Article
Multidisciplinary Sciences
Takashi Iizuka, Kousho Wakae, Masanori Ono, Takuma Suzuki, Yasunari Mizumoto, Kouichi Kitamura, Shin-ichi Horike, Masamichi Muramatsu, Hiroshi Fujiwara
Summary: The study revealed that AID plays a significant role in regulating the expression of GDF-9 and SCF in the ovary, possibly through a GDF-9 and SCF feedback system to modulate communication between oocytes and granulosa cells.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Xia Xie, Tingting Gan, Bing Rao, Weiwei Zhang, Rohit A. Panchakshari, Dingpeng Yang, Xiong Ji, Yu Cao, Frederick W. Alt, Fei-Long Meng, Jiazhi Hu
Summary: The mutant AID-delC protein fails to efficiently target antibody genes, forms condensates, and may exert a dominant-negative effect on wild-type AID.
Review
Genetics & Heredity
Tony M. Mertz, Christopher D. Collins, Madeline Dennis, Margo Coxon, Steven A. Roberts
Summary: The occurrence and development of cancer are closely related to mutations, and dysregulated activity of APOBECs can lead to mutations. The study of mutation signatures helps us understand the patterns and processes of mutations. In humans, APOBEC-generated genetic heterogeneity plays an important role in cancer development, metastasis, and resistance to therapy.
ANNUAL REVIEW OF GENETICS
(2022)
Article
Medicine, General & Internal
Shohei Kikuchi, Akinori Wada, Yusuke Kamihara, Yoshimi Nabe, Tomoki Minemura, Jun Murakami, Nam H. H. Dang, Tsutomu Sato
Summary: Biclonal gammopathy is a rare phenomenon characterized by the detection of 2 M proteins in the same patient. The etiology of this condition remains unclear. In this study, we found double positive cells in two cases of B-cell malignancy with biclonal gammopathy, suggesting a possible involvement of cell transition and class switch recombination. Immunostaining revealed the expression of activation induced cytidine deaminase in these cells, indicating its potential role in the pathogenesis of biclonal gammopathy.
Article
Biochemistry & Molecular Biology
Asami Nishikori, Yoshito Nishimura, Rei Shibata, Koh-ichi Ohshima, Yuka Gion, Tomoka Ikeda, Midori Filiz Nishimura, Tadashi Yoshino, Yasuharu Sato
Summary: AID expression in IgG4-related diseases is influenced by various factors, and AID may play a key role in driving fibrosis and oncogenesis in ocular adnexal organs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Joanne Watson, Michael Smith, Chiara Francavilla, Jean-Marc Schwartz
Summary: The correct subcellular localisation of proteins is crucial for their function, and can be quickly interpreted using the SubcellulaRVis tool.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Baole Qu, Yun Zhao, Lili An, Haiying Hang
Summary: This study demonstrates that adenine deaminase (ADA) can efficiently induce random A/T to G/C mutations on the target gene in CHO cell display, and can be applied in affinity maturation to improve antibody affinity. The combined use of ADA and activation-induced cytidine deaminase (AID) provides more mutant types, offering an opportunity to acquire new mutants with higher affinities than those obtained by only using AID.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Microbiology
Feixuan Li, Xiao-Yu Liu, Lei Ni, Fan Jin
Summary: Researchers developed a method called AIDmut-Seq to detect transcription factor targets on the genome. It involves simple steps and has been validated for various transcriptional activators. However, it has lower efficiency for some small transcriptional repressors. Despite potential false-positive and false-negative results, AIDmut-Seq shows promise as a complementary tool for studying protein-DNA interactions.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Tian-Ci Deng, Ji-Yun Yang, Mei-Ling Sun, Yun-Zhao Zhang, Yun-Ting Pan, Lin Huang
Summary: This study identified four Ena ATPases proteins in C. gloeosporioides and found that they play distinct roles in sodium accumulation, stress resistance, and full virulence through gene deletion experiments.
Review
Immunology
Junna Jiao, Zhuangwei Lv, Yurong Wang, Liye Fan, Angang Yang
Summary: Activation-induced cytidine deaminase (AID) plays a crucial role in promoting B cell diversification through somatic hypermutation (SHM) and class switch recombination (CSR). Apart from its physiological function of humoral immune response, AID has been linked to the initiation and progression of lymphomas. This review proposes an alternative role for AID and explores its off-target effects in regulating tumorigenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Xiaolin Zhu, Baoqiang Wang, Xiaohong Wei, Xuefeng Du
Summary: This study systematically explored the structures and functions of the CAMTA family in quinoa. The results indicate that CAMTAs may play vital roles in organ development, growth, and response to drought stress.
Article
Biochemistry & Molecular Biology
Junna Jiao, Zhuang Qian, Yurong Wang, Mei Liu, Liye Fan, Mengqing Liu, Zichen Hao, Junrong Jiao, Zhuangwei Lv
Summary: Sonodynamic therapy using MWO4-PEG NPs shows promising inhibitory effects on activation-induced cytidine deaminase (AID) in diffuse large B-cell lymphoma. The interaction between reactive oxygen species and AID was investigated, and the NPs were found to effectively neutralize the extensive carcinogenesis caused by AID. Cell apoptosis and ROS generation in DLBCL cells treated with these NPs were observed to confirm their sonosensitivity and toxicity, indicating their potential as a treatment for AID-positive hematopoietic cancers.
Article
Biochemistry & Molecular Biology
Sachiko Toma-Fukai, Yuto Sawada, Ayako Maeda, Hikaru Shimizu, Toshiharu Shikanai, Mizuki Takenaka, Toshiyuki Shimizu
Summary: The activation mechanism of DYW1-like proteins is achieved through complementation of the DYW domain and reconstitution of the substrate-binding pocket. This provides structural insight into the activation mechanism of cytidine deaminase.
Article
Medicine, General & Internal
Ege Sinan Torun, Aynur Daglar Aday, Meliha Nalcaci
Summary: The study found that AID expression is significantly increased in the peripheral blood of MDS patients compared to healthy controls. However, there was no significant difference in AID expression in lower risk and higher risk subgroups, as well as in patients treated with hypomethylating agents. This suggests that increased AID expression may be an early step in MDS pathogenesis.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Oncology
Grant Godsmark, Leonardo Alves De Souza Rios, Shaheen Mowla
Summary: The study demonstrated that AID is highly specific to B-cell-derived cancers, with ectopic overexpression leading to rapid cell death, and silencing AID significantly impacting genomic stability, proliferation, migration, and drug resistance. AID is identified as an important driver of lymphoma, affecting multiple cellular events, and potentially a strong candidate for targeted therapy in lymphoma.
ANTICANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rina Nagata, Nanami Akai, Shu Kondo, Kuniaki Saito, Shizue Ohsawa, Tatsushi Igaki
Summary: Mutations in the tumor-suppressor Hippo pathway activate the transcriptional coactivator Yorkie, leading to autonomous cell proliferation and non-autonomous cell death. This study reveals that Yki-induced supercompetition is crucial for tumorigenesis and is driven by non-autonomous induction of autophagy.
Article
Genetics & Heredity
Kohei Hamanaka, Keita Miyoshi, Jia-Hui Sun, Keisuke Hamada, Takao Komatsubara, Ken Saida, Naomi Tsuchida, Yuri Uchiyama, Atsushi Fujita, Takeshi Mizuguchi, Benedicte Gerard, Allan Bayat, Berardo Rinaldi, Mitsuhiro Kato, Jun Tohyama, Kazuhiro Ogata, Yun Stone Shi, Kuniaki Saito, Satoko Miyatake, Naomichi Matsumoto
Summary: A gain-of-function variant in the GRIA3 gene was found to cause a distinct neurodevelopmental disorder phenotype compared to loss-of-function variants. Drugs that suppress glutamatergic neurotransmission may improve the symptoms of this phenotype. This study is significant for the clinical management of GRIA3-related NDDs.
Article
Biochemistry & Molecular Biology
Kazuo Kunisawa, Jiajing Shan, Qiaohui Lu, Yang Yang, Aika Kosuge, Hitomi Kurahashi, Kuniaki Saito, Libo Zou, Toshitaka Nabeshima, Akihiro Mouri
Summary: Loureirin C and Xanthoceraside can alleviate depression-like behaviors induced by chronic unpredicted mild stress (CUMS) and inhibit inflammation.
NEUROCHEMICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Ryo Toda, Atsushi Teramoto, Masashi Kondo, Kazuyoshi Imaizumi, Kuniaki Saito, Hiroshi Fujita
Summary: This study proposes a pix2pix-based model called StylePix2pix, which allows the generation of diverse lesion images from tumor sketches. The one-to-many image generation capability of StylePix2pix suggests effectiveness in data-augmentation applications.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Hisayoshi Kubota, Kazuo Kunisawa, Moe Niijima, Mami Hirakawa, Yuko Mori, Masaya Hasegawa, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri
Summary: Phencyclidine (PCP) causes mental symptoms similar to schizophrenia by inhibiting the glutamatergic system. Deficiency of kynurenine 3-monooxygenase (KMO) may be associated with exacerbation of PCP-induced symptoms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Hitomi Yamamoto-Matsuda, Keita Miyoshi, Mai Moritoh, Hikari Yoshitane, Yoshitaka Fukada, Kuniaki Saito, Soichiro Yamanaka, Mikiko C. Siomi
Summary: Loss-of-function mutations in Drosophila lethal (3) malignant brain tumor [l(3) mbt] result in ectopic expression of germ-line genes and brain tumors. The study reveals that L(3) mbt genomic binding is not always linked to gene regulation and it controls piRNA pathway genes through multiple mechanisms. Furthermore, a novel co-regulator of L(3) mbt, Lint-O, is identified and shown to impact the levels of piRNA amplifiers.
Article
Chemistry, Multidisciplinary
Yoshitaka Isobe, Atsushi Teramoto, Fujio Morita, Kuniaki Saito, Hiroshi Fujita
Summary: In computed tomography colonography (CTC), an electronic cleansing method using CycleGAN was developed to assist diagnosis and accurately visualize the colon.
APPLIED SCIENCES-BASEL
(2022)
Article
Medicine, General & Internal
Atsushi Teramoto, Tomoyuki Shibata, Hyuga Yamada, Yoshiki Hirooka, Kuniaki Saito, Hiroshi Fujita
Summary: In this study, a cascaded deep learning model was proposed for the classification of endoscopic images and identification of the invasive region, achieving good detection results.
Article
Cardiac & Cardiovascular Systems
Eirin Sakaguchi, Akira Yamada, Hiroyuki Naruse, Hidekazu Hattori, Hideto Nishimura, Hideki Kawai, Takashi Muramatsu, Junnichi Ishii, Tadayoshi Hata, Kuniaki Saito, Hideo Izawa
Summary: Changes in GLS values are associated with the long-term prognosis of patients with a preserved LVEF and acute decompensated heart failure (HFpEF).
Article
Oncology
Tatsuya Ando, Masato Hoshi, Hiroyuki Tezuka, Hiroyasu Ito, Kentaro Nakamoto, Yasuko Yamamoto, Kuniaki Saito
Summary: The partial loss of liver due to liver transplantation or acute liver failure induces rapid liver regeneration. Recently, we reported that the selective inhibition of indoleamine 2,3-dioxygenase (Ido) 1 promotes early liver regeneration. However, the role of Ido2 in liver regeneration remains unclear.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Chikara Takeuchi, Moe Yokoshi, Shu Kondo, Aoi Shibuya, Kuniaki Saito, Takashi Fukaya, Haruhiko Siomi, Yuka W. Iwasaki
Summary: In Drosophila, specific splice variants of the insulator protein Mod(mdg4)-N repress HeT-A expression by blocking subtelomeric enhancers and associating with the subtelomeric sequences. Furthermore, Mod(mdg4)-N recruits RNA polymerase II to the subtelomeres, reinforcing its enhancer-blocking function.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Medicine, General & Internal
Atsushi Teramoto, Tetsuya Tsukamoto, Ayano Michiba, Yuka Kiriyama, Eiko Sakurai, Kazuyoshi Imaizumi, Kuniaki Saito, Hiroshi Fujita
Summary: This study proposes an automatic classification method for idiopathic interstitial pneumonia (IIP) using deep learning, and compensates for the lack of data on rare diseases by generating pathological images using a generative adversarial network (GAN). The results show that this method is effective for the diagnosis of idiopathic pulmonary fibrosis (IPF), with high accuracy.
Article
Engineering, Biomedical
Terumasa Kondo, Atsushi Teramoto, Eiichi Watanabe, Yoshihiro Sobue, Hideo Izawa, Kuniaki Saito, Hiroshi Fujita
Summary: In this study, a two-dimensional convolutional neural network (CNN) was used to predict the short-term prognosis of CCU patients by converting their ECG data into image data. The prediction accuracy was 77.3%. The results suggest that this method could be used to predict the short-term prognosis of CCU patients using ECG waveforms, which has clinical significance in determining treatment strategies and treatment intensity.
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2023)
Meeting Abstract
Oncology
Kuniaki Saito, Yuta Sasaki, Saki Shimizu, Jun Nagai, Yuki Yamagishi, Nobuyoshi Sasaki, Keiichi Kobayashi, Yoshiaki Shiokawa, Hirofumi Nakatomi, Motoo Nagane
Article
Neurosciences
Ryosuke Jozuka, Hiroki Kimura, Takashi Uematsu, Hidetsugu Fujigaki, Yasuko Yamamoto, Masato Kobayashi, Kazuya Kawabata, Haruki Koike, Toshiya Inada, Kuniaki Saito, Masahisa Katsuno, Norio Ozaki
Summary: This case highlights the importance of recognizing that even apparently mild COVID-19-related respiratory symptoms can lead to severe and persistent neuropsychiatric symptoms. It also underscores the need to elucidate the mechanisms, treatment, and long-term course of COVID-19-related neuropsychiatric symptoms in the future.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2022)
