akira Nguyen, Oliver Bannard, Tri Giang Phan
Summary: Germinal centers (GCs) in lymphoid follicles during antibody responses are areas of extensive cell death. Tingible body macrophages (TBMs) derived from lymph node-resident, CD169-lineage, CSF1R-blockade-resistant precursor. Non-migratory TBMs use cytoplasmic processes to capture migrating dead cell fragments using a lazysearch strategy. Follicular macrophages can mature into TBMs in the absence of GCs and activated by the nearby apoptotic cells. Single-cell transcriptomics analysis identified upregulated genes related to apoptotic cell clearance in TBMs, which prevent autoimmune diseases.
Article
Immunology
Michela Frascoli, Enxhi Ferraj, Bing Miu, Justin Malin, Nicholas A. Spidale, Jennifer Cowan, Susannah C. Shissler, Robert Brink, Ying Xu, Jason G. Cyster, Avinash Bhandoola, Joonsoo Kang, Andrea Reboldi
Summary: Dietary components and metabolites greatly influence immunity and inflammation. This study focuses on how cholesterol metabolite oxysterols sensed by y8 T cells impact their tissue residency and function. The findings suggest that oxysterols sensing through G protein receptor 183 (GPR183) is essential for the development and inflammatory responses of dermal IL-17-producing y8 T (Ty817) cells, which are crucial for skin-barrier homeostasis.
Article
Immunology
Etienne Masle-Farquhar, Yogesh Jeelall, Jacqueline White, Julia Bier, Elissa K. Deenick, Robert Brink, Keisuke Horikawa, Christopher Carl Goodnow
Summary: This study investigated the effects of CARD11 gene mutations on B and T lymphocytes in a disease associated with B cell expansion and T cell anergy, as well as in certain lymphomas. The results showed that the mutations increased the activation and proliferation of B and T lymphocytes following antigen receptor stimulation, and led to increased expression of checkpoint molecules on T cells. This study reveals CARD11 as an important positive regulator of T cells and highlights the cell-intrinsic effects of CARD11 mutations on T cell malignancies.
FRONTIERS IN IMMUNOLOGY
(2023)
Meeting Abstract
Immunology
Julia Bier, Robert Brink, Stuart Tangye, Elissa K. Deenick
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
Elissa Deenick, Anthony Lau, Tina Nguyen, Julia Bier, Robert Brink, Stuart Tangye
JOURNAL OF IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Marcia A. Munoz, Oliver P. Skinner, Etienne Masle-Farquhar, Julie Jurczyluk, Ya Xiao, Emma K. Fletcher, Esther Kristianto, Mark P. Hodson, Sean I. O'Donoghue, Sandeep Kaur, Robert Brink, David G. Zahra, Elissa K. Deenick, Kristen A. Perry, Avril A. B. Robertson, Sam Mehr, Pravin Hissaria, Catharina M. Mulders-Manders, Anna Simon, Michael J. Rogers
Summary: Research described genetically modified mice with specific mutations related to Mevalonate kinase deficiency, which replicated the biochemical phenotype of MKD, and found that elevated body temperature may be a trigger of inflammatory flares.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Niantao Deng, Andre Minoche, Kate Harvey, Meng Li, Juliane Winkler, Andrei Goga, Alex Swarbrick
Summary: In this study, deep whole genome sequencing was conducted on commonly used breast cancer cell lines and patient-derived xenograft models, leading to the identification of novel genomic alterations and features. This provides a comprehensive genome sequencing resource for these models.
BREAST CANCER RESEARCH
(2022)
