Tanshinone IIA Inhibits Hypoxia-Induced Pulmonary Artery Smooth Muscle Cell Proliferation via Akt/Skp2/p27-Associated Pathway

Tanshinone IIA: A Promising Natural Cardioprotective Agent

(2012) Qinghua Shang et al.   Evidence-based Complementary and Alternative Medicine

Tanshinone IIA Inhibits Angiotensin II-Induced Cell Proliferation in Rat Cardiac Fibroblasts

(2011) Paul Chan et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro

(2011) Yi Zhang et al.   ANTI-CANCER DRUGS

Cardiovascular actions and therapeutic potential of tanshinone IIA

(2011) Si Gao et al.   ATHEROSCLEROSIS

Pulmonary Hypertension in COPD: Pathophysiology and Therapeutic Targets

(2011) E. Zakynthinos et al.   CURRENT DRUG TARGETS

Tanshinone IIA activates calcium-dependent apoptosis signaling pathway in human hepatoma cells

(2011) Zhi-Kai Dai et al.   Journal of Natural Medicines

Activation of p53 Signaling and Inhibition of Androgen Receptor Mediate Tanshinone IIA Induced G1 Arrest in LNCaP Prostate Cancer Cells

(2011) Suk-Hyun Won et al.   PHYTOTHERAPY RESEARCH

Tanshinone IIA attenuates angiotensin II-induced apoptosis via Akt pathway in neonatal rat cardiomyocytes

(2010) Hong-jye Hong et al.   ACTA PHARMACOLOGICA SINICA

Deficiency of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 accelerates atherogenesis in apolipoprotein E-deficient mice

(2010) Levent M. Akyürek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tanshinone IIA Induces Mitochondria Dependent Apoptosis in Prostate Cancer Cells in Association with an Inhibition of Phosphoinositide 3-Kinase/AKT Pathway

(2010) Suk-Hyun Won et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Tanshinone IIA modulates pulmonary vascular response to agonist and hypoxia primarily via inhibiting Ca2+ influx and release in normal and hypoxic pulmonary hypertension rats

(2010) Jing Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inverse correlation between Skp2 and p27Kip1in normal endometrium and endometrial carcinoma

(2010) Tsutomu Miyamoto et al.   GYNECOLOGICAL ENDOCRINOLOGY

Thrombin Induces Tumor Cell Cycle Activation and Spontaneous Growth by Down-regulation of p27Kip1, in Association with the Up-regulation of Skp2 and MiR-222

(2009) L. Hu et al.   CANCER RESEARCH

Effects of sodium tanshinone II A sulphonate on hypoxic pulmonary hypertension in rats in vivo and on Kv2.1 expression in pulmonary artery smooth muscle cells in vitro

(2009) Yu-fang Huang et al.   JOURNAL OF ETHNOPHARMACOLOGY

S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo

(2009) Yih-Jer Wu et al.   JOURNAL OF VASCULAR SURGERY

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

(2009) Hui-Kuan Lin et al.   NATURE CELL BIOLOGY

Post-translational regulation of the tumor suppressor p27KIP1

(2008) J. Vervoorts et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest

(2008) Lingli Zhou et al.   LIFE SCIENCES

Tanshinone IIA fromSalvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway

(2007) Un-Ho Jin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY