Article
Biochemistry & Molecular Biology
Dahae Lee, Young-Mi Kim, Hyun Woo Kim, You-Kyoung Choi, Bang Ju Park, Sang Hoon Joo, Ki Sung Kang
Summary: Schisandrol A and schisandrin C enhanced insulin secretion and glucose uptake, with schisandrin C showing superior effects compared to gliclazide. Treatment with schisandrin C resulted in increased expression of associated proteins in cells, potentially benefiting in improving hyperglycemia.
Article
Nutrition & Dietetics
Yudai Nonaka, Reo Takeda, Yutaka Kano, Daisuke Hoshino
Summary: Reducing calorie intake (CR) was found to maintain blood insulin levels and improve glucose tolerance in late-stage diabetes, with decreased levels of insulin-degrading enzyme (IDE) in the liver.
Article
Biochemistry & Molecular Biology
Haiyan Wang, Amy Zheng, Edward B. Arias, Seong Eun Kwak, Xiufang Pan, Dongsheng Duan, Gregory D. Cartee
Summary: Exercise increases glucose uptake by skeletal muscle after exercise in both sexes, and the role of AS160 protein and its phosphorylation in this process has been studied in male rats, but not in females. This study manipulated AS160 expression and muscle GLUT4 protein expression, and found that AS160 expression plays an important role in increasing insulin-stimulated glucose uptake after exercise, while the phosphorylation status of AS160 has no effect on this process.
Article
Biochemistry & Molecular Biology
Geetali Pradhan, Jong Han Lee, Chia-Shan Wu, Hongying Wang, Ligen Lin, Taraka Donti, Brett H. Graham, Arun S. Rajan, Ashok Balasubramanyam, Susan L. Samson, Shaodong Guo, Yuxiang Sun
Summary: This study investigated the role of the Ghrelin receptor (GHS-R) in glucose-stimulated insulin secretion (GSIS) and its interaction with the insulin signaling pathway in pancreatic islets. The findings suggest that GHS-R affects key components of the insulin signaling pathway, likely regulating GSIS via the Akt-Pdx1-GLUT2 pathway.
Article
Neurosciences
Stewart W. C. Masson, Jonathan S. T. Woodhead, Randall F. D'Souza, Sophie C. Broome, Caitlin MacRae, Hyun C. Cho, Robert D. Atiola, Tumanu Futi, Jessica R. Dent, Peter R. Shepherd, Troy L. Merry
Summary: Beta-catenin plays a crucial role in regulating glucose uptake during exercise/contraction, potentially through facilitating actin cytoskeleton remodelling to support glucose transport.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Biochemistry & Molecular Biology
Rok Herman, Nika Aleksandra Kravos, Mojca Jensterle, Andrej Janez, Vita Dolzan
Summary: This review discusses the mechanisms of action of metformin, focusing on changes in insulin signaling pathway mediators, AMPK, GLUT4 translocation mediators, and the impact of posttranscriptional modifications. It aims to provide a comprehensive understanding of the interactions between metformin action, GLUT4 expression, GLUT4 translocation, and peripheral insulin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
K. Fehsel, J. Christl
Summary: Both osteoporosis and Alzheimer's disease are degenerative diseases that can lead to cognitive deficits. Multiple studies have identified common triggers for energy deficits in the brain and bones. This may explain the frequent association between osteoporosis and/or diabetes with Alzheimer's disease.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Tao Kang, Shengyou Zhao, Lina Shi, Jianzhen Li
Summary: The study reveals the significant role of glucose in oocyte maturation in zebrafish, suggesting its importance in inducing oocyte maturation in vitro. Glucose transport and metabolic pathways play crucial roles in this process, with the pentose phosphate pathway identified as essential for oocyte maturation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Environmental Sciences
Wenqi Li, Lu Wu, Qian Sun, Qianlei Yang, Junchao Xue, Ming Shi, Huanwen Tang, Jingshu Zhang, Qizhan Liu
Summary: Exposure to arsenic can lead to glucose metabolism disorder and hepatic insulin resistance, with miR-191 playing a role in inhibiting the IRS1/AKT pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Physiology
Milja Arponen, Niki Jalava, Nicko Widjaja, Kaisa K. Ivaska
Summary: Research indicates that different types of glucose transporters play different roles in the proliferation and differentiation of osteoblasts. Expression of GLUT4 is crucial for the proliferation and differentiation of osteoblasts, while GLUT1 is abundant in early precursors and GLUT3 shows stable expression during differentiation. Apart from GLUT1, 3, and 4, osteoblasts also express other types of glucose transporters to regulate glucose uptake.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Estifanos N. Habtemichael, Don T. Li, Joao Paulo Camporez, Xavier O. Westergaard, Chloe Sales, Xinran Liu, Francesc Lopez-Giraldez, Stephen G. DeVries, Hanbing Li, Diana M. Ruiz, Kenny Y. Wang, Bhavesh S. Sayal, Sofia Gonzalez Zapata, Pamela Dann, Stacey N. Brown, Sandro Hirabara, Daniel F. Vatner, Leigh Goedeke, William Philbrick, Gerald Shulman, Jonathan S. Bogan
Summary: Insulin-stimulated TUG cleavage pathway regulates gene expression to promote lipid oxidation and thermogenesis, linking glucose uptake to organismal energy expenditure. Attenuation of this mechanism may promote obesity as it contributes to the thermic effect of food.
Article
Biochemistry & Molecular Biology
Siresha Bathina, Tumininu S. Faniyan, Lauren Bainbridge, Autumn Davis, Kavaljit H. Chhabra
Summary: The role of beta-cell Glut2 in regulating insulin secretion and blood glucose levels in mice was investigated in this study. Knocking down Glut2 specifically in beta-cells did not affect glucose-stimulated insulin secretion and systemic glucose homeostasis in mice.
Review
Biochemistry & Molecular Biology
Heinrich Botha, Camile S. Farah, Kendrick Koo, Nicola Cirillo, Michael McCullough, Rita Paolini, Antonio Celentano
Summary: Research shows that in oral squamous cell carcinoma, glucose transporter 1 (GLUT-1) and GLUT-3 expression levels are correlated with tumor stage, treatment resistance, and poor prognosis. Other glucose transporters (GLUTs) are relatively understudied and may have the potential to improve patient care with further analysis.
Article
Nutrition & Dietetics
Amy Zheng, Haiyan Wang, Edward B. Arias, Gengfu Dong, Jiahui Zhao, Gregory D. Cartee
Summary: The effects of calorie restriction on female wildtype and Akt substrate of 160 kDa knockout rats were evaluated. The results showed that calorie restriction increased muscle glucose uptake and GLUT4 protein abundance, and AS160 expression was essential for these increases.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Takashi Kanamori, Yuto Miki, Masataka Katou, Shun-ichiro Ogura, Hideya Yuasa
Summary: We have developed a glucose-linked biphenyl photosensitizer with brighter fluorescence and enhanced photodamaging effect against cancer cells. This photosensitizer can pass through glucose transporters, allowing for selective uptake and potential use in cancer photodynamic therapy.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Gustavo Sanchez-Chavez, Miguel Angel Velazquez-Flores, Ruth Ruiz Esparza-Garrido, Rocio Salceda
NEUROCHEMISTRY INTERNATIONAL
(2017)
Article
Spectroscopy
Mariana Grigoruta, Alejandra Vargas-Caraveo, Emmanuel Vazquez-Mayorga, Hiram A. Castillo-Michel, Angel G. Diaz-Sanchez, Juan Reyes-Herrera, Alejandro Martinez-Martinez
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2018)
Article
Environmental Sciences
Keni Cota-Ruiz, Jose A. Hernandez-Viezcas, Armando Varela-Ramirez, Carolina Valdes, Jose A. Nunez-Gastelum, Alejandro Martinez-Martinez, Marcos Delgado-Rios, Jose R. Peralta-Videa, Jorge L. Gardea-Torresdey
ENVIRONMENTAL POLLUTION
(2018)
Article
Chemistry, Applied
J. A. Nunez-Gastelum, J. R. Rodriguez-Nunez, L. A. de la Rosa, A. G. Diaz-Sanchez, E. Alvarez-Parrilla, A. Martinez-Martinez, G. Villa-Lerma
REVISTA MEXICANA DE INGENIERIA QUIMICA
(2019)
Article
Neurosciences
Elizabeth Morales-Calixto, Miguel Angel Velazquez-Flores, Gustavo Sanchez-Chavez, Ruth Ruiz Esparza-Garrido, Rod Salceda
NEUROSCIENCE LETTERS
(2019)
Article
Neurosciences
Mariana Grigoruta, Alejandro Martinez-Martinez, Raul Y. Dagda, Ruben K. Dagda
MOLECULAR NEUROBIOLOGY
(2020)
Article
Spectroscopy
G. Barraza-Garza, J. A. Perez-Leon, H. Castillo-Michel, L. A. de la Rosa, A. Martinez-Martinez, M. Cotte, E. Alvarez-Parrilla
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2020)
Article
Biochemistry & Molecular Biology
Naun Lobo-Galo, Manuel Terrazas-Lopez, Alejandro Martinez-Martinez, Angel Gabriel Diaz-Sanchez
Summary: Given the current lack of specific antiviral treatment or vaccine for COVID-19, the search for drugs that can potentially inhibit essential viral enzymes is urgent. Through in silico testing, disulfiram and its metabolites are identified as potential antiviral drugs, with a proposed mechanism for their action.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Multidisciplinary Sciences
Mariana Grigoruta, Ruben K. Dagda, Angel G. Diaz-Sanchez, Alejandro Martinez-Martinez
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Mariana Grigoruta, Marbella Chavez-Solano, Armando Varela-Ramirez, Jorge A. Sierra-Fonseca, Ernesto Orozco-Lucero, Jameel N. Hamdan, Kristin L. Gosselink, Alejandro Martinez-Martinez
Article
Chemistry, Physical
Victor Gomez Flores, Alejandro Martinez-Martinez, Jorge A. Roacho Perez, Jazzely Acosta Bezada, Francisco S. Aguirre-Tostado, Perla Elvia Garcia Casillas
Summary: Innovative and effective new technologies in the treatment of various diseases are increasingly being applied. Nanomedicine techniques involving the combination of nanoparticles with biological membranes aim to improve interactions and minimize side effects. By conjugating gold nanoparticles with fluorescein isothiocyanate and depositing them onto the surface of hemoglobin-free erythrocytes, the study demonstrates enhanced imaging sensitivity in the context of biological membranes.
Review
Biochemistry & Molecular Biology
J. Abraham Dominguez-Avila, Norma J. Salazar-Lopez, Marcelino Montiel-Herrera, Alejandro Martinez-Martinez, Monica A. Villegas-Ochoa, Gustavo A. Gonzalez-Aguilar
Summary: Phenolic compounds have the potential to regulate immune response, counter inflammation, and maintain health, particularly that of the central nervous system.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Meeting Abstract
Respiratory System
Elisa Barrera Ramirez, Ruben E. Garrido Cardona, Edna Rico Escobar, Alejandro Martinez Martinez, Luis F. Plenge Tellechea, Alfredo Hernandez, Enrique Vanegas Venegas
EUROPEAN RESPIRATORY JOURNAL
(2018)
Review
Environmental Sciences
Keni Cota-Ruiz, Marcos Delgado-Rios, Alejandro Martinez-Martinez, Jose Alberto Nunez-Gastelum, Jose Ramon Peralta-Videa, Jorge Luis Gardea-Torresdey
CURRENT OPINION IN ENVIRONMENTAL SCIENCE & HEALTH
(2018)
Article
Cell Biology
Ernesto Hernandez-Ramirez, Gustavo Sanchez-Chavez, Luis A. Estrella-Salazar, Rock Salceda
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2017)