Article
Cell Biology
Xiao-Di Sun, Lu Han, Hong-Tao Lan, Ran-Ran Qin, Ming Song, Wei Zhang, Ming Zhong, Zhi-Hao Wang
Summary: The study showed that platelet activation was significantly higher in diabetic patients with coronary heart disease, and was associated with heart rate and EMPs levels. PDI activity on EMPs was also increased, activating platelets through allosteric GPIIb/IIIa receptors.
Article
Biochemistry & Molecular Biology
Leslie Marisol Lugo-Gavidia, Dylan Burger, Janis M. M. Nolde, Vance B. B. Matthews, Markus P. P. Schlaich
Summary: Elevated circulating platelet-derived extracellular vesicles (pEVs) have been associated with arterial hypertension, but their relationship with hypertension-mediated organ damage, endothelial function, and psychosocial status is unclear. Our study found that pEV levels were associated with macrovascular damage, but not with microvascular damage, endothelial function, or emotional status.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ziang Zhu, Tong Li, Jinya Chen, Jai Kumar, Princy Kumar, Jing Qin, Colleen Hadigan, Irini Sereti, Jason V. Baker, Marta Catalfamo
Summary: This study examines the impact of HIV infection on endothelial inflammation and repair by evaluating cell phenotypes and subsets in the blood of HIV-infected individuals. The researchers found that infection-induced phenotypic changes were associated with inflammatory biomarkers, suggesting that HIV infection may affect endothelial inflammation and repair.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Panagiotis Theofilis, Marios Sagris, Evangelos Oikonomou, Alexios S. Antonopoulos, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: This article provides an overview of platelet research advancements and their importance in human health and disease. It summarizes the structural and functional characteristics of platelets and focuses on platelet activation processes. Additionally, it discusses potential molecular mechanisms involving inflammation, endothelial dysfunction, and miRs. The article also presents available antiplatelet agents and drugs currently under investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xiaowan Han, Tong Li, Tieshan Wang, Baofu Wang, Yang Li, Lei Wang, Ziwen Lu, Aiming Wu, Lisong Liu, Guozhong Pan, Mingjing Zhao
Summary: This study evaluated the correlation between different microparticle phenotypes and plaque burden, and investigated the role of microparticles in atherosclerosis. The results showed that CD11a(+) LMP and CD11a(+)/CD45(+) LMP may be potential biomarkers for predicting carotid atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Heba Abdel Razik Sayed, Helal F. Hetta, Engy A. Shafik, Asmaa M. Zahran
Summary: The study found that pediatric patients with solid tumors have significantly higher levels of CECs and EPCs at diagnosis and even higher levels after chemotherapy; the increase in CECs levels on day 7 after chemotherapy may be an early predictor of treatment response and outcome.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Cell Biology
Olga Tura-Ceide, Isabel Blanco, Jessica Garcia-Lucio, Roberto del Pozo, Agustin Roberto Garcia, Elisabet Ferrer, Isabel Crespo, Diego A. Rodriguez-Chiaradia, Carmen Pilar Simeon-Aznar, Manuel Lopez-Meseguer, Clara Martin-Ontiyuelo, Victor I. Peinado, Joan Albert Barbera
Summary: The study found that the levels and ratio of circulating endothelial microvesicles (EMVs) and progenitor cells (PCs) in patients with PAH were altered, and these changes were not restored with PAH therapy. Combined measurement of circulating EMVs and PCs could be a potential biomarker of endothelial dysfunction in PAH.
Article
Nutrition & Dietetics
Fadlina Chany Saputri, Nuriza Ulul Azmi, Meidi Utami Puteri, Gracia Damayanti, Vivi Novita, Gracia Marisi, Elin Oktavira, Aninda Novika Sari, Khairunisa Ronaningtyas, Enny Herawati
Summary: This study assessed the impact of a high-fat diet on platelet activation and its association with PCSK9, as well as its effects on blood pressure in an animal model. The results showed that high-fat diet-induced hypercholesterolemia and hypertriglyceridemia significantly increased platelet activation and PCSK9 levels. These findings suggest a potential link between high-fat diet, PCSK9, and cardiovascular diseases.
Article
Peripheral Vascular Disease
Jianwen Liang, Xiaoyu Zhang, Wenhao Xia, Xinzhu Tong, Yanxia Qiu, Yumin Qiu, Jiang He, Bingbo Yu, Hui Huang, Jun Tao
Summary: Aerobic exercise can improve microvascular rarefaction in hypertensive patients, reduce blood pressure, and enhance endothelial progenitor cells' angiogenic capacity via the NOTCH 1/Akt/eNOS signaling pathway.
Article
Medicine, Research & Experimental
Mohammad Shafiq, Zahid Rasool Lone, Pragya Bharati, Himalaya Singh, Kumaravelu Jagavelu, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: This study demonstrates the important role of MK2 in inflammation and endothelial microparticle generation, suggesting that its inhibition may help improve endothelial function in patients with pulmonary hypertension.
Article
Pharmacology & Pharmacy
Maria Vazquez-Reza, Antia Custodia, Iria Lopez-Dequidt, Marta Aramburu-Nunez, Daniel Romaus-Sanjurjo, Alberto Ouro, Joao Botelho, Vanessa Machado, Ramon Iglesias-Rey, Juan Manuel Pias-Peleteiro, Rogelio Leira, Juan Blanco, Jose Castillo, Tomas Sobrino, Yago Leira
Summary: This study investigates the relationship between periodontitis and an increased number of circulating endothelial progenitor cells (EPCs) (CD34(+)/CD133(+)/KDR+). The results show that periodontitis patients have a higher concentration of EPCs compared to non-periodontitis patients, and there is a significant increase in EPCs over time in patients with periodontitis. These findings suggest a potential link between periodontitis and endothelial dysfunction.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Keishi Ichikawa, Toru Miyoshi, Kazuhiro Osawa, Takashi Miki, Kunihisa Kohno, Kazufumi Nakamura, Yasushi Koyama, Hiroshi Ito
Summary: This study investigated the association between the number of CD34-positive cells and the progression of coronary artery calcification (CAC), a marker of atherosclerosis. The results showed that low numbers of CD34-positive cells are associated with CAC progression in patients with hypercholesterolemia under statin therapy. The number of CD34-positive cells may help identify patients at increased cardiovascular risk.
CARDIOLOGY JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Qinbo Yang, Peiwei Wang, Yiqing Cai, Yimeng Cui, Jingang Cui, Xiaoye Du, Yu Chen, Teng Zhang
Summary: Our study demonstrates, for the first time, the pathophysiological significance of miR-505 in hypertension-associated endothelial dysfunction and inflammation. MiR-505 is elevated in hypertensive animal models and positively correlated with blood pressure and inflammatory markers in human subjects. In addition, miR-505 modulates the expression of inflammatory genes and endothelial activation markers, as well as the adhesion of monocytes to endothelial cells. These findings suggest that miR-505 may serve as a prognostic biomarker for hypertension-associated endothelial impairment and inflammatory injuries in target organs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Pilar Carrillo Torres, Maria Angeles Martinez-Zamora, Dolors Tassies, Helena Castillo, Meritxell Gracia, Georgina Feixas, Joan Carles Reverter, Francisco Carmona
Summary: There is increasing interest in studying the pathogenic mechanisms of endometriosis, especially in relation to the coagulation/fibrinolysis system and its connection with inflammation and tissue remodeling. This study aimed to evaluate the impact of hormonal treatments on microparticle levels in deep-infiltrating endometriosis (DE) patients. The results showed that DE patients receiving a continuous combined oral contraceptive regimen (CCOCR) had lower levels of total circulating microparticles (cMPs), indicating a decrease in chronic inflammation. However, cMP-TF levels were higher in DE patients receiving CCOCR, suggesting a suppression of the inhibitory pathway of tissue factor (TF) by estrogen-containing treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Qianjin Qi, Kui Sun, Ying Rong, Zhaoping Li, Yixia Wu, Di Zhang, Shuaihua Song, Haoran Wang, Li Feng
Summary: This study investigated the association between segmental body composition and metabolic diseases, specifically hypertension, hypercholesterolemia, and diabetes, in U.S. adults. The results showed that increased upper limb lean body mass was associated with a lower risk of these metabolic diseases, while increased upper limb fat mass was associated with an increased risk. Significant differences were also found between genders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. Filippi, N. Alexandru, G. Voicu, C. A. Constantinescu, M. Tucureanu, D. Rebleanu, M. Fenyo, D. Simionescu, A. Simionescu, I. Manduteanu, A. Georgescu
Article
Cell Biology
Nicoleta Alexandru, Eugen Andrei, Florentina Safciuc, Emanuel Dragan, Ana Maria Balahura, Elisabeta Badila, Adriana Georgescu
Review
Biochemistry & Molecular Biology
Alina Constantin, Alexandru Filippi, Nicoleta Alexandru, Miruna Nemecz, Adriana Georgescu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Adriana Georgescu, Maya Simionescu
Summary: Cells communicate with each other via extracellular vesicles (EVs). These EVs carry various types of cargo and can have different effects on recipient cells. They play important roles in atherosclerosis and COVID-19-related thrombosis, and have potential as signaling mediators, biomarkers, and therapeutic agents. More research is needed to fully understand the mechanisms of EVs in normal and pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Nicoleta Alexandru, Anastasia Procopciuc, Alexandra Vilcu, Ioana Karla Comarita, Elisabeta Badila, Adriana Georgescu
Summary: Extracellular vesicles (EVs) are small anuclear vesicles surrounded by a lipid bilayer, released by various cell types to transfer biologically active molecules like microRNAs to adjacent or distant cells, impacting their phenotype and function. EVs are implicated in the risk and progression of type 2 diabetes mellitus (T2DM), but little is known about their involvement in prediabetes states and associated complications.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Review
Pharmacology & Pharmacy
Natalia Simionescu, Radu Zonda, Anca Roxana Petrovici, Adriana Georgescu
Summary: Extracellular vesicles (EVs) play a critical role in the development and treatment resistance of glioblastoma (GB), potentially serving as diagnostic, prognostic, and disease monitoring biomarkers, as well as gene therapy nanocarriers.
Article
Pharmacology & Pharmacy
Alexandru Filippi, Alina Constantin, Nicoleta Alexandru, Cristina Ana Mocanu, Mihaela Loredana Vlad, Ioana Madalina Fenyo, Agneta Simionescu, Dan Teodor Simionescu, Ileana Manduteanu, Adriana Georgescu
Summary: The number and function of endothelial progenitor cells (EPCs) are reduced in diabetes. Genetically modified EPCs can be a safe treatment option for dyslipidemia and diabetes, preserving aortic valve function.
Article
Cell Biology
Ioana Karla Comarita, Alexandra Vilcu, Alina Constantin, Anastasia Procopciuc, Florentina Safciuc, Nicoleta Alexandru, Emanuel Dragan, Miruna Nemecz, Alexandru Filippi, Leona Chitoiu, Mihaela Gherghiceanu, Adriana Georgescu
Summary: Stem cell-derived EV therapies, especially EVs (ADSCs), led to regression of structural and functional changes in the vascular wall and key orchestrator expression in atherosclerosis-induced endothelial dysfunction. Transfection of EVs with Smad2/3siRNA amplified the ability of EVs (ADSCs) or EVs (MSCs) to regress the inflammation-mediated atherosclerotic process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
I. K. Comarita, A. Constantin, A. Vilcu, A. Procopciuc, F. Safciuc, N. Alexandru, E. Dragan, M. Nemecz, A. Filippi, A. Georgescu
CARDIOVASCULAR RESEARCH
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Nemecz, D. S. Stefan, A. Constantin, A. Procopciuc, K. Comarita, G. Tanko, A. Georgescu
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Natalia Simionescu, Miruna Nemecz, Anca-Roxana Petrovici, Ioan Sebastian Nechifor, Razvan-Cristian Buga, Marius Gabriel Dabija, Lucian Eva, Adriana Georgescu
Summary: This study focused on the relationship between the progression, recurrence, and therapeutic response of glioblastoma (GB) and certain microRNAs (miRNAs) and the circulating microvesicles (MVs) that transport them. The results showed that miR-625-5p has the potential to serve as a biomarker for GB regression or recurrence, but further research is needed for validation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Alina Constantin, Ioana Karla Comarita, Nicoleta Alexandru, Alexandru Filippi, Florina Bojin, Mihaela Gherghiceanu, Alexandra Vilcu, Miruna Nemecz, Loredan Stefan Niculescu, Virgil Paunescu, Adriana Georgescu
Summary: This study investigated the effects of stem cell-derived extracellular vesicles (EVs) on cardiac hypertrophy. The results showed that these EVs could reduce the expression of hypertrophic markers and molecules associated with inflammation in hypertrophic cardiomyocytes. The findings suggest that EVs have the potential to act as therapeutic mediators to reduce cardiac hypertrophy and subsequent cardiovascular events.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Polymer Science
Alexandru Scafa Udriste, Adelina-Gabriela Niculescu, Luminita Iliuta, Teodor Bajeu, Adriana Georgescu, Alexandru Mihai Grumezescu, Elisabeta Badila
Summary: Cardiovascular diseases are a major cause of illness and death globally, resulting in significant health and economic burden. The limited regeneration capacity of adult cardiac tissues and lack of therapeutic options are the main reasons for this phenomenon. Recent interdisciplinary research has focused on biomaterial-based approaches to repair and restore heart tissues, utilizing advancements in chemistry, biology, material science, medicine, and nanotechnology. This paper aims to present the advantages of these approaches, such as cardiac patches, injectable hydrogels, extracellular vesicles, and scaffolds, and reviews the latest developments in these fields.
Review
Biochemistry & Molecular Biology
Elisabeta Badila, Cristina Japie, Ana-Maria Vrabie, Adrian Badila, Adriana Georgescu
Summary: Cardiovascular disease and cancer remain significant causes of morbidity and mortality globally. The prevention and treatment of heart disease in cancer patients present ongoing challenges for improving their quality of life and survival. Limited progress has been made in early detection of cardiovascular disease in cancer patients, highlighting the importance of understanding the molecular mechanisms and disease-specific biomarkers in the communication between cancer and cardiovascular disease. Research on extracellular vesicles (EVs) as mediators of this cross talk is still in its early stages. Investigating EV-based biomarkers and therapies may provide insights into responsible mechanisms, early detection of cardiovascular damage, and new therapeutic approaches. The ultimate goal is to reduce the burden of cardiovascular diseases in oncological patients receiving anticancer drugs or radiotherapy.
Article
Cell & Tissue Engineering
Alexandru Filippi, Alina Constantin, Nicoleta Alexandru, Geanina Voicu, Cristina Ana Constantinescu, Daniela Rebleanu, Madalina Fenyo, Dan Simionescu, Agneta Simionescu, Ileana Manduteanu, Adriana Georgescu
CELL TRANSPLANTATION
(2020)