Article
Clinical Neurology
Zezhi Li, Shuning Wang, Yuping Chen, Xi Wu, Yinjun Gu, Xiaoe Lang, Fengchun Wu, Xiang Yang Zhang
Summary: Our study indicates that smoking schizophrenia patients have a higher prevalence of MetS and metabolic disorders than nonsmoking patients. Moreover, smoking and nonsmoking patients have different contributing components and associated factors for MetS.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Leila Mahmoudieh, Mina Amiri, Maryam Rahmati, Ali Siamak Habibi Moeini, Farzaneh Sarvghadi, Fereidoun Azizi, Fahimeh Ramezani Tehrani
Summary: Limited studies have investigated the impact of idiopathic hirsutism (IH) on cardiometabolic parameters. This study found that IH does not significantly affect metabolic risk factors and cardiometabolic outcomes, except for a marginal significance in type 2 diabetes mellitus (T2DM).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Clinical Neurology
M. P. Schuster, J. Borkent, M. Chrispijn, M. Ioannou, B. Doornbos, H. Burger, B. C. M. Haarman
Summary: This study found a higher prevalence of MetS in Dutch BD subjects compared to the control group, with factors such as smoking, body mass index, and antidepressant drug use being associated with MetS. BD subjects showed undertreatment for hypertension, hyperglycemia, and lipid disorders in this study.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Nutrition & Dietetics
Huan Yun, Qi-Bin Qi, Geng Zong, Qing-Qing Wu, Zhen-Hua Niu, Shuang-Shuang Chen, Huai-Xing Li, Liang Sun, Rong Zeng, Xu Lin
Summary: This study found that specific types of sphingolipids in plasma were significantly associated with the onset of metabolic syndrome, particularly those from ceramide and hydroxysphingomyelin subclasses. The findings suggest that elevated ceramide concentrations may increase the risk of MetS, while raised levels of hydroxysphingomyelin may decrease the risk.
Article
Endocrinology & Metabolism
Zhiyuan Wu, Yue Jiang, Di Zhou, Shuo Chen, Yu Zhao, Haiping Zhang, Yue Liu, Xia Li, Wei Wang, Jingbo Zhang, Xiaoping Kang, Lixin Tao, Bo Gao, Xiuhua Guo
Summary: Subclinical hypothyroidism is associated with incident metabolic syndrome in young men, but not in individuals aged 50 years or older.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Health Care Sciences & Services
Amalia Ivine Costa Santana, Magno Conceicao das Merces, Marcio Costa de Souza, Bruno Gil de Carvalho Lima, Maria Jose Quina Galdino, Nuno Damacio de Carvalho Felix, Lucelia Batista Neves Cunha Magalhaes, Julita Maria Freitas Coelho, Paulo Jose Bastos Barbosa, Erica Velasco Dias Gomes, Rodrigo Fernandes Weyll Pimentel, Anderson Reis de Sousa, Marcia Aparecida Ferreira de Oliveira, Aline Macedo de Queiroz, Raissa Millena Silva Florencio, Jorge Lopes Cavalcante Neto, Antonio Marcos Tosoli Gomes, Thadeu Borges Souza Santos, Silvana Lima Vieira, Danilo Guimaraes de Sousa, Priscila Cristina da Silva Thiengo de Andrade, Isolda Prado de Negreiros Nogueira Maduro, Sandra Lucia Fernandes, Kairo Silvestre Meneses Damasceno, Dandara Almeida Reis da Silva, Argemiro D'Oliveira Junior
Summary: This study assessed the interaction between work and metabolic syndrome (MS) among primary health care nursing professionals in Bahia, Brazil. The findings showed a synergistic interaction of work aspects for MS occurrence.
Article
Medicine, Research & Experimental
Davide Pietropaoli, Serena Altamura, Eleonora Ortu, Luca Guerrini, Theresa T. Pizarro, Claudio Ferri, Rita Del Pinto
Summary: This study used data from the third National Health and Nutrition Examination Survey (NHANES III) to analyze the relationship between multiple metabolic syndrome (MetS) components and periodontal diseases. The results showed that MetS components were associated with gingival bleeding but not with periodontitis. This association was observed only in women and not in men.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Environmental Sciences
Mingcong Chen, Yang Yang, Krishna Baral, Yicheng Fu, Yang Meng, Yang Zhang, Fang Sun, Mingyi Zhao
Summary: This study analyzed the relationship between bisphenol A (BPA) concentrations and metabolic risk factors for cardiovascular diseases (CVDs) using population-based data. The results showed that higher BPA concentrations were associated with increased metabolic risk for CVDs. Therefore, further regulation of BPA may be necessary for the prevention of CVDs in adults.
Article
Oncology
Joo-Hyun Park, Jung Y. Hong, Young S. Park, Gunseog Kang, Kyungdo Han, Joon O. Park
Summary: The study found that persistent metabolic syndrome (MetS) is associated with an increased risk of cholangiocarcinoma (CCA) if it persists for more than 2 years. Even after adjusting for multiple covariates, MetS-persistent status significantly increases the risk of CCA, while improved or newly developed MetS is not associated with CCA risk.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Hee Yeon Lee, Kyung-Do Han, In Sook Woo, Hyuk-Sang Kwon
Summary: The aim of this study was to determine the association of metabolic syndrome (MetS) with kidney cancer and the impact of age and gender on such an association. The study used the Korean National Health Insurance Service database to follow up 9,932,670 subjects who had check-ups in 2009 until the diagnosis of kidney cancer or death or until 2019. The results showed that kidney cancer was significantly associated with MetS, with a higher association in younger age groups and higher associations with obesity and central obesity in younger aged male population.
Article
Clinical Neurology
Hyewon Kim, Soorack Ryu, Hong Jin Jeon, Sungwon Roh
Summary: This study aimed to examine the association between lifestyle factors and suicide-related outcomes. Data from the Korea National Health and Nutrition Examination Survey in 2015 and 2017 were analyzed, and lifestyle factors including smoking, physical activity, alcohol intake, and the Healthy Eating Index (HEI) were identified. The results showed that smoking and heavy drinking were associated with an increased risk of suicide-related outcomes, while high-quality diets and non-heavy drinking were associated with a decreased risk. The associations between lifestyle factors and suicide-related outcomes were stronger in people with depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Nutrition & Dietetics
Jung-Hsiu Chang, I-Hua Chen, Jiun-Hung Geng, Pei-Yu Wu, Jiun-Chi Huang, Szu-Chia Chen
Summary: This study found significant associations between metabolic syndrome (MetS) and its components, such as low high-density lipoprotein cholesterol and hyperglycemia, with the risk of cataract. Additionally, there was a gradual increase in the prevalence of cataract corresponding to the number of MetS components.
Review
Cardiac & Cardiovascular Systems
Yuvaraj Krishnamoorthy, Sathish Rajaa, Sharan Murali, Jayaprakash Sahoo, Sitanshu S. Kar
Summary: Physical inactivity was found to have a significant association with the prevalence of metabolic syndrome, while smoking and alcohol did not show a statistically significant connection.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Oncology
Soo-Young Choi, Hyeon-Kyoung Cheong, Min-Kyeong Lee, Jeong-Wook Kang, Young-Chan Lee, In-Hwan Oh, Young-Gyu Eun
Summary: The development of head and neck cancer is influenced by metabolic diseases. Obesity reduces the risk of HNC in men, while underweight and diabetes are risk factors for both men and women. High cholesterol and LDL levels decrease the risk in men. Each metabolic disease affects HNC differently.
Article
Endocrinology & Metabolism
Hwi Seung Kim, Jiwoo Lee, Yun Kyung Cho, Joong-Yeol Park, Woo Je Lee, Ye-Jee Kim, Chang Hee Jung
Summary: The study explored the risk of incident heart failure based on the metabolic health and obesity status, as well as their transition over 2 years. Results showed that maintaining good metabolic health and a lean body may prevent the development of heart failure. Obese individuals with poor metabolic health had a significantly increased risk of incident heart failure.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Entomology
Ruqaiyyah Siddiqui, Yara Elmashak, Naveed Ahmed Khan
Summary: Cockroaches, one of the hardiest insects, have survived on Earth for millions of years. They thrive in unhygienic environments, can survive without food for up to 30 days, without air for around 45 min, and can be submerged under water for 30 min. They are omnivorous and can feed on cellulose and plastic. The gut microbiome of cockroaches and their metabolites may contribute to their hardiness, offering potential for the discovery of bioactive molecules for human health.
APPLIED ENTOMOLOGY AND ZOOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sutherland Kester Maciver, Sumayah Abdelnasir, Ayaz Anwar, Ruqaiyyah Siddiqui, Naveed Ahmed Khan
Summary: Protistan parasitic infections contribute significantly to morbidity and mortality, causing more than 2 billion human infections annually. Theranostics agents, specifically nanotheranostics, offer simultaneous detection, diagnosis, and treatment of these diseases, by using nanoparticles with multifunctional properties. Although the clinical application of nanotheranostics requires further research, they hold great potential as effective agents against protistan parasites, combining the concept of magic bullets with tracer bullets.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
(2023)
Article
Engineering, Chemical
Amir Sada Khan, Asma Sakina, Asma Nasrullah, Saadat Ullah, Zahoor Ullah, Zahid Khan, Naveed Ahmed Khan, Shahan Zeb Khan, Israf Ud Din
Summary: Ionic liquids (ILs) and deep eutectic solvents (DESs) are designable solvents with wide-ranging applications. They have gained significant attention due to their unique physicochemical properties, but limited research has been conducted on their phytotoxic effects. Despite being considered environmentally friendly, ILs and DESs have been found to have negative impacts on aquatic and terrestrial plants. This review examines the phototoxic problems associated with ILs and DESs, emphasizing the importance of determining their phytotoxicity before promoting their potential applications. It aims to assist researchers in developing eco-friendly ILs and DESs in accordance with the principles of green chemistry.
CHEMBIOENG REVIEWS
(2023)
Article
Parasitology
Usman Ahmed, Mehwish Manzoor, Sehrish Qureshi, Muzna Mazhar, Arj Fatima, Sana Aurangzeb, Mehwish Hamid, Khalid Mohammed Khan, Naveed Ahmed Khan, Yasmeen Rashid, Ayaz Anwar
Summary: In this study, ten synthetic Acridinone derivatives were synthesized and evaluated for their anti-amoebic and cysticidal activities against A. castellanii and N. fowleri. The results showed that these derivatives exhibited potential therapeutic activity against both amoebae. Compound VII showed strong anti-amoebic activity against A. castellanii, while compound IX showed strong activity against N. fowleri.
Article
Parasitology
Noor Akbar, Muhammad Kawish, Tooba Jabri, Naveed Ahmed Khan, Muhammad Raza Shah, Ruqaiyyah Siddiqui
Summary: In this study, cinnamic acid and lactobionic acid-based magnetic nanoparticles (MNPs) were synthesized and characterized. The drug-loaded nanoformulations showed enhanced anti-Acanthamoebic effects and inhibited encystation, excystation, and parasite binding capability. These findings suggest that conjugation of medically approved drugs with MNPs can lead to the development of potent therapeutic medications against Acanthamoeba.
EXPERIMENTAL PARASITOLOGY
(2023)
Article
Microbiology
Noor Akbar, Naveed Ahmed Khan, Alexander D. Giddey, Nelson C. Soares, Ahmad M. Alharbi, Hasan Alfahemi, Ruqaiyyah Siddiqui
Summary: The gut bacteria of water monitor lizards produce substances that can inhibit the growth of specific amoebic parasites and prevent their binding to host cells. These bacteria also produce various bioactive metabolites with antimicrobial, anticancer, neurotransmitter, and antidepressant functions.
Editorial Material
Microbiology
Ruqaiyyah Siddiqui, Naveed Ahmed Khan
Article
Microbiology
Ruqaiyyah Siddiqui, Jibran Sualeh Muhammad, Ahmad M. Alharbi, Hasan Alfahemi, Naveed Ahmed Khan
Summary: Acanthamoeba is known to house a variety of microorganisms and may facilitate viral transmission to susceptible hosts. The discovery of mimivirus from Acanthamoeba suggests that it may also harbor monkeypox virus. Additionally, animals may act as a mixing vessel between ubiquitously distributed Acanthamoeba and monkeypox virus, in addition to the environmental habitat that facilitates interactions between diverse microorganisms and the host.
Article
Infectious Diseases
Ruqaiyyah Siddiqui, Mutasem Rawas-Qalaji, Mohammed I. El-Gamal, Sreedevi Sajeev, Jayalakshmi Jagal, Seyed-Omar Zaraei, Rawan M. Sbenati, Hanan S. Anbar, Wolfgang Dohle, Barry V. L. Potter, Naveed Ahmed Khan
Summary: In this study, the effects of anticancer drugs Irosustat and STX140, as well as their nanoformulations, on pathogenic Acanthamoeba were evaluated. It was found that Irosustat significantly inhibited the growth and pathogenicity of Acanthamoeba, and also inhibited the transformation of amoebae cysts. Therefore, Irosustat has the potential to be developed as an anti-Acanthamoeba drug.
Article
Infectious Diseases
Tooba Jabri, Naveed Ahmed Khan, Zinb Makhlouf, Noor Akbar, Jasra Gul, Muhammad Raza Shah, Ruqaiyyah Siddiqui
Summary: The emergence of drug-resistant bacterial strains is a major concern, and finding new antibacterials or enhancing the potency of existing medications using nanotechnology is necessary. In this study, the antibacterial efficacy of two-dimensional glucosamine functionalized graphene-based nanocarriers loaded with sulfamethoxazole and ethacridine lactate was examined. The nanoformulations demonstrated significant antibacterial properties against both Gram-negative and Gram-positive bacteria, and showed limited toxicity effects on human cells.
Article
Chemistry, Multidisciplinary
Sumayah Abdelnasir, Mohammad Ridwane Mungroo, Jactty Chew, Ruqaiyyah Siddiqui, Naveed Ahmed Khan, Irfan Ahmad, Syed Shahabuddin, Ayaz Anwar
Summary: In this study, a conducting polymer-based nanocomposite including polyaniline (PANI) and molybdenum disulfide (MoS2) was synthesized and its anti-trophozoite and anti-cyst potentials against Acanthamoeba castellanii and Naegleria fowleri were explored. The 1:2 and 1:5 ratios of PANI/MoS2 at a concentration of 100 μg/mL demonstrated significant anti-amoebic effects, which were mediated by the generation of reactive oxygen species and physical alterations to amoeba morphology. Additionally, the nanocomposite showed cytocompatibility with human keratinocyte skin cells and primary human corneal epithelial cells.
Editorial Material
Pharmacology & Pharmacy
Ruqaiyyah Siddiqui, Naveed Ahmed Khan
THERAPEUTIC DELIVERY
(2023)
Editorial Material
Pharmacology & Pharmacy
Ruqaiyyah Siddiqui, Naveed A. Khan
PHARMACEUTICAL PATENT ANALYST
(2023)
Article
Environmental Sciences
Ruqaiyyah Siddiqui, Naveed Ahmed Khan
Summary: As insects like cockroaches possess unique abilities to endure high radiation, unsanitary circumstances, and digest various materials, their gut microbiota may produce enzymes that contribute to plastic digestion. This article discusses the potential use of cockroaches as an unconventional bioresource for plastic elimination, aligning with the sustainable development goals adopted by the United Nations and the global community to reduce or eliminate plastic pollution.
ENVIRONMENTAL MICROBIOLOGY REPORTS
(2023)
Article
Pharmacology & Pharmacy
Ruqaiyyah Siddiqui, Timothy Yu Yee Ong, Sutherland Maciver, Naveed Ahmed Khan
Summary: The study found that intranasal administration can reduce the adverse effects of Amphotericin B, which is important for treating brain infections caused by parasites.
THERAPEUTIC DELIVERY
(2023)