Article
Virology
Loai AbuEed, Isaac Makundi, Ariko Miyake, Junna Kawasaki, Chisa Minoura, Yushi Koshida, Kazuo Nishigaki
Summary: This study aimed to assess the possibility of domestic cats transmitting feline foamy virus (FFV) to Tsushima leopard cats (TLC). FFV was identified in 7.86% of TLC samples and 14.07% of domestic cat samples. Phylogenetic analysis showed that FFV sequences from domestic cats and TLCs clustered together, indicating a shared strain. Monitoring FFV infection in both domestic cats and TLC populations is recommended.
Review
Biochemistry & Molecular Biology
Hossein Ashrafian, Elaheh Hadi Zadeh, Rizwan Hasan Khan
Summary: Approximately 40 million people globally suffer from dementia, with Alzheimer's disease being the most common cause. Aggregation of Aβ outside of neuron cells and tau protein tangle formation inside cells are believed to play crucial roles. This paper reviews studies targeting the inhibition of these protein aggregations to suppress or postpone AD.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Clinical Neurology
Shama D. Karanth, Yuriko Katsumata, Peter T. Nelson, David W. Fardo, Jaclyn K. McDowell, Frederick A. Schmitt, Richard J. Kryscio, Steven R. Browning, Dejana Braithwaite, Susanne M. Arnold, Erin L. Abner
Summary: This study investigated the association between cancer diagnosis and neuropathological and cognitive features of dementia. The findings showed that cancer diagnosis was associated with a lower burden of Alzheimer's disease pathology and less cognitive impairment.
Review
Medicine, Research & Experimental
Mehdi Sanati, Samaneh Aminyavari, Amir R. Afshari, Amirhossein Sahebkar
Summary: Alzheimer's disease (AD) is a type of dementia characterized by memory decline and cognition impairment. There are similarities between AD and noninsulin-dependent diabetes mellitus (NIDDM), which suggests that metformin, a hypoglycemic agent, could be used as an alternative therapy for AD. Preclinical studies have shown that metformin can improve cognition and memory impairment in AD models through various mechanisms.
Review
Biochemistry & Molecular Biology
Pasquale Picone, Tiziana Sanfilippo, Sonya Vasto, Sara Baldassano, Rossella Guggino, Domenico Nuzzo, Donatella Bulone, Pier Luigi San Biagio, Emanuela Muscolino, Roberto Monastero, Clelia Dispenza, Daniela Giacomazza
Summary: Alzheimer's disease is the most common neurodegenerative disorder in the elderly, characterized by senile plaques and neurofibrillary tangles. There is currently a lack of treatment options aside from symptomatic medications. This review presents research results on the use of peptides of different sizes for the treatment of Alzheimer's disease.
Article
Clinical Neurology
Yalun Zhang, Yi Zhang, Yahyah Aman, Cheung Toa Ng, Wing-Hin Chau, Zhigang Zhang, Ming Yue, Christopher Bohm, Yizhen Jia, Siwen Li, Qiuju Yuan, Jennifer Griffin, Kin Chiu, Dana S. M. Wong, Binbin Wang, Dongyan Jin, Ekaterina Rogaeva, Paul E. Fraser, Evandro F. Fang, Peter St George-Hyslop, You-Qiang Song
Summary: Research has shown that the transcription factor PAX6 is increased in Alzheimer's disease, playing a key role in the hyperphosphorylation of tau protein induced by amyloid-beta. Downregulation of PAX6 can protect against amyloid-beta-induced neuronal death. This study provides novel potential targets for pharmaceutical intervention by modulating signaling pathways involving CDK/pRB/E2F1.
Review
Clinical Neurology
Jorge A. Trejo-Lopez, Anthony T. Yachnis, Stefan Prokop
Summary: Postmortem diagnosis remains central to Alzheimer's disease research, but advances in pathophysiology understanding and clinical diagnosis have shifted the perspective. In addition to the key pathological hallmarks, the diversity of accompanying pathological changes is gaining attention.
Review
Biochemistry & Molecular Biology
Luigi Donato, Domenico Morda, Concetta Scimone, Simona Alibrandi, Rosalia D'Angelo, Antonina Sidoti
Summary: Alzheimer's disease (AD) is the most widespread dementia globally, posing a major public health concern. Our understanding of this disease has significantly progressed, from a clinical and histopathologic description to a molecular comprehension. Unfortunately, there are no disease-modifying therapies currently available.
Article
Neurosciences
Manish Kumar, Nitin Bansal
Summary: Alzheimer's disease is a prevalent type of dementia in the elderly population, with complex pathophysiological processes involving cell apoptosis, tauopathy, beta-amyloidopathy, etc. Despite significant advancements in understanding the pathogenesis, treatment remains a challenge. The PI3K-Akt pathway may serve as a crucial therapeutic target in AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Geriatrics & Gerontology
Alexandra J. Malbon, Lorena Sordo, Liam A. Wilson, Danielle Gunn-Moore, Georgios Paraschou, Neil Macintyre, Tobias Schwarz, Bruce McGorum, Caroline Hahn
Summary: Neurodegenerative disorders are becoming increasingly important in ageing populations of animals and people. This study identified the characteristic lesions of Alzheimer's disease (AD) in the brains of donkeys, which may prompt further research on their metabolic status.
NEUROBIOLOGY OF AGING
(2022)
Article
Neurosciences
Carlo Abbate
Summary: Alzheimer's disease starts in neural stem cells and their migration processes, with amyloid pathology exacerbating tau pathology. The chronic inflammation triggered by extracellular amyloid-beta deposits further amplifies tau pathogenesis, leading to degeneration of neuronal networks. This cascade of events contributes to the development and spread of Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Cell Biology
Kunie Ando, Siranjeevi Nagaraj, Fahri Kucukali, Marie-Ange De Fisenne, Andreea-Claudia Kosa, Emilie Doeraene, Lidia Lopez Gutierrez, Jean-Pierre Brion, Karelle Leroy
Summary: This article provides an overview of the current knowledge about the PICALM gene, including its physiological functions, genetic variants, post-translational modifications, and relevance to Alzheimer's disease pathogenesis.
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Virology
Aya Matsuu, Kandai Doi, Keita Ishijima, Kango Tatemoto, Yushi Koshida, Ayako Yoshida, Kohei Kiname, Akio Iwashita, Shin-ichi Hayama, Ken Maeda
Summary: A study was conducted on Tsushima Island, Japan to investigate the seroprevalence of severe fever with thrombocytopenia syndrome (SFTS) among wild and companion animals. The results showed that a small number of animals, including wild boars and domestic cats, tested positive for anti-SFTSV antibodies, indicating the presence of SFTSV in a limited area of the island. Countermeasures are needed to prevent the spread of SFTSV and protect humans and animals, including the endangered Tsushima leopard cats.
Article
Clinical Neurology
Francesco Pellegrini, Mattia Rosso, Duong T. Chu
Summary: This article summarizes the significant role played by neuroscientist Gaetano Perusini in the research of Alzheimer's disease and suggests that the disease should be named Alzheimer-Perusini disease.
Article
Veterinary Sciences
Taisuke Nakagawa, Mari Kojima, Koichi Ohno, James K. Chambers, Kazuyuki Uchida, Aki Ohmi, Yuko Goto-Koshino, Hirotaka Tomiyasu, Hajime Tsujimoto
Summary: The study showed that continuous l-asparaginase administration is an effective and safe treatment option for dogs with large cell lymphoma of presumed GI origin. Most cases showed improvement in clinical signs at diagnosis, with a good treatment response.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Editorial Material
Pathology
F. Yvonne Schulman, Paola Roccabianca, Giancarlo Avallone, Christof A. Bertram, Mark Chalkley, James K. Chambers, Taryn A. Donovan, Robert A. Foster, Donald Meuten, Ilaria Porcellato, Simon L. Priestnall, Roberta Rasotto, Kazuyuki Uchida, Joshua D. Webster, Geoffrey A. Wood, Jeff L. Caswell
VETERINARY PATHOLOGY
(2022)
Article
Pathology
Kazuhiro Kojima, James K. Chambers, Takuya Mizuno, Kazuyuki Uchida
Summary: T-zone lymphoma (TZL) in dogs is characterized by clonal proliferation of CD8(+) T cells, while T-zone hyperplasia (TZH) consists of a heterogeneous population of CD45(+) T cells. Results suggest TZL as a monoclonal proliferation of cytotoxic T cells, and TZH as reflecting immune responses to various regional neoplastic lesions.
VETERINARY PATHOLOGY
(2022)
Article
Pathology
Tatshuhito Ii, James K. Chambers, Ko Nakashima, Yuko Goto-Koshino, Takuya Mizuno, Kazuyuki Uchida
Summary: The expression of cytotoxic molecules in feline intestinal T-cell lymphoma cells, particularly their infiltration in the mucosal epithelium, is associated with shorter survival times.
VETERINARY PATHOLOGY
(2022)
Article
Pathology
Soma Ito, James K. Chambers, Nguyen Vu Son, Chiaki Kita, Ken-ichiro Ise, Yasutsugu Miwa, Hiroyuki Nakayama, Kazuyuki Uchida
Summary: This study investigated the pathological characteristics of lymphomas in pet Syrian hamsters and examined the involvement of HaPyV. The results showed that HaPyV infection was highly associated with abdominal lymphomas in young pet Syrian hamsters. Polymerase chain reaction (PCR) and in situ hybridization (ISH) were useful in identifying the presence of HaPyV in the lymphomas.
VETERINARY PATHOLOGY
(2023)
Article
Pathology
Soma Ito, James K. Chambers, Ayumi Sumi, Tetsuo Omachi, Makoto Haritani, Hiroyuki Nakayama, Kazuyuki Uchida
Summary: In this study, the involvement of Felis catus papillomavirus type 2 (FcaPV2) in feline Merkel cell carcinoma (MCC) was investigated. The findings suggest that the expression of integrated FcaPV2 oncogenes might be associated with the downregulation of tumor suppressor proteins pRb and p53, and p53 mutations may be involved in both FcaPV2-positive and FcaPV2-negative MCC tumorigenesis.
VETERINARY PATHOLOGY
(2023)
Article
Pathology
Kio Yoshida, James K. K. Chambers, Kazuyuki Uchida
Summary: This study investigates the presence and characteristics of neural stem cells (NSCs) and their lineage in the normal canine brain and gliomas. The results suggest that gliomas share similar cell types with NSCs, and high-grade gliomas exhibit characteristics of neuronal progenitor cells and neurons. This indicates the pluripotent nature of these tumors.
VETERINARY PATHOLOGY
(2023)
Article
Veterinary Sciences
Aki Ohmi, Miho Tanaka, Jun Rinno, Masaya Tsuboi, James K. Chambers, Kazuyuki Uchida, Yuko Goto-Koshino, Hirotaka Tomiyasu, Koichi Ohno, Hajime Tsujimoto
Summary: Lymphoma with Mott cell change (MCL) is a rare variant of canine lymphoma. This study investigated the clinical characteristics and outcomes of MCL in miniature dachshunds, and found that MCL mainly occurs in the gastrointestinal tract of these dogs and has a longer survival compared to other types of lymphoma.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Veterinary Sciences
Hideyuki Kanemoto, Aki Fujiwara-Igarashi, Tetsuya Kobayashi, Kei Harada, Masanao Ichimata, Sangho Kim, Kenji Hosoya, Hirotaka Tomiyasu, Aki Ohmi, Hajime Tsujimoto
Summary: This multicentre, retrospective observational study aimed to describe the clinical presentation, diagnostic methods, treatment and outcomes of cats with tracheal masses. Lymphoma was the most prevalent diagnosis, and showed a good response to chemotherapy with or without radiation therapy. Ultrasound-guided fine-needle biopsy and cytology are good diagnostic procedures for cervical tracheal lesions.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2023)
Article
Veterinary Sciences
Mona Uchida, Yuki Matsumiya, Masaya Tsuboi, Kazuyuki Uchida, Takayuki Nakagawa, Wataru Fujii, Tetsuya Kobayashi, Hajime Tsujimoto, Aki Ohmi, Hirotaka Tomiyasu, Tomoki Motegi, Shingo Maeda, Yasuyuki Momoi, Tomohiro Yonezawa
Summary: Histiocytic sarcoma (HS) is a rare malignancy in dogs, with poor prognosis. This study investigated the involvement of apoptosis inhibitor of macrophage (AIM) in the development of HS in dogs. The expression of AIM in tumor tissue and serum AIM levels were evaluated, and the effects of AIM overexpression on HS cells were studied. The results suggest that elevated expression of AIM in tumor and serum could induce the progression of HS cells in dogs, and serum AIM levels may serve as a biomarker for HS.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Article
Pathology
Tatsuhito Ii, James K. K. Chambers, Mizuho Uneyama, Ayumi Sumi, Yutaro Nakayama, Nanae Tsurita, Yasutsugu Miwa, Kazuyuki Uchida
Summary: This study found that degus are susceptible to Mycobacterium genavense infection in the central nervous system, resulting in spinal cord necrosis, granulomatous myelitis, and brain necrosis.
VETERINARY PATHOLOGY
(2023)
Article
Pathology
Kio Yoshida, James K. K. Chambers, Kazumi Nibe, Yumiko Kagawa, Kazuyuki Uchida
Summary: NSC lineage cells were identified in feline brains using immunohistochemical markers. Feline glial tumors showed an NSC-like immunophenotype and exhibited characteristics of glial, oligodendrocyte precursor, and ependymal cells. Feline oligodendrogliomas displayed an OPC-like immunophenotype. Feline glial tumors may have multipotential stemness for differentiation into neuronal cells.
VETERINARY PATHOLOGY
(2023)
Letter
Pathology
F. Yvonne Schulman, Christof A. Bertram, Donald J. Meuten, Frances M. Moore, Giancarlo Avallone, Alexander Bartel, Pompei Bolfa, Melinda Camus, James K. Chambers, Michael J. Dark, Nick Dervisis, Melanie J. Dobromylskyj, Taryn A. Donovan, Robert A. Foster, Paula M. Krimer, Andrew Miller, Milan Milovancev, Paola Roccabianca, Laura E. Selmic, Geoff A. Wood
VETERINARY PATHOLOGY
(2023)
Article
Pathology
Mizuho Uneyama, James K. Chambers, Tadashi Fujii, Ko Nakashima, Kazuyuki Uchida
Summary: A novel cell line, FeLeco-G7, was established from a cat with metastatic colorectal adenocarcinoma, and successfully transplanted into mice, resulting in the formation of tumors similar to the original tumor. This provides valuable tools for further molecular and therapeutic research on feline colorectal adenocarcinoma.
VETERINARY PATHOLOGY
(2023)
Article
Pathology
Kazuhiro Kojima, James K. Chambers, Ko Nakashima, Kazuyuki Uchida
Summary: This study suggests that IFN-gamma and IL-21 play a role in the pathogenesis of IEL+CE, and IFN-gamma may be involved in T-cell activation and mucosal injury in CE. STAT1 and STAT3 activation in ITCL cells suggests a role for the upregulation of the STAT pathway in the pathogenesis of ITCL.
VETERINARY PATHOLOGY
(2023)