Review
Multidisciplinary Sciences
Jo Robinson, Kairi Kolves, Merike Sisask
Summary: More than 700,000 people lose their lives to suicide each year, and the COVID-19 pandemic has increased the risk factors for suicide and suicide-related behaviors, especially among young people. Prevention strategies should focus on high-risk populations, utilize novel approaches, and give voice to individuals with lived experience of suicide.
Article
Neurosciences
Weiming Sun, Baoming Li, Chaolin Ma
Summary: Counting ability is an important aspect of animal cognition and studying it in nonhuman animals can amplify our understanding of human cognition. In a study with rhesus monkeys, they were trained to count visual patterns and all monkeys learned to correctly choose the sixth pattern within 3 months, providing behavioral evidence of counting capacity in these monkeys.
Article
Biochemical Research Methods
Daniel Stukenberg, Tobias Hensel, Josef Hoff, Benjamin Daniel, Rene Inckemann, Jamie N. Tedeschi, Franziska Nousch, Georg Fritz
Summary: Vibrio natriegens, known for its incredibly fast growth rate, is being explored as a potential replacement for E. coli in synthetic and molecular biology applications. The Marburg Collection, consisting of 191 genetic parts optimized for V. natriegens, provides a flexible and efficient toolbox for researchers to construct plasmids using de novo assembly. This collection also includes novel connector parts for modular circuit assembly and the inversion of transcription units, offering valuable resources for the V. natriegens community.
ACS SYNTHETIC BIOLOGY
(2021)
Editorial Material
Multidisciplinary Sciences
Ryoichiro Kageyama
Summary: The discovery of a gene that mediates periodic segmentation of the developing backbone of vertebrate embryos has shed light on how the pace of development is controlled by a species-specific molecular clock rhythm.
Article
Biochemical Research Methods
Pengli Cai, Sheng Liu, Dachuan Zhang, Huadong Xing, Mengying Han, Dongliang Liu, Linlin Gong, Qian-Nan Hu
Summary: SynBioTools is a comprehensive tool registry that integrates synthetic biology databases, computational tools, and experimental methods. It provides users with a one-stop facility for searching and selecting synthetic biology tools, including resources not mentioned in bio.tools. The tools are categorized based on their potential biosynthetic applications and detailed comparisons of similar tools are included.
BMC BIOINFORMATICS
(2023)
Review
Biotechnology & Applied Microbiology
Kangsan Kim, Minjeong Kang, Byung-Kwan Cho
Summary: In recent years, there has been increasing interest in gut commensal engineering for therapeutic applications. Recent advancements in synthetic biology and systems biology have enabled effective utilization of gut commensals for therapy and diagnosis, including the rational design of synthetic microbial consortia and the construction of synthetic cells that can detect specific signals in the intestine and deliver therapeutic drugs in real-time.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Brett J. Kagan, Christopher Gyngell, Tamra Lysaght, Victor M. Cole, Tsutomu Sawai, Julian Savulescu
Summary: This article reviews the key aspects of Synthetic Biological Intelligence (SBI), its potential applications, and the associated ethical concerns. It aims to provide a robust framework for the responsible research and application of SBI technology.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Engineering, Environmental
Bjorn Olav Rosseland
Summary: Research on acid rain and acidification is a multidisciplinary field that has evolved over time and has had significant impacts on public awareness, political decisions, and environmental regulations. While acid precipitation and acidification problems still persist, they are now under lower pressure, and the process of biological recovery is slow. The legacy of the acid rain era emphasizes the need for basic science, multidisciplinary studies, and high-quality long-term data for future environmental projects.
Review
Chemistry, Multidisciplinary
Yuval Elani
Summary: The construction of artificial cells is a major challenge today, with potential applications in clinical and industrial settings. Artificial cells currently cannot match the complexity of biological cells, leading researchers to explore hybrid living/synthetic systems that combine the advantages of both.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Layla Malouf, Diana A. Tanase, Giacomo Fabrini, Ryan A. Brady, Miguel Paez-Perez, Adrian Leathers, Michael J. Booth, Lorenzo Di Michele
Summary: This paper demonstrates how microphase separation can be used to engineer synthetic cells with programmable morphology and compartment-targeted activity. The synthetic cells are self-assembled from amphiphilic DNA nanostructures and can undergo lipid deposition and phase-selective etching to generate core-shell condensates, a porous pseudo-membrane, cytoplasm analog, and membrane-less organelles. The research exemplifies how architectural and functional complexity can emerge from a limited number of distinct building blocks.
Review
Mechanics
Andrea Micheletti, Paolo Podio-Guidugli
Summary: The passage from artistic interest to practical applications of tensegrity structures is documented in this article, highlighting the development of modern tensegrity metamaterials and the diverse range of applications. The importance of tensegrity structures and their potential for future research is emphasized.
ARCHIVE OF APPLIED MECHANICS
(2022)
Article
Medicine, General & Internal
Vicky Ehlers, Angelika Callaway, Michael Patyna, Alexandra Pelkner, Birgul Azrak, James Deschner
Summary: The study assessed the oral health of children following dental treatment under general anaesthesia and found that these children still had a high caries risk, indicating the need for further prophylaxis programs to prevent caries and reduce the use of general anaesthesia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Tiziana Julia Nadjeschda Schmidt, Barbara Berarducci, Soultana Konstantinidou, Vittoria Raffa
Summary: The CRISPR/Cas system, originally discovered as a defense mechanism in bacteria, is now being used as a precise gene editing tool. Safety, specificity, and delivery concerns limit its potential. The concept of nanogenetics is introduced as a way to advance the biomedical field through the rational engineering of the CRISPR/Cas machinery, enabling the design of safer and more specific genome editing platforms.
DRUG DISCOVERY TODAY
(2023)
Article
Biotechnology & Applied Microbiology
Xinlei Wei, Qiangzi Li, Congcong Hu, Chun You
Summary: A novel approach for stoichiometric synthesis of mannitol through an in vitro synthetic enzymatic biosystem using low-cost starch as substrate is proposed in this study. The overall reaction pathway is divided into three modules which could be executed sequentially in one pot. High product yields of around 95-98% were achieved under optimized conditions.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Jiwei Chen, Yifan Huang, Yuexuan Shu, Xiaoyue Hu, Di Wu, Hangjin Jiang, Kui Wang, Weihua Liu, Weiqi Fu
Summary: This review discusses the potential applications of microalgae, with a focus on diatoms, as a sustainable source for developing bioactive compounds, functional foods, feeds, and biofuels. The review highlights the advantages of diatoms in developing photosynthetic cell factories and the obstacles limiting their commercialization. The review also explores the use of systems and synthetic biology to improve the efficiency of diatom cell factories, including genome engineering technologies such as CRISPR gene-editing. The review concludes by providing critical insights into the future direction of algal production and identifying bottlenecks in algal engineering development.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Genetics & Heredity
Neil R. Adames, Jenna E. Gallegos, Jean Peccoud
Article
Biochemistry & Molecular Biology
Yolanda Schaerli, Alba Jimenez, Jose M. Duarte, Ljiljana Mihajlovic, Julien Renggli, Mark Isalan, James Sharpe, Andreas Wagner
MOLECULAR SYSTEMS BIOLOGY
(2018)
Editorial Material
Biotechnology & Applied Microbiology
Neil R. Adames, Jenna E. Gallegos, Sonia Y. Hunt, William K. So, Jean Peccoud
TRENDS IN BIOTECHNOLOGY
(2019)
Article
Multidisciplinary Sciences
Jenna E. Gallegos, Sergei Hayrynen, Neil R. Adames, Jean Peccoud
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Anand Banerjee, Neil Adames, Jean Peccoud, John J. Tyson
Article
Multidisciplinary Sciences
Andreas K. Brodel, Rui Rodrigues, Alfonso Jaramillo, Mark Isalan
Article
Mathematical & Computational Biology
Jenna E. Gallegos, Neil R. Adames, Mark F. Rogers, Pavel Kraikivski, Aubrey Ibele, Kevin Nurzynski-Loth, Eric Kudlow, T. M. Murali, John J. Tyson, Jean Peccoud
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Jenna E. Gallegos, Mark F. Rogers, Charlotte A. Cialek, Jean Peccoud
NUCLEIC ACIDS RESEARCH
(2020)
Article
Biochemical Research Methods
Jenna E. Gallegos, Diptendu M. Kar, Indrakshi Ray, Indrajit Ray, Jean Peccoud
ACS SYNTHETIC BIOLOGY
(2020)
Review
Biotechnology & Applied Microbiology
Martina Oliver Huidobro, Jure Tica, Georg K. A. Wachter, Mark Isalan
Summary: Engineering multicellular patterning and spatial control over gene expression have the potential to revolutionize developmental biology and medicine. Classifying engineered patterns into four levels of complexity and identifying diffusive signals to regulate gene expression can help synthetic biologists engineer increasingly intricate spatial structures.
MICROBIAL BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Alicia Broto, Erika Gaspari, Samuel Miravet-Verde, Vitor A. P. Martins dos Santos, Mark Isalan
Summary: This study provides a robust genetic toolkit for Mycoplasma, demonstrating the application of gene circuit engineering to control and limit the growth of Mycoplasma. The synthetic gene circuits developed were found to be stable and robust in the long-term, laying the foundation for developing viable biosafety systems using a synthetic Mycoplasma chassis.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Lara Selles Vidal, Mark Isalan, John T. Heap, Rodrigo Ledesma-Amaro
Summary: Directed evolution is a powerful tool for protein engineering, allowing for the rapid selection of biomolecule variants with desired properties. Since its initial development in 1967, various techniques have been developed to facilitate genetic diversification and variant isolation. This review discusses the advantages, drawbacks, and recent developments in directed evolution methodologies, highlighting the ability to handle larger library sizes and address new research questions.
RSC CHEMICAL BIOLOGY
(2023)
Editorial Material
Computer Science, Hardware & Architecture
Douglas Densmore, Nathan J. Hillson, Eric Klavins, Chris Myers, Jean Peccoud, Giovanni Stracquadanio
ACM JOURNAL ON EMERGING TECHNOLOGIES IN COMPUTING SYSTEMS
(2023)
Article
Computer Science, Information Systems
Diptendu Mohan Kar, Indrajit Ray, Jenna Gallegos, Jean Peccoud, Indrakshi Ray
JOURNAL OF COMPUTER SECURITY
(2020)
Article
Mathematical & Computational Biology
Mansooreh Ahmadian, John J. Tyson, Jean Peccoud, Yang Cao
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2020)