Article
Multidisciplinary Sciences
Gozde Erturk Zararsiz, Serkan Bolat, Ahu Cephe, Necla Kochan, Serra Ilayda Yerlita, Halef Okan Dogan, Gokmen Zararsiz
Summary: Multiple studies have shown a high prevalence of dyslipidemia in children, emphasizing the importance of early recognition to prevent future coronary heart disease. Among the various equations for estimating LDL-C, the extended Martin-Hopkins formula was found to provide the most reliable results in a large pediatric population.
Review
Biochemistry & Molecular Biology
Chih-Kuo Lee, Che-Wei Liao, Shih-Wei Meng, Wei-Kai Wu, Jiun-Yang Chiang, Ming-Shiang Wu
Summary: Despite advancements in pharmacotherapy and intervention devices, residual cardiovascular risks remain a significant burden on public health. Molecular modifications of lipid and lipoprotein components play a critical role in atherogenicity, with levels of certain lipids and proteins closely associated with atherosclerotic cardiovascular disease. Therapies targeting these modifications are showing promising results in trials for reducing risks and enhancing cardiovascular health.
Article
Endocrinology & Metabolism
Faidon Magkos, Elisa Fabbrini, Bruce W. Patterson, Bettina Mittendorfer, Samuel Klein
Summary: This study aimed to investigate the influence of physiological variation in endogenous estradiol on VLDL-Triglyceride (TG) and VLDL-apoB-100 metabolism and free fatty acid (FFA) release in premenopausal women. The results showed that plasma estradiol concentration is not an important correlate of basal plasma FFA, VLDL-TG, and VLDL-apoB-100 kinetics in premenopausal women.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhen Wang, Xin Zhang, Yanling Qu, Shuyang Zhang, Yundai Chen, Xiaoping Chen, Xin Qi, Peijing Liu, Shuqin Liu, Shan Jiang, Ronghai Man, Liping He, Ling Wu, Zhanquan Li, Yijun Shang, Zhaohui Qiu, Feng Liu, Chenhong Xu, Chunlin Lai, Junbo Ge
Summary: This study assessed the safety and efficiency of IPE in treating very high TG levels in a Chinese population. Results showed that daily treatment with 4 g of IPE significantly reduced TG levels and other atherogenic lipids. LDL-C levels did not increase significantly compared to the placebo group.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Benjamin N. Wadstrom, Kasper M. Pedersen, Anders B. Wulff, Borge G. Nordestgaard
Summary: This study found that elevated remnant cholesterol and plasma triglycerides were associated with an increased mortality rate from cardiovascular and other causes, but not from cancer, according to data from the Copenhagen General Population Study. This novel finding should be confirmed in other cohorts.
EUROPEAN HEART JOURNAL
(2023)
Review
Medicine, General & Internal
Jun Watanabe, Masato Hamasaki, Kazuhiko Kotani
Summary: Eradication of Helicobacter pylori increases HDL-C levels and triglyceride levels, but does not significantly affect low-density lipoprotein-cholesterol levels. Further studies are needed to clarify the effects of lipid changes following H. pylori eradication on cardiovascular diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Enchen Zhou, Zhuang Li, Hiroyuki Nakashima, Ahlam Choukoud, Sander Kooijman, Jimmy F. P. Berbee, Patrick C. N. Rensen, Yanan Wang
Summary: Accelerating lipolytic processing of VLDL by brown fat activation can further lower (V)LDL levels and reduce the risk of atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jessica G. G. Woo, John T. T. Melchior, Debi K. K. Swertfeger, Alan T. T. Remaley, Ebrima A. A. Sise, Fatou Sosseh, Jeffrey A. A. Welge, Andrew M. M. Prentice, W. Sean Davidson, Sophie E. E. Moore, Laura A. A. Woollett
Summary: The study evaluated the impact of pregnancy on lipoprotein particle concentrations and compositions. It found that lipoprotein subfraction concentrations changed during gestation but were not associated with infant birth weights. Changes in the proteome of HDL were observed to support gestation.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Clinical Neurology
Anisa F. Khalfan, Susan C. Campisi, Ronda F. Lo, Brian W. McCrindle, Daphne J. Korczak
Summary: This study investigated whether adolescents with major depressive disorder (MDD) show evidence of dyslipidemia, and found that they had similar levels of dyslipidemia as healthy controls. The severity of depressive symptoms was associated with high density lipoprotein levels and triglyceride-to-HDL ratio.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Kathryn M. Spitler, Shwetha K. Shetty, Emily M. Cushing, Kelli L. Sylvers-Davie, Brandon S. J. Davies
Summary: Hepatocyte-specific loss of ANGPTL4 does not improve triglyceride phenotypes during high-fat feeding, but these mice show improved glucose tolerance after chronic high-fat diet. Additionally, Angptl4(LivKO) mice have decreased fasting plasma triglyceride levels after an 18-h fast, but not after a 6-h fast.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Nutrition & Dietetics
Ewa Wieczorek, Agnieszka Cwiklinska, Agnieszka Kuchta, Barbara Kortas-Stempak, Anna Gliwinska, Maciej Jankowski
Summary: This study aimed to evaluate the impact of hypercholesterolemia and hypertriglyceridemia on the efficiency of lipoprotein lipase-mediated VLDL-triglyceride lipolysis, as well as the role of HDL in this process. The results showed that VLDL from patients with hypercholesterolemia and hypertriglyceridemia are more resistant to lipolysis, with HDL helping to enhance the efficiency of lipolysis in these groups.
Article
Environmental Sciences
Hao Zhao, Wei Gui, Xin Tan, Ying Chen, Yao Ning, Xin Wang
Summary: This study investigated the relationship between neonicotinoid insecticides (NNIs) and their metabolites in urine with serum lipid profiles in adults. The results showed a significant positive correlation between N-desmethyl-acetamiprid and total cholesterol (TC) levels, especially in participants aged over 46 years. Body mass index (BMI) also modified the association between N-desmethyl-acetamiprid and LDL-C and Apo-B levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Geriatrics & Gerontology
Irene Zolfaroli, Ester Ortiz, Miguel-Angel Garcia-Perez, Juan Jose Hidalgo-Mora, Juan J. Tarin, Antonio Cano
Summary: This study found a positive association between high-density lipoprotein cholesterol (HDL-C) levels and bone mineral density (BMD) at the lumbar spine and femoral neck in postmenopausal women, while other lipid parameters did not show significant associations. Additionally, factors such as age and body mass index were also related to BMD.
Article
Biochemistry & Molecular Biology
Yuan Kong, Yong-Jia Yi, Xiao-Qing Liu, Pan Yu, Lin-Guo Zhao, Dong-Dong Li
Summary: In this study, a series of berberine analogs were synthesized and evaluated for their lipid-lowering activities. Compound 1m was found to exhibit potent cholesterol inhibitory activity and had significant effects on LDLC and HDLC levels. The results suggest that 1m has the potential to be a new lipid-lowering agent.
BIOORGANIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Bibiana Fabre, Nahuel Fernandez Machulsky, Carolina Olano, Dario Jacobsen, Maria Eugenia Gomez, Beatriz Perazzi, Valeria Zago, Damian Zopatti, Andres Ferrero, Laura Schreier, Gabriela Berg
Summary: Patients with severe complications of COVID-19, such as cardiovascular disease, hypertension, and type-2 diabetes, have metabolic alterations including insulin resistance and dyslipidemia. This study found that levels of remnant lipoprotein cholesterol were associated with the severity and death of COVID-19 patients.
SCIENTIFIC REPORTS
(2022)
Review
Physiology
Faidon Magkos, Dominic N. Reeds, Bettina Mittendorfer
Summary: This paper provides an overview of the evolution of hyperglycemia definition and the changes in glucose dynamics that lead to fasting and postprandial hyperglycemia. Extensive research has contributed to our understanding of different types of hyperglycemia, such as prediabetes and diabetes, and their subtypes, as well as their relationships with medical complications and strategies for prevention and treatment.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Nutrition & Dietetics
Adam D. Seal, Abigail T. Colburn, Evan C. Johnson, Francois Peronnet, Lisa T. Jansen, J. D. Adams, Costas N. Bardis, Isabelle Guelinckx, Erica T. Perrier, Stavros A. Kavouras
Summary: The purpose of this study was to determine the total water intake requirement for healthy adults to maintain optimal hydration, and it suggests that following the National Academy of Medicine guidelines should be sufficient for most individuals in the United States to maintain 24-h urine osmolality < 500 mmol center dot kg(-1).
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Floris C. Wardenaar, Ryan G. N. Seltzer, Stavros A. Kavouras
Summary: This study investigated student athletes' ability to score artificial urine color samples and found inconsistent ratings and a tendency to rate samples lighter than their actual color, which may affect the classification of urine concentration.
INTERNATIONAL JOURNAL OF SPORTS SCIENCE & COACHING
(2023)
Article
Clinical Neurology
Maria I. Maraki, Mary Yannakoulia, Georgia Xiromerisiou, Leonidas Stefanis, Sokratis Charisis, Nikolaos Giagkou, Mary H. Kosmidis, Efthimios Dardiotis, Georgios M. Hadjigeorgiou, Paraskevi Sakka, Nikolaos Scarmeas, Maria Stamelou
Summary: This study investigated the association between adherence to a Mediterranean diet and the development of prodromal Parkinson's disease (pPD) and Parkinson's disease (PD) in older adults. The results showed that adherence to a Mediterranean diet was associated with a lower risk of developing pPD and PD, and also slowed down the increase in pPD probability over time.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mahsa Jalili, Maryam Nazari, Faidon Magkos
Summary: Fermented foods, rich in probiotics and prebiotics, are widely consumed in many countries and populations. They can improve digestion, enhance immunity, and aid in weight loss, making them a potential tool for combating obesity. This article provides a comprehensive overview of the health effects of fermented foods and their mechanisms of action in obesity and related metabolic abnormalities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Stacy D. Hunter, Stavros A. Kavouras, Mitra Rahimi
Summary: The purpose of this study was to examine whether hot yoga could attenuate sodium-induced pressor responses and endothelial dysfunction in Black females. The study found that after 4 weeks of hot yoga, sodium loading increased endothelial function but did not alter blood pressure responses.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Review
Food Science & Technology
Jaap Keijer, Xavier Escote, Sebastia Galmes, Andreu Palou-March, Francisca Serra, Mona Adnan Aldubayan, Kristina Pigsborg, Faidon J. Magkos, Ella C. Baker, Philip Calder, Joanna Goralska, Urszula Razny, Malgorzata Malczewska-Malec, David Sunol, Mar A. Galofre, Miguel Rodriguez, Nuria G. Canela, Radu Malcic, Montserrat Bosch, Claudia Favari, Pedro Mena, Daniele Del Rio, Antoni Caimari, Biotza M. Gutierrez, Josep del Bas
Summary: Personalized nutrition (PN) is a tool that empowers consumers to make dietary changes, improve health, and prevent diet-related diseases. However, the implementation of PN faces obstacles due to the complexity of individual metabolic characterization. This study proposes a conceptual framework that focuses on dysregulation of key processes and specific markers to assess metabolic health. Machine learning and data analysis algorithms can integrate omics and genetic markers, and digital tools can simplify their implementation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Environmental Sciences
Abigail Tran Colburn, Matthew P. Buman, Amber Wutich, Sonia Vega-Lopez, Punam Ohri-Vachaspati, Stavros A. Kavouras
Summary: The purpose of this investigation was to identify the factors that contribute to tap water mistrust among Latinx adults in Phoenix, Arizona. The study found that 51.2% of participants perceived their tap water to be unsafe. Factors such as preferring bottled water, negative experiences with home tap water, use of alternatives to tap water, and decreased water quality and acceptability were associated with higher levels of mistrust. On the other hand, relying on public water supply and having better water access were associated with lower levels of mistrust.
JOURNAL OF WATER AND HEALTH
(2023)
Article
Nutrition & Dietetics
Sofie Hauerberg Henninger, Anna Yde Fibieger, Faidon Magkos, Christian Ritz
Summary: Current treatment options for overweight and obesity rely on strict diet and exercise regimes, making it difficult to sustain as a lifelong routine. This study explored the effects of mindful eating and YogaDance, individually and in combination, as alternative approaches to manage obesity. The findings suggest modest benefits of an 8-week combination of mindful eating and YogaDance, supporting previous research on the effectiveness of mindful eating, yoga, and dance.
Article
Nutrition & Dietetics
Mona Adnan Aldubayan, Xiaotian Mao, Martin Frederik Laursen, Kristina Pigsborg, Lars H. Christensen, Henrik M. Roager, Dennis S. Nielsen, Mads Fiil Hjorth, Faidon Magkos
Summary: This study found that a high fiber plant-based diet can reduce body weight and improve cardiometabolic health in individuals with obesity. Additionally, the addition of inulin-type fructans (ITF) can alter gut microbiota composition and attenuate some of the realized cardiometabolic benefits.
FRONTIERS IN NUTRITION
(2023)
Review
Nutrition & Dietetics
Julie Marvel Mansfeldt, Faidon Magkos
Summary: This paper reviews studies on the changes in non-exercise physical activity (NEPA) in response to exercise-induced energy expenditure. The majority of studies show a compensatory decrease in NEPA upon starting a structured exercise training program, which may attenuate the energy deficit caused by exercise and prevent weight loss.
CURRENT NUTRITION REPORTS
(2023)
Editorial Material
Endocrinology & Metabolism
Faidon Magkos, Anahita Ataran, Ali Javaheri, Bettina Mittendorfer
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2023)
Article
Endocrinology & Metabolism
Michelle H. H. Lee, Eveline Febriana, Maybritte Lim, Sonia Baig, Jeffrey B. B. Halter, Faidon Magkos, Sue-Anne Toh
Summary: This study aimed to investigate the effect of sex on obesity-driven changes in the mechanisms regulating glucose metabolism. The results showed that the adverse effects of obesity on insulin action and secretion were more pronounced in males than females, and females had greater insulin sensitivity and lower insulin secretion compared to males among participants with obesity.
Article
Nutrition & Dietetics
Kristina Pigsborg, Valdemar Stentoft-Larsen, Samuel Demharter, Mona Adnan Aldubayan, Alessia Trimigno, Bekzod Khakimov, Soren Balling Engelsen, Arne Astrup, Mads Fiil Hjorth, Lars Ove Dragsted, Faidon Magkos
Summary: A predictive model was developed using machine learning to predict successful weight loss on a New Nordic Diet. The study found that individual responses to weight loss vary and the optimal diet for successful weight loss may differ for different individuals. This research is important for improving precision dietary treatment for obesity.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Sasha A. S. Kjeldsen, Mads N. Thomsen, Mads J. Skytte, Amirsalar Samkani, Michael M. Richter, Jan Frystyk, Faidon Magkos, Elizaveta Hansen, Henrik S. Thomsen, Jens J. Holst, Sten Madsbad, Steen B. Haugaard, Thure Krarup, Nicolai J. Wewer Albrechtsen
Summary: This study aimed to investigate the dependency of body weight loss following a reduction in hepatic steatosis on markers of glucagon resistance in type 2 diabetes. The results showed that weight loss may contribute to the improvement of glucagon resistance in individuals with type 2 diabetes.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
