Article
Biochemistry & Molecular Biology
Nicolas Cardinault, Franck Tourniaire, Julien Astier, Charlene Couturier, Lauriane Bonnet, Eva Seipelt, Esma Karkeni, Claire Letullier, Naima Dlalah, Stephane George, Lourdes Mounien, Jean-Francois Landrier
Summary: The study showed that poplar propolis extract is effective in reducing weight gain and improving glucose homeostasis, while other two propolis extracts did not have the same effect. Poplar propolis extract induced gene expression related to lipid catabolism and antioxidant enzymes in adipose tissue, suggesting its potential benefits in preventing obesity and associated comorbidities.
Article
Endocrinology & Metabolism
Neha Tawar, Basu Dev Banerjee, Sri Venkata Madhu, Vivek Agrawal, Sanjay Gupta
Summary: This study found the presence of organochlorine pesticides (OCPs) and their metabolites in visceral adipose tissue of subjects with type 2 diabetes mellitus (T2DM). The levels of delta-HCH, heptachlor, endrin, and p,p ' DDT were higher in the T2DM group and correlated with fasting and postprandial plasma glucose levels. There was also a positive association between OCPs and central adiposity and ER stress markers.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Minglan Yang, Jie Chen, Jiang Yue, Shenyun He, Jingjing Fu, Yicheng Qi, Wen Liu, Hua Xu, Shengxian Li, Qing Lu, Jing Ma
Summary: This study found that liver fat content (LFC) is associated with the risk of impaired glucose regulation (IGR) in overweight/obese patients, while there is no significant association between visceral and pancreatic fat accumulation and IGR. Patients with high LFC and low visceral fat or high LFC and high visceral fat have a higher prevalence of IGR than those with low liver fat and low visceral fat. However, there is no difference in the prevalence of IGR between the low liver fat-low visceral fat group and the low liver fat-high visceral fat group.
DIABETES OBESITY & METABOLISM
(2023)
Article
Chemistry, Analytical
Maryam Nazari, Soheila Kashanian, Kobra Omidfar, Sirous Ghobadi, Hector C. Goicoechea, Hui-Wen Gu, Reza Khodarahmi, Ali R. Jalalvand
Summary: This research project investigates the interactions of acarbose with normal human serum albumin and glycated HSA using chemometrics assisted-electrochemical and spectroscopic techniques. By combining various analytical methods and chemometric algorithms, the study sheds light on the binding mechanisms between ACB and HSA/GHSA. Additionally, a novel electrochemical technique was developed for the determination of GHSA as a potential biomarker in diabetes, showing successful validation using synthetic and real samples.
MICROCHEMICAL JOURNAL
(2021)
Article
Medical Laboratory Technology
Nasheeta Peer, Jaya George, Carl Lombard, Naomi Levitt, Andre -Pascal Kengne
Summary: The study examined the potential of glycated albumin (GA) and fructosamine (FA) as alternative tests for diabetes screening in South Africans. Results showed promising associations, but longitudinal studies are needed for further validation.
CLINICA CHIMICA ACTA
(2021)
Article
Medicine, General & Internal
Ashot Mkrtumyan, Alexander Ametov, Tatiana Demidova, Anna Volkova, Ekaterina Dudinskaya, Arkady Vertkin, Sergei Vorobiev
Summary: Subetta therapy effectively improves 2-hour plasma glucose levels in patients with IGT, with a low incidence of adverse events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Food Science & Technology
Stefan Kabisch, Caroline Honsek, Margrit Kemper, Christiana Gerbracht, Nina Marie Tosca Meyer, Ayman M. Arafat, Andreas L. Birkenfeld, Juergen Machann, Ulrike Dambeck, Martin A. Osterhoff, Martin O. Weickert, Andreas F. H. Pfeiffer
Summary: The Optimal Fibre Trial (OptiFiT) investigated the metabolic effects of insoluble cereal fibre in subjects with impaired glucose tolerance (IGT), showing moderate glycemic and anti-inflammatory benefits, especially in those with an obesity-related phenotype. Additional analysis on body fat distribution in a subgroup showed that the fibre group experienced reductions in visceral and non-visceral fat, fasting glucose, HbA1c, fasting insulin, insulin resistance, and uric acid, compared to the placebo group, but after adjusting for weight loss, no significant between-group differences were found. There was a statistical trend for fibre-driven liver fat reduction in subjects with confirmed non-alcoholic fatty liver disease (NAFLD), suggesting further research is needed to explore the beneficial effects of insoluble cereal fibre on visceral and hepatic fat storage.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Endocrinology & Metabolism
Elena Tarabra, Jessica Nouws, Alla Vash-Margita, Marc Hellerstein, Veronika Shabanova, Sarah McCollum, Bridget Pierpont, Dejian Zhao, Gerald I. Shulman, Sonia Caprio
Summary: The study revealed that reduced expression of CIDEA in girls with high visceral adipose tissue is associated with adipocyte hypertrophy and insulin resistance.
Article
Endocrinology & Metabolism
Hanying Liu, Di Yang, Shaobo Li, Yunfeng Xiao, Yinfang Tu, Danfeng Peng, Yuqian Bao, Junfeng Han, Haoyong Yu
Summary: A simple model to predict VFA using age, waist circumference, and neck circumference was developed and validated in overweight and obese Chinese individuals, demonstrating good predictive power for both men and women. The equations provide an ideal tool for early detection of visceral obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemical Research Methods
Parsa Bazdar, Ali R. Jalalvand, Vali Akbari, Reza Khodarahmi, Hector C. Goicoechea
Summary: This article discusses the investigation of interactions between miglitol and normal human serum albumin and glycated HSA, using spectroscopic and electrochemical data. Chemometric methods were employed to extract useful information for justifying these interactions, and molecular docking techniques were used for further investigation. A novel chemometrics-assisted electroanalytical method was developed for diagnostic and monitoring of diabetes.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Yuki Komatsu, Kiyoshi Aoyama, Mamoru Yoneda, Shogo Ito, Yusuke Sano, Yumeno Kawai, Xixi Cui, Yuichiro Yamada, Nozomi Furukawa, Katsuhide Ikeda, Kohzo Nagata
Summary: The removal of interscapular brown adipose tissue (iBAT) attenuated the exacerbation of cardiac inflammation and fibrosis induced by salt loading in DS/obese rats, but did not affect the development of hypertension. Salt loading led to adipocyte hypertrophy and increased inflammation in white adipose tissue, while the conversion of iBAT to white adipose tissue-like tissue contributed to elevated levels of circulating interleukin-6, exacerbating cardiac pathology.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Multidisciplinary Sciences
Lisa Dowling, Philip Jakeman, Catherine Norton, Maeve M. Skelly, Hamid Yousuf, Miranda G. Kiernan, Margaret Toomey, Sheila Bowers, Suzanne S. Dunne, J. Calvin Coffey, Colum P. Dunne
Summary: Crohn's disease is a global inflammatory bowel condition that differs from healthy population in terms of body fat distribution, specifically showing elevated gynoid fat and reduced android fat. There is a potential rationale to refer to Crohn's disease as a fatty intestine condition, similar to fatty liver conditions, which may require further investigation in a larger patient cohort.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Pernille Heimdal Holm, Louise Hindso, Kristine Boisen Olsen, Jytte Banner
Summary: The study explores the associations between obesity, myocardial fat, visceral adipose tissue, and cardiovascular disease. It finds that myocardial fat is correlated with obesity and epicardial adipose tissue, but not with waist-hip ratio or visceral adipose tissue measures. The findings suggest that myocardial fat plays a role in cardiovascular health, particularly in the right ventricle.
Article
Endocrinology & Metabolism
Cyrus Desouza, Julio Rosenstock, Takuji Kohzuma, Vivian A. Fonseca
Summary: This study compared the relationship between continuous glucose monitoring parameters and glycated albumin, glycated hemoglobin A(1c), and fructosamine. The results showed that glycated albumin is the most accurate predictor of continuous glucose monitoring time.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Hubert Kolb
Summary: Obesity-induced inflammation of adipose tissue is initially a protective response, but may contribute to tissue damage later on. The metabolic imbalance of adipocytes in obesity leads to activation of resident immune cells, enhancing tissue protective responses. However, chronic overnutrition results in insufficient protective actions, leading to adipocyte death and cellular senescence. This can cause influx and activation of immune cells, as well as intensified matrix remodeling and angiogenesis.
Letter
Surgery
Yunfeng Xiao, Zongke Yang
ASIAN JOURNAL OF SURGERY
(2023)
Article
Endocrinology & Metabolism
Fengjing Liu, Si Chen, Xiao Li, Shaobo Li, Yunfeng Xiao, Junfeng Han, Yinfang Tu, Yuqian Bao, Wenkun Bai, Haoyong Yu
Summary: This study explored whether visceral fat accumulation mediates the development of hepatic steatosis in overweight and obese individuals. The results showed a positive correlation between visceral fat accumulation and hepatic steatosis, especially in women. This suggests the need to focus on reducing visceral fat in obese individuals.
Editorial Material
Endocrinology & Metabolism
Si Chen, Jingyi Lu, Danfeng Peng, Fengjing Liu, Wei Lu, Wei Zhu, Jian Zhou, Weiping Jia
Article
Pharmacology & Pharmacy
Peng Dong, Hongshuai Lv, Weiping Jia, Jiaojiao Liu, Si Wang, Xiaohai Li, Jinghua Hu, Ling Zhao, Yikang Shi
Summary: Polysaccharide-based dual-drug conjugates represent an effective way to improve chemotherapeutic agents by enhancing drug solubility and increasing drug accumulation in tumor tissues.
Article
Pharmacology & Pharmacy
Jing Wang, Hua Liang, You Wang, Xueying Zheng, Fei Chen, Jian Shao, Zhaoxu Geng, Li Zheng, Wenying Yang, Jianping Weng, Tao Xu, Kaixin Zhou
Summary: Using data from Chinese patients with newly diagnosed type 2 diabetes, the study found that mitochondrial DNA copy number (mtDNA-CN) can serve as a biomarker to guide the choice between metformin and acarbose.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Chemistry, Medicinal
Yang Xiao, Mengcong Ma, Yichen Li, Yunfeng Xiao
Summary: This study obtained 86 component-disease intersection genes by intersecting drug targets and Flos Daturae targets, and further screened and identified AKT1, MYC, EGFR, MAPK14, PTGS2, and VEGFA as the six core genes. The results indicated that Flos Daturae has multiple components and targets that regulate body functions for the treatment of breast cancer. It was also inferred that polygenic regulation is more effective than the single-gene approach in breast cancer treatment.
LETTERS IN DRUG DESIGN & DISCOVERY
(2023)
Article
Chemistry, Multidisciplinary
Xi Yang, Shui-Jing Tang, Jia-Wei Meng, Pei-Ji Zhang, You -Ling Chen, Yun-Feng Xiao
Summary: Liquid-crystal microcavity lasers exhibit extraordinary tunability and sensitivity to external stimuli. In this study, a liquid-crystal microcavity laser operated in the phase transition is demonstrated, showing significant wavelength shift and improved sensitivity for thermal sensing. The phase-transition microcavity laser offers great potential for high-performance sensors, optical modulators, and soft matter photonics.
Article
Nutrition & Dietetics
Rong Yu, Xiaoqi Ye, Xiangning Wang, Qiang Wu, Lili Jia, Keqing Dong, Zhijun Zhu, Yuqian Bao, Xuhong Hou, Weiping Jia
Summary: This study found a positive association between serum cholinesterase (ChE) and the incidence of diabetic retinopathy (DR). High levels of ChE were associated with an increased risk of DR. ChE may serve as a potential biomarker for predicting the occurrence of DR.
NUTRITION & METABOLISM
(2023)
Article
Physics, Multidisciplinary
Hao Zhang, Teng Tan, Hao-Jing Chen, Yan Yu, Wenting Wang, Bing Chang, Yupei Liang, Yanhong Guo, Heng Zhou, Handing Xia, Qihuang Gong, Chee Wei Wong, Yunjiang Rao, Yun-Feng Xiao, Baicheng Yao
Summary: By combining Kerr and Brillouin nonlinearities in an over-modal microcavity, soliton microcombs can be spatially multiplexed under a single external laser pumping operation, resulting in highly coherent dual-comb sources with low beating noise. The repetition rate difference of a dual-comb pair can be flexibly switched by selecting the dual-comb modes. Additionally, the high-density mode geometry allows the co-generation of up to 5 space-multiplexing frequency combs in distinct mode families, offering a versatile tool for comb interferometry, comb metrology, spectroscopy, and ranging.
PHYSICAL REVIEW LETTERS
(2023)
Editorial Material
Optics
You-Ling Chen, Qi-Tao Cao, Yun-Feng Xiao
Summary: An optical black-hole cavity based on transformation optics is capable of enhancing Q-factor and confining strong fields, by eliminating radiation loss in conventional whispering-gallery modes. This has potential applications in energy harvesting and optoelectronics.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Yi Zhang, Yangyang Zhu, Jinghui Wang, Li Jin, Mingwei Guo, Liwei Chen, Lina Zhang, Yangyang Li, Baocheng Wan, Rong Zhang, Weiping Jia, Cheng Hu
Summary: Nrg4 is an adipose tissue-enriched factor that regulates glucose and lipid metabolism and is closely associated with obesity. It acts on ErbB4 in the hypothalamus, excites PVN neurons, and influences energy balance. Its effects on reducing obesity are mediated through ErbB4-mediated excitation of Oxt release from Oxt neurons.
Article
Endocrinology & Metabolism
Yanping Yuan, Xianghai Zhou, Weiping Jia, Jian Zhou, Fan Zhang, Jianling Du, Linong Ji
Summary: The study aimed to develop an HbA1c prediction model with both fasting and postprandial capillary blood glucose to estimate HbA1c in type 2 diabetes. The new HbA1c prediction model using ridge regression showed better prediction ability and good agreement.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Junping Zhang, Jian Pu, Jie Chen, Haolin Fu, Yongzhi Tao, Shihmin Wang, Qi Chen, Yunfeng Xiao, Siming Chen, Yuan Cheng, Hongming Shan, Dewang Chen, Fei-Yue Wang
Summary: Data science is dedicated to extracting valuable data from noisy data to generate actionable insights. It finds broad applications in internet search, tourism, social media, and many other domains. However, there have been limited systematic studies on the application of data science in the field of intelligent vehicles. With the increasing size of data in intelligent vehicles, it is essential to provide a high-level overview of how data science can be utilized to enhance intelligent vehicle performance. This paper retrospectively examines the history of data science and highlights the potential and prospects of data science in the domain of intelligent vehicles, discussing topics such as data management, trusted data, interpretability, and the high-order relationship of intelligent vehicle data. Additionally, the paper examines the relationship between data science and practical intelligent vehicle applications, including self-driving systems, data visualization, and parallel intelligent vehicle systems.
IEEE TRANSACTIONS ON INTELLIGENT VEHICLES
(2023)
Article
Health Care Sciences & Services
Lee-Ling Lim, Eric S. H. Lau, Alice P. S. Kong, Amy W. C. Fu, Vanessa Lau, Weiping Jia, Wayne H. H. Sheu, Leorino Sobrepena, K. H. Yoon, Alexander T. B. Tan, Yook-Chin Chia, Aravind Sosale, Banshi D. Saboo, Jothydev Kesavadev, Su-Yen Goh, Thy Khue Nguyen, Yotsapon Thewjitcharoen, Raymond Suwita, Ronald C. W. Ma, Elaine Y. K. Chow, Andrea O. Y. Luk, Juliana C. N. Chan
Summary: Diabetes-related death due to cardiorenal diseases is higher in women than men in Asia, possibly due to gender disparity in quality of care and health habits. A study assessed adults with type 2 diabetes from 11 Asian countries/areas and compared treatment target attainment, use of cardiorenal-protective drugs, and health habits by gender. The findings showed that in most countries/areas, men had higher rates of achieving treatment targets than women.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Optics
Shui-Jing Tang, Mingjie Zhang, Jialve Sun, Jia-Wei Meng, Xiao Xiong, Qihuang Gong, Dayong Jin, Qi-Fan Yang, Yun-Feng Xiao
Summary: Researchers demonstrate real-time measurement of natural vibrations of single mesoscopic particles using photoacoustic excitation and acoustic coupling to an optical microresonator for readout. This technology extends the reach of vibrational spectroscopy and is applied for biomechanical fingerprinting of microorganisms at the single-cell level.
