Alleviation of Gut Inflammation by Cdx2/Pxr Pathway in a Mouse Model of Chemical Colitis

Suppression of Colonic Polyposis by Homeoprotein CDX2 through its Nontranscriptional Function that Stabilizes p27Kip1

(2011) Koji Aoki et al.   CANCER RESEARCH

Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: Synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis

(2011) Marta Perro Neves et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

Identification of the metabolites of baicalein in human plasma

(2011) Xiao-Yu Guo et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

(2011) Hongwei Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Total Synthesis and Pharmacological Characterization of Solomonsterol A, a Potent Marine Pregnane-X-Receptor Agonist Endowed with Anti-Inflammatory Activity

(2011) Valentina Sepe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Probiotics Modulate Intestinal Expression of Nuclear Receptor and Provide Counter-Regulatory Signals to Inflammation-Driven Adipose Tissue Activation

(2011) Andrea Mencarelli et al.   PLoS One

Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells

(2010) Andrea Mencarelli et al.   BIOCHEMICAL PHARMACOLOGY

The role ofCdxgenes in the gut and in axial development

(2010) Felix Beck et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The role of CDX2 in intestinal homeostasis and inflammation

(2010) Mehmet Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

CDX2 Regulates Multidrug Resistance 1 Gene Expression in Malignant Intestinal Epithelium

(2010) Y. Takakura et al.   CANCER RESEARCH

Baicalein inhibits nuclear factor-κB and apoptosis via c-FLIP and MAPK in d-GalN/LPS induced acute liver failure in murine models

(2010) Yan-Ling Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalein, chlorogenic acid, and ginsenoside Rf through constitutive androstane receptor- and pregnane X receptor-mediated pathways

(2010) Yue Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cdx2 regulates endo-lysosomal function and epithelial cell polarity

(2010) N. Gao et al.   GENES & DEVELOPMENT

Inhibition of β-catenin/Tcf signaling by flavonoids

(2010) Seyeon Park et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Therapeutic Role of Rifaximin in Inflammatory Bowel Disease: Clinical Implication of Human Pregnane X Receptor Activation

(2010) J. Cheng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The PXR is a drug target for chronic inflammatory liver disease

(2010) Karen Wallace et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Flavonoid Pharmacokinetics and Tissue Distribution after Repeated Dosing of the Roots ofScutellaria baicalensisin Rats

(2010) Yu-Chi Hou et al.   PLANTA MEDICA

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

(2010) B. D. Wallace et al.   SCIENCE

Evolutionary inspirations for drug discovery

(2010) Hong-Yu Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study

(2010) Ya-He Liu et al.   XENOBIOTICA

Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives

(2010) N. R. Srinivas   XENOBIOTICA

Effects of Baicalin and Octreotide on the Serum TNF-α Level and Apoptosis in Multiple Organs of Rats with Severe Acute Pancreatitis

(2009) Tian Hua et al.   INFLAMMATION

Cloning and Expression of β-Glucuronidase from Lactobacillus brevis in E. coli and Application in Bioconversion of Baicalin and Wogonoside

(2009) Hyun Sung Kim   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Elucidating the ‘Jekyll and Hyde’ Nature of PXR: The Case for Discovering Antagonists or Allosteric Antagonists

(2009) Arunima Biswas et al.   PHARMACEUTICAL RESEARCH

Increased Oral AUC of Baicalin in Streptozotocin-Induced Diabetic Rats due to the Increased Activity of Intestinal β-Glucuronidase

(2009) Li Liu et al.   PLANTA MEDICA