Article
Medicine, General & Internal
Robert Ryczek, Przemyslaw J. Kwasiborski, Agnieszka Rzeszotarska, Jolanta Dymus, Agata Galas, Anna Kazmierczak-Dziuk, Anna M. Karasek, Marta Mielniczuk, Malgorzata Buksinska-Lisik, Jolanta Korsak, Pawel Krzesinski
Summary: Measurements of NSE and S100B at admission can accurately identify patients with poor clinical outcomes after OHCA with 100% specificity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Emergency Medicine
Zhenghui Li, Jin Zhang, Steffen Halbgebauer, Akila Chandrasekar, Rida Rehman, Albert Ludolph, Tobias Boeckers, Markus Huber-Lang, Markus Otto, Francesco Roselli, Florian Olde Heuvel
Summary: The study found that NFL, NSE and S100B concentrations all increased at 3 hours post-TBI. Ethanol blood concentrations showed an inverse correlation with NSE but not with NFL or S100B. Claudin-5 levels were correlated with NFL but not with NSE or S100B.
Article
Clinical Neurology
Aurelie Hanin, Sophie Demeret, Jerome Alexandre Denis, Vi-Huong Nguyen-Michel, Benjamin Rohaut, Clemence Marois, Francoise Imbert-Bismut, Dominique Bonnefont-Rousselot, Pierre Levy, Vincent Navarro, Virginie Lambrecq
Summary: The study discussed the relationship between neuron-specific enolase (NSE) and S100-beta (S100B) levels with EEG activity to evaluate seizure risk in patients with acute brain injury. It was found that NSE levels were positively correlated with EEG scores, and higher NSE levels were associated with an increased risk of seizure recurrence.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jing Chen, Yan Cheng, Xiaogang Zhang, Fukun Wang, Xia Chuai
Summary: This study aimed to investigate the clinical value of serum neuron-specific enolase (NSE) combined with serum S100B protein in the diagnosis of systemic lupus erythematosus (SLE). The results showed a positive correlation between the levels of serum S100B protein and NSE and the activity of SLE. The combined diagnosis had higher value, sensitivity, and specificity in diagnosing SLE.
CONTRAST MEDIA & MOLECULAR IMAGING
(2022)
Article
Chemistry, Physical
Liya Ye, Liguang Xu, Hua Kuang, Xinxin Xu, Chuanlai Xu
Summary: Traumatic brain injury is a serious public health problem, and the identification of sensitive and specific biochemical markers is crucial for timely diagnosis and treatment. The S100B protein has been extensively studied and shows promise as a marker for brain injury. This study developed a rapid and quantitative biosensor for S100B using colloidal gold labeling and sandwich immunochromatography. The biosensor showed high sensitivity and specificity, with a detection limit of 4.6 pg mL(-1) and a linear range of 0.01-2 ng mL(-1). The method correlated well with a chemiluminescence immunoassay when tested on clinical serum samples. This biosensor has potential for early diagnosis, disease progression assessment, and prognosis of traumatic brain injury.
NANOSCALE HORIZONS
(2023)
Article
Neurosciences
Maryna Polyakova, Karsten Mueller, Katrin Arelin, Leonie Lampe, Francisca S. Rodriguez, Tobias Luck, Juergen Kratzsch, Karl-Titus Hoffmann, Steffi Riedel-Heller, Arno Villringer, Peter Schoenknecht, Matthias L. Schroeter
Summary: This study found evidence of neuronal and glial injury in patients with mild neurocognitive disorder. However, the biomarkers NSE and S100B were not sufficiently discriminatory to establish a pathological threshold for mild NCD. Further research is needed to investigate whether younger patients with mild NCD are at risk of developing major NCD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Litao Zhang, Jing Zhao, Qingqing Hao, Xin Xu, Hu Han, Jianguo Li
Summary: In patients with acute carbon monoxide poisoning, levels of neuron-specific enolase (NSE) and S100B protein are significantly associated with coma duration >= 72 hours, serving as predictive indicators. Furthermore, NSE and S100B levels are also correlated with severity of impaired consciousness.
Article
Clinical Neurology
Murat Gonen, Sevim Ozdogan, Ferhat Balgetir, Caner Feyzi Demir, Emrah Aytac, Bulent Mungen
Summary: Recent studies have shown that serum NSE and S100B levels are significantly elevated in both episodic and chronic migraine patients, indicating neuronal and glial involvement in the pathophysiology of migraine. Furthermore, the higher levels of these markers in cases of chronic migraine suggest an ongoing pathological process even during the interictal period.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Pharmacology & Pharmacy
Noha O. Mansour, Mohamed A. Shama, Rehab H. Werida
Summary: The study showed that early use of doxycycline in TBI patients reduced NSE serum levels and improved GCS scores, potentially mitigating secondary brain injury. Therefore, larger clinical trials are needed to confirm these findings.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Clinical Neurology
Giulio Disanto, Michele Villa, Aleksandra Maleska Maceski, Chiara Prosperetti, Claudio Gobbi, Jens Kuhle, Tiziano Cassina, Pamela Agazzi
Summary: Serum neurofilament light (sNfL) is a promising marker for predicting the outcome of cardiac arrest. The study found that sNfL levels were similar between survivors and non-survivors upon admission, but significant differences were observed after 24 hours. sNfL concentrations showed high predictive value for death, especially when early samples were unavailable or prognosis remained uncertain.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Review
Pharmacology & Pharmacy
Noha O. Mansour, Mohamed Hassan Elnaem, Doaa H. Abdelaziz, Muna Barakat, Inderpal Singh Dehele, Mahmoud E. Elrggal, Mahmoud S. Abdallah
Summary: This review aimed to discuss and summarize the current evidence on the effectiveness of adjuvant neuroprotective treatments in TBI patients. After systematic searching and assessment, four therapeutic options were found to show potential treatment effects for TBI patients. However, further research is needed to validate these findings due to heterogeneity and methodological flaws.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Weiliang Chen, Guanjun Wang, Chunyu Yao, Zujian Zhu, Rui Chen, Wen Su, Rongcai Jiang
Summary: The study included 115 patients with moderate-to-severe TBI who underwent NSE measurements within 6 hours after injury and brain MRI within 30 days. The NGR on admission was found to be significantly lower in patients without DAI compared to those with DAI, showing high diagnostic accuracy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medical Laboratory Technology
Xiao-Min Liu, Xiao-Hua Liu, Min-Jie Mao, Yi-Jun Liu, Jun-Ye Wang, Shu-Qin Dai
Summary: This study aimed to establish a solution integrated with laboratory information system to clear the bias from hemolysis on serum NSE test. The results showed that the agreement between individual correction equation and NSE assay was satisfactory, indicating the effectiveness of the automated processing algorithm in correcting positive bias from specimen hemolysis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Urology & Nephrology
Tibor Szarvas, Anita Csizmarik, Tamas Fazekas, Andras Huttl, Peter Nyirady, Boris Hadaschik, Viktor Gruenwald, Lukas Puellen, Zsolt Juranyi, Zsuzsa Kocsis, Shahrokh F. Shariat, Sabina Sevcenco, Agnieszka Maj-Hes, Gero Kramer
Summary: The study assessed chromogranin A (CGA) and neuron-specific enolase (NSE) levels and changes in different stages of prostate cancer. Results showed higher levels of CGA and NSE in castration-resistant patients compared to hormone-naive patients, with high baseline CGA levels associated with poor survival. Serum CGA levels could assist in tailoring and monitoring therapy for advanced prostate cancer.
Article
Medicine, General & Internal
Xiaoping Wang
Summary: This study revealed that the NSE level in patients with craniocerebral injury is correlated with indexes of neuron injury and apoptosis, which can predict the severity of the injury.
ACTA MEDICA MEDITERRANEA
(2021)
Review
Neurosciences
Sook-Lei Liew, Artemis Zavaliangos-Petropulu, Neda Jahanshad, Catherine E. Lang, Kathryn S. Hayward, Keith R. Lohse, Julia M. Juliano, Francesca Assogna, Lee A. Baugh, Anup K. Bhattacharya, Bavrina Bigjahan, Michael R. Borich, Lara A. Boyd, Amy Brodtmann, Cathrin M. Buetefisch, Winston D. Byblow, Jessica M. Cassidy, Adriana B. Conforto, R. Cameron Craddock, Michael A. Dimyan, Adrienne N. Dula, Elsa Ermer, Mark R. Etherton, Kelene A. Fercho, Chris M. Gregory, Shahram Hadidchi, Jess A. Holguin, Darryl H. Hwang, Simon Jung, Steven A. Kautz, Mohamed Salah Khlif, Nima Khoshab, Bokkyu Kim, Hosung Kim, Amy Kuceyeski, Martin Lotze, Bradley J. MacIntosh, John L. Margetis, Feroze B. Mohamed, Fabrizio Piras, Ander Ramos-Murguialday, Genevieve Richard, Pamela Roberts, Andrew D. Robertson, Jane M. Rondina, Natalia S. Rost, Nerses Sanossian, Nicolas Schweighofer, Na Jin Seo, Mark S. Shiroishi, Surjo R. Soekadar, Gianfranco Spalletta, Cathy M. Stinear, Anisha Suri, Wai Kwong W. Tang, Gregory T. Thielman, Daniela Vecchio, Arno Villringer, Nick S. Ward, Emilio Werden, Lars T. Westlye, Carolee Winstein, George F. Wittenberg, Kristin A. Wong, Chunshui Yu, Steven C. Cramer, Paul M. Thompson
Summary: The ENIGMA Stroke Recovery working group aims to understand the relationship between brain and behavior using meta- and mega-analytic approaches. They have developed neuroinformatics protocols and methods to manage large-scale data from over 2,100 stroke patients. The challenges and recommendations for data harmonization in stroke research are discussed.
HUMAN BRAIN MAPPING
(2022)
Article
Psychiatry
Susanne Roehr, Felix Wittmann, Christoph Engel, Cornelia Enzenbach, A. Veronica Witte, Arno Villringer, Markus Loeffler, Steffi G. Riedel-Heller
Summary: Social isolation has negative effects on physical and brain health. The prevalence of social isolation in the adult population was 12.3%, with higher rates in men and increasing with age. Socioeconomic status also played a significant role, with lower prevalence in high SES and higher prevalence in low SES groups. Effective prevention and intervention strategies should take into account these sociodemographic and socioeconomic factors.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Psychology, Experimental
Josefin Robbig, Miray Erbey, Anahit Babayan, Andrea M. F. Reiter, Deniz Kumral, H. Lina Schaare, Janis D. Reinelt, Michael Gaebler, Ute Kunzmann, Arno Villringer
Summary: This study examines the differences in emotion regulation strategy choices between younger and older adults, finding that only older adults' regulation choices are influenced by the emotional intensity of autobiographical memories and habitual reappraisal. The significance of habitual reappraisal in emotion regulation choices for older adults is highlighted.
Article
Neurosciences
Natalie Kohler, Giacomo Novembre, Katarzyna Gugnowska, Peter E. Keller, Arno Villringer, Daniela Sammler
Summary: Joint music performance requires flexible sensorimotor coordination between self and other, influenced by shared knowledge and temporal synchrony. A study found that pianists who practiced their partner's part showed stronger activity and connectivity within cortico-cerebellar audio-motor networks, indicating internal model simulation and anticipation of partner's feedback. However, when there were subtle asynchronies between model-based anticipations and perceived sensory outcomes of partner actions, pianists exhibited stronger cerebellar activity and reduced behavioral adaptation, indicating a shift towards self-other segregation.
Article
Neurosciences
Ahmed A. Khalil, Ayse C. Tanritanir, Ulrike Grittner, Evgeniya Kirilina, Arno Villringer, Jochen B. Fiebach, Ralf Mekle
Summary: In this study, the reproducibility of BOLD delay was assessed in 136 subjects with normal cerebral perfusion. The highest reproducibility was observed in the posterior cerebral artery territory. Overall, BOLD delay showed good reproducibility, but caution should be exercised when interpreting longitudinal BOLD delay changes that are either very small or located in certain brain regions.
HUMAN BRAIN MAPPING
(2023)
Article
Multidisciplinary Sciences
H. Lina Schaare, Maria Bloechl, Deniz Kumral, Marie Uhlig, Lorenz Lemcke, Sofie L. Valk, Arno Villringer
Summary: The study demonstrates an association between blood pressure and depressive symptoms, well-being, and emotion-related brain activity, which may be relevant to hypertension. Using extensive data from the UK Biobank, the study resolves contradictions and explores the relationship between mental health, systolic blood pressure, and hypertension. It shows that higher systolic blood pressure is associated with fewer depressive symptoms, greater well-being, and lower emotion-related brain activity.
NATURE COMMUNICATIONS
(2023)
Article
Psychiatry
Dirk Alexander Wittekind, Juergen Kratzsch, Roland Mergl, Kerstin Wirkner, Ronny Baber, Christian Sander, A. Veronica Witte, Arno Villringer, Michael Kluge
Summary: The study found that childhood trauma has long-term effects on the ghrelin system, with childhood sexual abuse being significantly associated with higher ghrelin serum levels. However, other childhood traumas did not show a significant association with ghrelin levels.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Haiko Schloegl, Arno Villringer, Konstanze Miehle, Mathias Fasshauer, Michael Stumvoll, Karsten Mueller
Summary: This study replicated previous findings on the increase of brain connectivity in the hypothalamus and posterior cingulate gyrus in patients with lipodystrophy (LD) undergoing metreleptin treatment. These results contribute to understanding the central nervous effects of leptin and provide a foundation for future research.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Endocrinology & Metabolism
Haiko Schloegl, Lieneke Janssen, Mathias Fasshauer, Konstanze Miehle, Arno Villringer, Michael Stumvoll, Karsten Mueller
Summary: Using functional MRI, the study investigated the effects of metreleptin on the reward system in a non-eating behavior reward task. The results showed that patients with lipodystrophy treated with metreleptin experienced a decrease in reward-related brain activity, suggesting that leptin has functions in the human reward system that are unrelated to eating behavior.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Clinical Neurology
Karsten Mueller, Friederike Thiel, Birol Taskin, Frank Beutner, Andrej Teren, Vladimir K. Dubovoy, Harald E. Moeller, Arno Villringer, Matthias L. Schroeter
Summary: The study aimed to detect the functional correlates of heart failure in terms of alterations in functional brain connectivity related to cognitive performance. The results show that heart failure is associated with reduced functional connectivity between the precuneus and widely distributed brain regions, and decline in cognitive performance is specifically correlated with diminished functional brain connectivity in patients with heart failure.
BRAIN COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Evelyn Medawar, Frauke Beyer, Ronja Thieleking, Sven-Bastiaan Haange, Ulrike Rolle-Kampczyk, Madlen Reinicke, Rima Chakaroun, Martin von Bergen, Michael Stumvoll, Arno Villringer, A. Veronica Witte
Summary: This study investigated the effects of high-dosed prebiotic fiber on reward-related food decision-making in overweight young adults. The results showed that prebiotic intake decreased brain activation towards high-caloric food stimuli and caused shifts in gut microbiota.
Article
Neurosciences
Julia Huck, Anna-Thekla Jaeger, Uta Schneider, Sophia Grahl, Audrey P. Fan, Christine Tardif, Arno Villringer, Pierre-Louis Bazin, Christopher J. Steele, Claudine J. Gauthier
Summary: Resting-state functional magnetic resonance imaging (rs-fMRI) is used to detect low-frequency fluctuations in the BOLD signal across brain regions. Venous biases can affect the amplitude and location of the BOLD signal, as well as connectivity measures derived from rs-fMRI. This study investigated the impact of vein diameter and distance on various rs-fMRI measures in the grey matter. It was found that smaller veins had higher values across all distances, while values associated with larger veins decreased with increasing distance. Models were proposed to correct for this venous bias in rs-fMRI metrics.
HUMAN BRAIN MAPPING
(2023)
Article
Psychology, Biological
Felix Klotzsche, Michael Gaebler, Arno Villringer, Werner Sommer, Vadim Nikulin, Sven Ohl
Summary: Virtual reality (VR) is a powerful tool for studying cognitive processes, allowing researchers to observe behaviors and mental states in complex and controlled scenarios. This study used a VR headset to investigate the spatial limitations of two well-known EEG markers in visual short-term memory. The results showed that the amplitude of the contralateral delay activity (CDA) differed between high and low memory load at smaller eccentricities, but not at the largest eccentricity. Memory load and eccentricity had no significant effect on lateralized alpha power. The study concluded that commercial VR hardware can be used to study these EEG markers of visual memory, with some limitations.
Article
Multidisciplinary Sciences
Daniel S. Kluger, Carina Forster, Omid Abbasi, Nikos Chalas, Arno Villringer, Joachim Gross
Summary: Bodily rhythms such as respiration modulate neural oscillations underlying human action, perception, and cognition. The link between respiration and aperiodic brain activity has been unstudied, but this study shows that fluctuations of aperiodic brain activity are synchronized with the respiratory cycle. These findings highlight the role of respiration as a physiological influence on brain signaling.
NATURE COMMUNICATIONS
(2023)
Article
Food Science & Technology
Evelyn Medawar, Marie Zedler, Larissa de Biasi, Arno Villringer, A. Veronica Witte
Summary: Adopting plant-based diets high in fiber may reduce global warming and obesity prevalence, but the physiological and psychological determinants of plant-based food intake remain unclear.
NPJ SCIENCE OF FOOD
(2023)
