Article
Pharmacology & Pharmacy
Tingting Li, Huanqing Liu, Chunsheng Dong, Jun Lyu
Summary: Genes related to pyroptosis play a crucial role in tumor immunity and can predict the prognosis of LUSC. By evaluating the cancer genome atlas, researchers identified 28 genes related to pyroptosis in LUSC samples and healthy lung tissues. These genes can be used to divide LUSC patients into two subtypes, and a risk score based on these genes is an independent predictor of overall survival.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Hui Wang, Chanjuan Su, Ziteng Li, Changchun Ma, Liangli Hong, Zhe Li, Xiaonan Ma, Yien Xu, Xiaolong Wei, Yiqun Geng, Weifeng Zhang, Penghao Li, Jiang Gu
Summary: Recent reports suggest that immune cells in solid cancers play a significant role in predicting and treating the disease. IgG4, a subclass of IgG, has been found to inhibit tumor immunity. This study aimed to assess the importance of IgG4 and T cell subtypes in tumor prognosis. Through immunostaining and analysis of clinical data, the density and distribution of immune markers CD4, CD8, Foxp3, IL-10, and IgG4 were investigated in esophageal squamous cell carcinoma (ESCC). The results showed that higher levels of CD4(+) and CD8(+) T cells predicted better prognosis, and the density of IgG4(+) B lymphocytes was correlated with CD4(+) and IL-10(+) cell densities. Increased serum concentration of IgG4 indicated a poorer prognosis. These findings highlight the potential of T cells and serum IgG4 as predictors of prognosis in ESCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Tianwen Yin, Peiliang Wang, Jinming Yu, Feifei Teng
Summary: Treatment-related lymphopenia (TRL) is an independent predictor of poor outcomes in patients with esophageal squamous cell carcinoma (ESCC) receiving anti-PD-1 therapy. Radiotherapy (RT) is a key factor affecting TRL. A shorter time interval of <33.5 days between RT and anti-PD-1 therapy can lead to a poor prognosis by increasing the occurrence of TRL.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Genetics & Heredity
Ruoxin Xu, Wenxiong Zhang
Summary: This study identified m5C-associated lncRNAs and established a prognosis model with good prediction efficiency in lung squamous cell carcinoma (LUSC). The model, combined with clinical features, could be applied in clinical settings. Pathway enrichment analysis and immune infiltration analysis revealed the mechanisms and immune status of high-risk patients. Additionally, high-risk patients were found to be more sensitive to certain treatments.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Jingyi Li, Yuxia Song, Huihong Cai, Bo Zhou, Jun Ma
Summary: Esophageal squamous cell carcinoma (ESCC) is a common and aggressive type of esophageal cancer. Abnormal expression of circular RNAs (circRNAs) has been linked to ESCC and are believed to play a crucial role in the complex gene regulation system involved in ESCC formation. This review explores the role of circRNAs in the tumor microenvironment (TME) of ESCC, including their impact on the immune microenvironment, angiogenesis, cell transition, hypoxia, metabolism, and radiotherapy resistance. Further research on circRNAs in the TME of ESCC may lead to their use as therapeutic targets, delivery systems, and diagnostic/prognostic indicators.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yuan Zhuang, Sihan Li, Chang Liu, Guang Li
Summary: This study used 15 IRGs to construct an effective risk prediction model, demonstrating the significance of IRGs-based personalized immune scores in LUSC prognosis. IRGs were closely correlated with patients' age and immune cell infiltration.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Mengmeng Fan, Makoto Arai, Akinobu Tawada, Tetsuhiro Chiba, Reo Fukushima, Katsuhiro Uzawa, Masashi Shiiba, Naoya Kato, Hideki Tanzawa, Yuichi Takiguchi
Summary: The study revealed the roles of EPSTI1 in conferring malignant characteristics to oral squamous cell carcinoma (OSCC) and lung squamous cell carcinoma (LSCC), with the gene showing oncogenic roles in OSCC and tumor-suppressive roles in LSCC. Additionally, PCR array analyses identified some genes with altered expression levels along with modified EPSTI1 expression in both OSCC and LSCC cell lines, suggesting EPSTI1 may be a therapeutic target for both types of cancer.
Article
Cell Biology
Chang Gu, Xin Shi, Wenli Qiu, Zhenyu Huang, Yan Yu, Feng Shen, Yumei Chen, Xufeng Pan
Summary: This study explored the prognostic role and mutational characteristics of m6A-related genes in LUSC, identifying three potential independent prognostic m6A-related genes (WTAP, YTHDC1, and YTHDF1) for OS in LUSC patients. The study used LUSC gene expression data and mutational data from The Cancer Genome Atlas database, identifying differentially expressed genes and exploring gene mutations in LUSC patients, investigating the correlations among m6A-related genes, and developing a nomogram model. The study also found significant co-occurrence frequencies among certain m6A-related genes and identified prognostic factors for OS in LUSC patients through multivariate Cox analysis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Junfan Pan, Zhidong Huang, Hancui Lin, Wenfang Cheng, Jinhuo Lai, Jiancheng Li
Summary: This study established a prognostic risk model based on six m7G-related lncRNAs in lung squamous cell carcinoma (LUSC) and validated its prognostic value. The risk model holds promise as a prognostic tool for guiding individualized patient treatment.
Article
Oncology
Xiaoshan Hu, Liyi Guo, Guihong Liu, Zili Dai, Li Wang, Jian Zhang, Jun Wang
Summary: By using six cellular senescence-related genes, a new classification of LUSC was discovered, which helps identify patients who will benefit from anti-PD-1 treatment. The high-risk group was associated with immune cell inactivation and insensitivity to immunotherapy in IMvigor210, and had a worse prognosis. Targeting senescence-related genes could be another option for improving clinical therapy for LUSC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Zhixing Hao, Mingjie Lin, Feng Du, Zhongwei Xin, Dang Wu, Qun Yu, Yimin Wu, Zhouyu Zhu, Wenshan Li, Yongyuan Chen, Xiaoke Chen, Ying Chai, Shenghang Jin, Pin Wu
Summary: This study identified systemic immune dysregulation in the peripheral blood of early NSCLC patients and demonstrated the correlation between these dysregulations and clinical features. These findings suggest that systemic immune dysregulation is involved in cancer development and may be a promising candidate for high-risk screening and treatment strategies for early NSCLC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jumpei Kashima, Tsunekazu Hishima, Yusuke Okuma, Hirotoshi Horio, Masumi Ogawa, Yukiko Hayashi, Shin-ichiro Horiguchi, Toru Motoi, Tetsuo Ushiku, Masashi Fukayama
Summary: CD70 is widely expressed in TSCC but not in thymoma or thymic carcinoid, with a correlation with PD-L1 expression. CD27-positive TIL in TSCC is associated with better survival outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chenghao Wang, Tong Lu, Ran Xu, Shan Luo, Jiaying Zhao, Linyou Zhang
Summary: In this study, two subtypes of lung squamous carcinoma (LUSC) with different lactate metabolism patterns were identified. The lactate metabolism levels in LUSC had extensive effects on tumor immune infiltration patterns, adaptation to the hypoxia environment, and energy metabolic reprogramming. A lactate metabolism-related prognostic index (LMRPI) was developed to predict the prognosis of LUSC patients and guide their individualized treatment, including immunotherapy.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Medicine, General & Internal
Bo Zhou, Manxiang Li, Tianjun Chen, Jianqing She
Summary: This case report presents a rare case of myocarditis after PD-L1 inhibitor therapy. The patient developed myocardial injury after receiving durvalumab monotherapy, but quickly recovered to normal after glucocorticoids treatment.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Min Tang, Yukun Li, Xianyu Luo, Jiao Xiao, Juan Wang, Xin Zeng, Qihao Hu, Xiaoyan Chen, Si-jie Tan, Jun Hu
Summary: The study analyzed LSCC expression data and identified a close relationship between LSCC and CD8(+) T cells, verifying six hub genes associated with cancer development. METTL8 was selected as a prognostic biomarker and its inhibition can induce G1 cell cycle arrest and suppress proliferation, making it a potential biomarker and gene therapy target in LSCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Preston Ngo, David E. Goldsbury, Deme Karikios, Sarsha Yap, Mei Ling Yap, Sam Egger, Dianne L. O'Connell, David Ball, Kwun M. Fong, Nick Pavlakis, Nicole M. Rankin, Shalini Vinod, Karen Canfell, Marianne F. Weber
Summary: This study in New South Wales, Australia examined patterns of systemic therapy use for lung cancer, particularly small-cell lung cancer, before the introduction of immunotherapy and latest targeted therapies. Despite a universal healthcare system, the analysis revealed disparities in health service utilization based on socioeconomic factors and relatively low overall utilization of systemic therapy.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Environmental Sciences
Salma M. Ahmed, Gita D. Mishra, Katrina M. Moss, Ian A. Yang, Kate Lycett, Luke D. Knibbs
Summary: The study found that exposure to moderate and high levels of PM2.5 was associated with increased risk of emotional and behavioral problems, and gross motor delay in children. However, there was insufficient evidence to suggest that NO2 exposure or living near major roads was associated with children's emotional and behavioral problems or developmental delay.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Daniel B. Odo, Ian A. Yang, Sagnik Dey, Melanie S. Hammer, Aaron van Donkelaar, Randall Martin, Guang-Hui Dong, Bo-Yi Yang, Perry Hystad, Luke D. Knibbs
Summary: The study investigated the association between annual average exposure to ambient PM2.5 and acute respiratory infections (ARI) in children under 5 years old in 35 low- and middle-income countries (LMICs). The results showed that an increase in PM2.5 was associated with higher odds of ARI, and there was evidence of effect modification by sex, age, and place of residence, indicating that PM2.5 may have a greater impact on ARI in certain subgroups.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Oncology
Martin C. Tammemagi, Mamta Ruparel, Alain Tremblay, Renelle Myers, John Mayo, John Yee, Sukhinder Atkar-Khattra, Ren Yuan, Sonya Cressman, John English, Eric Bedard, Paul MacEachern, Paul Burrowes, Samantha L. Quaife, Henry Marshall, Ian Yang, Rayleen Bowman, Linda Passmore, Annette McWilliams, Fraser Brims, Kuan Pin Lim, Lin Mo, Stephen Melsom, Bann Saffar, Mark Teh, Ramon Sheehan, Yijin Kuok, Renee Manser, Louis Irving, Daniel Steinfort, Mark McCusker, Diane Pascoe, Paul Fogarty, Emily Stone, David C. L. Lam, Ming-Yen Ng, Varut Vardhanabhuti, Christine D. Berg, Rayjean J. Hung, Samuel M. Janes, Kwun Fong, Stephen Lam
Summary: This study compared the effectiveness of the USPSTF2013 and PLCOm2012 model eligibility criteria for lung cancer screening. The results showed that the PLCOm2012 model is more efficient in selecting individuals for lung cancer screening and provides more accurate predictions of cumulative life expectancy compared to the USPSTF2013 criteria.
Article
Respiratory System
Hancy Issac, Gerben Keijzers, Ian A. Yang, Jackie Lea, Melissa Taylor, Clint Moloney
Summary: This study developed an electronic proforma to aid in the guideline adherence and management of emergency department patients with chronic obstructive pulmonary disease (COPD). The proforma achieved good internal consistency through expert consensus and quantitative surveys, and it has the potential to improve holistic care and health-related quality of life for patients with COPD.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Linh Ngo, Richard Woodman, Russell Denman, Tomos E. Walters, Ian A. Yang, Isuru Ranasinghe
Summary: Long-term clinical outcomes following catheter ablation of atrial fibrillation (AF) are positive, with good survival rates and low rehospitalization rates.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Oncology
Henry M. Marshall, Mounavi Vemula, Karen Hay, Elizabeth McCaul, Linda Passmore, Ian A. Yang, Rayleen Bowman, Kwun M. Fong
Summary: This study provides data on smoking cessation rates in Australian lung cancer screenees and supports screening as a teachable moment. Several factors associated with continued smoking were identified, which could be used to develop effective smoking cessation interventions as part of lung cancer screening tailored to individual risk profiles.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Editorial Material
Respiratory System
Ramon Rami-Porta, Kwun M. Fong
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Oncology
Peter A. Johansson, Nicholas K. Hayward, Antonia L. Pritchard
Summary: Immune checkpoint inhibitors (ICIs) have improved survival in advanced cutaneous melanoma. Gene expression associated with response to ICI has been investigated and found to be predictive of survival not only in ICI-treated patients but also in those who never received ICI.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Editorial Material
Respiratory System
Henry M. Marshall, Coral E. Gartner, Kwun M. Fong
Article
Oncology
Hansol Lee, Angela L. Ferguson, Camelia Quek, Ismael A. Vergara, Ines Pires daSilva, Ruth Allen, Tuba Nur Gide, Jordan W. Conway, Lambros T. Koufariotis, Nicholas K. Hayward, Nicola Waddell, Matteo S. Carlino, Alexander M. Menzies, Robyn P. M. Saw, Elena Shklovskaya, Helen Rizos, Serigne Lo, Richard A. Scolyer, Georgina V. Long, Umaimaintha Palendira, James S. Wilmott
Summary: This study characterized intratumoral macrophage populations in melanoma biopsies and investigated the association between CD16-expressing macrophage densities and treatment outcomes for patients receiving anti-PD-1 monotherapy or a combination with anti-CTLA-4. The results showed that patients who responded to combination therapy had higher CD16 macrophage densities compared to those who did not respond. Additionally, patients with high intratumoral densities of CD16 macrophages had a significantly longer progression-free survival. These findings suggest that CD16 macrophages may serve as a potential biomarker for response to combination immunotherapies in metastatic melanoma patients.
CLINICAL CANCER RESEARCH
(2023)
Letter
Dermatology
Peter A. Johansson, Jane M. Palmer, Hayley R. Hamilton, David C. Whiteman, Antonia L. Pritchard, Nicholas K. Hayward
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Editorial Material
Respiratory System
Nico van Zandwijk, Henry M. Marshall, Kwun M. Fong
Editorial Material
Respiratory System
Edward K. H. Stephens, Henry M. M. Marshall, Venessa Chin, Kwun M. M. Fong
Article
Allergy
Dennis Thomas, Vanessa M. McDonald, Sean Stevens, Erin S. Harvey, Melissa Baraket, Philip Bardin, Jeffrey J. Bowden, Simon Bowler, Jimmy Chien, Li Ping Chung, Andrew Gillman, Mark Hew, Sandra Hodge, Alan James, Christine Jenkins, Constance H. Katelaris, Gregory P. Katsoulotos, David Langton, Joy Lee, Guy Marks, Matthew Peters, Naghmeh Radhakrishna, Paul N. Reynolds, Janet Rimmer, Pathmanathan Sivakumaran, John W. Upham, Peter Wark, Ian A. Yang, Peter G. Gibson
Summary: This study evaluated the effectiveness of two biologics (mepolizumab/omalizumab) in achieving asthma remission in severe asthma patients. The results showed that biologic treatment with mepolizumab or omalizumab induced asthma remission in a subgroup of patients. Better lung function, lower body mass index, mild disease, and absence of comorbidities were predictors of achieving clinical remission.