Review
Cell Biology
Brianna N. Rogers, Jacqueline M. Stephens, Jenny L. Sones
Summary: Preeclampsia (PE) in pregnant women may be associated with obesity, leukocytosis, and impaired placental development. The use of rodent models can help to better understand the pathogenesis of PE.
PHYSIOLOGICAL GENOMICS
(2022)
Article
Peripheral Vascular Disease
Zhiyin Wang, Dan Liu, Yimin Dai, Ruotian Li, Yaowu Zheng, Guangfeng Zhao, Jingmei Wang, Zhenyu Diao, Chenrui Cao, Haining Lv, Ning Gu, Hang Zhou, Hailin Ding, Jie Li, Xiangyu Zhu, Honglei Duan, Li Shen, Qun Zhang, Jing Chen, Huilian Hu, Xiaoyan Wang, Mingming Zheng, Yan Zhou, Yali Hu
Summary: It has been found that placental miR-155 levels are elevated in preeclamptic patients. This study aims to investigate the characteristics of patients with high levels of miR-155. The preeclamptic patients were divided into a high miR-155 group (>= P95) and a normal miR-155 group based on the 95th percentile (P95) of miR-155 in controls.
Review
Biotechnology & Applied Microbiology
Andja Cirkovic, Dejana Stanisavljevic, Jelena Milin-Lazovic, Nina Rajovic, Vedrana Pavlovic, Ognjen Milicevic, Marko Savic, Jelena Kostic Peric, Natasa Aleksic, Nikola Milic, Tamara Stanisavljevic, Zeljko Mikovic, Vesna Garovic, Natasa Milic
Summary: This study conducted a systematic review and meta-analysis to investigate the disrupted miRNA expression in women with preeclampsia (PE) compared to those without PE. The results indicated significant differences in expression levels of certain miRNAs in placenta and peripheral blood of women with PE, suggesting the important role of miRNAs in the pathophysiology of PE.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Sophia Indira Romberg, Nina-Naomi Kreis, Alexandra Friemel, Susanne Roth, Alice Steglich Souto, Samira Catharina Hoock, Kyra Fischer, Thorsten Nowak, Christine Solbach, Frank Louwen, Andreas Ritter, Juping Yuan
Summary: This study found that the functionality of hCV-MSCs is dependent on primary cilia and that primary cilia are impaired in hCV-MSCs from preeclamptic placentas.
Article
Developmental Biology
C. Perera, S. Zheng, M. I. Kokkinos, H. M. Georgiou, M. Schoppet, P. F. James, S. P. Brennecke, B. Kalionis
Summary: In preeclampsia, the presence of PE-DMSCs in the vascular niche contributes to endothelial cell dysfunction due to increased release of ENG. Conversely, in normotensive pregnancies, DMSC secretion of ENG likely has a beneficial effect on endothelial cells.
Article
Biochemistry & Molecular Biology
Elizabeth S. Taglauer, Angeles Fernandez-Gonzalez, Gareth R. Willis, Monica Reis, Vincent Yeung, Xianlan Liu, Lawrence S. Prince, S. Alex Mitsialis, Stella Kourembanas
Summary: Preeclamptic pregnancies can negatively impact fetal lung development, but treatment with MEx administered to the mother can improve inflammatory mediator expression, normalize fetal lung development, and prevent lung developmental abnormalities.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Reproductive Biology
Elizabeth S. Taglauer, Angeles Fernandez-Gonzalez, Gareth R. Willis, Monica Reis, Vincent Yeung, Xianlan Liu, S. Alex Mitsialis, Stella Kourembanas
Summary: The study investigates the therapeutic potential of MEx in improving preeclamptic disease, demonstrating through experiments that MEx have the ability to optimize the intrauterine immune environment and prevent maternal and fetal complications of preeclampsia.
BIOLOGY OF REPRODUCTION
(2021)
Article
Cell Biology
Colleen G. Julian, Julie A. Houck, Sahand Fallahi, Litzi Lazo-Vega, Christopher J. Matarazzo, Breea Diamond, Valquiria Miranda-Garrido, Bernardo J. Krause, Lorna G. Moore, Jonathan A. Shortt, Lilian Toledo-Jaldin, Ramon A. Lorca
Summary: Residing at high altitudes increases the risk of pregnancy vascular disorders. Genetic attributes of highland ancestry protect against these disorders. In high-altitude preeclamptic placentas, certain ion-channel genes are downregulated while others are upregulated.
PHYSIOLOGICAL GENOMICS
(2023)
Article
Chemistry, Multidisciplinary
Mohammadrahim Kazemzadeh, Miguel Martinez-Calderon, Song Y. Paek, MoiMoi Lowe, Claude Aguergaray, Weiliang Xu, Lawrence W. Chamley, Neil G. R. Broderick, Colin L. Hisey
Summary: Placental extracellular vesicles (EVs) play important roles in pregnancy, but they are also implicated in the progression of preeclampsia. A fabrication process called laser-induced nano-structuring of SERS-active thin films (LINST) was developed to produce substrates that allow the biochemical fingerprinting of EVs. The findings encourage the exploration of surface-enhanced Raman spectroscopy (SERS) of EVs as a promising method for preeclampsia liquid biopsies.
Article
Developmental Biology
Johanne Johnsen Rakner, Gabriela Brettas Silva, Siv Boon Mundal, Astrid Josefin Thaning, Mattijs Elschot, Jenny Ostrop, Liv Cecilie Vestrheim Thomsen, Line Bjorge, Lobke Marijn Gierman, Ann-Charlotte Iversen
Summary: Inflammation in preeclampsia affects the interaction between maternal immune cells and fetal trophoblasts, with the pattern recognition receptor nucleotide-binding oligomerization domain-containing protein (NOD)1 playing a significant role. It was found that in preeclamptic pregnancies, there is an increase in NOD1 expression density, and strong expression of NOD1 is associated with trophoblast types.
Review
Pharmacology & Pharmacy
Yang Zhang, Yanqi Zhong, Li Zou, Xiaoxia Liu
Summary: Well-developed placenta plays a fundamental role in successful pregnancy, while defective placental development is the underlying cause of preeclampsia. Placenta-derived mesenchymal stem cells (PMSCs) have the ability to differentiate into vessel wall cells and improve placental vasculature, artery remodeling, and immunoregulation. Recent studies have shown that preeclamptic PMSCs disrupt the balance and development in the placenta. However, transplantation or exosome therapies of PMSCs tend to improve placental vascular network and trophoblastic functions, suggesting a potential therapeutic strategy for preeclampsia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maja Gajic, Bianca Schroeder-Heurich, Monika Horvat Mercnik, Mila Cervar-Zivkovic, Christian Wadsack, Frauke von Versen-Hoeynck, Karoline Mayer-Pickel
Summary: This study isolated arterial feto-placental endothelial cells from control and preeclamptic placentas to investigate the potential protective effects of hydroxychloroquine (HCQ) in an in vitro model of endothelial activation. The results showed that HCQ did not adversely affect wound healing and endothelial barrier integrity, and it had a slight regulatory effect on IL-8 and VCAM-1 gene expression in the presence of inflammation. These findings support the safety of HCQ and highlight the need for clinical trials to evaluate its therapeutic effects in preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Manon Jammes, Romain Contentin, Fabrice Audigie, Frederic Casse, Philippe Galera
Summary: This study tested the effects of different storage conditions on the secretome of mesenchymal stromal cells (MSCs) and investigated the enhancement of MSC secretome properties through cytokine priming. The results showed that secretome stored at -80°C, -20°C, and 4°C improved collagen protein accumulation, cell proliferation, and inflammation reduction in chondrocytes. Cytokine priming had different effects on the expression of immunomodulatory molecules and influenced the behavior of equine articular chondrocytes (eACs). These findings demonstrate the potential of MSC-conditioned media for improving the management of equine osteoarthritis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Karin Engstroem, Yumjirmaa Mandakh, Lana Garmire, Zahra Masoumi, Christina Isaxon, Ebba Malmqvist, Lena Erlandsson, Stefan R. Hansson
Summary: Exposure to ambient nitrogen oxides during early pregnancy influences DNA methylation in placentas of preeclampsia cases, leading to placental immaturity and showing sexual dimorphism. No differentially expressed genes were found in this study.
Article
Pharmacology & Pharmacy
Salwa A. Abuiessa, Mai M. Helmy, Hanan M. El-Gowelli, Sahar M. El-Gowilly, Mahmoud M. El-Mas
Summary: Gestational modulation of renin-angiotensin system (RAS) components can alleviate cardiovascular hyperresponsiveness of weaning preeclamptic (PE) mothers to postpartum endotoxemia, reducing gestational systolic blood pressure and proteinuria. Pioglitazone and Ang 1-7 are more effective in reversing cardiac dysfunction.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Andrea Iannello, Simona Rolla, Alessandro Maglione, Giulio Ferrero, Valentina Bardina, Ilenia Inaudi, Stefania De Mercanti, Francesco Novelli, Lucrezia D'Antuono, Simona Cardaropoli, Tullia Todros, Maria Vittoria Turrini, Cinzia Cordioli, Giorgia Puorro, Angela Marsili, Roberta Lanzillo, Vincenzo Brescia Morra, Francesca Cordero, Michele De Bortoli, Luca Durelli, Andrea Visconti, Santina Cutrupi, Marinella Clerico
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Neurosciences
Catherine E. Aiken, Jane L. Tarry-Adkins, Ana-Mishel Spiroski, Anna M. Nuzzo, Thomas J. Ashmore, Alessandro Rolfe, Megan J. Sutherland, Emily J. Camm, Dino A. Giussani, Susan E. Ozanne
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Genetics & Heredity
Andrea Gazzin, Diana Carli, Fabio Sirchia, Cristina Molinatto, Simona Cardaropoli, Giuseppe Palumbo, Giuseppe Zampino, Giovanni Battista Ferrero, Alessandro Mussa
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2019)
Review
Nutrition & Dietetics
Alessandro Rolfo, Anna Maria Nuzzo, Ramona De Amicis, Laura Moretti, Simona Bertoli, Alessandro Leone
Review
Biochemistry & Molecular Biology
Tullia Todros, Luana Paulesu, Simona Cardaropoli, Alessandro Rolfo, Bianca Masturzo, Leonardo Ermini, Roberta Romagnoli, Francesca Ietta
Summary: This review focuses on the role of proinflammatory cytokines in pregnancy, particularly macrophage migration inhibitory factor (MIF), and suggests that low MIF production in early pregnancy may contribute to abnormal placental development, leading to placental hypoxia and high MIF release in later pregnancy, which are associated with pre-eclampsia. Further studies are needed to clarify the role of MIF in maternal pre-eclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Stefano Cosma, Andrea Roberto Carosso, Fulvio Borella, Jessica Cusato, Marialuisa Bovetti, Federica Bevilacqua, Marco Carosso, Fiammetta Gervasoni, Andrea Sciarrone, Luca Marozio, Alberto Revelli, Alessandro Rolfo, Claudia Filippini, Valeria Ghisetti, Giovanni Di Perri, Chiara Benedetto
Summary: This study found that asymptomatic or mildly symptomatic SARS-CoV-2 infection during the first trimester of pregnancy did not predispose affected women to more fetal anomalies than unaffected women, and COVID-19 had a favorable maternal course at the beginning of pregnancy in the healthy cohort.
Article
Biochemistry & Molecular Biology
Leonardo Ermini, Anna Maria Nuzzo, Francesca Ietta, Roberta Romagnoli, Laura Moretti, Bianca Masturzo, Luana Paulesu, Alessandro Rolfo
Summary: This study examined the expression of GLUT1 and GLUT4 in placental tissue from overweight (OW) and normal weight (NW) pregnant women, revealing different responses to BPA. While GLUT1 expression increased in NW mothers and decreased in OW mothers, GLUT4 expression was lower in OW mothers. Placental biopsies showed no difference between OW and NW in terms of transporter expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anna Maria Nuzzo, Laura Moretti, Paolo Mele, Tullia Todros, Carola Eva, Alessandro Rolfo
Summary: The conditioned media derived from human placenta-derived mesenchymal stromal cells (hPDMSCs) has shown pro-angiogenic and anti-inflammatory effects on a mouse model of preeclampsia, a severe pregnancy-related syndrome characterized by hypertension, proteinuria, inflammation, and fetal growth restriction. It was found that the hPDMSCs-derived conditioned media could reverse the preeclampsia-like features, including reducing maternal blood pressure, proteinuria, and levels of inflammatory markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Giulia Parpinel, Gianluca Rosso, Arianna Galante, Chiara Germano, Elena Aragno, Flavia Girlando, Alessandro Messina, Maria Elena Laudani, Alessandro Rolfo, Rossella Attini, Alberto Revelli, Giuseppe Maina, Bianca Masturzo
Summary: Depressive disorders in pregnant women lead to poorer outcomes, including higher rates of cesarean section, preterm delivery, induction of labor, low neonatal weights, and lower 5-min APGAR scores. Pharmacotherapy reduces the rate of cesarean section, but does not affect the 5-min APGAR scores, which are associated with neonatal weight.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Alessandro Rolfo, Stefano Cosma, Anna Maria Nuzzo, Chiara Salio, Laura Moretti, Marco Sassoe-Pognetto, Andrea Roberto Carosso, Fulvio Borella, Juan Carlos Cutrin, Chiara Benedetto
Summary: This study observed oxidative stress and mitochondrial pathological changes in the placenta of pregnant women with SARS-CoV-2 infection during the third trimester, but the pregnant women maintained a good physiological state. This suggests that the placenta has a certain inhibitory effect on oxidative stress during SARS-CoV-2 infection.
Article
Biochemistry & Molecular Biology
Luca Marozio, Anna Maria Nuzzo, Eugenio Gullo, Laura Moretti, Emilie M. Canuto, Annalisa Tancredi, Margherita Goia, Stefano Cosma, Alberto Revelli, Alessandro Rolfo, Chiara Benedetto
Summary: Recurrent Pregnancy Loss (RPL) refers to two or more miscarriages before 20 weeks gestation. The cause of RPL remains unexplained in more than 50% of cases, but abnormal immune activity during placentation is believed to be a possible cause. This study analyzed gene expression and protein levels of immune checkpoints in the endometrium of women with RPL and found defective immune regulation and overactivation of immune response compared to controls with dysfunctional uterine bleeding and normal reproductive history.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)