Article
Biochemistry & Molecular Biology
James D. West, Eric D. Austin, Elise M. Rizzi, Ling Yan, Harikrishna Tanjore, Amber L. Crabtree, Christy S. Moore, Gladson Muthian, Erica J. Carrier, David A. Jacobson, Rizwan Hamid, Peggy L. Kendall, Susan Majka, Anandharajan Rathinasabapathy
Summary: Loss of function KCNK3 mutation alters various physiological processes through inflammation, affecting factors such as inflammation and metabolism in response to hypoxia, dysregulation of bone marrow cells, and the role of inflammation in driving pulmonary arterial hypertension (PAH). Studies on both animal models and human samples suggest that altered circulating immune cells may play a key role in driving PAH susceptibility in patients with KCNK3 mutation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Kandasamy Rajamanickam, Venkatasubramanian Leela, Gopalakrishnan Suganya, Sabiha Hayath Basha, Manoharan Parthiban, Pasuvalingam Visha, Ayyasamy Elango
Summary: This study aimed to investigate the molecular and functional responses of bovine monocyte-derived macrophages to thermal and lipopolysaccharide-induced stress. The results showed that the combined stimulation of heat and lipopolysaccharide led to increased apoptosis, reduced mitochondrial membrane potential and cell viability, decreased oxidative and phagocytosis ability, as well as dysregulation of gene expressions related to heat shock, cell signaling, and inflammation.
JOURNAL OF THERMAL BIOLOGY
(2022)
Article
Critical Care Medicine
Julia Leonhardt, Mirrin J. Dorresteijn, Sophie Neugebauer, Diana Mihaylov, Julia Kunze, Ignacio Rubio, Frank-Stephan Hohberger, Silke Leonhardt, Michael Kiehntopf, Klaus Stahl, Christian Bode, Sascha David, Frank A. D. T. G. Wagener, Peter Pickkers, Michael Bauer
Summary: The study found that circulating bile acids capable of inducing immunosuppression are present in septic shock patients, particularly in those with severe liver failure. Future research may need to explore whether modulating bile acid metabolism can improve the clinical course and outcome of sepsis in these patients.
Article
Biochemistry & Molecular Biology
Yujie Han, Weihao Shao, Dan Zhong, Cui Ma, Xiaona Wei, Abrar Ahmed, Tingting Yu, Wei Jing, Lili Jing
Summary: Multicentric carpotarsal osteolysis (MCTO) is a rare skeletal dysplasia characterized by osteolysis at the carpal and tarsal bones. Patients with MCTO have been found to have heterozygous missense mutations in the transcription factor MAFB. Utilizing CRISPR/Cas9 technology, a zebrafish MAFB homolog mafbb mutant was generated in this study, demonstrating enhanced osteoclast cell differentiation and abnormal cartilage and bone development resembling MCTO patients. Additionally, it was shown that MAFB MCTO mutations were unable to rescue the defective osteoclastogenesis in mafbb(-/-) embryos, indicating a likely haploinsufficiency mechanism for MCTO mutations.
Article
Endocrinology & Metabolism
Helmut Hiller, Dawn E. Beachy, Joseph J. Lebowitz, Stefanie Engler, Justin R. Mason, Douglas R. Miller, Irina Kusmarteva, Laura M. Jacobsen, Amanda L. Posgai, Habibeh Khoshbouei, Richard A. Oram, Desmond A. Schatz, Andrew T. Hattersley, Bernd Bodenmiller, Mark A. Atkinson, Harry S. Nick, Clive H. Wasserfall
Summary: This study found dysregulated expression of monogenic diabetes genes in the pancreas of individuals with T1D and at risk for T1D, with some genes related to cellular stress responses. Three arms of the ISR were significantly repressed in the pancreas of autoantibody+ individuals.
Article
Biochemistry & Molecular Biology
Florian Rosier, Nicolas Fernandez Nunez, Magali Torres, Beatrice Loriod, Pascal Rihet, Lydie C. Pradel
Summary: In this study, the transcriptional response of mice injected with LPS was compared to human cells stimulated with LPS in vitro and the blood cells of septic patients. The results showed a significant overlap in gene regulation and disease processes between mouse and human sepsis, supporting the hypothesis of common molecular and cellular mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Xiyue Duan, Zhou Fang, Li Tao, Huiyue Chen, Xiaoyu Zhang, Yufen Li, Hansheng Wang, Aotian Li, Xueyan Zhang, Ya Pang, Min Gu, Jiahui Wu, Fajin Lv, Tianyou Luo, Oumei Cheng, Jin Luo, Zheng Xiao, Weidong Fang
Summary: This study revealed local and inter-ROI FC differences in frontal-cerebellar-anterior cingulate cortex circuits in depressed ET patients, suggesting that cerebellum lobules IX, middle prefrontal cortices and anterior cingulate cortices may function as pathogenic structures underlying depression in ET patients.
Article
Cell Biology
Helen Williams, Sasithorn Suda, Suat Dervish, Yen Tien Yap, Andrew J. A. Holland, Heather J. Medbury
Summary: The study revealed that an enhanced inflammatory monocyte response may contribute to the development of hypertrophic scars, while a decrease in M2 macrophages could slow down the healing process. Additionally, CD120b may serve as an indicator of healing delay.
WOUND REPAIR AND REGENERATION
(2021)
Article
Immunology
Gloria Tucci, Cristina Garufi, Ilenia Pacella, Marta Zagaglioni, Alessandra Pinzon Grimaldos, Fulvia Ceccarelli, Fabrizio Conti, Francesca Romana Spinelli, Silvia Piconese
Summary: This study verifies the effects of Baricitinib on STAT phosphorylation in monocytes of rheumatoid arthritis (RA) patients and suggests that monocyte frequency and STAT1 phosphorylation could serve as early markers of response to Baricitinib therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Psychiatry
Lea Sirignano, Josef Frank, Laura Kranaster, Stephanie H. Witt, Fabian Streit, Lea Zillich, Alexander Sartorius, Marcella Rietschel, Jerome C. Foo
Summary: This study investigated the effects of electroconvulsive therapy (ECT) on the methylome of depressed patients and identified differentially methylated CpG sites associated with ECT response. Despite the limited sample size, the results suggest that this approach has the potential to inform the study of mechanisms involved in ECT and treatment-resistant depression.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Thomas P. Buters, Pieter W. Hameeteman, Iris M. E. Jansen, Floris C. van Hindevoort, Wouter Ten Voorde, Edwin Florencia, Michelle Osse, Marieke L. de Kam, Hendrika W. Grievink, Mascha Schoonakker, Amit A. Patel, Simon Yona, Derek W. Gilroy, Erik Lubberts, Jeffrey Damman, Gary Feiss, Robert Rissmann, Manon A. A. Jansen, Jacobus Burggraaf, Matthijs Moerland
Summary: This study aimed to characterize the intradermal LPS response in healthy volunteers as a local inflammation model for clinical pharmacology studies. Results showed that intradermal LPS administration induced a visible response, with acute interleukin and tumor necrosis factor protein response followed by different cellular responses. The study suggests that intradermal LPS administration may be a valuable inflammation model for evaluating the pharmacological activity of anti-inflammatory compounds.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kenneth Chappell, Abd El Kader Ait Tayeb, Romain Colle, Jerome Bouligand, Khalil El-Asmar, Florence Gressier, Severine Trabado, Denis Joseph David, Bruno Feve, Laurent Becquemont, Emmanuelle Corruble, Celine Verstuyft
Summary: This study found that genetic variants of ARRB1 may influence the response to antidepressant drug treatment in depressed patients. The analysis of rare variants showed significant associations with changes in HDRS scores and remission. The results suggest that beta-arrestin 1 and genetic variants of ARRB1 may serve as useful clinical biomarkers for clinical improvement following antidepressant drug treatment in depressed individuals.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Virginia Camacho, Valeriya Kuznetsova, Robert S. Welner
Summary: The immune microenvironment plays a crucial role in regulating hematopoiesis and immune cell dysfunction significantly contributes to neoplastic disease. Leukemic inflammatory cytokines can alter immune cells, and targeting the immune landscape may have therapeutic value in limiting leukemia growth. Further research is needed to understand how leukemic cytokines impact immune cells and potential immunotherapeutic approaches for patients with hematological myeloid malignancies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Kevin O. Murray, Jason O. Brant, John D. Iwaniec, Laila H. Sheikh, Lucas de Carvalho, Christian K. Garcia, Gerard P. Robinson, Jamal M. Alzahrani, Alberto Riva, Orlando Laitano, Michael P. Kladde, Thomas L. Clanton
Summary: Exposure to exertional heat stroke (EHS) may lead to DNA methylation reprogramming in monocytes, resulting in altered immune response and heat shock responsiveness after 30 days. These findings suggest that EHS exposure can induce long-term physiological changes through epigenetic mechanisms.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Behavioral Sciences
Jasmin Obermanns, Hanna Meiser, Saskia Hoberg, Cynthia Segura Vesterager, Frank Schulz, Georg Juckel, Barbara Emons
Summary: This study found higher concentrations of AEA and decreased concentrations of 2-AG in patients with depression compared to healthy participants. Lower concentrations of 2-AG were correlated with higher levels of anxiety symptoms. Male patients had increased concentrations of 2-AG, while female patients had increased anxiety symptoms. Genotypic variations of 5-HT1A rs6295 and 5-HT2A rs6311 were associated with altered serotonergic activity and serotonin content in patients.
BRAIN AND BEHAVIOR
(2023)
Article
Obstetrics & Gynecology
Stefania Triunfo, Marta Tomaselli, Maria Immacolata Ferraro, Elisabetta Latartara, Giulia Maria Sassara, Cinzia Carrozza
Summary: This study aimed to compare the effects of one-drug therapy (UDCA) and combined therapy (UDCA plus SAMe) on pregnancies complicated by mICP. The results showed no significant differences in adverse perinatal outcomes and placental histopathology between the two treatment methods. Further research and data sharing may lead to changes in the therapeutic plan.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Cinzia Dello Russo, Kathryn Anne Scott, Munir Pirmohamed
Summary: Dimethyl fumarate (DMF) is a first line medication for multiple sclerosis, but concerns have been raised regarding its adverse effects such as lymphopenia. The molecular mechanisms underlying these effects are not well understood, and the relative toxicity of DMF and its metabolite MMF in vivo remains unclear.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Cinzia Dello Russo, Natalia Cappoli, Daniela Pilunni, Pierluigi Navarra
Summary: In phase 2 oncology trials, local investigators significantly overestimate ORR compared to paired blinded reviewers. This may pose a risk in drug development, especially when deciding whether to move to more expensive phase 3 trials. Blinded independent central review should be used for a more conservative estimate of treatment efficacy.
JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lorenzo Moccia, Pierluigi Lanzotti, Maria Pepe, Laura Palumbo, Delfina Janiri, Giovanni Camardese, Anna Rita Bentivoglio, Marco Di Nicola, Paolo Calabresi, Gabriele Sani
Summary: Functional movement disorders (FMD) are abnormal involuntary movements not consistent with neurological diseases. They often co-occur with mood and anxiety disorders and have poor clinical outcomes. This case report presents the successful treatment of FMD symptoms in a patient with treatment-resistant depression (TRD) using esketamine.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Cinzia Dello Russo, Tiziano Bandiera, Monica Monici, Leonardo Surdo, Vincent Lai Ming Yip, Virginia Wotring, Lucia Morbidelli
Summary: As human spaceflight progresses, there is an increasing demand for effective and safe drugs. However, the physiological changes caused by the space environment may alter the pharmacokinetics of drugs. Research on the pharmacokinetics in space is still incomplete, and there is a need to fill the research gaps.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Irene L. Gutierrez, Cinzia Dello Russo, Fabiana Novellino, Javier R. Caso, Borja Garcia-Bueno, Juan C. Leza, Jose L. M. Madrigal
Summary: This article summarizes the role of noradrenaline in Alzheimer's disease and suggests the use of noradrenaline-modulating drugs as a therapeutic option.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Cinzia Dello Russo, Pierluigi Navarra
Summary: Several drugs have gained market authorization based on improved progression-free survival as the primary endpoint in Phase 3 clinical trials. An increasing number of drugs have also been approved based on overall response rate evaluation in Phase 1 and 2 trials. However, these outcomes can be influenced by subjective factors, and a blinded independent central review is often adopted to overcome bias.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Rosa Maria Paragliola, Cinzia Carrozza, Salvatore M. Corsello, Roberto Salvatori
Summary: This article discusses the challenges in measuring growth hormone and insulin-like growth factor I, including biological changes, comorbidities, and assay variability. Interpretation of these measurements is crucial for early diagnosis of acromegaly, avoiding misdiagnosis, and determining if surgery has achieved cure.
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Natalia Cappoli, Michael D. Jenkinson, Cinzia Dello Russo, David Dickens
Summary: LAT1 plays a crucial role in glioblastoma development and progression, and its modulation could be a novel therapeutic strategy. LAT1 also plays an important role in the peripheral immune system by regulating the activation status of immune cells. Its function in the reprogramming of the immune component in the glioblastoma tumor microenvironment is still poorly understood.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Clinical Neurology
Gregorio Spagni, Matteo Gastaldi, Pietro Businaro, Zeineb Chemkhi, Cinzia Carrozza, Giovanni Mascagna, Silvia Falso, Silvia Scaranzin, Diego Franciotta, Amelia Evoli, Valentina Damato
Summary: This study compared the performance of fixed and live cell-based assays in patients with radioimmunoassay-double seronegative myasthenia gravis (dSN-MG). The results showed that the live cell-based assay had a higher ability to detect antibodies in dSN samples. In addition, the live assay was able to detect antibodies that were negative in the fixed assay, further increasing the antibody detection rate.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Pharmacology & Pharmacy
Evelien G. E. Hurkmans, Marije J. Klumpers, Cinzia Dello Russo, Ward De Witte, Henk-Jan Guchelaar, Hans Gelderblom, Anne-Marie Cleton-Jansen, Sita H. Vermeulen, Suzanne Kaal, Winette T. A. van der Graaf, Uta Flucke, Corrie E. M. Gidding, Hendrik W. B. Schreuder, Eveline S. J. M. de Bont, Huib N. Caron, Giovanna Gattuso, Elisabetta Schiavello, Monica Terenziani, Maura Massimino, Geoff McCowage, Sumanth Nagabushan, Anuja Limaye, Victoria Rose, Daniel Catchpoole, Andrea L. Jorgensen, Christopher Barton, Lucy Delaney, Daniel B. Hawcutt, Munir Pirmohamed, Barry Pizer, Marieke J. H. Coenen, D. Maroeska W. M. te Loo
Summary: This study aimed to identify novel genetic variants involved in platinum-induced ototoxicity. A genome-wide association study was conducted in two cohorts, and the results were combined in a meta-analysis. Variants in TSPAN5, RBBP4P5, AC010090.1, and RNU6-38P were suggestively associated with platinum-induced ototoxicity.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Paola Concolino, Linda Tartaglione, Elisa De Paolis, Cinzia Carrozza, Andrea Urbani, Angelo Minucci, Dario Pitocco, Concetta Santonocito
Summary: Maturity-onset diabetes of the young (MODY) is a rare form of non-autoimmune diabetes with an autosomal dominant inheritance. The GCK gene, encoding the glucokinase enzyme, was the first MODY gene to be identified and is responsible for GCK-MODY or MODY2 subtype. However, gene deletions are rarely found in GCK-MODY.
Editorial Material
Pharmacology & Pharmacy
Cinzia Dello Russo, Pierluigi Navarra
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
JesseJ Swen, Cathelijne H. van der Wouden, Lisanne E. N. Manson, Heshu Abdullah-Koolmees, Kathrin Blagec, Tanja Blagus, Stefan Boehringer, Anne Cambon-Thomsen, Erika Cecchin, Ka-Chun Cheung, Vera H. M. Deneer, Mathilde Dupui, Magnus Ingelman-Sundberg, Siv Jonsson, Candace Joefield-Roka, Katja S. Just, Mats O. Karlsson, Lidija Konta, Rudolf Koopmann, Marjolein Kriek, Thorsten Lehr, Christina Mitropoulou, Emmanuelle Rial-Sebbag, Victoria Rollinson, Rossana Roncato, Matthias Samwald, Elke Schaeffeler, Maria Skokou, Matthias Schwab, Daniela Steinberger, Julia C. Stingl, Roman Tremmel, Richard M. Turner, Mandy H. van Rhenen, Cristina L. Davila Fajardo, Vita Dolzan, George P. Patrinos, Munir Pirmohamed, Gere Sunder-Plassmann, Giuseppe Toffoli, Henk-Jan Guchelaar
Summary: This study assessed the clinical utility of pharmacogenetic testing in patients receiving their first prescription drugs. The results showed that using a pharmacogenetic panel significantly reduced the incidence of clinically relevant adverse drug reactions, and this strategy was feasible across diverse European healthcare system organizations and settings.
Article
Biology
Cinzia Dello Russo, Natalia Cappoli, Elisabetta Tabolacci, Liliana Sollazzi, Pierluigi Navarra, Paola Aceto
Summary: Remifentanil is a potent analgesic drug used in anesthesia. It may be associated with hyperalgesia, but a study on human microglial cells suggests that it does not have direct immune modulatory actions.