Article
Immunology
Hongbo Liu, Ming Zhang, Changzeng Feng, Shanri Cong, Danhan Xu, Hao Sun, Zhaoqing Yang, Shaohui Ma
Summary: CVA6 is a key pathogen causing hand, foot and mouth disease, and the KYN-A1205 strain adapted to KMB17 cells shows stronger virulence, virus tropism, and immunogenicity, making it a potential vaccine candidate.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Yu Zhang, Shuaiyin Chen, Tiantian Sun, Guangcai Duan, Haiyan Yang, Huifen Feng, Wenjie Jiang, Dong Li, Wangquan Ji, Peiyu Zhu, Yuefei Jin
Summary: Coxsackievirus A6 (CVA6) infection is associated with myocardial injury in hand, foot, and mouth disease (HFMD). Neutrophil infiltration is linked to the occurrence of myocardial injury. Depletion of neutrophils reduces cardiac enzymes, pathology in the heart, and inflammatory cytokine production. Clinical observations also support the role of neutrophils in myocardial injury.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Genetics & Heredity
Wenwei Lu, Zhangming Pei, Mengning Zang, Yuan-kun Lee, Jianxin Zhao, Wei Chen, Hongchao Wang, Hao Zhang
Summary: The research found that Bifidobacterium bifidum has an open pan-genome and a conserved core genome, with genetic diversity mainly reflected in carbohydrate metabolism and immune/competition-related factors. In addition, a novel CRISPR-Cas system was discovered in B. bifidum through this study.
Article
Multidisciplinary Sciences
Pirom Noisumdaeng, Pilaipan Puthavathana
Summary: This study characterized the molecular evolution of hand, foot and mouth disease (HFMD) viruses in Thailand over a period of twenty years. The findings revealed the co-circulation and subgenotypic changes of the major pathogens causing HFMD outbreaks. The study provided valuable insights into molecular epidemiology and supported the development and implementation of genotype-matched vaccines.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Everlyn Kamau, Dung Nguyen, Cristina Celma, Soile Blomqvist, Peter Horby, Peter Simmonds, Heli Harvala
Summary: The seroprevalence of EV-A71 and CVA6 viruses increases with age, reaching over 75% by 10 years old, but antibody titers decline after 20 years. Despite a marked increase in CVA6-related HFMD incidence from 2010, age profiles for acquiring infections and mean titers remained comparable in the three testing years. This suggests a change in CVA6's pathogenicity over the 11-year study period, as indicated by seroprevalence data.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Microbiology
Belen Gonzalez-Santamarina, Silvia Garcia-Soto, Helmut Hotzel, Diana Meemken, Reinhard Fries, Herbert Tomaso
Summary: S. Derby is a common cause of salmonellosis in humans and animals. Understanding its genetic diversity and resistance to antimicrobial treatment is crucial for epidemiological control. In this study, 15 S. Derby strains from Germany were analyzed, showing similar genetic diversity among strains from different sources, with most isolates carrying resistance genes and plasmids carrying antimicrobial resistance genes.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
Weijie Gao, Lei Yue, Ting Yang, Hua Li, Xia Song, Tianhong Xie, Xing He, Zhongping Xie
Summary: This study analyzed ten CVA10 strains, all falling into Genotype C, through genotyping and culture experiments. The results showed that the infectious titer of these strains increased with each generation in cell culture, causing limb paralysis in mice. The strains induced a good immune response and could potentially serve as candidates for CVA10 vaccines.
Article
Biology
Carina R. Buettner, Radovan Spurny, Tibor Fuezik, Pavel Plevka
Summary: CV-A6 has become the primary causative agent of hand, foot, and mouth disease worldwide. Unlike other enteroviruses, CV-A6 uses altered particles to infect cells. The structure of CV-A6 virion is similar to other enteroviruses and plays a crucial role in infection.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Sadia Mahboob, Nimat Ullah, Muhammad Farhan Ul Haque, Waqar Rauf, Mazhar Iqbal, Amjad Ali, Moazur Rahman
Summary: This study characterized novel bovine isolates of Pasteurella multocida serotype B:2 from Pakistan and found that these strains lack the surface antigens OmpH and PlpE, which are important for protective immunity against the infection. The findings can contribute to the development of targeted therapeutic agents and diagnostic tools for HS-associated P. multocida serotype B:2 strains.
Article
Biochemistry & Molecular Biology
Qi Zhou, Kaijie Mai, Dehong Yang, Junfa Liu, Zhuanqiang Yan, Cuifen Luo, Yangtong Tan, Sheng Cao, Qingfeng Zhou, Li Chen, Feng Chen
Summary: Sequencing and analysis of 15 Mycoplasma anatis strains revealed the genomic structure and functional characteristics, identifying numerous virulence-related genes, most of which are highly conserved across all strains. This information provides insights into molecular mechanisms of drug resistance, adaptive evolution of pathogens, population structure, and vaccine development.
Article
Pediatrics
Fang-Fang Cheng, Bing-Bing Zhang, Meng-Lu Cao, Qian Zhang, Qing-Hui Chen, Zhao-Fang Hui, Jian-Mei Tian, Wen-Hua Yan
Summary: Atypical HFMD caused by CV-A6 infection primarily affects children under 5 years old, with bullous skin lesions being the main characteristic and a relatively high misdiagnosis rate. The morphologies of the rashes exhibit greater variation in the infant group, while the rashes in the preschool group are more widely distributed. These findings provide valuable guidance for clinical diagnosis and treatment.
TRANSLATIONAL PEDIATRICS
(2022)
Article
Environmental Sciences
Lei Gao, Bao-Zhu Fang, Chun-Yan Lu, Kun-Hui Hong, Xin-Yu Huang, Ting-Ting She, Min Xiao, Wen-Jun Li
Summary: During an investigation of microbial diversity in sediments, seven strains of Demequina were found. These strains have the potential to degrade complex carbon sources and oxidize sulfides, and provide insights into their metabolic model and ecological roles.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Virology
Rita C. C. Carmona, Braulio C. Machado, Fabricio C. Reis, Adriana M. V. Jorge, Audrey Cilli, Amanda M. N. Dias, Daniele R. Morais, Lucas Leme, Ana L. F. Yu, Marcela R. Silva, Telma R. M. P. Carvalhanas, Maria C. S. T. Timenetsky
Summary: This study investigated a large outbreak of Hand, foot, and mouth disease during the COVID-19 pandemic in 2021, and found the reemergence of CVA6 in HFMD. It highlights the importance of continued surveillance of circulating enterovirus types in the post-COVID pandemic era.
JOURNAL OF CLINICAL VIROLOGY
(2022)
Review
Virology
Yingying Shi, Peiqing Chen, Yijing Bai, Xuan Xu, Yongjuan Liu
Summary: This study conducted a systematic review and meta-analysis to assess the serological prevalence of EV-A71 and CVA6 antibodies in different populations. The results showed that the seroprevalence of EV-A71 and CVA6 antibodies is related to age rather than gender or region. Children under five years of age have lower rates of seropositivity, but the rates gradually increase with age. This study provides a basis for understanding the risk factors for EV-A71 and CVA6 infection in China and formulating preventive measures to prevent the spread of the virus.
ARCHIVES OF VIROLOGY
(2023)
Article
Fisheries
Bintong Yang, Chong Chen, Yufeng Sun, Linan Cao, Dongxing Zhang, Wuwen Sun, Lei Zhang, Guiqin Wang, Xiaofeng Shan, Yuanhuan Kang, Aidong Qian
Summary: Aeromonas veronii is an important zoonotic and aquatic agent, with increasing virulence possibly related to specific virulence factors and gene clusters. Research has shown that the virulent strain TH0426 harbors various virulence factors and unique type III secretion systems and iron ion transport systems.
JOURNAL OF FISH DISEASES
(2021)
Article
Immunology
Chung-Guei Huang, Li-Ang Lee, Tuan-Jen Fang, Hsueh-Yu Li, Chun-Ta Liao, Chung-Jan Kang, Tzu-Chen Yen, Kuo-Chien Tsao, Tse-Ching Chen, Shin-Ru Shih
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2020)
Article
Virology
Rei-Lin Kuo, Chi-Jene Chen, Robert Y. L. Wang, Hsing-I Huang, Ya-Han Lin, Ee-Hong Tam, Wen-Jung Tu, Shang-En Wu, Shin-Ru Shih
JOURNAL OF VIROLOGY
(2019)
Article
Multidisciplinary Sciences
Mei-Ling Li, Jing-Yi Lin, Bo-Shiun Chen, Kuo-Feng Weng, Shin-Ru Shih, Jesse Davila Calderon, Blanton S. Tolbert, Gary Brewer
Article
Pediatrics
Sheng-Yuan Ho, Cheng-Hsun Chiu, Yhu-Chering Huang, Chih-Jung Chen, Reyin Lien, Shih-Ming Chu, Chung-Guei Huang, Kuo-Chien Tsao, Shin-Ru Shih, Jen-Fu Hsu
PEDIATRICS AND NEONATOLOGY
(2020)
Article
Microbiology
Peng-Nien Huang, Hsiang-Ching Wang, Hui-Chen Hung, Sung-Nien Tseng, Teng-Yuan Chang, Min-Yuan Chou, Yu-Jen Chen, Yun-Ming Wang, Shin-Ru Shih, John Tsu-An Hsu
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Biochemistry & Molecular Biology
Kuo-Ming Lee, Chih-Ching Wu, Shang-En Wu, Ya-Han Lin, Li-Ting Wang, Chun-Ru Chang, Peng-Nien Huang, Shin-Ru Shih, Rei-Lin Kuo
Review
Microbiology
Bo-Shiun Chen, Hou-Chen Lee, Kuo-Ming Lee, Yu-Nong Gong, Shin-Ru Shih
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Immunology
Hsing- Huang, Jhao-Yin Lin, Hsiao-Chu Chiang, Pen-Nien Huang, Qing-Dong Lin, Shin-Ru Shih
JOURNAL OF INFECTIOUS DISEASES
(2020)
Review
Biochemistry & Molecular Biology
Yen-Chin Liu, Rei-Lin Kuo, Shin-Ru Shih
BIOMEDICAL JOURNAL
(2020)
Article
Microbiology
Chung-Guei Huang, Kuo-Ming Lee, Mei-Jen Hsiao, Shu-Li Yang, Peng-Nien Huang, Yu-Nong Gong, Tzu-Hsuan Hsieh, Po-Wei Huang, Ya-Jhu Lin, Yi-Chun Liu, Kuo-Chien Tsao, Shin-Ru Shih
JOURNAL OF CLINICAL MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Daming Zhou, Helen M. E. Duyvesteyn, Cheng-Pin Chen, Chung-Guei Huang, Ting-Hua Chen, Shin-Ru Shih, Yi-Chun Lin, Chien-Yu Cheng, Shu-Hsing Cheng, Yhu-Chering Huang, Tzou-Yien Lin, Che Ma, Jiandong Huo, Loic Carrique, Tomas Malinauskas, Reinis R. Ruza, Pranav N. M. Shah, Tiong Kit Tan, Pramila Rijal, Robert F. Donat, Kerry Godwin, Karen R. Buttigieg, Julia A. Tree, Julika Radecke, Neil G. Paterson, Piyada Supasa, Juthathip Mongkolsapaya, Gavin R. Screaton, Miles W. Carroll, Javier Gilbert-Jaramillo, Michael L. Knight, William James, Raymond J. Owens, James H. Naismith, Alain R. Townsend, Elizabeth E. Fry, Yuguang Zhao, Jingshan Ren, David Stuart, Kuan-Ying A. Huang
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2020)
Editorial Material
Medicine, General & Internal
Ville Peltola, Shin-Ru Shih, Kelvin Kai-Wang To
FRONTIERS IN MEDICINE
(2020)
Article
Cell Biology
Su-Jhen Hung, Yin-Mei Hsu, Sheng-Wen Huang, Huey-Pin Tsai, Leo Yi Yang Lee, Aeron C. Hurt, Ian G. Barr, Shin-Ru Shih, Jen-Ren Wang
JOURNAL OF BIOMEDICAL SCIENCE
(2020)
Review
Cell Biology
Jing-Yi Lin, Yu-An Kung, Shin-Ru Shih
JOURNAL OF BIOMEDICAL SCIENCE
(2019)
Article
Cell Biology
Ruey-Wen Lin, Guang-Wu Chen, Hsiang-Hsuan Sung, Ren-Jye Lin, Li-Chen Yen, Yu-Ling Tseng, Yung-Kun Chang, Shu-Pei Lien, Shin-Ru Shih, Ching-Len Liao
JOURNAL OF BIOMEDICAL SCIENCE
(2019)