Review
Neurosciences
Minkyung Kang, Yao Yao
Summary: Oligodendrocytes are crucial cells in the central nervous system responsible for myelinating axons and supporting the function of neurons. The function and development of oligodendrocytes are tightly regulated by various molecules, with laminin playing a significant role in processes such as survival, migration, proliferation, differentiation, and myelination. Understanding the specific molecular targets and signaling pathways in oligodendrocyte biology may have implications for therapeutic interventions in demyelinating diseases.
Article
Neurosciences
He Wang, Mengjia Liu, Zhuoyang Ye, Cuihua Zhou, Huiru Bi, Long Wang, Chen Zhang, Hui Fu, Ying Shen, Jian-Jun Yang, Yimin Hu, Guiquan Chen
Summary: This study reveals that the phosphorylation of FoxO1 by Akt plays a critical role in Sox10 expression and OL differentiation. Deletion of all three Akt isoforms leads to downregulation of Sox10, and mutant FoxO1 inhibits Sox10 promoter activity.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Jinxing Hou, Huiru Bi, Zhuoyang Ye, Wenhui Huang, Gang Zou, Xiaochuan Zou, Yun Stone Shi, Ying Shen, Quanhong Ma, Frank Kirchhoff, Yimin Hu, Guiquan Chen
Summary: Mutations on gamma-secretase subunits are linked to neurological diseases. While the role of gamma-secretase in neurogenesis is well-studied, its involvement in astrogliogenesis remains unclear. Recent evidence suggests that astrocytes can be derived from oligodendrocyte precursor cells (OPCs), but the mechanism controlling this differentiation is not fully understood.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Virology
Hong-Shuai Gao, Rong-Min Hu, Ze-Hua Wang, Xi-Qian Ye, Xiao-Tong Wu, Jian-Hua Huang, Zhi-Zhi Wang, Xue-Xin Chen
Summary: In this study, a PTP gene, CvBV_12-6, derived from CvBV was characterized and found to negatively regulate the immune response in the host P. xylostella. It suppressed the phenoloxidase activity and antibacterial abilities of hemocytes, as well as reduced the host's melanization and viability.
Article
Biochemistry & Molecular Biology
Ruyi Mei, Wanwan Qiu, Yingying Yang, Siyu Xu, Yueyu Rao, Qingxin Li, Yuhao Luo, Hao Huang, Aifen Yang, Huaping Tao, Mengsheng Qiu, Xiaofeng Zhao
Summary: This study reveals that Ddr1 is selectively upregulated in newly differentiated oligodendrocytes in the early postnatal CNS and plays a crucial role in oligodendrocyte differentiation and myelination. Ddr1 deficiency leads to compromised axonal myelination and motor dysfunction, activating the ERK pathway in the CNS. Additionally, Ddr1 is important for myelin repair after lysolecithin-induced demyelination. Overall, this study sheds light on the role of Ddr1 in myelin development and repair in the CNS and provides a novel target for treating demyelinating diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Sheng Zhang, Yan Wang, Jie Xu, Bokyung Kim, Wenbin Deng, Fuzheng Guo
Summary: This study reveals the important role of HIF-alpha in developmental myelination, demonstrating its requirement in controlling OPC differentiation for efficient myelination. Contrary to previous beliefs, it was found that HIF-alpha's regulation of CNS myelination is independent of canonical Wnt signaling, and instead involves the HIF-alpha-Sox9 regulatory axis. This discovery represents a shift in understanding the mechanisms of HIF-alpha-regulated CNS myelination from a Wnt-dependent view to a Wnt-independent one.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Assia Tiane, Melissa Schepers, Renzo Riemens, Ben Rombaut, Patrick Vandormael, Veerle Somers, Jos Prickaerts, Niels Hellings, Daniel van den Hove, Tim Vanmierlo
Summary: In this study, researchers identified Id2 and Id4 as targets of DNA methylation during the differentiation of oligodendrocyte precursor cells. Using CRISPR technology, they confirmed that methylation of Id2/Id4 could drive cell differentiation. Furthermore, they found alterations in methylation and gene expression levels of these genes in multiple sclerosis patients compared to controls.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Michel Desjarlais, Pakiza Ruknudin, Maelle Wirth, Isabelle Lahaie, Rabah Dabouz, Jose Carlos Rivera, Tiffany Habelrih, Samy Omri, Pierre Hardy, Alain Rivard, Sylvain Chemtob
Summary: The study suggests that hyperoxia alters the paracrine proangiogenic activity of bone marrow-derived pro-angiogenic cells (PACs) through inducing PTPN9, which impairs post-ischemic revascularization in Oxygen-Induced Retinopathy (OIR). Inhibiting PTPN9 restores the angiogenic properties of PACs, providing a potential target for vessel integrity in ischemic retinopathies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Yu Teng, Ping Hu, Yangyang Chen, Yanyu Zang, Xiaolian Ye, Jingmin Ou, Guiquan Chen, Yun Stone Shi
Summary: Leucine-rich glioma-inactivated protein 1 (LGI1) plays a key role in autosomal dominant lateral temporal lobe epilepsy (ADLTE). A novel mutation on the Lgi1 gene was identified, which may cause white matter abnormalities by inhibiting Sox10-dependent oligodendrocyte differentiation and myelination in the central nervous system.
Article
Neurosciences
Ruyi Mei, Linyu Huang, Mengyuan Wu, Chunxia Jiang, Aifen Yang, Huaping Tao, Kang Zheng, Junlin Yang, Wanhua Shen, Xianjun Chen, Xiaofeng Zhao, Mengsheng Qiu
Summary: Itpr2 plays a crucial role in the developmental process of oligodendrocytes, with its deficiency leading to increased myelination of small-diameter axons by oligodendrocytes, hence affecting the normal functioning of the nervous system.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Lu Chen, Zhuo Yu, Li Xie, Xiaoxiao He, Xingmei Mu, Chiqi Chen, Wenqian Yang, Xiaoping Tong, Junling Liu, Zhengliang Gao, Suya Sun, NanJie Xu, Zhigang Lu, Junke Zheng, Yaping Zhang
Summary: This study reveals the interaction between ANGPTL2 and MAG, which contributes to the promotion of oligodendrocyte differentiation and is crucial for remyelination. The study also demonstrates the regulatory role of the environmental protein and its receptor in oligodendrocyte differentiation, which is significant for the treatment of demyelinating disorders such as multiple sclerosis.
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jing Xin, Shanshan Guo, Xiaolei Zhang, Jiahui Tian, Yu Sun, Jian-Xiu Shang
Summary: Protein tyrosine phosphatases play crucial roles in plant growth, development, and stress responses, with DSP3 and DSP5 acting as negative regulators of plant salt tolerance. Interactions between DSP5 and MPK3/6 highlight a novel mechanism for salt stress regulation in Arabidopsis.
PLANT SIGNALING & BEHAVIOR
(2021)
Article
Neurosciences
Veronica T. Cheli, Diara A. Santiago Gonzalez, Rensheng Wan, Shaina L. Rosenblum, Giancarlo E. Denaroso, Christina G. Angeliu, Zachary Smith, Congying Wang, Pablo M. Paez
Summary: By disrupting the expression of the Tf receptor gene in oligodendrocyte progenitor cells, researchers found that the Tf cycle is uniquely important for the development and function of oligodendrocytes. Deleting the Tfr gene resulted in impaired iron absorption and hypomyelination in mice. The Tf cycle plays a crucial role in iron homeostasis and energy production in oligodendrocyte progenitor cells.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Nana Fukushima, Remina Shirai, Takanari Sato, Sayumi Nakamura, Arisa Ochiai, Yuki Miyamoto, Junji Yamauchi
Summary: This study reveals that Rab7B negatively regulates morphological differentiation of oligodendroglial precursor cells, while Rab7A positively regulates it. Additionally, knockdown of Rab7B can recover the inhibition of morphological differentiation induced by endoplasmic reticulum stress, which is relevant to hereditary hypomyelinating disorders.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ning Li, Min Yao, Jiaxin Liu, Zhiyuan Zhu, Tsz-Lung Lam, Pingde Zhang, Karrie Mei-Yee Kiang, Gilberto Ka-Kit Leung
Summary: The study showed that VitD treatment improved hindlimb movement in rats post-TSCI, but those with prior deficiency did not benefit. Maintaining sufficient VitD levels was essential for preserving myelin integrity after injury.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Takeshi Y. Hiyama, Akari N. Utsunomiya, Masahito Matsumoto, Akihiro Fujikawa, Chia-Hao Lin, Keiichi Hara, Reiko Kagawa, Satoshi Okada, Masao Kobayashi, Mayumi Ishikawa, Makoto Anzo, Hideo Cho, Shinobu Takayasu, Takeshi Nigawara, Makoto Daimon, Tomohiko Sato, Kiminori Terui, Etsuro Ito, Masaharu Noda
Article
Behavioral Sciences
Ryoko Suzuki, Akihiro Fujikawa, Yukio Komatsu, Kazuya Kuboyama, Naomi Tanga, Masaharu Noda
NEUROBIOLOGY OF LEARNING AND MEMORY
(2018)
Article
Neurosciences
Yang Yu, Takafumi Shintani, Yasushi Takeuchi, Takuji Shirasawa, Masaharu Noda
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Naomi Tanga, Kazuya Kuboyama, Ayako Kishimoto, Hiroshi Kiyonari, Aki Shiraishi, Ryoko Suzuki, Toshio Watanabe, Akihiro Fujikawa, Masaharu Noda
Article
Multidisciplinary Sciences
Naomi Tanga, Kazuya Kuboyama, Ayako Kishimoto, Miho Kihara, Hiroshi Kiyonari, Toshio Watanabe, Akihiro Fujikawa, Masaharu Noda
Article
Biochemistry & Molecular Biology
Akihiro Fujikawa, Hajime Sugawara, Naomi Tanga, Kentaro Ishii, Kazuya Kuboyama, Susumu Uchiyama, Ryoko Suzuki, Masaharu Noda
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Physiology
Hiraki Sakuta, Chia-Hao Lin, Takeshi Y. Hiyama, Takashi Matsuda, Katsushi Yamaguchi, Shuji Shigenobu, Kenta Kobayashi, Masaharu Noda
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2020)
Article
Neurosciences
Surangi N. Perera, Ruth M. Williams, Rachel Lyne, Oliver Stubbs, Dennis P. Buehler, Tatjana Sauka-Spengler, Masaharu Noda, Gos Micklem, E. Michelle Southard-Smith, Clare V. H. Baker
Article
Multidisciplinary Sciences
Kazuya Kuboyama, Takafumi Inoue, Yuki Hashimotodani, Takuya Itoh, Tohsuke Suzuki, Aya Tetsuzawa, Yosuke Ohtsuka, Ryo Kinoshita, Ren Takara, Tohru Miyazawa, Pooja Gusain, Masanobu Kano, Maki K. Yamada
SCIENTIFIC REPORTS
(2020)
Article
Immunology
Chihiro Kurematsu, Masato Sawada, Masaki Ohmuraya, Motoki Tanaka, Kazuya Kuboyama, Takashi Ogino, Mami Matsumoto, Hisashi Oishi, Hiroyuki Inada, Yuri Ishido, Yukina Sakakibara, Huy Bang Nguyen, Truc Quynh Thai, Shinichi Kohsaka, Nobuhiko Ohno, Maki K. Yamada, Masato Asai, Masahiro Sokabe, Junichi Nabekura, Kenichi Asano, Masato Tanaka, Kazunobu Sawamoto
Summary: This study demonstrates the involvement of phosphatidylserine (PS) in the synaptic pruning and functional maturation of adult-born neurons in the olfactory bulb and hippocampus. Using an inducible transgenic mouse model, the researchers found that impaired microglial spine pruning and altered electrophysiological properties of adult-born neurons occurred when PS exposure was masked by a dominant-negative form of milk fat globule-EGF-factor 8 (MFG-E8). These findings highlight the significance of PS in microglial pruning and the maturation of adult-born neurons.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Takashi Matsuda, Takeshi Y. Hiyama, Kenta Kobayashi, Kazuto Kobayashi, Masaharu Noda
NATURE COMMUNICATIONS
(2020)
Article
Neurosciences
Kazuya Kuboyama, Yuki Shirakawa, Koji Kawada, Naoki Fujii, Daiki Ojima, Yasushi Kishimoto, Tohru Yamamoto, Maki K. Yamada
NEUROPSYCHOPHARMACOLOGY REPORTS
(2020)