Article
Dentistry, Oral Surgery & Medicine
Doris H. Rosero-Salazar, Paola L. Carvajal-Monroy, Frank A. D. T. G. Wagener, Johannes W. Von den Hoff
Summary: This study aimed to analyze the function of palatal muscles in vivo by real-time wireless electromyography in rats. The results showed impaired palatal function after wounding, providing valuable insights for improving soft palate function in patients in the future.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Doris H. Rosero Salazar, Rene E. M. van Rheden, Manon van Hulzen, Paola L. Carvajal Monroy, Frank A. D. T. G. Wagener, Johannes W. Von den Hoff
Summary: The study demonstrated that implanting fibrin constructs enhanced with laminin-nidogen in wounded rat soft palates can reduce fibrosis and improve muscle regeneration. This promising strategy may enhance cleft soft palate repair and other severe muscle injuries.
Article
Chemistry, Multidisciplinary
Bin Luo, Qiangqiang Zhou, Wenyi Chen, Lijie Sun, Lei Yang, Yifan Guo, Huijie Liu, Zekai Wu, Rasoul Esmaeely Neisiany, Xiaohong Qin, Jie Pan, Zhengwei You
Summary: In this study, we proposed a general strategy to facilitate tissue repair by modulating endogenous electric fields using nonadjacent wireless electrotherapy. We developed a 3D printed entirely soft and bioresorbable triboelectric nanogenerator-based stimulator which has biomimetic mechanical properties similar to those of soft tissue. The feasibility of constructing an electrical double layer with tissue for nonadjacent wireless electrotherapy was demonstrated and significant improvements in tissue repair were observed in the treated groups compared to the control group.
Article
Biology
Xia Han, Jifan Feng, Tingwei Guo, Yong-Hwee Eddie Loh, Yuan Yuan, Thach-Vu Ho, Courtney Kyeong Cho, Jingyuan Li, Junjun Jing, Eva Janeckova, Jinzhi He, Fei Pei, Jing Bi, Brian Song, Yang Chai
Summary: This translation describes the important role of cranial neural crest cells in craniofacial muscle development, revealing the crucial roles of Runx2 and Twist1 in regulating the fate of CNC-derived cells.
Article
Cell & Tissue Engineering
R. El-Habta, G. Andersson, P. J. Kingham, L. J. Backman
Summary: This study investigates the effects of stromal vascular fraction (SVF) on muscle cell apoptosis following denervation. Results show that SVF can significantly reduce apoptosis in denervated muscles, both in vitro and in vivo, thereby preserving muscle tissue and potentially providing therapeutic benefits for muscle nerve injuries.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Dermatology
Pin Ha, Timothy P. Liu, Chenshuang Li, Zhong Zheng
Summary: Orofacial structures play a crucial role in speech and eating, but regeneration in this region is challenging due to its unique cell populations, tissue architecture, and healing microenvironments. Recent advances have led to the development of novel strategies and technologies that specifically target orofacial soft tissue regeneration.
ADVANCES IN WOUND CARE
(2023)
Article
Robotics
R. S. Diteesawat, T. Helps, M. Taghavi, J. Rossiter
Summary: The study introduces a lightweight, flexible electro-pneumatic pump (EPP) that provides portable, local energy for soft robots, overcoming the limitations of existing pneumatic power sources. Experimental results show that the EPP has high pressure and volumetric flow rates, and can drive various physical devices of soft robots.
Article
Biotechnology & Applied Microbiology
Peng Li, Marco Laudato, Mihai Mihaescu
Summary: Obstructive Sleep Apnea Syndrome is a common sleep-related disorder, and increasing respiratory flow rate leads to larger structural deformation.
BIOENGINEERING-BASEL
(2023)
Article
Biology
Anirban Roy, Meiricris Tomaz da Silva, Raksha Bhat, Kyle R. Bohnert, Takao Iwawaki, Ashok Kumar
Summary: IRE1 alpha, along with its downstream target XBP1, play a crucial role in regulating skeletal muscle regeneration by promoting proliferation of satellite cells. The ablation of IRE1 alpha diminishes Notch signaling and canonical NF-kappa B pathway, leading to reduced satellite cell abundance and impaired muscle regeneration in both normal and Duchenne muscular dystrophy models.
Review
Biochemical Research Methods
Iman Roohani, Giselle C. Yeo, Suzanne M. Mithieux, Anthony S. Weiss
Summary: Human bones have a natural ability to regenerate, but for severe bone diseases or large defects, bone grafts or substitutes are needed. Tissue-engineered materials have limited regenerative capacity compared to native bone grafts, which is due to a lack of understanding of key events during bone healing and the inability to recreate the structure and composition of the target tissue. New strategies and advanced biomaterials have emerged to overcome this limitation.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rou Wan, Arif Hussain, Atta Behfar, Steven L. Moran, Chunfeng Zhao
Summary: Soft tissue defects resulting from trauma or tumor extirpation can be improved with regenerative strategies. Exosomes, as nanosized extracellular particles, have shown potential in promoting the healing process of tendons, skeletal muscles, and peripheral nerves through various mechanisms. They can be stored and produced cost-effectively, making them a promising tool in regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Katsuhiro Tokutake, Masaru Takeuchi, Shigeru Kurimoto, Sota Saeki, Yuta Asami, Keiko Onaka, Masaomi Saeki, Tadayoshi Aoyama, Yasuhisa Hasegawa, Hitoshi Hirata
Summary: This study proposes a novel therapeutic strategy for lower motor neuron disease and injury by integrating neural stem cell transplantation with a new functional electrical stimulation control system. The findings demonstrate that reinnervation of denervated muscles and achieving highly responsive limb movement is possible using this innovative technology. It has significant implications for improving the condition of patients with paralysis and traumatic injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eun Ju Lee, Sibhghatulla Shaikh, Khurshid Ahmad, Syed Sayeed Ahmad, Jeong Ho Lim, Soyoung Park, Hye Jin Yang, Won-Kyung Cho, Sang-Joon Park, Yong-Ho Lee, So-Young Park, Jin-Yeul Ma, Inho Choi
Summary: Research shows that the extract from G. uralensis can promote myoblast proliferation and differentiation, as well as enhance muscle regeneration after cardiotoxin-induced muscle injury. The active compounds in the extract have the potential to increase myoblast proliferation and differentiation, indicating a possible therapeutic effect for muscle-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Lisa Van Geneugden, Anna Verdonck, Guy Willems, Greet Hens, Maria Cadenas de Llano-Perula
Summary: This study compared the maximum oral muscle pressure in patients with and without cleft palate or unilateral cleft lip and palate, and investigated its influence on their dentoalveolar characteristics and the influence of functional habits. The results showed that tongue pressure was consistently greater than lip pressure in cleft patients, and a larger maxillary width was associated with higher imbalance scores favoring the tongue.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Simone Vumbaca, Giulio Giuliani, Valeria Fiorentini, Flavia Tortolici, Andrea Cerquone Perpetuini, Federica Riccio, Simona Sennato, Cesare Gargioli, Claudia Fuoco, Luisa Castagnoli, Gianni Cesareni
Summary: The study investigated changes in skeletal muscle secretome during regeneration process to identify potential regulatory circuits and cell-cell interactions. The analysis included profiling gene expression of various cell types and cytokines, and testing the modulation of adipogenesis and proliferation by selected cytokines. Furthermore, the study explored the interaction mediated by extracellular vesicles and their influences on cell fate during muscle regeneration.
Article
Dentistry, Oral Surgery & Medicine
Rami S. Kantar, Elcin Esenlik, Omar S. Al Abyad, Antonio Melhem, Robert A. Younan, Mario Haddad, Kristen Keith, Serena Kassam, Beyhan Annan, Charanya Vijayakumar, Arnaud Picard, Bonnie L. Padwa, Brian Sommerlad, Cassio Eduardo Raposo-Amaral, Christopher R. Forrest, David A. Gillett, Derek M. Steinbacher, Christopher M. Runyan, Daniela Y. S. Tanikawa, David K. Chong, David M. Fisher, Hans Mark, Halil Ibrahim Canter, Joseph E. Losee, Krishna G. Patel, Larry D. Hartzell, Adam B. Johnson, Marcus Vinicius Martins Collares, Nivaldo Alonso, Philip Kuo-Ting Chen, Raymond Tse, Robert J. Mann, Jose Rolando Prada-Madrid, Shinji Kobayashi, Syed Altaf Hussain, Ann Kummer, Debbie A. Sell, Valerie J. Pereira, Kelly Mabry, Courtney K. Gonsoulin, Martin Persson, Gareth Davies, Navil F. Sethna, Jennifer C. Munoz-Pareja, Anne Marie Kuijpers-Jagtman, Barry H. Grayson, Bruno Grollemund, Daniela G. Garib, Maria Costanza Meazzini, Om P. Kharbanda, Pedro E. Santiago, Prasad Nalabothu, Puneet Batra, Erin Stieber, Dushyant Prasad, Hugh Brewster, Ruben Ayala, Elif Erbay, M. Okan Akcam, J. Peter W. Don Griot, Raj M. Vyas, Roberto L. Flores, Corstiaan C. Breugem, Usama S. Hamdan
Summary: This study describes the first hybrid global simulation-based comprehensive cleft care workshop, evaluates its impact on participants, and compares the experiences of in-person and virtual attendance. The results show that the workshop was well received by participants and had a positive perceived impact on their clinical practices. In-person attendance was associated with higher satisfaction and perceived impact on practice.
CLEFT PALATE CRANIOFACIAL JOURNAL
(2023)
Article
Genetics & Heredity
Marijn Creton, Frank Wagener, Maarten Massink, Willem Fennis, Marjon Bloemen, Jan Schols, Miranda Aarts, Aebele Mink van der Molen, Gijs van Haaften, Marie Jose van den Boogaard
Summary: This study describes a girl with multiple craniofacial anomalies including cleft lip, alveolus, and palate, tooth agenesis, and dysmorphic features. Various genetic diagnostic tests were performed, including cleft gene panel analysis, SNP array, WGS, WES, and Q-PCR analysis. The results identified a maternal deletion at 16q24.1 encompassing the candidate gene USP10 and a de novo Loss-of-Function variant in the ZFHX4 gene. The mRNA expression of certain putative target genes involved in orofacial clefting was found to be lowered in the patient compared to controls, suggesting the involvement of ZFHX4 as a novel cleft gene and the potential contribution of USP10 to the etiology of orofacial clefts in humans.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Pharmacology & Pharmacy
Jyoti Kumari, Tirza Wubs, Arjan P. M. van Caam, Daphne N. Dorst, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: This study describes an in vitro 3D culture system using biocompatible polyisocyanide hydrogel and systemic sclerosis patient-derived fibroblasts. The system maintains the native phenotype and functionality of the primary cells and can be used to study fibrosis process.
ADVANCED THERAPEUTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Akhter Husain, Ewald M. Bronkhorst, Hari Kishore Bhat, Mette A. R. Kuijpers, Shafees Koya, Anne Marie Kuijpers-Jagtman
Summary: This study aimed to develop a simple pictorial chart for smile analysis and investigate its reliability and validity. The newly developed smile chart was found to be able to record essential smile parameters and can be helpful for diagnosis, treatment planning, and research.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2023)
Article
Biochemistry & Molecular Biology
Roel C. Op't Veld, Lieke Joosten, Peter Laverman, Ewald M. Bronkhorst, John A. Jansen, X. Frank Walboomers, Frank A. D. T. G. Wagener
Summary: Polyisocyanopeptide (PIC) hydrogels are proposed as promising wound dressings due to their thermo-sensitivity and easy removal. Evaluation on murine wounds showed that regular application and removal of PIC dressings resulted in smaller and less encapsulated wounds compared to the control treatment. The gel could be easily washed out of wounds with cold irrigation solution but personal technique influenced the outcome. No morphological damage related to the removal procedure was observed, indicating that PIC gels are atraumatic and perform similarly to currently used wound dressings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Mirrin J. Dorresteijn, Douwe Dekker, Jelle Zwaag, Suzanne Heemskerk, Hennie M. J. Roelofs, Paul Smits, Johannes G. van der Hoeven, Frank A. D. T. G. Wagener, Peter Pickkers
Summary: Inflammation-induced free radical release is important in the pathogenesis of several diseases. This study investigated the impact of atazanavir-induced hyperbilirubinemia on antioxidant capacity, inflammation, and vascular dysfunction in human experimental endotoxemia. The results showed that hyperbilirubinemia increased antioxidant capacity, attenuated interleukin-10 release, and prevented vascular hyporesponsiveness during systemic inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Hayo C. van der Helm, Arjan J. A. Dieters, Pieter U. Dijkstra, Wicher J. van der Meer, Anne Marie Kuijpers-Jagtman
Summary: In this study, the validity of the 4D-Jaw Motion module of the ProMax 3D Mid CBCT scanner was tested in vitro. However, the differences between the 4D-JM models and the gold standard exceeded the predefined standards.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Sophie T. Raterman, Johannes W. Von Den Hoff, Sietske Dijkstra, Cheyenne De Vriend, Tim Te Morsche, Sanne Broekman, Jan Zethof, Erik De Vrieze, Frank A. D. T. G. Wagener, Juriaan R. Metz
Summary: This study investigates the relationship between mutations in the FOXE1 gene and cleft palate and thyroid dysgenesis in zebrafish. A zebrafish mutant with a disruption in the nuclear localization signal of the foxe1 gene was generated to study skeletal development and thyroidogenesis. The mutant larvae showed abnormal skeletal phenotypes and reduced levels of Ca, Mg, and P, indicating the importance of foxe1 in early skeletal development. Additionally, differential expression of markers for bone and cartilage cells was observed in mutants.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jaap C. Maltha, Anne Marie Kuijpers-Jagtman
Summary: The purpose of this review is to provide an update on the changes at the cellular and tissue level during orthodontic force application. The understanding of the mechanobiology of the periodontal ligament and the alveolar bone is crucial for this process. Despite improved understanding of signaling mechanisms, it is largely unknown how mechanical stresses regulate cell differentiation into osteoblast and osteoclast lineages, which is important for advancing orthodontics.
JOURNAL OF THE WORLD FEDERATION OF ORTHODONTISTS
(2023)
Article
Medicine, General & Internal
Jennifer Kluge, Robin Bruggink, Nikolaos Pandis, Alexey Unkovskiy, Paul-Georg Jost-Brinkmann, Anne Marie Kuijpers-Jagtman, Theodosia Bartzela
Summary: This longitudinal study evaluated facial growth and soft tissue changes in infants with complete unilateral cleft lip, alveolus, and palate (CUCLAP) at ages 3, 9, and 12 months. The results showed significant growth in the entire face, particularly in the forehead, eyes, lower lip, chin, and cheeks, from 3 to 9 months. However, there was no significant growth from 9 to 12 months. Uneven growth was observed in the upper lip, philtrum, and nostrils throughout both intervals, with an overall decline in growth from 9 to 12 months.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Julia Leonhardt, Mirrin J. Dorresteijn, Sophie Neugebauer, Diana Mihaylov, Julia Kunze, Ignacio Rubio, Frank-Stephan Hohberger, Silke Leonhardt, Michael Kiehntopf, Klaus Stahl, Christian Bode, Sascha David, Frank A. D. T. G. Wagener, Peter Pickkers, Michael Bauer
Summary: The study found that circulating bile acids capable of inducing immunosuppression are present in septic shock patients, particularly in those with severe liver failure. Future research may need to explore whether modulating bile acid metabolism can improve the clinical course and outcome of sepsis in these patients.
Article
Dentistry, Oral Surgery & Medicine
Stephanie A. Meuffels, Anne Marie Kuijpers-Jagtman, Stephen T. H. Tjoa, Clarissa C. Bonifacio, Paola L. Carvajal Monroy
Summary: The complexity of malocclusion and the need for orthodontic treatment are significantly higher in children with autism spectrum disorder (ASD) compared to children without ASD. Furthermore, children with ASD have a higher prevalence of increased overjet and overbite.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
B. J. van Leeuwen, P. U. Dijkstra, J. A. Dieters, H. P. J. Verbeek, A. M. Kuijpers-Jagtman, Y. Ren
Summary: This study found that CBCT imaging can magnify the surface area of dehiscences in the anterior buccal region of the mandible, resulting in larger deviations, but cannot detect fenestrations.
CLINICAL ORAL INVESTIGATIONS
(2022)
Correction
Dentistry, Oral Surgery & Medicine
Maria Cadenas de Llano-Perula, Chen Zong, Jeroen Van Dessel, Anne Marie Kuijpers-Jagtman, Guy Willems
CLINICAL ORAL INVESTIGATIONS
(2022)
