Shp2 Activates Fyn and Ras to Regulate RBL-2H3 Mast Cell Activation following FcεRI Aggregation

A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells

(2011) L. Li et al.   BLOOD

G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase

(2011) M. Futami et al.   BLOOD

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

Gab2, via PI-3K, Regulates ARF1 in Fc RI-Mediated Granule Translocation and Mast Cell Degranulation

(2011) K. Nishida et al.   JOURNAL OF IMMUNOLOGY

Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development

(2010) Y. Pan et al.   DEVELOPMENT

Cooperation of adapter molecules in proximal signaling cascades during allergic inflammation

(2009) Taku Kambayashi et al.   IMMUNOLOGICAL REVIEWS

Negative Regulation of Stat3 by ActivatingPTPN11Mutants Contributes to the Pathogenesis of Noonan Syndrome and Juvenile Myelomonocytic Leukemia

(2009) Wenjun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SH2 Domain-Containing Phosphatase-2 Protein-Tyrosine Phosphatase Promotes Fc RI-Induced Activation of Fyn and Erk Pathways Leading to TNF  Release from Bone Marrow-Derived Mast Cells

(2009) V. A. McPherson et al.   JOURNAL OF IMMUNOLOGY

Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation

(2009) T. Araki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

(2007) Marie Dance et al.   CELLULAR SIGNALLING