Hypoxia-Induced Modulation of Apoptosis and BCL-2 Family Proteins in Different Cancer Cell Types

Hypoxia-Induced Decrease in p53 Protein Level and Increase in c-jun DNA Binding Activity Results in Cancer Cell Resistance to Etoposide

(2015) Jean-Philippe Cosse et al.   NEOPLASIA

Tumour Hypoxia Affects the Responsiveness of Cancer Cells to Chemotherapy and Promotes Cancer Progression

(2012) Jean-Philippe Cosse et al.   Anti-Cancer Agents in Medicinal Chemistry

P53 and its molecular basis to chemoresistance in breast cancer

(2012) Stian Knappskog et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Autophagy as a mediator of chemotherapy-induced cell death in cancer

(2011) Annick Notte et al.   BIOCHEMICAL PHARMACOLOGY

Hypoxia-induced cisplatin resistance is reversible and growth rate independent in lung cancer cells

(2011) Christoph Wohlkoenig et al.   CANCER LETTERS

CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL

(2011) Rebecca Gilley et al.   CELLULAR SIGNALLING

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

Spindle Poisons and Cell Fate: A Tale of Two Pathways

(2011) D. R. Matson et al.   MOLECULAR INTERVENTIONS

Reciprocal influence of the p53 and the hypoxic pathways

(2011) A Sermeus et al.   Cell Death & Disease

Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts

(2010) Baosheng Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

BNIP3 protects HepG2 cells against etoposide-induced cell death under hypoxia by an autophagy-independent pathway

(2010) Jean-Philippe Cosse et al.   BIOCHEMICAL PHARMACOLOGY

Controlling the cell death mediators Bax and Bak: puzzles and conundrums

(2010) Jamie I. Fletcher et al.   CELL CYCLE

Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim

(2010) Diane Moujalled et al.   EMBO REPORTS

BH3 Domains other than Bim and Bid Can Directly Activate Bax/Bak

(2010) Han Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Suppression of Bim and Bmf Blocks Anoikis and Luminal Clearing during Mammary Morphogenesis

(2010) Kelly A. Whelan et al.   MOLECULAR BIOLOGY OF THE CELL

Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxia

(2010) Lionel Flamant et al.   Molecular Cancer

Hypoxia-activated Smad3-specific Dephosphorylation by PP2A

(2009) Pekka T. Heikkinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BCL-xL Is a Target Gene Regulated by Hypoxia-inducible Factor-1α

(2009) Ni Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-1α modulation by topoisomerase inhibitors in non-small cell lung cancer cell lines

(2009) Yun Jung Choi et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

βTrCP- and Rsk1/2-Mediated Degradation of BimEL Inhibits Apoptosis

(2009) Elinor Dehan et al.   MOLECULAR CELL

Noxa: at the tip of the balance between life and death

(2009) C Ploner et al.   ONCOGENE

Effects of lentivirus-mediated HIF-1α knockdown on hypoxia-related cisplatin resistance and their dependence on p53 status in fibrosarcoma cells

(2008) J Hao et al.   CANCER GENE THERAPY

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

(2008) E M Michalak et al.   CELL DEATH AND DIFFERENTIATION

Regulation of Bcl-2 Family Proteins by Posttranslational Modifications

(2008) Anthony Letai et al.   CURRENT MOLECULAR MEDICINE

Epidermal Growth Factor Abrogates Hypoxia-Induced Apoptosis in Cultured Human Trophoblasts through Phosphorylation of BAD Serine 112

(2008) Rachel G. Humphrey et al.   ENDOCRINOLOGY

Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity

(2008) Audrey Sermeus et al.   Molecular Cancer

Multisite Phosphorylation Regulates Bim Stability and Apoptotic Activity

(2008) Anette Hübner et al.   MOLECULAR CELL

Hypoxia and Aggressive Tumor Phenotype: Implications for Therapy and Prognosis

(2008) P. Vaupel   ONCOLOGIST

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY