Article
Anesthesiology
David A. C. Messerer, Thomas Datzmann, Anke Baranowsky, Leandra Peschel, Andrea Hoffmann, Michael Groeger, Michael Amling, Martin Wepler, Benedikt L. Nussbaum, Shan Jiang, Paul Knapstein, Antonia Donat, Enrico Calzia, Peter Radermacher, Johannes Keller
Summary: The study found that CGRP receptor antagonism with olcegepant was not beneficial in a porcine model of polymicrobial sepsis, which closely mimics human sepsis.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Nutrition & Dietetics
Robert Percy Marshall, Jan-Niklas Droste, Juergen Giessing, Richard B. Kreider
Summary: Creatine monohydrate (CrM) is a popular nutritional supplement used to enhance exercise performance and training adaptations. It has potential therapeutic effects in chronic and traumatic diseases, improving cellular energy and providing neuroprotective and antioxidant benefits. Moreover, CrM supplementation may have a role in managing mitochondrial dysfunction-related diseases, ischemic conditions, and injury pathology. However, further research is needed to establish its effectiveness in these therapeutic applications.
Article
Multidisciplinary Sciences
Tazio Maleitzke, Alexander Hildebrandt, Tamara Dietrich, Jessika Appelt, Denise Jahn, Ellen Otto, Dario Zocholl, Anke Baranowsky, Georg N. Duda, Serafeim Tsitsilonis, Johannes Keller
Summary: Calcitonin has potential protective effects against joint inflammation, cartilage degradation, and excessive bone remodeling in experimental RA.
Article
Emergency Medicine
Tobias Dust, Maximilian J. Hartel, Julian-Elias Henneberg, Alexander Korthaus, Tobias Malte Ballhause, Johannes Keller, Malte Ohlmeier, Kai-Jonathan Maas, Karl-Heinz Frosch, Matthias Krause
Summary: This study evaluated the reliability of modern CT-based classification systems for tibial plateau fractures and investigated the diagnostic-added value of 3D printing on these classification systems. The results showed that the new classification systems had overall slight to fair reliability, and the use of 3D printing technology was beneficial for the preoperative diagnosis of tibial plateau fractures. Among the classification systems, the 10-Segment classification system demonstrated the highest clinical value across all levels of user experience.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Biology
Jan-Niklas Droste, Robert Percy Marshall, Stephan Borte, Sebastian Seyler, Helge Riepenhof
Summary: The study revealed significantly lower average time loss caused by COVID-19 infection in La Liga compared to the other three leagues studied, and a positive, significant correlation between national environmental COVID-19 incidence level and the incidence of COVID-19 cases in football leagues.
Article
Cell Biology
Tazio Maleitzke, Tamara Dietrich, Alexander Hildebrandt, Jerome Weber, Jessika Appelt, Denise Jahn, Ellen Otto, Dario Zocholl, Shan Jiang, Anke Baranowsky, Georg N. Duda, Serafeim Tsitsilonis, Johannes Keller
Summary: The study found that procalcitonin (PCT) is applied as a sensitive biomarker to exclude bacterial infections in patients with rheumatoid arthritis (RA) flare-ups. Little is known about the pathophysiological role of PCT in RA. The study revealed that the lack of PCT protected Calca-deficient mice from joint inflammation.
INFLAMMATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Tobias Malte Ballhause, Shan Jiang, Weixin Xie, Jan Sevecke, Christine Dowling, Tobias Dust, Sabine Brandt, Peter R. Mertens, Timur Alexander Yorgan, Thorsten Schinke, Karl-Heinz Frosch, Anke Baranowsky, Johannes Keller
Summary: Notch signaling regulates cell fate in multiple tissues including the skeleton. A rare inherited disease called Hajdu-Cheney-Syndrome (HCS), caused by Notch2 gene mutations, is characterized by early-onset osteoporosis and increased risk for fractures and non-union. In this study, bone regeneration in mice with HCS mutation was examined and it was found that structural indices of bone regeneration were normal, but there were signs of increased callus turnover and impaired biomechanical stability of healed fractures.
SCIENTIFIC REPORTS
(2023)
Article
Cell & Tissue Engineering
N. Hinz, S. Butscheidt, N. M. Jandl, H. Rohde, J. Keller, F. T. Beil, J. Hubert, T. Rolvien
Summary: This study characterized local bone microstructure and metabolism in patients with chronic PJI, showing osteosclerosis with high bone turnover. Staphylococcus aureus infection was associated with increased osteoclast indices, suggesting the need for early surgical treatment to prevent periprosthetic bone alterations.
BONE & JOINT RESEARCH
(2023)
Article
Multidisciplinary Sciences
Antonia Donat, Shan Jiang, Weixin Xie, Paul Richard Knapstein, Lilly-Charlotte Albertsen, Judith Luisa Kokot, Jan Sevecke, Ruben Augustin, Denise Jahn, Timur Alexander Yorgan, Karl-Heinz Frosch, Serafeim Tsitsilonis, Anke Baranowsky, Johannes Keller
Summary: This study found that regular use of the SNRI reboxetine has specific effects on bone tissue, with different regions of the skeleton being affected to varying degrees. Reboxetine does not impair early and intermediate stages of fracture healing and can even improve outcomes in the late stages of healing.
Article
Cardiac & Cardiovascular Systems
J. Kandels, S. Stoebe, A. Kogel, P. Hepp, H. Riepenhof, J. N. Droste, T. Stoeggl, R. P. Marshall, U. Rudolph, U. Laufs, S. Fikenzer, A. Hagendorff
Summary: This study aimed to investigate the immediate effects of maximum physical exercise by different exercise testing methods on early post exercise left ventricular (LV) deformation parameters in competitive athletes and analyze their correlation with cardiopulmonary exercise capacity. The results showed that maximum physical exercise has an immediate effect on LV deformation, and there is a correlation between relative VO2max and Delta GWI in the early post exercise period.
ECHO RESEARCH AND PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
J. Kandels, M. Metze, A. Hagendorff, R. P. Marshall, P. Hepp, U. Laufs, S. Stoebe
Summary: In addition to LV ejection fraction (LVEF), global longitudinal strain (GLS) and global myocardial work index (GWI) are crucial for evaluating left ventricular (LV) function in athletes. This study investigated the effects of upright posture on GLS and GWI during echocardiography. The results showed that GLS and GWI were lower in upright posture, particularly in the mid-basal inferior and/or posterolateral segments. These findings highlight the importance of considering the impact of upright posture in athletes' echocardiographic assessments.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Biochemical Research Methods
Tazio Maleitzke, Jerome Weber, Alexander Hildebrandt, Tamara Dietrich, Sijia Zhou, Serafeim Tsitsilonis, Johannes Keller
Summary: The article presents a standardized protocol for inducing arthritis in mice using intraperitoneal injection of autoantibodies. It also includes daily assessments of arthritis, as well as techniques for harvesting joint and bone tissues for analysis. The importance of animal welfare and 3R considerations in experimental arthritis studies is emphasized.
Article
Cardiac & Cardiovascular Systems
Yvonne Bewarder, Lucas Lauder, Saarraaken Kulenthiran, Ortwin Schafer, Christian Ukena, Robert Percy Marshall, Pierre Hepp, Ulrich Laufs, Stephan Stoebe, Andreas Hagendorff, Michael Bohm, Felix Mahfoud, Sebastian Ewen
Summary: This study explored whether extended echocardiographic measurements such as E/e' and global longitudinal strain (GLS) can differentiate between pathological and physiological hypertrophy. The results showed that GLS and E/e' were reliable parameters to distinguish between the two types of hypertrophy, unlike left ventricular mass or LV ejection fraction.
IJC HEART & VASCULATURE
(2022)
Review
Cell & Tissue Engineering
Justus M. Grewe, Paul-Richard Knapstein, Antonia Donat, Shan Jiang, Daniel J. Smit, Weixin Xie, Johannes Keller
Summary: Osteoporosis is a global bone disease that affects a large population, and sphingosine-1-phosphate (S1P) plays a significant role in bone metabolism. S1P promotes osteoblast proliferation and bone formation, while regulating the recruitment of osteoclast precursors to resorption sites. Studies have also shown that elevated systemic S1P blood levels may be associated with an increased risk of osteoporosis-related fractures.
Article
Cell & Tissue Engineering
Anke Baranowsky, Denise Jahn, Shan Jiang, Timur Yorgan, Peter Ludewig, Jessika Appelt, Kai K. Albrecht, Ellen Otto, Paul Knapstein, Antonia Donat, Jack Winneberger, Lana Rosenthal, Paul Koehli, Cordula Erdmann, Melanie Fuchs, Karl-Heinz Frosch, Serafeim Tsitsilonis, Michael Amling, Thorsten Schinke, Johannes Keller
Summary: This study revealed that mice lacking ProCT showed increased bone resorption and excessive osteoclast formation during iPTH treatment. ProCT inhibits osteoclast formation by arresting macrophage migration, leading to reduced bone resorption during iPTH.