Outside-In Signalling Generated by a Constitutively Activated Integrin αIIbβ3 Impairs Proplatelet Formation in Human Megakaryocytes

Heterozygous ITGA2B R995W mutation inducing constitutive activation of the  IIb 3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia

(2011) S. Kunishima et al.   BLOOD

Abnormal VWF modifies megakaryocytopoiesis: studies of platelets and megakaryocyte cultures from patients with von Willebrand disease type 2B

(2010) P. Nurden et al.   BLOOD

ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing

(2010) M. Bender et al.   BLOOD

Dominant inheritance of a novel integrin  3 mutation associated with a hereditary macrothrombocytopenia and platelet dysfunction in two Italian families

(2009) P. Gresele et al.   HAEMATOLOGICA

The GPIIb/IIIa (integrin  IIb 3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend

(2008) B. S. Coller et al.   BLOOD

A new case of acquired Glanzmann's thrombasthenia: Diagnostic value of flow cytometry

(2008) S. Giannini et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Adhesive receptors, extracellular proteins and myosin IIA orchestrate proplatelet formation by human megakaryocytes

(2008) A. BALDUINI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Proplatelet formation in heterozygous Bernard-Soulier syndrome type Bolzano

(2008) A. BALDUINI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

(2008) Jianghai Zhu et al.   MOLECULAR CELL

A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the  IIb 3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia

(2007) C. Ghevaert et al.   BLOOD