Article
Urology & Nephrology
Ofer Isakov, Bhanu K. Patibandla, Doron Shwartz, Eytan Mor, Kenneth B. Christopher, Tammy Hod
Summary: This study analyzed the relationship between uric acid levels post renal transplantation and allograft outcome, finding that hyperuricemia was associated with increased death-censored graft loss but not with allograft function.Increased UA levels were not an independent predictor of long-term allograft function despite the known association of hyperuricemia with the progression of cardiovascular and renal disease.
Review
Urology & Nephrology
Qian Luo, Yuzi Cai, Qihan Zhao, Lei Tian, Yuning Liu, Wei Jing Liu
Summary: This meta-analysis examined the efficacy and safety of allopurinol in patients with diabetes mellitus. The results demonstrated that allopurinol effectively reduced serum uric acid levels and protected renal function in patients with diabetes.
Review
Medicine, General & Internal
Alberto Piana, Alessio Pecoraro, Flavio Sidoti, Enrico Checcucci, Muhammet Irfan Donmez, Thomas Prudhomme, Beatriz Banuelos Marco, Alicia Lopez Abad, Riccardo Campi, Romain Boissier, Michele Di Dio, Francesco Porpiglia, Alberto Breda, Angelo Territo
Summary: The study evaluated the safety and clinical outcomes of robot-assisted radical prostatectomy in renal transplant recipients. The results showed that this treatment is relatively safe and feasible, but has higher rates of positive surgical margins and biochemical recurrence in terms of oncological outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Da-Hoon Lee, Hana Lee, Ha-Young Yoon, Jeong Yee, Hye-Sun Gwak
Summary: There is a correlation between the POR*28 genotype and the pharmacokinetics of TAC in early post-transplantation period in adult renal transplant recipients. Recipients with the POR*28 allele have lower standardized trough concentrations of TAC.
Article
Pharmacology & Pharmacy
Hui Yang, Qing Chen, Aiwen Huang, Xiaojia Yu, Gang Chen, Xiaopeng Hu, Wei Wang, Hang Liu, Xiaodong Zhang, Lihong Liu
Summary: Hyperuricemia may have negative effects on long-term outcomes after renal transplantation, increasing the risk of decreased estimated glomerular filtration rate, graft loss, death, and cardiovascular events.
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
(2021)
Review
Urology & Nephrology
Kang Zhang, Long Tang, Shang-shang Jiang, Yue-fen Wang, Yuan Meng, Meng-di Wang, Fang-qiang Cui, Zhen Cai, Wen-jing Zhao
Summary: This systematic review and meta-analysis found that hyperuricemia and elevated serum uric acid (SUA) were both independently associated with an increased incidence of kidney failure events in IgA nephropathy (IgAN) patients.
Review
Urology & Nephrology
Dongxu Zhang, Liqian Yu, Bowen Xia, Xin Zhang, Pu Liang, Xiaopeng Hu
Summary: Appropriate exercise intervention can improve renal function, cardiopulmonary function, and physical performance in kidney transplant recipients.
WORLD JOURNAL OF UROLOGY
(2023)
Review
Gastroenterology & Hepatology
Panupong Hansrivijit, Angkawipa Trongtorsak, Max M. Puthenpura, Boonphiphop Boonpheng, Charat Thongprayoon, Karn Wijarnpreecha, Avishek Choudhury, Wisit Kaewput, Shennen A. Mao, Michael A. Mao, Caroline C. Jadlowiec, Wisit Cheungpasitporn
Summary: HEV infection is common in solid organ transplant recipients, especially in middle-income countries. The prevalence of HEV infection in lung transplant recipients is considerably lower compared to other organ transplants. More studies are needed to examine the clinical impacts of HEV infection in SOT recipients, such as graft failure, rejection, and mortality.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Cell Biology
Xingyao Tang, Yi-Peng Han, Yin-He Chai, Hong-Jian Gong, Hui Xu, Ikramulhaq Patel, Yu-Shun Qiao, Jin-Yan Zhang, Marly Augusto Cardoso, Jian-Bo Zhou
Summary: This study aimed to evaluate the bidirectional association between kidney dysfunction and brain health. The results showed a positive association between kidney dysfunction and structural and functional brain abnormalities. However, the relationship between kidney dysfunction and structural brain abnormalities remains controversial.
AGEING RESEARCH REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Zhihui Yuan, Sheng Chao, Yuan Xu, Yulin Niu
Summary: A systematic review and meta-analysis investigated the efficacy and safety of isoniazid prophylaxis in preventing tuberculosis infection in kidney transplant recipients. The results showed that the risk of active TB infection was lower in the INH treatment group, but there were no significant differences in mortality, acute rejection, and hepatotoxicity between the two groups.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Petros Ioannou, Konstantinos Alexakis, Diamantis P. Kofteridis
Summary: This systematic review focuses on IE in liver transplant recipients, discussing epidemiology, microbiology, clinical characteristics, treatment, and outcomes. Gram-positive microorganisms were the most common causative pathogens, with the aortic valve being the most commonly infected valve. The clinical cure rate was 57.4%, while the overall mortality rate was 43.5%.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Jeong-Ju Yoo, Dong Keon Yon, Seung Won Lee, Jae Il Shin, Beom Kyung Kim
Summary: After SARS-CoV-2 vaccination, OLT recipients had a 70% humoral immune response rate, lower than healthy controls but favorable compared to other solid organ transplant recipients. Factors such as male sex, old age, chronic kidney disease, obesity, and high immunosuppressant doses increased the risk of unresponsiveness in OLT patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Medicine, General & Internal
Anand Kulkarni, Harsh Vardhan Tevethia, Madhumita Premkumar, Juan Pablo Arab, Roberto Candia, Karan Kumar, Pramod Kumar, Mithun Sharma, Padaki Nagaraja Rao, Duvvuru Nageshwar Reddy
Summary: This study analyzed the outcomes of liver transplant recipients with COVID-19 infection and found that there was no significant difference in mortality rates between liver transplant and non-liver transplant patients. The risk of developing severe COVID-19 infection in LT recipients was approximately 23%.
Review
Infectious Diseases
Xinpei Chen, De Luo, Bingjie Mei, Juan Du, Xiangdong Liu, Hui Xie, Lin Liu, Song Su, Gang Mai
Summary: This study evaluated the immunogenicity of COVID-19 vaccines in solid organ transplant (SOT) recipients. The results showed that the immune response rates after the 1st, 2nd, and 3rd vaccine doses were 9.5%, 43.6%, and 55.1% respectively. The study suggests that booster vaccination enhances the immunogenicity of COVID-19 vaccines in SOT recipients, but a significant portion of recipients still do not have a detectable immune response after receiving the 3rd dose.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Surgery
James Tang, Jasmijn Kerklaan, Germaine Wong, Martin Howell, Nicole Scholes-Robertson, Chandana Guha, Ayano Kelly, Allison Tong
Summary: Medicine-taking among transplant recipients is a complex task that impacts outcomes significantly. Transplant recipients face threats to identity, uncertainty and distrust, treatment burdens, seeking and gaining confidence, recalibrating to a new normal post-transplant, and preserving graft survival. Interventions supporting adaptation to medicine-taking and addressing treatment burdens may improve patient satisfaction and medication adherence.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)