Modeling of Tumor Progression in NSCLC and Intrinsic Resistance to TKI in Loss of PTEN Expression

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

(2016) Linda S. Steelman et al.   Aging-US

Blocking the PI3K/AKT and MEK/ERK signaling pathways can overcome Gefitinib-resistance in non-small cell lung cancer cell lines

(2011) H Li et al.   Advances in Medical Sciences

Total ERK1/2 activity regulates cell proliferation

(2011) Renaud Lefloch et al.   CELL CYCLE

Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair

(2011) Arun Gupta et al.   CELL CYCLE

GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration

(2011) Jin-San Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity

(2011) J. Yuan et al.   MOLECULAR CANCER THERAPEUTICS

Fusion protein based on Grb2-SH2 domain for cancer therapy

(2010) Yuriko Saito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis

(2010) Alberto M. Martelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Spatio-temporal modeling of signaling protein recruitment to EGFR

(2010) Ming-yu Hsieh et al.   BMC Systems Biology

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Epidermal Growth Factor Receptor Signaling in Nonsmall Cell Lung Cancer

(2010) Apar Kishor Ganti   CANCER INVESTIGATION

Loss of PTEN Expression by Blocking Nuclear Translocation of EGR1 in Gefitinib-Resistant Lung Cancer Cells Harboring Epidermal Growth Factor Receptor-Activating Mutations

(2010) C. Yamamoto et al.   CANCER RESEARCH

Role of Survivin in EGFR Inhibitor-Induced Apoptosis in Non-Small Cell Lung Cancers Positive for EGFR Mutations

(2010) K. Okamoto et al.   CANCER RESEARCH

Hot-spot mutations in p110α of phosphatidylinositol 3-kinase (PI3K): Differential interactions with the regulatory subunit p85 and with RAS

(2010) Li Zhao et al.   CELL CYCLE

Synergy in ERK activation by cytokine receptors and tyrosine kinase growth factor receptors

(2010) Xin Li et al.   CELLULAR SIGNALLING

Classic and contemporary approaches to modeling biochemical reactions

(2010) W. W. Chen et al.   GENES & DEVELOPMENT

Overexpression of STAT3 Potentiates Growth, Survival, and Radioresistance of Non-Small-Cell Lung Cancer (NSCLC) cells

(2010) Zhen-Jie Yin et al.   JOURNAL OF SURGICAL RESEARCH

Association of Phosphorylated Epidermal Growth Factor Receptor with Survival in Patients with Locally Advanced Non-small Cell Lung Cancer Treated with Radiotherapy

(2010) Theodoros Tsakiridis et al.   Journal of Thoracic Oncology

The role of epidermal growth factor receptor in photodynamic therapy: a review of the literature and proposal for future investigation

(2010) Pedro A. Martínez-Carpio et al.   LASERS IN MEDICAL SCIENCE

Dynamic Disorder in Quasi-Equilibrium Enzymatic Systems

(2010) Srabanti Chaudhury et al.   PLoS One

Response to gefitinib and erlotinib in Non-small cell lung cancer: a retrospective study

(2009) Ivette F Emery et al.   BMC CANCER

PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR

(2009) M. L. Sos et al.   CANCER RESEARCH

Evaluation of PTEN and Mcl-1 expressions in NSCLC expressing wild-type or mutated EGFR

(2009) Zafer Cetin et al.   MEDICAL ONCOLOGY

A Mek1–Mek2 heterodimer determines the strength and duration of the Erk signal

(2009) Federica Catalanotti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors

(2009) A F Gazdar   ONCOGENE

Alterations in Genes of the EGFR Signaling Pathway and Their Relationship to EGFR Tyrosine Kinase Inhibitor Sensitivity in Lung Cancer Cell Lines

(2009) Jeet Gandhi et al.   PLoS One

Role of Network Branching in Eliciting Differential Short-Term Signaling Responses in the Hypersensitive Epidermal Growth Factor Receptor Mutants Implicated in Lung Cancer

(2008) J. Purvis et al.   BIOTECHNOLOGY PROGRESS

Better survival with EGFR exon 19 than exon 21 mutations in gefitinib-treated non-small cell lung cancer patients is due to differential inhibition of downstream signals

(2008) Jian-quan Zhu et al.   CANCER LETTERS

Simulation of the regulation of EGFR endocytosis and EGFR-ERK signaling by endophilin-mediated RhoA-EGFR crosstalk

(2008) Choong Yong Ung et al.   FEBS LETTERS

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

(2008) Ana Silva et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy

(2008) J A McCubrey et al.   LEUKEMIA