Article
Multidisciplinary Sciences
Darian Lawrence-Sidebottom, Michelle A. Schmidt, Daniel O. Harvey, Hans P. A. Van Dongen, Christopher J. Davis
Summary: The Vibration Actuating Search Task (VAST) uses gradient floor vibration to motivate rodents to navigate towards a target destination. Results show that rats exhibit place preference for vibration, have lower corticosterone levels when exposed to vibration, and that VAST performance is sensitive to sleep deprivation.
Article
Clinical Neurology
Tommi Vayrynen, Heta Helakari, Vesa Korhonen, Johanna Tuunanen, Niko Huotari, Johanna Piispala, Mika Kallio, Lauri Raitamaa, Janne Kananen, Matti Jarvela, J. Matias Palva, Vesa Kiviniemi
Summary: The study found that slow cortical potentials and respiration are both coupled with the amplitude of fast neuronal oscillations, with stronger coupling during sleep. The phases of ISF and respiration drive the amplitude dynamics of fast oscillations in both sleeping and waking states, with different contributions.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Guangjing Xie, Xiaoyu Huang, Hao Li, Ping Wang, Panpan Huang
Summary: Caffeine acts as a stimulant on the central nervous system, with low-dose improving cognitive function after sleep deprivation and high-dose potentially worsening cognitive impairment. Sleep deprivation leads to ultrastructure damage and neuronal loss in the hippocampus, and accelerates neuropeptide-associated apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neuroimaging
Dan Xu, Xinyuan Chen, Yun Tian, Xiaoyong Wan, Xu Lei
Summary: The study found that lying posture preference and position can affect sleep onset latency and duration of sleep stages, leading to alterations in brain activity patterns. Different sleep positions also influenced brain activity in specific regions, with individuals who prefer supine posture showing higher activity in the right putamen during wakefulness.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Medicine, Research & Experimental
Su Yeon Seo, Yeonhee Ryu
Summary: Acupuncture stimulation at HT7 can alleviate caffeine-induced sleep disruption by regulating the BDNF-mediated endoplasmic reticulum stress response, improving wake time and REM sleep dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Psychology, Developmental
Michael O. Mireku
Summary: The study found that adolescents spend a significant amount of time on digital media, and more time spent on personal care and travel increases the risk of short sleep duration.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Clinical Neurology
Jasna Todorovic, Marko Dincic, Danijela Z. Krstic, Mirjana B. Colovic, Jelena Nesovic Ostojic, Sanjin Kovacevic, SrCan Lopicic, Svetolik Spasic, Predrag Brkic, Aleksandar Milovanovic
Summary: This study aimed to simultaneously evaluate the effects of hypothyroidism and paradoxical sleep deprivation on synaptosomal ATPases and AChE activities in the rat brain. The results showed that hypothyroidism increased Na+/K+-ATPase activity and decreased AChE activity, while paradoxical sleep deprivation increased AChE activity. When hypothyroidism and sleep deprivation occurred simultaneously, the activity of all three enzymes decreased. These findings can inform appropriate therapy in related conditions.
Article
Psychology, Experimental
Ana Lucia Cardenas-Egusquiza, Dorthe Berntsen
Summary: We spend a significant portion of our lives sleeping and experiencing spontaneous thoughts. However, little is known about the relationship between sleep and spontaneous thoughts. Previous studies have focused on specific aspects of sleep and certain forms of spontaneous thought, which limits the understanding of this relationship. This comprehensive survey study suggests that poorer sleep quality, daytime sleepiness, and insomnia symptoms are consistently associated with disruptive spontaneous thoughts, while only daytime sleepiness is related to positive-constructive daydreaming.
CONSCIOUSNESS AND COGNITION
(2022)
Article
Nutrition & Dietetics
Barry William McDonald, Patricia Ellyett Watson
Summary: This study investigated the relationship between time in bed and sleeping difficulties with demographic variables and nutrient intakes in pregnant women during the second and third trimester. The findings showed that time in bed was associated with welfare or disability status, marital status, and age. Additionally, there were correlations between dietary intake and sleep. The study highlights the importance of various factors in influencing sleep during pregnancy and confirms previous research on the relationship between diet and sleep.
Article
Clinical Neurology
Dan-dan Zhang, Jiao Fang, Lei Zhang, Jing-yi Yuan, Yu-hui Wan, Pu-yu Su, Fang-biao Tao, Ying Sun
Summary: The study found that the effect of parent-child separation on HPA axis stress reactivity is time-dependent, with children in early puberty experiencing blunted HPA axis reactivity and persistent separation leading to decreased HPA axis reactivity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Agriculture, Dairy & Animal Science
Ali Hussein Hussein, Amlan Kumar Patra, Ryszard Puchala, Blake Kenyon Wilson, Arthur Louis Goetsch
Summary: This study assessed the effects of restricted water availability on blood characteristics and constituent concentrations in different breeds of hair sheep from different regions of the USA. The results showed that hair sheep breeds, especially St. Croix, displayed considerable adaptability to limited drinking water availability.
Article
Biology
Maude Bouchard, Jean-Marc Lina, Pierre-Olivier Gaudreault, Alexandre Lafreniere, Jonathan Dube, Nadia Gosselin, Julie Carrier
Summary: Two types of slow waves, slow switchers and fast switchers, were found to coexist in humans. Older individuals showed lower temporal dissipation of sleep pressure and decreased flexibility in EEG connectivity at the microscale of the oscillations.
Article
Biology
Amina Aboufares El Alaoui, Edgar Buhl, Sabrina Galizia, James J. L. Hodge, Luisa de Vivo, Michele Bellesi
Summary: This study found that sleep deprivation leads to endoplasmic reticulum (ER) stress, which is mainly caused by increased interaction between ER and mitochondria.
Article
Neurosciences
Dubravka Aleksic, Joko Poleksic, Gorana Agatonovic, Vuk Djulejic, Maja Vulovic, Miljana Aksic, Gebhard Reiss, Mohammad I. K. Hamad, Igor Jakovcevski, Milan Aksic
Summary: There is increasing evidence linking traumatic experiences during early development to later psychopathology. In this study, researchers examined the effects of maternal deprivation on GABAergic interneurons in the amygdala and nucleus accumbens of 9-day-old rats. The results showed that early stress leads to changes in the number and morphology of these inhibitory interneurons, providing further understanding of the impact of maternal deprivation on brain development.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Fabio Squarcio, Timna Hitrec, Marco Luppi, Davide Martelli, Alessandra Occhinegro, Emiliana Piscitiello, Ludovico Taddei, Domenico Tupone, Roberto Amici, Matteo Cerri
Summary: Rats emit a distress call of 22-kHz ultrasonic vocalisation to warn their group of danger. Surprisingly, this study found that rats can emit these vocalisations during REM sleep, but not during non-REM sleep. The emission occurs during the expiratory phase and can happen singularly or as a train. This is the first report to demonstrate rats vocalising during REM sleep.
JOURNAL OF SLEEP RESEARCH
(2023)
Letter
Surgery
Matteo Ravaioli, Giuliana Germinario, Matteo Cerri, Enrico Prosperi, Guido Fallani, Francesco Vasuri, Matteo Serenari, Federica Odaldi, Lorenzo Maroni, Antonio Siniscalchi, Matteo Cescon, Matteo Renzulli
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Physiology
Gianluca Sgarbi, Timna Hitrec, Roberto Amici, Alessandra Baracca, Alessia Di Cristoforo, Francesca Liuzzi, Marco Luppi, Giancarlo Solaini, Fabio Squarcio, Giovanni Zamboni, Matteo Cerri
Summary: The ability to induce hypothermia resembling natural torpor has significant benefits. Two pharmacological procedures based on central nervous manipulation have proven effective in lowering body temperature in non-hibernating rats. The role of mitochondria in centrally induced hypothermia in non-hibernators is still not well understood.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2022)
Article
Neurosciences
Michael Ambler, Timna Hitrec, Andrew Wilson, Matteo Cerri, Anthony Pickering
Summary: Recent research has discovered that the preoptic area of the hypothalamus and the dorsomedial hypothalamus (DMH) are involved in the regulation of daily torpor in mice. Using activity-dependent genetic techniques, scientists were able to target and manipulate DMH neurons to promote or inhibit torpor. This study further supports the role of these neurons in controlling torpor.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Davide Martelli, Virginia L. L. Brooks
Summary: It is widely accepted that decreases in plasma leptin levels, such as during fasting, signal starvation and lead to increased hunger and decreased energy expenditure. These effects are mainly mediated by the suppression of leptin actions in the hypothalamus, particularly on orexigenic neuropeptide Y neurons and anorexic pro-opiomelanocortin neurons in the arcuate nucleus. However, this review explores whether increased leptin levels also play a significant role in long-term energy balance control, contrary to conventional wisdom. We focus on leptin's actions to decrease food intake, increase sympathetic nerve activity, and support the hypothalamic-pituitary-thyroid axis, with a particular emphasis on sex differences. We also discuss the impact of obesity-induced inflammation on leptin's actions during obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Alessandra Occhinegro, Robin M. M. McAllen, Michael J. J. McKinley, Davide Martelli
Summary: In this review, we argue that the immune system is regulated by an endogenous neural reflex, known as the inflammatory reflex, which suppresses the acute immune response during a systemic immune challenge. We examine the involvement of different sympathetic nerves as potential pathways of the inflammatory reflex. Additionally, we discuss the role of the adrenal glands in the reflex control of inflammation, highlighting how the release of catecholamines by neural means enhances the anti-inflammatory cytokine IL10, but does not inhibit the pro-inflammatory cytokine TNF. Ultimately, we conclude that the splanchnic anti-inflammatory pathway, involving sympathetic fibers targeting various organs such as the spleen and adrenal glands, serves as the efferent arm of the inflammatory reflex, independently regulating TNF and IL10 responses in distinct populations of leukocytes.
NEUROIMMUNOMODULATION
(2023)
Article
Physiology
Fabio Squarcio, Timna Hitrec, Emiliana Piscitiello, Matteo Cerri, Catia Giovannini, Davide Martelli, Alessandra Occhinegro, Ludovico Taddei, Domenico Tupone, Roberto Amici, Marco Luppi
Summary: The study reveals that synthetic torpor induces reversible hyperphosphorylation of Tau protein in the rat brain, involving various cellular and systemic factors. This process is accompanied by transient neuroinflammation.
FRONTIERS IN PHYSIOLOGY
(2023)
Letter
Multidisciplinary Sciences
Matteo Cerri, Jurgen Bereiter-Hahn, Gerhard Heldmaier, Alexander Chouker, Leopold Summerer
Article
Physiology
Timna Hitrec, Fabio Squarcio, Emiliana Piscitiello, Matteo Cerri, Davide Martelli, Alessandra Occhinegro, Ludovico Taddei, Domenico Tupone, Roberto Amici, Marco Luppi
Summary: A short-term sleep deprivation soon after regaining euthermia can enhance the reversibility of Tau protein hyperphosphorylation induced by torpor, possibly due to higher body temperature, melatonin levels, and resting phenotype of microglia. This finding suggests that sleep deprivation may boost a latent neuroprotective mechanism.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2023)
Article
Clinical Neurology
Fabio Squarcio, Timna Hitrec, Marco Luppi, Davide Martelli, Alessandra Occhinegro, Emiliana Piscitiello, Ludovico Taddei, Domenico Tupone, Roberto Amici, Matteo Cerri
Summary: Rats emit a distress call of 22-kHz ultrasonic vocalisation to warn their group of danger. Surprisingly, this study found that rats can emit these vocalisations during REM sleep, but not during non-REM sleep. The emission occurs during the expiratory phase and can happen singularly or as a train. This is the first report to demonstrate rats vocalising during REM sleep.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Multidisciplinary Sciences
Anggraeini Puspitasari, Fabio Squarcio, Martina Quartieri, Cristina Totis, Timna Hitrec, Akihisa Takahashi, Yukari Yoshida, Kenji Hanamura, Tomoko Yako, Matteo Cerri, Palma Simoniello, Marco Durante, Walter Tinganelli
Summary: Hibernation or torpor is a potential method to protect astronauts from space radiation, and it involves reducing skin temperature and increasing survival rate. Synthetic torpor also delays DNA repair and suppresses radiation-induced mitotic catastrophe.
SCIENTIFIC REPORTS
(2022)
Meeting Abstract
Clinical Neurology
A. Occhinegro, R. Amici, M. Cerri, T. Hitrec, D. Martelli, E. Piscitiello, F. Squarcio, L. Taddei, D. Tupone, M. Luppi