Article
Neurosciences
Mengran Wang, Teng Wang, Xin Li, Yi Yuan
Summary: Attention deficit hyperactivity disorder is characterized by changes in brain function and blood flow. Low-intensity ultrasound stimulation can modulate brain activity in ADHD. This study found that low-intensity ultrasound stimulation can improve abnormal brain function and neurovascular coupling in ADHD.
Article
Chemistry, Multidisciplinary
Zhaowei Chen, Vassiliy Tsytsarev, Y. Zou Finfrock, Olga A. Antipova, Zhonghou Cai, Hiroyuki Arakawa, Fritz W. Lischka, Bryan M. Hooks, Rosemarie Wilton, Dongyi Wang, Yi Liu, Brandon Gaitan, Yang Tao, Yu Chen, Reha S. Erzurumlu, Huanghao Yang, Elena A. Rozhkova
Summary: This study demonstrates the use of radioluminescent nanoparticles to stimulate neurons expressing specific genes through external X-rays, advancing optogenetic neural control towards minimally invasive deep brain stimulation.
Article
Multidisciplinary Sciences
Adam Institoris, Milene Vandal, Govind Peringod, Christy Catalano, Cam Ha Tran, Xinzhu Yu, Frank Visser, Cheryl Breiteneder, Leonardo Molina, Baljit S. Khakh, Minh Dang Nguyen, Roger J. Thompson, Grant R. Gordon
Summary: Functional hyperemia, the process of increasing local cerebral blood flow to meet regional energy demand, is mediated by astrocyte Ca2+ signaling and shows distinct early and late components. Astrocyte Ca2+ plays a fundamental role in amplifying functional hyperemia during sustained neuronal activation.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Osman Shabir, Ben Pendry, Llywelyn Lee, Beth Eyre, Paul S. Sharp, Monica A. Rebollar, David Drew, Clare Howarth, Paul R. Heath, Stephen B. Wharton, Sheila E. Francis, Jason Berwick
Summary: Neurovascular coupling is key for brain health, but its disruption is linked to neurological diseases like dementia. This study examines cortical haemodynamics in mouse models of Alzheimer's disease and atherosclerosis, finding reduced blood volume, altered haemoglobin levels, and neuroinflammation in atherosclerosis, as well as increased amyloid-beta plaques in the hippocampus. Importantly, electrode insertion worsens cortical spreading depression and leads to prolonged hypoxia in diseased animals. Atherosclerosis can negatively affect neurovascular health, and cardiovascular comorbidities can worsen Alzheimer's-related plaques.
Article
Neurosciences
Stephanie Holstein-Ronsbo, Yiming Gan, Michael J. Giannetto, Martin Kaag Rasmussen, Bjorn Sigurdsson, Felix Ralf Michael Beinlich, Laura Rose, Verena Untiet, Lauren M. Hablitz, Douglas H. Kelley, Maiken Nedergaard
Summary: Holstein-Ronsbo et al. demonstrate that functional hyperemia enhances glymphatic CSF inflow and clearance. They found that direct stimulation of vascular smooth muscle cells also increases glymphatic flow. This study investigates the relationship between functional hyperemia and waste clearance through the glymphatic system.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Congping Chen, Zhentao She, Peng Tang, Zhongya Qin, Jufang He, Jianan Y. Qu
Summary: The study presented an approach for imaging neurovascular dynamics in live mouse cortices using multi-contrast mesoscopic and two-photon microscopic imaging, revealing the spatiotemporal correlation between neuronal and vascular responses. The research uncovered significant differences in NVC at regional and microvascular levels, as well as the impact of different brain states on NVC, particularly showing that anesthesia and sedation disrupt NVC.
Article
Anatomy & Morphology
Vanesa Munoz, Manuel Munoz-Caracuel, Brenda Y. Angulo-Ruiz, Carlos M. Gomez
Summary: This study explores the relationship between intensity-dependent amplitude changes (IDAP) and neurovascular coupling using functional near-infrared spectroscopy (fNIRS). The results show correlations between auditory intensity and ERP components N1, P2, and N1-P2 peak-to-peak amplitude, as well as oxyhemoglobin and deoxyhemoglobin concentrations. These findings support the potential of fNIRS as a complementary technique to ERPs, enhancing our understanding of its application in auditory paradigms.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Chemistry, Physical
Marvin Asido, Rajiv K. Kar, Clara Nassrin Kriebel, Markus Braun, Clemens Glaubitz, Igor Schapiro, Josef Wachtveitl
Summary: A transient near-UV absorption signature was identified in Krokinobacter eikastus rhodopsin 2 (KR2) which could serve as a marker for retinal configuration. Hybrid quantum mechanics/molecular mechanics simulations revealed that this signature corresponds to S-0 -> S-3 and/or S-0 -> S-5 transitions, and these transitions show negligible spectral shift with changes in the protein environment. The study also explored potential optogenetic applications through near-UV quenching experiments, demonstrating ultrafast regeneration of the parent state of KR2.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Geriatrics & Gerontology
Antonietta Canna, Fabrizio Esposito, Gioacchino Tedeschi, Francesca Trojsi, Carla Passaniti, Irene di Meo, Rita Polito, Maria Ida Maiorino, Giuseppe Paolisso, Mario Cirillo, Maria Rosaria Rizzo
Summary: Functional and metabolic neural changes in Type 2 diabetes mellitus (T2DM) can lead to altered neurovascular conditions, as demonstrated by reduced neurovascular coupling in the default mode network (DMN) and increased neurovascular coupling in attention networks. These alterations in neurovascular coupling are associated with reduced visuo-spatial cognitive performances.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Amy R. Nippert, Pei-Pei Chiang, Eric A. Newman
Summary: Hypoglycemia is a serious complication of insulin treatment in diabetes. Previous studies suggested that neurovascular coupling, which increases glucose availability to active neurons, might be reduced during hypoglycemia. However, this study found that neurovascular coupling did not change significantly during hypoglycemia and that there was an increase in vessel diameter, suggesting active mechanisms to maintain glucose supply to the brain during hypoglycemia.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Multidisciplinary Sciences
Ana M. Fernandez, Laura Martinez-Rachadell, Marta Navarrete, Julia Pose-Utrilla, Jose Carlos Davila, Jaime Pignatelli, Sonia Diaz-Pacheco, Santiago Guerra-Cantera, Emilia Viedma-Moreno, Rocio Palenzuela, Samuel Ruiz de Martin Esteban, Ricardo Mostany, Cristina Garcia-Caceres, Matthias Tschop, Teresa Iglesias, Maria L. de Ceballos, Antonia Gutierrez, Ignacio Torres Aleman
Summary: Insulin receptors in astrocytes play a role in neurovascular coupling by modulating glucose uptake and angiogenesis. Lack of insulin receptors in astrocytes leads to uncoupling of brain blood flow with glucose uptake, disturbed mitochondrial function, and abnormal angiogenesis. Treatment with the antioxidant N-acetylcysteine can normalize these effects.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cardiac & Cardiovascular Systems
Motoki Nakao, Masaya Watanabe, Lucile Miquerol, Hiroyuki Natsui, Takuya Koizumi, Takahide Kadosaka, Taro Koya, Hikaru Hagiwara, Rui Kamada, Taro Temma, Antoine A. F. de Vries, Toshihisa Anzai
Summary: Recent studies have shown that optogenetic therapy using light-gated ion channels can effectively terminate atrial fibrillation without causing pain. This study investigated the mechanism of optogenetic termination of atrial tachyarrhythmia by examining the changes in action potential duration and refractory period induced by brief pulsed light stimulation in transgenic mice.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Review
Neurosciences
Patrick J. Drew
Summary: In the brain, increases in neural activity lead to changes in local blood flow through neurovascular coupling. However, the traditional explanation that increased blood flow supplies the metabolic needs of active neurons is inconsistent with a large body of evidence. Neurovascular coupling is irregular or absent in many brain regions and states, and increased respiration can improve brain oxygenation without changes in blood flow. Simulation studies suggest that low blood flow areas are inevitable due to the brain's vascular architecture and cannot be eliminated by functional hyperemia. This article discusses potential alternative functions of neurovascular coupling such as supplying oxygen for neuromodulator synthesis, regulating brain temperature, signaling to neurons, optimizing cerebral vascular structure, accommodating non-Newtonian blood flow, and driving cerebrospinal fluid circulation.
TRENDS IN NEUROSCIENCES
(2022)
Review
Clinical Neurology
Winston M. Zhu, Ain Neuhaus, Daniel J. Beard, Brad A. Sutherland, Gabriele C. DeLuca
Summary: To meet the metabolic demands of the brain, mechanisms have evolved to couple neuronal activity to vasodilation, increasing cerebral blood flow. The release of vasoactive molecules by neurons and astrocytes plays a key role in signaling pathways that induce vasodilation. Understanding neurovascular coupling is especially important in Alzheimer's disease, where disrupted cerebral blood flow regulation is a prominent feature.
Article
Biology
Jiaming Cao, Pulkit Grover, Jana M. Kainerstorfer
Summary: In this paper, a mathematical model is proposed to relate neuronal activities to predict vascular changes in cortical spreading depolarization (CSD). The study shows that near-infrared spectroscopy (NIRS) signals and functional magnetic resonance imaging (fMRI) signals are substantially distinct in the two cases of CSD, while fMRI is unable to reliably distinguish between spreading hyperemia and spreading ischemia.
JOURNAL OF THEORETICAL BIOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Yuyao Guan, Yite Li, Junli Zhou, Tao Zhang, Jun Ding, Zhigang Xie, Lei Wang
Summary: This study developed a solid adsorbent based on metal-organic frameworks using defect-engineering strategy which showed great promise for handling radioactive iodine waste.
INORGANIC CHEMISTRY
(2021)
Article
Engineering, Environmental
Yite Li, Junli Zhou, Yuannan Chen, Qing Pei, Yao Li, Lei Wang, Zhigang Xie
Summary: A novel sulfonating strategy was reported to synthesize a spindle-shaped metal-organic framework with enhanced near-infrared absorption. The sulfonated material showed improved photoactivity under near-infrared irradiation and effectively triggered immunogenic cell death.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Applied
Junli Zhou, Yite Li, Lei Wang, Zhigang Xie
Summary: The study synthesized ACF@PCN-222@MnO2-PEG (APM) nanoparticles with good colloidal stability, biocompatibility and H2O2-triggered drug releasing. The amorphous MnO2 layer on APM's surface quickly decomposes after reacting with endogenous H2O2 to generate abundant oxygen, compensating for the oxygen consumed during photodynamic process.
Review
Construction & Building Technology
Xue Xiao, Junli Zhou, Wei Yang
Summary: This paper summarizes calculation models for unsteady natural ventilation, which involve continuous airflow, pulsating flow, eddy penetration, and diffusion phenomena. The theories of different ventilation mechanisms and the differences between various research reports are expounded and discussed.
INDOOR AND BUILT ENVIRONMENT
(2022)
Article
Chemistry, Inorganic & Nuclear
Junli Zhou, Liqian Liu, Yite Li, Lei Wang, Zhigang Xie
Summary: In this study, a nanoscale Ru-doped metal-organic framework Hf-Ru with framework-boosted photoactivities was prepared, showing superior performance in bioimaging and ROS generation compared to molecular agents. The enhanced cellular uptake and imaging capabilities of Hf-Ru nanocrystals were well demonstrated in vitro.
INORGANIC CHEMISTRY
(2022)
Article
Immunology
Juan Li, Yiyong Wei, Junli Zhou, Helin Zou, Lulin Ma, Chengxi Liu, Zhi Xiao, Xingfeng Liu, Xinran Tan, Tian Yu, Song Cao
Summary: Selective activation of the LC:SC pathway alleviates neuropathic pain in mice by increasing noradrenaline release and reducing neuroinflammation of astrocytes and microglia in the spinal dorsal horn.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Multidisciplinary Sciences
Jian Li, Kuanji Zhou, Zheng Wang, Junli Zhou, Xing Wang Deng
Summary: As one of the most important staple crops, wheat breeders strive to increase yield. Hybrid wheat is a preferred method to achieve this. This article summarizes the systems for hybrid wheat breeding based on recessive nuclear male-sterile mutants and discusses possible solutions to promote commercial-scale application.
CHINESE SCIENCE BULLETIN-CHINESE
(2022)
Article
Biochemistry & Molecular Biology
Yi Li, Xupin Jiang, Ze Zhang, Jie Liu, Chao Wu, Ying Chen, Junli Zhou, Jiaping Zhang, Xuanfen Zhang
Summary: Autophagy plays a pivotal role in the directed migration of endothelial cells guided by electric fields, and this process is mediated by the ROS/SIRT1/FOXO1 pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Physical
Zhonghui Wu, Xinjian He, Junli Zhou, Xiongzhi Yang, Linghao Sun, Hehong Li, Yuede Pan, Lin Yu
Summary: This study presents a novel Ni(OH)2/C/PP separator modification approach for lithium-sulfur batteries, which effectively alleviates the shuttle effect and enhances the electrochemical performance of the batteries, including capacity, rate performance, and cyclability.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Nanoscience & Nanotechnology
Xiongzhi Yang, Jinzhu Jia, Linghao Sun, Guangsheng Huang, Junli Zhou, Ruanming Liao, Zhonghui Wu, Lin Yu, Zhenbo Wang
Summary: The regeneration of harmful activated sludge into an energy source is a valuable strategy for municipal sludge treatment and recycling. In this study, SiO2-modified N,S auto-doped porous carbon (NSC@SiO2) was successfully obtained through a simple calcination method. The introduction of P-doped NSC@SiO2 (NSPC@SiO2) further enhanced its surface area, pore volume, and carbon defects, making it an excellent sulfur host for lithium-sulfur batteries.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Inorganic & Nuclear
Yang Xiao-Lan, Wu Zhong-Hui, Zhang Ya-Jun, He Xin-Jian, Jia Jin-Zhu, Yang Xiong-Zhi, Zhou Jun-Li
Summary: NiCo2O4@CC composites, with a needle-like network structure, exhibit excellent performance in adsorbing polysulfide and alleviating volume expansion in lithium-sulfur batteries, showing good cycling performance.
CHINESE JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Materials Science, Biomaterials
Junli Zhou, Yite Li, Lei Wang, Zhigang Xie
Summary: Photoactive MOF-based delivery systems have great potential for photodynamic therapy, with the study of porphyrinic MOF isomers revealing the impact of molecular distances and polarization on photoactivity. The confirmed endocytic pathways, cytotoxicity, and biocompatibility of these isomers without chemical modification provide new insights for in vivo applications and clinical translation.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Agronomy
Lei Chen, Gang Gu, Chengxu Wang, Zhufeng Chen, Wei Yan, Man Jin, Gang Xie, Junli Zhou, Xing Wang Deng, Xiaoyan Tang
Summary: Herbicide resistance is valuable for integrated weed management in agriculture, particularly in rice fields where weedy rice poses a challenge. This study obtained three mutant variants of the OsALS gene in rice through ethyl methyl sulfonate mutagenesis, with W-548 M mutant showing high levels of resistance to a broad spectrum of herbicides. The stable inheritance of herbicide resistance in rice lines makes W-548 M mutation a valuable resource for breeding herbicide resistant rice and weed management.
Article
Environmental Sciences
Junli Zhou, Yong Hua, Yuan Xiao, Cheng Ye, Wei Yang
Summary: This paper presents a detailed analysis of the ventilation effectiveness in a building with a single opening, evaluating the impact of various parameters on ventilation efficiency and establishing a mixing coefficient for predicting the short-circuit ratio of ventilation rate through openings.
AEROSOL AND AIR QUALITY RESEARCH
(2021)
Article
Materials Science, Biomaterials
Yingjie Liu, Xiaohua Zheng, Junli Zhou, Zhigang Xie
Summary: A merocyanine-paclitaxel conjugate was developed and self-assembled into nanoparticles that efficiently released paclitaxel upon light illumination, showing a satisfactory anticancer effect on cancer cells. This nanomedicine offers a novel strategy for small molecular chemotherapy with enhanced chemotherapeutic efficacy.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)