Article
Biology
Qian Chen, Yuyan Liu, Jiping Ren, Panpan Zhong, Manni Chen, Dongsheng Jia, Hongyan Chen, Taiyun Wei
Summary: Research has shown that an important rice reovirus uses small vesicles called exosomes to spread from leafhopper vectors' salivary glands into plant tissues. This process relies on the small GTPase Rab27a and the exosomal biogenesis inhibitor GW4869. Interaction between a 15-nm-long domain of the viral outer capsid protein and a specific protein RabS induces packaging of virions into exosomes, activating the Rab27a-dependent exosomal release pathway.
Article
Biochemistry & Molecular Biology
Ritankar Majumdar, Aidin Tavakoli Tameh, Subhash B. Arya, Carole A. Parent
Summary: LTB4 is synthesized in multivesicular bodies and released via exosomes to activate neutrophil chemotactic activity. Inhibition of exosome release results in loss of LTB4 release, affecting neutrophil motility and recruitment.
Article
Biochemistry & Molecular Biology
Beatriz Cardenes, Irene Clares, Victor Toribio, Lucia Pascual, Soraya Lopez-Martin, Alvaro Torres-Gomez, Ricardo Sainz de la Cuesta, Esther M. Lafuente, Manuel Lopez-Cabrera, Maria Yanez-Mo, Carlos Cabanas
Summary: Research has shown that the interaction between integrin alpha 5 beta 1 on CRC cells and their ligand ADAM17 mediates the binding and uptake of CRC-derived exosomes, while the expression of CD9 on exosomes negatively regulates this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Katerina Tischenko, Yifat Brill-Karniely, Eliana Steinberg, Hadas Segev-Yekutiel, Ofra Benny
Summary: Cancer cell malignancy is correlated with cell deformability and shape distortion during the engulfment of external particles. The cell's adherence state and substrate rigidity influence particle uptake. Cancer cells of the same origin may exhibit different capacities to uptake particles based on attachment to surfaces with varying rigidities. Our study demonstrates a wave-like dependence of cell uptake on substrate rigidity and suggests that phosphorylated paxillin plays a role in limiting complete particle uptake.
APL BIOENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Xiong Jia, Weishuai Liu
Summary: Vaccarin, a flavonoid found in vaccaria seeds, can ameliorate obesity and insulin resistance induced by a high-fat diet. The mechanism involves reducing fat accumulation, improving insulin sensitivity, and activating the insulin signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Environmental Sciences
Cheng Sun, Qilin Yu, Zhiqiang Zhao, Yaobin Zhang
Summary: In this study, the CO2 fixation of photosynthetic bacteria was enhanced in the dark through extracellular electron uptake from the electrode. The electrochemical activity of the bacteria was found to increase, possibly due to structural modifications of protein-like substances, resulting in enhanced proton-coupled electron transfer. This study suggests that electrostimulation of extracellular respiration can maintain photosynthesis in the dark.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Damir Zubac, Vladimir Ivancev, Vincent Martin, Antonio Dello Iacono, Cecil J. W. Meulenberg, Adam C. McDonnell
Summary: This study investigated the effects of posture on indicators of exercise intensity during supine cycling. The results showed that the rate of oxygen uptake and peak oxygen uptake were lower in the supine position compared to the upright position. The study suggests that including moderate-intensity step-transitions before a ramp CPET could help determine appropriate exercise intensity domains for supine cycling.
Article
Microbiology
Dawn E. Holmes, Jinjie Zhou, Toshiyuki Ueki, Trevor Woodard, Derek R. Lovley
Summary: The study demonstrates that the genetically tractable methanogen Methanosarcina acetivorans can grow via direct interspecies electron transfer (DIET) in coculture with Geobacter metallireducens. Transcriptomic analysis reveals higher expression of outer-surface multi-heme c-type cytochrome MmcA during DIET-based growth, while deletion of mmcA inhibits DIET. Additionally, the study provides insights into the potential role of aromatic amino acids in forming electrically conductive archaella and the involvement of membrane-bound complexes in energy production from carbon dioxide reduction during DIET.
Article
Biodiversity Conservation
Dan Zhu, Yilong Wang, Philippe Ciais, Frederic Chevallier, Shushi Peng, Yao Zhang, Xuhui Wang
Summary: The relationship between spring temperatures and carbon uptake in the northern high latitudes remains positively correlated, despite fluctuations in the correlation over the past few decades.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Environmental Sciences
Hans-Christian Teien, Olena Kashparova, Brit Salbu, Sviatoslav Levchuk, Valentyn Protsak, Dag Markus Eide, Karl Andreas Jensen, Valery Kashparov
Summary: The transfer of radionuclides Cs-137 and Sr-90 to fish is highly dependent on seasons, especially water temperature, with significant deviations in transfer data obtained during low water temperature seasons compared to literature data.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Virology
Igor Kudryavtsev, Olga Kalinina, Vadim Bezrukikh, Olesya Melnik, Alexey Golovkin
Summary: New investigation results suggest that extracellular vesicles may play a role in the pathogenesis of coronavirus infection. A method for phenotyping and quantitative analysis of plasma EVs was demonstrated, revealing potential markers associated with COVID-19 clinical manifestation.
Article
Environmental Sciences
Joanna E. Dyson, Lisa K. Whalley, Eloise J. Slater, Robert Woodward-Massey, Chunxiang Ye, James D. Lee, Freya Squires, James R. Hopkins, Rachel E. Dunmore, Marvin Shaw, Jacqueline F. Hamilton, Alastair C. Lewis, Stephen D. Worrall, Asan Bacak, Archit Mehra, Thomas J. Bannan, Hugh Coe, Carl J. Percival, Bin Ouyang, C. Nicholas Hewitt, Roderic L. Jones, Leigh R. Crilley, Louisa J. Kramer, W. Joe F. Acton, William J. Bloss, Supattarachai Saksakulkrai, Jingsha Xu, Zongbo Shi, Roy M. Harrison, Simone Kotthaus, Sue Grimmond, Yele Sun, Weiqi Xu, Siyao Yue, Lianfang Wei, Pingqing Fu, Xinming Wang, Stephen R. Arnold, Dwayne E. Heard
Summary: The impact of heterogeneous uptake of HO2 on aerosol surfaces on radical concentrations and the O-3 production regime in Beijing in summertime was investigated. The average uptake coefficient of HO2 was calculated as 0.070 +/- 0.035, significantly lower than commonly used values. The result suggests that under most conditions, HO2 uptake onto aerosol surfaces is not important, but at low NO concentrations, it can contribute significantly to the loss of HO2.
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Shachar G. Bressler, Amit Mitrany, Alon Wenger, Inke Nathke, Assaf Friedler
Summary: One of the most important properties of intrinsically disordered proteins is their ability to undergo liquid-liquid phase separation and form droplets. The Adenomatous Polyposis Coli (APC) protein, which plays a key role in Wnt signaling and can initiate cancer, forms droplets via its 20R domains and self-association domain (ASAD) in the context of Axin. The molecular mechanism and regulation of APC droplet formation were studied using peptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yuko Ito, Kohei Taniguchi, Yuki Kuranaga, Nabil Eid, Yosuke Inomata, Sang-Woong Lee, Kazuhisa Uchiyama
Summary: Edible plant cells produce EVs containing various miRNAs, which are released into central vacuoles, and these exogenous plant EVs can be taken up by mammalian enterocytes in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Unji Kim, Jin-Hee Kim, Se-Wook Oh
Summary: Multi-species biofilms are prevalent worldwide and pose a concern in the food industry due to their resistance to antimicrobial therapies and potential to cause foodborne diseases. Effective removal of multi-species biofilms involves controlling the formation of EPS and QS. Strategies such as EPS disruption, QS inhibition, and disinfection have been employed for removing multi-species biofilms.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)