Deficiencies of the Lipid-Signaling Enzymes Phospholipase D1 and D2 Alter Cytoskeletal Organization, Macrophage Phagocytosis, and Cytokine-Stimulated Neutrophil Recruitment

Nck and Cdc42 co-operate to recruit N-WASP to promote FcγR-mediated phagocytosis

(2012) Anna E. Dart et al.   JOURNAL OF CELL SCIENCE

Key Roles for the Lipid Signaling Enzyme Phospholipase D1 in the Tumor Microenvironment During Tumor Angiogenesis and Metastasis

(2012) Q. Chen et al.   Science Signaling

The mechanism of cell membrane ruffling relies on a phospholipase D2 (PLD2), Grb2 and Rac2 association

(2011) Madhu Mahankali et al.   CELLULAR SIGNALLING

Phagocytosis

(2011) Roberto J. Botelho et al.   CURRENT BIOLOGY

Type III Secretion System-Dependent Translocation of Ectopically Expressed Yop Effectors into Macrophages by Intracellular Yersinia pseudotuberculosis

(2011) Yue Zhang et al.   INFECTION AND IMMUNITY

The Synaptic Ribbon Is a Site of Phosphatidic Acid Generation in Ribbon Synapses

(2011) K. Schwarz et al.   JOURNAL OF NEUROSCIENCE

A Novel Phospholipase D2-Grb2-WASp Heterotrimer Regulates Leukocyte Phagocytosis in a Two-Step Mechanism

(2011) S. Kantonen et al.   MOLECULAR AND CELLULAR BIOLOGY

Imaging signal transduction during phagocytosis: phospholipids, surface charge, and electrostatic interactions

(2010) Sergio Grinstein   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Macrophage podosomes go 3D

(2010) Emeline Van Goethem et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Pancreas-Specific Ablation of β1 Integrin Induces Tissue Degeneration by Disrupting Acinar Cell Polarity

(2010) Lorenzo Bombardelli et al.   GASTROENTEROLOGY

Structural Basis of Membrane Targeting by the Dock180 Family of Rho Family Guanine Exchange Factors (Rho-GEFs)

(2010) Lakshmanane Premkumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase D2 Ablation Ameliorates Alzheimer's Disease-Linked Synaptic Dysfunction and Cognitive Deficits

(2010) T. G. Oliveira et al.   JOURNAL OF NEUROSCIENCE

The Molecular Basis of Phospholipase D2-Induced Chemotaxis: Elucidation of Differential Pathways in Macrophages and Fibroblasts

(2010) K. Knapek et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphatidic Acid Plays a Regulatory Role in Clathrin-mediated Endocytosis

(2010) Costin N. Antonescu et al.   MOLECULAR BIOLOGY OF THE CELL

Phospholipase D2-Dependent Inhibition of the Nuclear Hormone Receptor PPARγ by Cyclic Phosphatidic Acid

(2010) Tamotsu Tsukahara et al.   MOLECULAR CELL

Mutual regulation of plant phospholipase D and the actin cytoskeleton

(2010) Roman Pleskot et al.   PLANT JOURNAL

Impaired  IIb 3 Integrin Activation and Shear-Dependent Thrombus Formation in Mice Lacking Phospholipase D1

(2010) M. Elvers et al.   Science Signaling

The phospholipase D1 pathway modulates macroautophagy

(2010) Claudia Dall'Armi et al.   Nature Communications

Reversible bleb formation in mast cells stimulated with antigen is Ca2+/calmodulin-dependent and bleb size is regulated by ARF6

(2009) Yuhki Yanase et al.   BIOCHEMICAL JOURNAL

Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases

(2009) Yueqiang Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inter-regulatory dynamics of phospholipase D and the actin cytoskeleton

(2009) Simon A. Rudge et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mechanisms underlying neutrophil-mediated monocyte recruitment

(2009) O. Soehnlein et al.   BLOOD

Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis

(2009) Wenjuan Su et al.   Future Oncology

Localized Diacylglycerol-dependent Stimulation of Ras and Rap1 during Phagocytosis

(2009) Roberto J. Botelho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells

(2009) Ellen J. Ezratty et al.   JOURNAL OF CELL BIOLOGY

Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages

(2009) A. Dovas et al.   JOURNAL OF CELL SCIENCE

Diacylglycerol Kinase ζ Regulates Actin Cytoskeleton Reorganization through Dissociation of Rac1 from RhoGDI

(2009) Hanan Abramovici et al.   MOLECULAR BIOLOGY OF THE CELL

Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis

(2009) A. Nishikimi et al.   SCIENCE

Grab, stick, pull and digest: the functional diversity of actin-associated matrix-adhesion structures. Workshop on Invadopodia, Podosomes and Focal Adhesions in Tissue Invasion

(2008) Laura Machesky et al.   EMBO REPORTS

Podosome-type adhesions and focal adhesions, so alike yet so different

(2008) M BLOCK et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Type III Secretion Decreases Bacterial and Host Survival following Phagocytosis of Yersinia pseudotuberculosis by Macrophages

(2008) Y. Zhang et al.   INFECTION AND IMMUNITY

Phospholipase D Activity Regulates Integrin-mediated Cell Spreading and Migration by Inducing GTP-Rac Translocation to the Plasma Membrane

(2008) Young Chan Chae et al.   MOLECULAR BIOLOGY OF THE CELL

A Lipid-signaled Myosin Phosphatase Surge Disperses Cortical Contractile Force Early in Cell Spreading

(2008) Guangwei Du et al.   MOLECULAR BIOLOGY OF THE CELL

5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a Phospholipase D Pharmacological Inhibitor That Alters Cell Spreading and Inhibits Chemotaxis

(2008) W. Su et al.   MOLECULAR PHARMACOLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance

(2008) Jia-Shu Yang et al.   NATURE CELL BIOLOGY

Shaping cups into phagosomes and macropinosomes

(2008) Joel A. Swanson   NATURE REVIEWS MOLECULAR CELL BIOLOGY