Article
Urology & Nephrology
Faeq Husain-Syed, Matthew F. DiFrancesco, Rajat Deo, R. Graham Barr, Julia J. Scialla, David A. Bluemke, Richard A. Kronmal, Joao A. C. Lima, Amy Praestgaard, Russell P. Tracy, Michael Shlipak, Steven M. Kawut, John S. Kim
Summary: Low glomerular filtration rate (GFR) and increased albuminuria are associated with all-cause and cardiovascular mortality. Limited data are available on the independent associations of GFR and albuminuria with cardiac morphology, especially in early chronic kidney disease (CKD). This study found that reductions in eGFR within the normal range and higher albuminuria were associated with smaller right ventricular volumes, and albuminuria had a stronger association with mortality among those with smaller RV volumes.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Critical Care Medicine
Michael J. Lanspa, Meghan M. Cirulis, Brandon M. Wiley, Troy D. Olsen, Emily L. Wilson, Sarah J. Beesley, Samuel M. Brown, Eliotte L. Hirshberg, Colin K. Grissom
Summary: This study found that right ventricular dysfunction is common in septic patients and is associated with over threefold higher 28-day mortality. LV systolic dysfunction, on the other hand, was not found to be significantly associated with increased mortality.
Article
Cardiac & Cardiovascular Systems
Emilio A. Mendiola, Denielli da Silva Goncalves Bos, Dana M. Leichter, Alexander Vang, Peng Zhang, Owen P. Leary, Richard J. Gilbert, Reza Avazmohammadi, Gaurav Choudhary
Summary: This study investigated the effect of architectural remodeling on right ventricular (RV) adaptation in pulmonary hypertension (PH) using two rodent models. The results showed that in rats with mild RV maladaptation, there was a decrease in fiber orientation helical range in the RV free wall, preserved global circumferential strain, and less reduction in RV-pulmonary arterial coupling. These findings suggest that adaptive RV architectural remodeling could improve RV function in PH.
CIRCULATION-HEART FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Masanori Hirota, Takanori Suezawa, Yasuyuki Kobayashi, Takuya Kawabata, Yosuke Kuroko, Yasuhiro Kotani, Hiroshi Ito, Shingo Kasahara
Summary: Primary cardiac tumors can occur in any location of the right and left cardiac chambers, and complete excision is generally recommended to minimize functional deterioration post-surgery. This case report discusses details of preserving right ventricular volume and tricuspid valve function during surgery for an endocardial hemangioma on the free wall of the right ventricle.
ANNALS OF THORACIC SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Kerstin Boengler, Susanne Rohrbach, Norbert Weissmann, Rainer Schulz
Summary: This article focuses on the importance of connexin 43 (Cx43) for the developing heart, discussing its expression and localization in diseased right ventricle (RV) conditions such as tetralogy of Fallot and pulmonary hypertension. Other connexin molecules involved in RV pathophysiology are also introduced, along with therapeutic strategies aiming to improve RV function in pulmonary hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Federica Ilardi, Mario Crisci, Cecilia Calabrese, Anna Scognamiglio, Fortunato Arenga, Rachele Manzo, Domenica F. Mariniello, Valentino Allocca, Anna Annunziata, Antonello D'Andrea, Raffaele Merenda, Vittorio Monda, Giovanni Esposito, Giuseppe Fiorentino
Summary: The aim of this study was to investigate subclinical cardiac dysfunction in recovered COVID-19 patients with a history of pulmonary embolism (PE). The study included 44 patients without known cardiopulmonary disease and divided them into two groups based on PE diagnosis. The results showed a significant reduction in right-ventricle global longitudinal strain (RV-GLS) and RV free wall longitudinal strain (RV-FWLS) in PE+ patients compared to PE- patients. RV-FWLS < 21% was independently associated with COVID-related PE.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
F. T. Bekedam, M. J. Goumans, H. J. Bogaard, F. S. de Man, A. Llucia-Valldeperas
Summary: Right ventricular fibrosis is a stress response caused by activation of cardiac fibroblasts, leading to increased synthesis and remodeling of the extracellular matrix. While it provides structural protection in response to damage, it also contributes to increased myocardial stiffness and dysfunction. This review summarizes current knowledge and studies on the development of right ventricular fibrosis in response to pressure overload and its potential for improving cardiac function. (c) 2023 Published by Elsevier Inc.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Cardiac & Cardiovascular Systems
Benjamin D. D. McNair, Samantha K. K. Shorthill, Danielle R. R. Bruns
Summary: Fibroblasts play a crucial role in the organization and regulation of the extracellular matrix (ECM) in the heart. Excess deposition of ECM proteins leads to fibrosis, resulting in disrupted signaling conduction and contributing to cardiac dysfunction. While the mechanisms of left ventricle (LV) fibrosis are well-studied, the mechanisms of right ventricle (RV) fibrosis remain unclear. This review discusses the differences in ECM regulation and the importance of fibrosis in RV disease, highlighting the need for further research on the shared and distinct mechanisms of RV and LV fibrosis.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anna Reka Kiss, Zsofia Gregor, Adrian Popovics, Kinga Grebur, Liliana Erzsebet Szabo, Zsofia Dohy, Attila Kovacs, Balint Karoly Lakatos, Bela Merkely, Hajnalka Vago, Andrea Szucs
Summary: This study aimed to investigate the involvement of the right ventricle (RV) in left ventricular non-compaction (LVNC) patients. The results showed that RV involvement was present in LVNC patients, with higher RV volumes, poorer RV function, and the presence of RV non-compaction. RV non-compaction was correlated with RV volume and function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Christophe Beyls, Pierre Huette, Paul Vangreveninge, Florent Leviel, Camille Daumin, BenAmmar Ammar, Gilles Touati, Bouzerar Roger, Thierry Caus, Herve Dupont, Osama Abou-Arab, Diouf Momar, Yazine Mahjoub
Summary: This study aimed to determine whether measurements of right ventricle longitudinal shortening fraction (RV-LSF) were interchangeable in the perioperative setting. By performing TTE and TEE echocardiography in 90 patients undergoing cardiac surgery, the study found excellent agreement between RV-LSFTTE and RV-LSFTEE measurements. Therefore, RV-LSF can be a helpful parameter for assessing perioperative changes in right ventricle systolic function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mario Boehm, Xuefei Tian, Md Khadem Ali, Yuqiang Mao, Kenzo Ichimura, Mingming Zhao, Kazuya Kuramoto, Svenja Dannewitz Prosseda, Giovanni Fajardo, Melanie J. Dufva, Xulei Qin, Vitaly O. Kheyfets, Daniel Bernstein, Sushma Reddy, Ross J. Metzger, Roham T. Zamanian, Francois Haddad, Edda Spiekerkoetter
Summary: The study shows that increasing cardiac BMP signaling with FK506 improves RV structure and function independently from its previously described beneficial effects on pulmonary vascular remodeling.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Raquel F. Videira, Anne-Marie C. Koop, Lara Ottaviani, Ella M. Poels, Jordy M. M. Kocken, Cristobal Dos Remedios, Pedro Mendes-Ferreira, Kees W. Van de Kolk, Gideon J. Du Marchie Sarvaas, Andre Lourenco, Aida Llucia-Valldeperas, Diana S. Nascimento, Leon J. De Windt, Frances S. De Man, Ines Falcao-Pires, Rolf M. F. Berger, Paula A. da Costa Martins
Summary: Research on the pathophysiology of right ventricular (RV) failure has lagged behind compared to the left ventricle (LV), despite high mortality and morbidity. Previous studies showed that Hand2 reactivation in adult hearts contributes to pathological remodeling, but hand2 depletion led to severe cardiac dysfunction in response to RV pressure overload. This study emphasized the importance of understanding molecular mechanisms driving pathological remodeling of RV.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemical Research Methods
Mitchel J. Colebank, Naomi C. Chesler
Summary: This study combines experiments and computational models to analyze the progression of right ventricular dysfunction in the presence of pulmonary hypertension. The researchers assess the feasibility of parameter inference before designing experiments. The results show that calibrating the model with only right ventricular pressure has limitations, while including pressure and volume data from both ventricles reduces parameter identifiability and forecast uncertainty.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Di Zhou, Xin Li, Gang Yin, Shuang Li, Shihua Zhao, Zhihong Liu, Minjie Lu
Summary: By using cardiac MR feature tracking to assess right ventricular strain in patients with pulmonary hypertension, it is possible to stratify risk, predict prognosis, and provide crucial information on right ventricular remodeling, pulmonary hemodynamic condition, and exercise capacity.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Marit Kristine Smedsrud, Monica Chivulescu, Marianne Inngjerdingen Forsa, Isotta Castrini, Eivind Westrum Aabel, Christine Rootwelt-Norberg, Martin Proven Bogsrud, Thor Edvardsen, Nina Eide Hasselberg, Andreas Fruh, Kristina Hermann Haugaa
Summary: The study aimed to investigate the incidence of severe cardiac events in paediatric arrhythmogenic right ventricular cardiomyopathy (ARVC) patients and the ARVC penetrance in paediatric relatives. The results showed a high incidence of severe cardiac events in paediatric ARVC cohort, with half occurring in children aged 12 or below. Additionally, the ARVC penetrance in genotype positive paediatric relatives was 18%.
EUROPEAN HEART JOURNAL
(2022)
Editorial Material
Critical Care Medicine
Elizabeth R. Volkmann, Jill Siegfried, Tim Lahm, Corey E. Ventetuolo, Stephen C. Mathai, Virginia Steen, Erica L. Herzog, Rebecca Shansky, Montserrat C. Anguera, Sonye K. Danoff, Jon T. Giles, Yvonne C. Lee, Wonder Drake, Lisa A. Maier, Marrah Lachowicz-Scroggins, Heiyoung Park, Koyeli Banerjee, Josh Fessel, Lora Reineck, Louis Vuga, Elliott Crouser, Carol Feghali-Bostwick
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Navneet Singh, Peter Dorfmuller, Oksana A. Shlobin, Corey E. Ventetuolo
Summary: Pulmonary hypertension (PH) due to chronic lung disease is a common type of PH that requires effective treatment options. The recent approval of a therapy for pulmonary arterial hypertension related to interstitial lung disease is a positive advancement. This review examines the molecular mechanisms contributing to pulmonary vasculopathy in chronic hypoxia, the pathology and epidemiology of Group 3 PH, right ventricular dysfunction in this population, and clinical trial data on the use of pulmonary vasodilators in Group 3 PH.
CIRCULATION RESEARCH
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
David A. Bluemke
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sarah L. Atzen, David A. Bluemke
Article
Cardiac & Cardiovascular Systems
Hilary F. Armstrong, David Lederer, Gina S. Lovasi, Grant Hiura, Corey E. Ventetuolo, RGraham Barr
Summary: This study investigated the relationship between depression and the use of selective serotonin reuptake inhibitors (SSRIs) in patients with chronic obstructive pulmonary disease (COPD). The results showed that patients taking SSRIs had lower FEV1 and a higher likelihood of experiencing dyspnea compared to those not taking antidepressants.
RESPIRATORY MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Emilia A. A. Hermann, Amin Motahari, Eric A. A. Hoffman, Norrina Allen, Alain G. G. Bertoni, David A. A. Bluemke, Ali Eskandari, Sarah E. E. Gerard, Junfeng Guo, Grant T. T. Hiura, David W. W. Kaczka, Erin D. D. Michos, Prashant Nagpal, Jim Pankow, Sanjiv Shah, Benjamin M. M. Smith, Karen Hinckley Stukovsky, Yifei Sun, Karol Watson, R. Graham Barr
Summary: The study found that pulmonary blood volume decreases substantially with advanced age in older adults, and this is independently associated with greater symptom scores.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Charlene A. Mauger, Kathleen Gilbert, Avan Suinesiaputra, David A. Bluemke, Colin O. Wu, Joao A. C. Lima, Alistair A. Young, Bharath Ambale-Venkatesh
Summary: This study aimed to quantify the relationship between left ventricular (LV) three-dimensional shape at MRI and incident cardiovascular events over 10 years. Results showed that adding LV remodeling signatures to traditional cardiovascular risk factors improved the prediction of heart failure, coronary heart disease, and cardiovascular disease events over 10 years.
Article
Cardiac & Cardiovascular Systems
Maria Doughan, Omar Chehab, Henrique Doria de Vasconcellos, Ralph Zeitoun, Vinithra Varadarajan, Bassel Doughan, Colin O. Wu, Michael J. Blaha, David A. Bluemke, Joao A. C. Lima
Summary: A self-reported history of periodontal disease was found to be associated with increased measures of interstitial myocardial fibrosis in men, but not in women. This suggests a possible link between periodontal disease and subclinical myocardial fibrosis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Critical Care Medicine
Bryan S. Blette, Jude Moutchia, Nadine Al-Naamani, Corey E. Ventetuolo, Chao Cheng, Dina Appleby, Ryan J. Urbanowicz, Jason Fritz, Jeremy A. Mazurek, Fan Li, Steven M. Kawut, Michael O. Harhay
Summary: This study aimed to determine whether pulmonary arterial hypertension (PAH) risk scores could serve as adequate surrogates for clinical worsening or mortality outcomes in PAH randomized clinical trials (RCTs). Through an individual participant data meta-analysis, the study found that these risk scores were not accurate predictors of long-term clinical worsening and survival improvement. Therefore, further study is necessary before using these risk scores or other scores as surrogate outcomes in PAH RCTs or clinical care.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Urology & Nephrology
Faeq Husain-Syed, Matthew F. DiFrancesco, Rajat Deo, R. Graham Barr, Julia J. Scialla, David A. Bluemke, Richard A. Kronmal, Joao A. C. Lima, Amy Praestgaard, Russell P. Tracy, Michael Shlipak, Steven M. Kawut, John S. Kim
Summary: Low glomerular filtration rate (GFR) and increased albuminuria are associated with all-cause and cardiovascular mortality. Limited data are available on the independent associations of GFR and albuminuria with cardiac morphology, especially in early chronic kidney disease (CKD). This study found that reductions in eGFR within the normal range and higher albuminuria were associated with smaller right ventricular volumes, and albuminuria had a stronger association with mortality among those with smaller RV volumes.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tarek Zghaib, Thiago Quinaglia A. C. Silva, Bharath Ambale-Venkatesh, Eric Xie, Mohammad R. Ostovaneh, Mohammadali Habibi, David A. Bluemke, Elsayed Z. Soliman, Colin O. Wu, Susan R. Heckbert, Saman Nazarian, Joao A. C. Lima
Summary: The purpose of this study was to investigate the prevalence and correlates of left atrial late gadolinium enhancement (LGE) at cardiac MRI and its association with atrial fibrillation (AF). The results showed that LA LGE was associated with adverse atrial remodeling and independently predicted the development of AF in a multiethnic population-based sample.
RADIOLOGY-CARDIOTHORACIC IMAGING
(2023)
Article
Respiratory System
Corey E. Ventetuolo, Jude Moutchia, Grayson L. Baird, Dina H. Appleby, Robyn L. McClelland, Jasleen Minhas, Jeff Min, John H. Holmes, Ryan J. Urbanowicz, Nadine Al-Naamani, Steven M. Kawut
Summary: This study found that sex differences have an impact on baseline 6-minute walk distance, hemodynamics, and functional class in pulmonary arterial hypertension (PAH). Females had shorter 6MWD, higher cardiac index, and lower right atrial pressure and mean pulmonary artery pressure. Age and body mass index modulated the relationship between sex and these outcomes. The study suggests that sex, age, and body size should be taken into consideration in the evaluation and interpretation of surrogate outcomes in PAH.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Cardiac & Cardiovascular Systems
Katherine Cox-Flaherty, Grayson L. Baird, Julie Braza, Brianna D. Guarino, Amy Princiotto, Corey E. Ventetuolo, Elizabeth O. Harrington
Summary: This study investigates the possible influence of biological sex on the behavior of commercially available human pulmonary artery endothelial cells (HPAECs). The results suggest that there are subtle sex-based differences in HPAECs' behavior, which depend on the sex and age of the donors. Female cells show decreased proliferation and increased apoptosis compared to male cells, but exhibit stronger migration under certain conditions. These differences may affect the reliability and reproducibility of experiments, and further research is needed to determine the importance of biological sex in HPAECs' function in health and disease.
PULMONARY CIRCULATION
(2022)
Correction
Critical Care Medicine
J. Min, D. Badesch, M. Chakinala, J. Elwing, R. Frantz, E. Horn, J. Klinger, M. Lammi, S. Mazimba, J. Sager, O. Shlobin, M. Simon, T. Thenappan, D. Grinnan, C. Ventetuolo, N. Al-Naamani
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Daniel C. Yee, Debasree Banerjee, Sara E. Vargas, Melissa Allahua, Mary E. Whittenhall, Nicholas Perry, Corey E. Ventetuolo, Kate M. Guthrie
Summary: Women with pulmonary arterial hypertension (PAH) face challenges and burdens regarding sexual health-related quality of life (SHRQoL), including decreased frequency of sex, fear of intercourse due to cardiopulmonary symptoms, compensatory behaviors/strategies during sex, negative body image related to medications and oxygen supplementation, and the desire for more communication and discussion with healthcare professionals regarding sexual practices.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
