Review
Medicine, Research & Experimental
Diogo Neves, Ivan L. Salazar, Ramiro D. Almeida, Raquel M. Silva
Summary: Excitotoxicity is the neuronal damage caused by excessive release of glutamate and subsequent activation of excitatory plasma membrane receptors. This phenomenon is mainly driven by excessive activation of glutamate receptors. Excitotoxicity is common in chronic disorders of the CNS and is considered the primary mechanism of neuronal loss of function and cell death in acute CNS diseases.
Article
Neurosciences
Yan He, Sandra J. Hewett
Summary: Understanding the mechanisms of ischemic brain injury is important for developing new therapies. Previous studies have shown that the cystine/glutamate antiporter system x(c)(-) promotes neuronal injury in vitro, but its role in ischemic brain damage in vivo is limited. This study found that the contribution of system x(c)(-) to cerebral ischemic damage varies depending on the model used, highlighting the complex biochemical events involved in stroke-induced damage.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Lopmudra P. Sarode, Trupti Ghatage, Vishal Mardhekar, Bhavesh Verma, Anand Prakash, Rajesh R. Ugale
Summary: Recent studies have shown that cerebrolysin has neuroprotective properties similar to endogenous neurotrophic factors, making it a potential treatment for neurodegenerative disorders such as ischemic stroke. Our research found that cerebrolysin significantly reduced neuronal cell death and decreased the expression of important cell death proteins, providing evidence for its antiexcitotoxic action in delayed ischemic reperfusion injuries.
METABOLIC BRAIN DISEASE
(2023)
Article
Neurosciences
Nicole L. Rumian, Nicholas E. Chalmers, Jonathan E. Tullis, Paco S. Herson, K. Ulrich Bayer
Summary: CaMKIIα plays a dual role in synaptic plasticity and may have a similar role in neuronal cell death and survival. Research suggests that long-term inhibition of CaMKIIα in neurons does not lead to sensitization but instead provides neuroprotection.
Editorial Material
Reproductive Biology
Mohammad Saied Salehi, Sareh Pandamooz, Amin Tamadon, Mohammad Reza Jafarzadeh Shirazi, Afshin Borhani-Haghighi
Summary: Some studies have shown that stroke may increase the risk of pregnancy complications and early menopause. Preclinical investigations have also found that middle cerebral artery occlusion could affect the hypothalamus, potentially leading to long-lasting reproductive disorders.
BIOLOGY OF REPRODUCTION
(2022)
Article
Neurosciences
Bartosz Pomierny, Weronika Krzyzanowska, Alicja Skorkowska, Jakub Jurczyk, Beata Bystrowska, Boguslawa Budziszewska, Joanna Pera
Summary: Brain ischemia is a major cause of death and disability worldwide, and the release of glutamate after ischemia induces neuronal excitotoxicity. VGLUT1 and VGLUT2 are involved in filling presynaptic vesicles with glutamate. This study explores the effect of cerebral ischemia on the expression of VGLUT1 and VGLUT2, and the impact of VGLUT inhibition on glutamate release and stroke outcome.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cheng-Wei Lu, Yu-Chen Huang, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin, Su-Jane Wang
Summary: The study showed that enmein inhibited glutamate release in cortical nerve terminals by suppressing Ca2+ influx and PKC, and also reduced hippocampal neuronal death induced by KA by increasing glutamate uptake.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Cell Biology
Matthew V. Green, Anne E. West
Summary: The activation of NMDA-type glutamate receptors (NMDARs) can both promote neuronal survival and induce excitotoxic cell death. A recent study reveals that a novel interaction between NMDARs and TRPM4 is required for NMDAR-induced neuronal death. Disrupting this interaction reduces excitotoxicity without blocking physiological NMDAR signaling.
Article
Chemistry, Multidisciplinary
Alexandra Chovsepian, Daniel Berchtold, Katarzyna Winek, Uta Mamrak, Ines Ramirez Alvarez, Yanina Dening, Dominika Golubczyk, Luis Weitbrecht, Claudia Dames, Marine Aillery, Celia Fernandez-Sanz, Zdzislaw Gajewski, Marianne Dieterich, Miroslaw Janowski, Peter Falkai, Piotr Walczak, Nikolaus Plesnila, Andreas Meisel, Francisco Pan-Montojo
Summary: The study demonstrates that glycolic acid has a significant protective effect during ischemic reperfusion, reducing ischemic damage and improving functional outcomes. This protective effect may be achieved by counteracting the glutamate-induced increase in intracellular calcium.
Review
Pharmacology & Pharmacy
Oykum Kaplan-Arabaci, Alperen Acari, Pinar Ciftci, Devrim Gozuacik
Summary: Stroke is the second leading cause of death and disability globally. Ischemic stroke, caused by blood vessel blockage, has limited treatment options. Previous studies aimed at reducing glutamate in ischemic stroke and other neurodegenerative diseases have failed due to delivery obstacles. Systemic glutamate scavenging, a new therapeutic approach, offers the advantage of working in the circulating blood without interfering with brain neurophysiology.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Bradley S. Heit, Patricia Dykas, Alex Chu, Abhay Sane, John Larson
Summary: The key event in the pathophysiology of stroke is anoxic depolarization (AD) of neurons in the ischemic core, and the time between AD and re-oxygenation determines the synaptic recovery after anoxic challenge. Adenosine released during anoxia suppresses synaptic glutamate release, while antagonism of glutamate receptors prolongs AD latency and alters depolarizing waves. In experiments, AD latency was longer in CA1 than CA3, with differences between genders.
Article
Chemistry, Medicinal
Xing Xing Zheng, Ying Chun Li, Kai Lin Yang, Zhou Xiao He, Zhao Liang Wang, Xing Wang, Hui Ling Jing, Yan Jun Cao
Summary: Icariin demonstrated protective effects against Glu-induced excitatory neurotoxicity, enhancing cell viability and reducing apoptosis, oxidative stress, and other negative impacts. These findings suggest that Icariin could be a potential therapeutic candidate for neurological disorders associated with glutamate toxicity.
PHYTOTHERAPY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Natalia Orti-Casan, Ate S. S. Boerema, Karina Kopke, Amber Ebskamp, Jan Keijser, Yuequ Zhang, Tingting Chen, Amalia M. M. Dolga, Kerensa Broersen, Roman Fischer, Klaus Pfizenmaier, Roland E. E. Kontermann, Ulrich L. M. Eisel
Summary: Tumor necrosis factor alpha (TNF-α) has been recognized as a therapeutic target for inflammatory and neurodegenerative diseases. In this study, the TNFR1-specific antagonist Atrosimab was found to attenuate cognitive impairments, reduce neuroinflammation, and neuronal cell death in an acute neurodegenerative mouse model. These results suggest that Atrosimab may be a promising candidate for the treatment of neurodegenerative diseases.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Yaqiong An, Haibo Li, Mengxiao Wang, Zhaohua Xia, Lexi Ding, Xiaobo Xia
Summary: This study investigates the protective effect of tert-Butylhydroquinone (TBHQ) against glutamate excitotoxicity-induced retinal cell damage. It suggests that TBHQ activates the Nrf2 signaling pathway, reduces oxidative stress and inflammation, and inhibits NF-Kappa B activation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Antonio Gamez, Norma Alva, Teresa Carbonell, Ramon Rama
Summary: The study found that high extracellular ferritin concentrations can exacerbate excitotoxic effects caused by excessive exogenous glutamate, with the iron exacerbating glutamate excitotoxicity, and this effect depending on the toxicity of glutamate.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Yu Wen Lin, Tsung Ying Chen, Chia Yang Hung, Shih Huang Tai, Sheng Yang Huang, Che Chao Chang, Hsin Yi Hung, E. Jian Lee
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2018)
Article
Surgery
Ya-Ying Chang, Ming-Chang Kao, Jui-An Lin, Tsung-Ying Chen, Ching-Feng Cheng, Chih-Shung Wong, I-Shiang Tzeng, Chun-Jen Huang
JOURNAL OF SURGICAL RESEARCH
(2018)
Article
Clinical Neurology
Sheng-Tzung Tsai, Tsung-Ying Chen, Sheng-Huang Lin, Shin-Yuan Chen
PARKINSONS DISEASE
(2019)
Article
Immunology
Ya-Ying Chang, Tzu-Yu Lin, Ming-Chang Kao, Tsung-Ying Chen, Ching-Feng Cheng, Chih-Shung Wong, Chun-Jen Huang
INFLAMMOPHARMACOLOGY
(2019)
Correction
Surgery
Ya-Ying Chang, Ming-Chang Kao, Jui-An Lin, Tsung-Ying Chen, Ching-Feng Cheng, Chih-Shung Wong, I-Shiang Tzeng, Chun-Jen Huang
JOURNAL OF SURGICAL RESEARCH
(2019)
Correction
Clinical Neurology
Sheng-Tzung Tsai, Tsung-Ying Chen, Sheng-Huang Lin, Shin-Yuan Chen
PARKINSONS DISEASE
(2019)
Article
Cell Biology
Hock-Kean Liew, Wei-Fen Hu, Peter Bor-Chian Lin, Po-Kai Wang, Andy Po-Yi Tsai, Cheng-Yoong Pang, Tsung-Ying Chen
Article
Anesthesiology
Sheng-Tzung Tsai, Guo-Fang Tseng, Chang-Chih Kuo, Tsung-Ying Chen, Shin-Yuan Chen
Article
Anesthesiology
Yu-Chen Chen, Shin-Yuan Chen, Tsung-Ying Chen, Jiann-I Pan, Sheng-Tzung Tsai
Summary: Desflurane and sevoflurane produced different neurophysiological profiles in STN during deep brain stimulation (DBS) surgery in patients with Parkinson's disease. Desflurane resulted in lower neuronal firing rate while sevoflurane entrained greater gamma oscillation power. The choice of anesthetic did not affect STN mapping accuracy or the clinical outcome of DBS electrode implantation.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Education & Educational Research
Ting-Chun Tseng, Tsung-Ying Chen, Shao-Yin Chu, Hung-Che Wang, Ching-Yuan Chang
Summary: This study explored the role functions of mentors in a unique mentoring program offered by Tzu Chi University in Taiwan. Medical students showed preferences for different types of guidance from faculty mentors, TC/YD senior volunteers, and school counselors. Faculty mentors excelled in educational guidance, while TC/YD specialized in humanistic/moral and career counseling. School counselors were less preferred but still provided guidance when needed.
BMC MEDICAL EDUCATION
(2021)
Article
Biochemistry & Molecular Biology
Yu-Chen Chen, Chang-Chih Kuo, Shin-Yuan Chen, Tsung-Ying Chen, Yan-Hong Pan, Po-Kai Wang, Sheng-Tzung Tsai
Summary: Deep brain stimulation (DBS) improves Parkinson's disease (PD) symptoms by suppressing neuropathological oscillations. Inhalational anesthetics used during DBS surgery can modulate these oscillations and affect electrode placement accuracy. Research found that neuronal oscillations in the subthalamic nucleus (STN) were associated with motor disabilities in PD patients, and median nerve stimulation (MNS) aided in localizing the sensorimotor STN.
Article
Education & Educational Research
Ming-Chen Hsieh, Tsung-Ying Chen
MEDICAL EDUCATION ONLINE
(2019)
Article
Medicine, General & Internal
Hsiu-Chen Yeh, Sin-Yi Huang, Tsung-Ying Chen, Ming-Chen Hsieh
TZU CHI MEDICAL JOURNAL
(2019)
Review
Medicine, General & Internal
Tsung-Ying Chen
TZU CHI MEDICAL JOURNAL
(2018)
Article
Medicine, General & Internal
Sheng-Po Kao, Tsung-Ying Chen, Mei-Lin Hsieh
TZU CHI MEDICAL JOURNAL
(2018)