Article
Substance Abuse
Robert Suchting, Charles E. Green, Constanza de Dios, Jessica Vincent, F. Gerard Moeller, Scott D. Lane, Joy M. Schmitz
Summary: The study compared two doses of citalopram (20 mg and 40 mg) with placebo in terms of cocaine abstinence duration, with the 40 mg dose showing moderate-to-strong evidence for positive effects on both abstinence duration and cocaine-negative urine drug screens. The 40 mg dose was declared the winner in this drop-the-loser trial.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Editorial Material
Clinical Neurology
Tanya N. Turan, Marios-Nikos Psychogios
Summary: The CASSISS trial, published in JAMA, adds to the growing body of evidence that percutaneous angioplasty and stenting does not provide a benefit over medical therapy for preventing stroke due to intracranial atherosclerotic stenosis. Current guidelines recommend against routine use of this intervention for stroke prevention in these patients. The trial may offer valuable insights for future trial design.
Article
Medicine, General & Internal
Jennifer L. Grasch, Maged M. Costantine, Devra D. Doan Mast, Baylee Klopfenstein, Jessica R. Russo, Taryn L. Summerfield, Kara M. Rood
Summary: This randomized clinical trial investigated the use of a noninvasive high-frequency electrical stimulation device for pain control and opioid reduction after cesarean delivery. The results showed that the device effectively decreased opioid use in the immediate postoperative period without compromising pain control.
Article
Biology
Cassandre Vielle, Christian Montanari, Yann Pelloux, Christelle Baunez
Summary: Studies show that rats can recognize the identity of the emitter of 50 kHz ultrasonic vocalizations and that only stranger rats' 50 kHz USVs can reduce cocaine self-administration. Additionally, rats with subthalamic nucleus lesions show decreased lever pressing for USV playback and an inability to differentiate between familiar and stranger peers.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Nicky Solomonidi, Panayiotis G. Vlachoyiannopoulos, Maria Pappa, Georgia Liantinioti, Sofia Ktena, Evangelos Theotikos, Antonia Elezoglou, Mihai G. Netea, Evangelos J. Giamarellos-Bourboulis
Summary: This study found that increased concentrations of IL-1 alpha are present in SSc patients. Treatment with the IL-1 alpha blocking antibody, bermekimab, effectively inhibits disease progression and reduces inflammation.
Article
Substance Abuse
Violaine Mongeau-Perusse, Suzanne Brissette, Julie Bruneau, Patricia Conrod, Simon Dubreucq, Guillaume Gazil, Emmanuel Stip, Didier Jutras-Aswad
Summary: This study tested the efficacy of CBD for reducing craving and preventing relapse in people with CUD. However, the findings showed that CBD treatment did not reduce cocaine craving or relapse among participants being treated for CUD.
Article
Endocrinology & Metabolism
Wismandari Wisnu, Idrus Alwi, Nafrialdi Nafrialdi, Kuntjoro Harimurti, Tjokorda Gede D. Pemayun, Sri Widia A. Jusman, Dewi Irawati S. Santoso, Alida R. Harahap, Suhendro Suwarto, Imam Subekti
Summary: This study investigated the effect of antithyroid drugs on markers of vascular atherosclerosis in Graves' hyperthyroidism. The results showed that PTU had a better improvement in adhesion molecules compared to methimazole, with no significant changes in PWV or cIMT in either group.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Behavioral Sciences
Paul W. Czoty, Robert W. Gould, Cormac A. O'Donovan, Michael A. Nader
Summary: The study assessed the modulating effects of chronically administered levetiracetam on the reinforcing strength of cocaine in monkeys. Lower doses of levetiracetam caused non-systematic fluctuations in cocaine injections received, while the highest tested dose significantly increased cocaine reinforcement. After termination of levetiracetam treatment, sensitivity to cocaine was increased in two monkeys.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Medicine, General & Internal
Serena Coppola, Rita Nocerino, Lorella Paparo, Giorgio Bedogni, Antonio Calignano, Carmen Di Scala, Anna Fiorenza de Giovanni di Santa Severina, Francesca De Filippis, Danilo Ercolini, Roberto Berni Canani
Summary: Oral butyrate supplementation may be effective in the treatment of pediatric obesity.
Article
Medicine, General & Internal
Seth M. Noar, Nisha C. Gottfredson, Talia Kieu, Jacob A. Rohde, Marissa G. Hall, Haijing Ma, Nicholas J. Fendinger, Noel T. Brewer
Summary: This study found that vaping prevention advertisements from the FDA Real Cost campaign reduced adolescent susceptibility to vaping and had positive spillover effects on cigarette smoking outcomes.
Article
Behavioral Sciences
William W. Stoops, Justin C. Strickland, Kevin W. Hatton, Lon R. Hays, Abner O. Rayapati, Joshua A. Lile, Craig R. Rush
Summary: This study aimed to investigate the impact of orexin antagonists on cocaine restraint behavior. The results showed that suvorexant attenuated motivation for cocaine and cocaine conditioned place preference in rodents, and increased self-administration of 10 mg/70 kg cocaine in humans while decreasing oral temperature.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Clinical Neurology
Giovanni Martinotti, Mauro Pettorruso, Chiara Montemitro, Primavera Alessandra Spagnolo, Cecilia Acuti Martellucci, Francesco Di Carlo, Fabrizio Fanella, Massimo di Giannantonio
Summary: This study aimed to evaluate the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) in patients with cocaine use disorder (CUD). The results showed that active rTMS treatment significantly improved symptoms of CUD and particularly depressive symptoms. However, no significant differences were observed in cocaine craving and consumption between treatment groups.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Chemistry, Multidisciplinary
Ana-Petra Lazar, Timea Dako, Anamaria Bud, Alexandru Vlasa, Alina Ormenisan, Maria-Alexandra Martu, Mariana Pacurar, Luminita Lazar
Summary: This study aimed to evaluate the effect of low-level laser therapy on pain caused by orthodontic treatment. The results showed that laser therapy significantly reduced pain levels in patients undergoing fixed orthodontic treatment.
APPLIED SCIENCES-BASEL
(2022)
Article
Medicine, General & Internal
Timothy B. Baker, Megan E. Piper, Stevens S. Smith, Daniel M. Bolt, James H. Stein, Michael C. Fiore
Summary: Among adults smoking 5 cigarettes/d or more, there were no significant differences in 7-day point prevalence abstinence at 52 weeks among those treated with combined varenicline plus nicotine patch therapy vs varenicline monotherapy, or among those treated for 24 weeks vs 12 weeks. These findings do not support the use of combined therapy or of extended treatment duration.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Nutrition & Dietetics
Chiara Ricci, Fernando Rizzello, Maria Chiara Valerii, Enzo Spisni, Paolo Gionchetti, Silvia Turroni, Marco Candela, Federica D'Amico, Renato Spigarelli, Irene Bellocchio, Giovanni Marasco, Giovanni Barbara
Summary: Geraniol, an acyclic monoterpene alcohol, has demonstrated anti-inflammatory and antimicrobial properties and positive effects on gut microbiota in IBS patients. In this study, IBS patients treated with a low-absorbable geraniol food supplement (LAGS) showed a significant reduction in IBS symptoms severity score compared to placebo. Geraniol administration also resulted in changes in gut microbiota composition, with a decrease in Oscillospira and an increase in Faecalibacterium. The findings suggest that LAGS is effective in treating overall IBS symptoms and improving gut microbiota profile, particularly in the IBS mixed subtype.
Article
Psychology, Biological
Jin H. Yoon, Robert Suchting, Rachel N. Cassidy, Peter K. Bolin, Yasmine Omar, Gregory S. Brown, Richard De la Garza
Summary: The study aimed to assess demand for MA using a hypothetical drug purchasing task and found multiple positive relationships between self-reported drug use and demand for each drug. Comparing MA to cigarettes, it revealed greater abuse liability for MA compared to cigarettes.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Oncology
Deepti Chopra, Richard De La Garza, Tamara E. Lacourt
Summary: This study evaluated the previously suggested BIS cut point score of >= 10 as an indicator of psychological distress, finding a positive association with depression, anxiety, and distress scores. A BIS score >= 10 was a significant predictor of moderate depression and anxiety, suggesting the importance of follow-up and appropriate referral for patients with higher scores.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Neurosciences
Jack E. Henningfield, Sherecce Fields, James C. Anthony, Lawrence S. Brown, Carlos A. Bolanos-Guzman, Sandra D. Comer, Richard De La Garza, Debra Furr-Holden, Albert Garcia-Romeu, Dorothy K. Hatsukami, Armin Raznahan, Carlos A. Zarate
Summary: Higher levels of excellence and innovation in research can be achieved by promoting equity, diversity, and inclusion in organizations. ACNP has made progress in increasing diversity, especially in female membership and leadership positions, but there is still room for improvement in areas like African American and other ethnic populations. Collaboration with other organizations committed to these goals may help accelerate progress towards fostering diversity and inclusion in scientific organizations.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Shannon E. Reilly, Katherine L. Zane, William T. McCuddy, Zachary A. Soulliard, David M. Scarisbrick, Liv E. Miller, James J. Mahoney
JMIR MENTAL HEALTH
(2020)
Article
Psychology, Clinical
Katherine L. Zane, Nicholas S. Thaler, Shannon E. Reilly, James J. Mahoney, David M. Scarisbrick
Summary: The field of neuropsychology rapidly adapted during the COVID-19 pandemic, with an increased focus on tele-neuropsychology services. Most neuropsychologists reported experiencing distress and anxiety related to the pandemic, yet this did not significantly impact their overall ability to practice. Further research is necessary to evaluate the long-term viability and sustainability of tele-neuropsychology practice.
CLINICAL NEUROPSYCHOLOGIST
(2021)
Article
Psychology, Clinical
James J. Mahoney, Erin L. Winstanley, Laura R. Lander, James H. Berry, Patrick J. Marshalek, Marc W. Haut, Jennifer L. Marton, Wesley D. Kimble, Matthew Armistead, Sijin Wen, Yilin Cai, Sally L. Hodder
Summary: This study in West Virginia found that the prevalence of co-occurring substance use among patients with opioid use disorder (OUD) is high at 72.8%, with benzodiazepines being the most common co-occurring substance. Patients who used co-occurring substances were younger and had a higher prevalence of hepatitis C virus (HCV) compared to those who used opioids alone, with minimal gender differences.
ADDICTIVE BEHAVIORS
(2021)
Letter
Neurosciences
Jack E. Henningfield, Sherecce Fields, James C. Anthony, Lawrence S. Brown, Carlos A. Bolanos-Guzman, Sandra D. Comer, Richard De La Garza, Debra Furr-Holden, Albert Garcia-Romeu, Dorothy Hatsukami, Armin Raznahan, Carlos A. Zarate
NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Substance Abuse
Erin L. Winstanley, James J. Mahoney, Felipe Castillo, Sandra D. Comer
Summary: This review analyzed 70 studies on neurocognitive impairments and brain abnormalities associated with opioid-related overdoses, finding methodological limitations in existing research, but overall supporting the link between opioid overdoses and brain injuries and cognitive impairments.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Oncology
Alan Valentine, Jessica Brown, Tamara Lacourt, Minxing Chen, Richard De La Garza, Eduardo Bruera
Summary: The study found that self-reported depression and anxiety are common symptoms among patients at a psychiatric oncology center for an initial visit. ESAS-A and ESAS-D have good sensitivity for anxiety and depression screening of cancer patients.
Article
Clinical Neurology
Claire K. Morice, Luba Yammine, Jin Yoon, Scott D. Lane, Joy M. Schmitz, Thomas R. Kosten, Richard De la Garza, Christopher D. Verrico
Summary: Individuals with both PTSD and AUD have more severe symptoms and poorer treatment outcomes compared to those with PTSD or AUD alone. However, there is a lack of evidence and FDA-approved treatments for comorbid PTSD and AUD. This manuscript reviews a potential target for treating comorbid AUD in persons with PTSD.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Johannes Petzold, Andy C. Dean, Jean-Baptiste Pochon, Dara G. Ghahremani, Richard De la Garza, Edythe D. London
Summary: Methamphetamine use disorder is associated with thinner cortex in regions related to craving and depressive symptoms. Identifying this brain structure abnormality may help identify patients with Methamphetamine Use Disorder who will benefit from antidepressant medication.
Article
Substance Abuse
Peter K. Bolin, Ellen M. Nielsen, David A. Nielsen, Richard De la Garza
Summary: This study investigated the impact of a promoter variant of the TH gene (rs10770141) on the subjective effects of cocaine in 65 nontreatment-seeking individuals with cocaine dependence. Participants received intravenous cocaine/saline, and the TH genotypes were evaluated. Homozygous individuals for the minor T allele reported stronger positive and negative subjective effects to cocaine compared to those with the major C allele. The findings suggest that TH rs10770141 modulates the subjective effects of cocaine in individuals with cocaine dependence.
AMERICAN JOURNAL ON ADDICTIONS
(2023)
Letter
Neurosciences
James J. Mahoney III, Daisy G. Y. Thompson-Lake, Manish Ranjan, Jennifer L. Marton, Jeffrey S. Carpenter, Wanhong Zheng, James H. Berry, Daniel L. Farmer, Pierre D'Haese, Victor S. Finomore, Padma Tirumalai, Ashley S. Mears, Jacob Suffridge, Ashley Ames, Sally L. Hodder, Ali R. Rezai
BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychology, Biological
James J. Mahoney, Marc W. Haut, Sally L. Hodder, Wanhong Zheng, Laura R. Lander, James H. Berry, Daniel L. Farmer, Jennifer L. Marton, Manish Ranjan, Nicholas J. Brandmeir, Victor S. Finomore, Jeremy L. Hensley, Will M. Aklin, Gene-Jack Wang, Dardo Tomasi, Ehsan Shokri-Kojori, Ali R. Rezai
Summary: This study evaluated the safety of DBS for substance use disorder and its effects on substance use, craving, emotional symptoms, and frontal/executive functions. The results showed that DBS of the NAc/VC was safe and effective in reducing substance use and craving, as well as improving frontal and executive functions. Confirmation of these findings with future studies is needed.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Psychology, Multidisciplinary
Shannon E. Reilly, Zachary A. Soulliard, William T. McCuddy, James J. Mahoney
Summary: The study surveyed 888 mental health practitioners on the coping strategies they used during the COVID-19 pandemic. The majority of respondents utilized behavioral coping strategies, such as distraction, spending time with loved ones, and exercise. While some used alcohol to cope, trainees were more likely to use supervision and substances other than alcohol or tobacco to manage anxiety/distress.
CURRENT PSYCHOLOGY
(2021)