An Integrated Computational Approach to Rationalize the Activity of Non-Zinc-Binding MMP-2 Inhibitors

Pyrone-Based Inhibitors of Metalloproteinase Types 2 and 3 May Work as Conformation-Selective Inhibitors

(2011) Jacob D. Durrant et al.   Chemical Biology & Drug Design

Insights into the Complex Formed by Matrix Metalloproteinase-2 and Alloxan Inhibitors: Molecular Dynamics Simulations and Free Energy Calculations

(2011) Ilenia Giangreco et al.   PLoS One

Updated Biological Roles for Matrix Metalloproteinases and New “Intracellular” Substrates Revealed by Degradomics

(2009) Georgina S. Butler et al.   BIOCHEMISTRY

Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors

(2009) Alexander Heim-Riether et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

(2009) Mark E. Schnute et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Managing protein flexibility in docking and its applications

(2009) Chandrika B-Rao et al.   DRUG DISCOVERY TODAY

Independent-Trajectories Thermodynamic-Integration Free-Energy Changes for Biomolecular Systems: Determinants of H5N1 Avian Influenza Virus Neuraminidase Inhibition by Peramivir

(2009) Morgan Lawrenz et al.   Journal of Chemical Theory and Computation

Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S1′ Subsite of Matrix Metalloproteinase 8 (MMP-8)†

(2009) Giorgio Pochetti et al.   JOURNAL OF MEDICINAL CHEMISTRY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Quinazolinones and Pyrido[3,4-d]pyrimidin-4-ones as Orally Active and Specific Matrix Metalloproteinase-13 Inhibitors for the Treatment of Osteoarthritis

(2008) Jie Jack Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Progress in matrix metalloproteinase research

(2008) G MURPHY et al.   MOLECULAR ASPECTS OF MEDICINE

MMPs as therapeutic targets—Still a viable option?

(2007) B FINGLETON   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY