Review
Oncology
Luigi Wolkmer Spagnol, Jossimara Polettini, Daniela Augustin Silveira, Gustavo Roberto Minetto Wegner, Daniel Felipe Fernandes Paiva
Summary: This study investigated the association of p16 gene promoter methylation with gastric carcinogenesis and progression through a systematic review and meta-analysis. The results demonstrated a significant association between p16 methylation and gastric oncogenesis, as well as several clinical indicators. Additionally, Epstein-Barr virus was found to play a crucial role in triggering p16 methylation.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Cell Biology
James A. Cain, Bertille Montibus, Rebecca J. Oakey
Summary: The mammalian genome is generally lacking in CG dinucleotides, except for CpG islands (CGIs) found in protected regions. CGIs serve as gene regulatory hubs, with a quarter of them located within genes. These intragenic CGIs play a crucial role in gene regulation, influencing transcription activity and transcriptome diversity within genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daiki Oshikawa, Shintaro Inaba, Yudai Kitagawa, Kaori Tsukakoshi, Kazunori Ikebukuro
Summary: CpG methylation alters the stability and structure of the i-motif in CpG islands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Siti Aisyah Faten Mohamed Sa'dom, Sweta Raikundalia, Shaharum Shamsuddin, Wei Cun See Too, Ling Ling Few
Summary: The study revealed that DNA methylation of CpG4C region in the promoter of ck alpha gene can promote the binding of repressive transcription factors, leading to downregulation of CK alpha expression.
Article
Multidisciplinary Sciences
Roza H. Ali Masalmeh, Francesca Taglini, Cristina Rubio-Ramon, Kamila I. Musialik, Jonathan Higham, Hazel Davidson-Smith, Ioannis Kafetzopoulos, Kamila P. Pawlicka, Hannah M. Finan, Richard Clark, Jimi Wills, Andrew J. Finch, Lee Murphy, Duncan Sproul
Summary: Aberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours, which may silence tumour suppressors like MLH1. By studying ectopically integrated CpG islands in colorectal cancer cells, researchers found that these abnormally methylated CpG islands exhibit low levels of de novo DNA methylation, with the de novo DNA methylation activity primarily targeting CpG islands marked by the histone modification H3K36me3.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Izaskun Mallona, Ioana Mariuca Ilie, Ino Dominiek Karemaker, Stefan Butz, Massimiliano Manzo, Amedeo Caflisch, Tuncay Baubec
Summary: Studies reveal that DNMT3A and DNMT3B exhibit distinct preferences during de novo methylation, which are attributed to differences in their catalytic domains rather than genome recruitment. These preferences are also observed at non-CpG sites, providing new insights into the complex regulation of DNA methylation patterns.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemical Research Methods
Dicle Yalcin, Hasan H. Otu
Summary: This study aimed to develop machine learning models to predict the methylation propensity of CGIs, with results indicating that combined features in the model provide more accurate predictions. This can lead to a better understanding of disease mechanisms, gene classification based on methylation propensity, and potential preventative treatment strategies.
CURRENT BIOINFORMATICS
(2021)
Article
Oncology
Hossein Dehdari, Fatemeh Moradian, Ali Barzegar, Mohammed Ali Ebirahimzadeh
Summary: This study found that increased transcription of CYP1A1 in breast cancer is correlated with hypermethylation of a specific CpG block and upregulation of antiapoptotic protein BCL-2. The hypermethylation of this CpG block may serve as a potential biomarker for diagnosis and progression of breast cancer.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Tobias Hallen, Gudmundur Johannsson, Rahil Dahlen, Camilla A. M. Glad, Charlotte Orndal, Angelica Engvall, Helena Caren, Thomas Skoglund, Daniel S. Olsson
Summary: This study explored DNA methylation patterns associated with tumor progression in patients with nonfunctioning pituitary adenomas (NFPAs). The results showed that some methylation sites were associated with tumor progression and could potentially serve as biomarkers for early identification of tumor progression.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Maria del Carmen Turpin-Sevilla, Fernando Perez-Sanz, Jose Garcia-Solano, Patricia Sebastian-Leon, Javier Trujillo-Santos, Pablo Carbonell, Eduardo Estrada, Anne Tuomisto, Irene Herruzo, Lochlan J. Fennell, Markus J. Makinen, Edith Rodriguez-Braun, Vicki L. J. Whitehall, Ana Conesa, Pablo Conesa-Zamora
Summary: Aberrant methylation patterns at specific genome sequences (CpG) are driving forces for carcinogenesis processes. Different histological subtypes of colorectal cancer (CRC) exhibit distinct global methylation patterns, with a shift from promoter hypermethylation to genomic hypomethylation occurring at a small sequence between 250 bp and 1 Kb from the gene TSS.
Article
Oncology
Jiyin Wang, Ruixiang Yang, Yuning Cheng, Yue Zhou, Tongjia Zhang, Shujie Wang, Hui Li, Wei Jiang, Xiaowei Zhang
Summary: This study demonstrates that PRMT1-mediated methylation of HBP1 at R378 decreases its protein stability, promoting tumor metastasis and growth. Additionally, GSN is identified as a novel target gene of HBP1. Methylation of HBP1 downregulates GSN levels, leading to actin cytoskeleton remodeling and tumor progression.
Article
Pathology
Maja Sutic, Jurica Baranasic, Lana Kovac Bilic, Mario Bilic, Antonija Jakovcevic, Luka Brcic, Sven Seiwerth, Marko Jakopovic, Miroslav Samarzija, Ulrich Zechner, Jelena Knezevic
Summary: The methylation status of genes in primary HNSCC and LuSCC significantly differs, with hypermethylation in specific CpG sites in HNSCC compared to LuSCC. ROC curve analysis demonstrates that these selected CpG sites are useful for distinguishing between primary LuSCC and primary HNSCC, with AUC values of 85-95%. Further studies with a larger sample size, particularly including metastatic samples, are needed to validate the usefulness of this approach in distinguishing second primary LuSCC from HNSCC metastasis.
DIAGNOSTIC PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Byeong Seong Ki, Sung Han Shim, Chanhyeok Park, Hyunjin Yoo, Hyeonwoo La, Ok-Hee Lee, Youngjoo Kwon, David G. Skalnik, Yuki Okada, Ho-Geun Yoon, Jin-Hoi Kim, Kwonho Hong, Youngsok Choi
Summary: A protein called Cfp1 has been found to play an important role in the development of sperm cells in mice. Its absence interferes with the process of meiosis, which leads to abnormal sperm formation. Cfp1 controls gene expression, including genes related to meiosis and homologous recombination.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Junjun Li, Yuan Qian, Chao Zhang, Wei Wang, Yisheng Qiao, Hao Song, Liyan Li, Jiazhi Guo, Di Lu, Xingli Deng
Summary: The study suggests that LINC00473 is upregulated in invasive pituitary adenoma (IPA) and promotes the proliferation of PA cells through the ceRNA mechanism, possibly involving the miR-502-3p/KMT5A signaling pathway.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Vahid Omarmeli, Alireza Sharafshah, Ali Albonaim, Parvaneh Keshavarz
Summary: There is no association between opium addiction and methylation of the MAOA promoter regions in opium-addicted males undergoing methadone treatment.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2022)
Article
Oncology
Ziyu Li, Xiaolong Wu, Xiangyu Gao, Fei Shan, Xiangji Ying, Yan Zhang, Jiafu Ji
Summary: The newly established MMLN staging system based on the number of PMLN and EMLN shows independent and superior prognostic performance in predicting overall survival in patients undergoing curative gastrectomy with D2 or D2 plus lymphadenectomy.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Jinyao Shi, Zhouqiao Wu, Xiaolong Wu, Fei Shan, Yan Zhang, Xiangji Ying, Ziyu Li, Jiafu Ji
Summary: This study aimed to develop clinically tools for early detection of anastomotic leakage (AL) by analyzing inflammatory factors (IFs) in abdominal drainage. The research proposed an Anastomotic Score system (AScore-POD3) based on IFs with high diagnostic efficacy, which was validated in an independent cohort. A nomogram combining AScore-POD3 with other clinical risk factors showed high C-index, suggesting the potential for early diagnosis of AL after gastric cancer surgery.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Feng Su, Jianmin Li, Xinya Zhao, Beining Wang, Yajie Hu, Yu Sun, Jiafu Ji
Summary: The study demonstrates the use of a deep learning system to achieve intelligent tumor differentiation grading and microsatellite instability status recognition in gastric cancer. The system shows high accuracy and interpretability, making it a promising tool for artificial intelligence healthcare.
LABORATORY INVESTIGATION
(2022)
Article
Oncology
Zhiyuan Fan, Yu Qin, Jing Zhou, Ru Chen, Jianhua Gu, Minjuan Li, Jiachen Zhou, Xinqing Li, Dongmei Lin, Jinwu Wang, Dajun Deng, Wenqiang Wei
Summary: P16 methylation was found to be associated with the development of esophageal squamous cell dysplasia (ESCdys) and esophageal squamous cell carcinoma (ESCC). P16 methylation in cytology specimens was positively associated with the risk of ESCC and ESCdys, while P16 methylation in biopsy specimens was only associated with a higher risk of developing ESCC. Adding P16 methylation in cytology specimens to the prediction model significantly improved its predictive capacity for ESCC and high-grade ESCdys.
Article
Surgery
Jinyao Shi, Zhouqiao Wu, Xiaolong Wu, Fei Shan, Yan Zhang, Xiangji Ying, Ziyu Li, Jiafu Ji
Summary: This study found that analyzing inflammatory factors in abdominal drainage fluid can be a useful method for early diagnosis of anastomotic leakage after colorectal surgery. By analyzing six inflammatory factors, researchers were able to accurately predict the occurrence of anastomotic leakage as early as the first day after surgery.
Article
Oncology
Wei Tian, Hongfan Yuan, Sisi Qin, Wensu Liu, Baozhen Zhang, Liankun Gu, Jing Zhou, Dajun Deng
Summary: The study found that AKT1 can phosphorylate the Kaiso protein, causing its accumulation in the cytoplasm and de-repressing the Kaiso target gene CDH1 through binding to 14-3-3 proteins/P120ctn. Decreased phosphorylation of Kaiso may contribute to the development of gastrointestinal cancer.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaohong Wang, Lianhai Zhang, Francis K. L. Chan, Jiafu Ji, Jun Yu, Jessie Qiaoyi Liang
Summary: GGT7 is frequently downregulated in gastric cancer and its methylation is correlated with patient survival. GGT7 inhibits gastric cancer cell growth and migration by inducing autophagy.
Article
Biochemistry & Molecular Biology
Abin You, Wei Tian, Hongfan Yuan, Liankun Gu, Jing Zhou, Dajun Deng
Summary: TTC22 interacts with RPL4 to promote the binding of WTAP mRNA to RPL4, enhancing the stability and translation efficiency of WTAP mRNA and increasing the level of WTAP protein. TTC22 also triggers a positive feedback loop between WTAP expression and WTAP mRNA m6A modification, leading to an increased m6A level in total RNA. Additionally, TTC22 upregulates SNAI1 expression by increasing m6A level, promoting colon cancer metastasis.
Review
Oncology
Jiafu Ji, Leiyu Shi, Xiangji Ying, Xinpu Lu, Fei Shan
Summary: The study found that gastric cancer patients who underwent surgery in high-volume centers had better overall survival, lower short-term mortality, more adequate lymphadenectomy, and shorter length of stay. However, hospital volume was not significantly associated with surgical complications, negative margin resection, or disease-free survival.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Xiaohong Wang, Lianhai Zhang, Qiaoyi Liang, Chi Chun Wong, Huarong Chen, Hongyan Gou, Yujuan Dong, Weixin Liu, Ziyu Li, Jiafu Ji, Jun Yu
Summary: This study elucidated the functional significance and molecular mechanisms of DUSP5P1 lncRNA in gastric carcinogenesis. High expression of DUSP5P1 was associated with shortened survival in gastric cancer patients and promoted migration, invasion, and metastasis of gastric cancer cells. Mechanistically, DUSP5P1 activated the transcription of ARHGAP5 and dysregulated focal adhesion and MAPK signaling pathways. DUSP5P1 also played a role in platinum drug resistance.
Article
Cell Biology
Zhuoqi Li, Juanli Qiao, Wanru Ma, Jing Zhou, Liankun Gu, Dajun Deng, Baozhen Zhang
Summary: This study reveals that CBX7 is essential for P14AS to upregulate the expression of P16 (INK4A), P14 (ARF), P15 (INK4B), and ANRIL genes. P14AS may upregulate these genes' expression through competitively blocking CBX7-binding to ANRIL lncRNA and target gene promoters.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Xiaokang Lei, Yinkui Wang, Fei Shan, Shuangxi Li, Yongning Jia, Rulin Miao, Kan Xue, Zhemin Li, Jiafu Ji, Ziyu Li
Summary: This meta-analysis compared the short- and long-term outcomes of laparoscopic gastrectomy (LG) versus open gastrectomy (OG) for gastric cancer. The results showed that the intraoperative complication rate was similar between the two groups, but LG had fewer postoperative complications. The severe postoperative complication rate and perioperative mortality were comparable. LG had a lower number of retrieved lymph nodes and a shorter proximal resection margin distance compared to OG. However, the distal resection margin distance was similar. LG resulted in shorter recovery time, including time to first ambulation and time to first flatus. Additionally, LG had a shorter postoperative length of stay. The 5-year overall survival and disease-free survival were similar between the two groups.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Meng He, Zi-Fan Chen, Li Zhang, Xiangyu Gao, Xiaoyi Chong, Hao-shen Li, Lin Shen, Jiafu Ji, Xiaotian Zhang, Bin Dong, Zi-Yu Li, Tang Lei
Summary: This study aimed to assess the correlation between CT-derived body composition parameters and SII and OS in patients with advanced gastric cancer receiving dual PD-1 and HER2 blockade. The study found that high SII and high SFA were associated with OS, while sarcopenia was not an independent prognostic factor.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Multidisciplinary Sciences
Jinyao Shi, Zhouqiao Wu, Xiaolong Wu, Longtao Huangfu, Ting Guo, Xiaojing Cheng, Jing Han, Ziyu Li, Xiaofang Xing, Jiafu Ji
Summary: This study used multi-omics data of 2471 gastric cancer samples to identify glycometabolic subtypes and immune clustering subgroups of gastric cancer, and established a scoring system to predict the survival and response of chemotherapy and immunotherapy. The assessment of tumor glucose metabolism and immune microenvironment in gastric cancer has application value for predicting curative effects and formulating combined treatment strategies.
Article
Cell Biology
Hongfan Yuan, Qianwen Ren, Yantao Du, Yuwan Ma, Liankun Gu, Jing Zhou, Wei Tian, Dajun Deng
Summary: In this study, it was found that miR663AHG is mainly distributed in the nucleus of colon cancer cells and is positively correlated with miR663a. The expression level of miR663AHG is downregulated in colon cancer tissues and is associated with advanced disease stage, lymph metastasis, and shorter overall survival. Furthermore, miR663AHG can inhibit colon cancer cell proliferation, migration, and invasion, and its function is mediated through its binding to miR663a/pre-miR663a.
CELL DEATH DISCOVERY
(2023)
