Article
Engineering, Environmental
Bin Wang, Chengfan Wu, Shufang He, Yaguang Wang, Di Wang, Hui Tao, Chenchen Wang, Xiaoxi Pang, Fei Li, Yue Yuan, Eric R. Gross, Gaolin Liang, Ye Zhang
Summary: In this study, a new supramolecular hydrogel V1-Cal/NapFFY was developed, which significantly enhanced the therapeutic effects of V1-Cal on myocardial infarction and improved cardiac function. The hydrogel demonstrated sustained release of V1-Cal for more than two weeks and effectively reduced TRPV1 expression, apoptosis, and inflammatory factors in vivo experiments.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Miranda D. Diaz, Elaine Tran, Martin Spang, Raymond Wang, Roberto Gaetani, Colin G. Luo, Rebecca Braden, Ryan C. Hill, Kirk C. Hansen, Anthony N. DeMaria, Karen L. Christman
Summary: The myocardial matrix hydrogel shows potential efficacy in chronic myocardial infarction patients by mitigating negative left ventricular remodeling through modulation of the immune response, down-regulation of pathways involved in heart failure progression and fibrosis, and up-regulation of genes important for cardiac muscle contraction.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Ahmet Demirkiran, Rob J. van der Geest, Luuk H. G. A. Hopman, Lourens F. H. J. Robbers, M. Louis Handoko, Robin Nijveldt, John P. Greenwood, Sven Plein, Pankaj Garg
Summary: LV hemodynamic assessment by LV blood flow kinetic energetics in STEMI patients shows a significant inverse association with adverse LV-remodeling. Late-diastolic LV blood flow kinetic energetics early after acute MI is independently associated with adverse LV-remodeling.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alberto Aimo, Giorgia Panichella, Andrea Barison, Silvia Maffei, Matteo Cameli, Stefano Coiro, Flavio D'Ascenzi, Carlo Di Mario, Riccardo Liga, Rossella Marcucci, Doralisa Morrone, Iacopo Olivotto, Isabella Tritto, Michele Emdin
Summary: Gender differences exist in the epidemiology, clinical features, and outcome of myocardial infarction, with women showing lower propensity to develop spherical geometry and left ventricular dysfunction after MI, attributed to various physiological factors including hormonal influences. Future studies should focus on clarifying these sex differences and potential therapeutic targets.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Engineering, Biomedical
E. Garbayo, A. Ruiz-Villalba, S. C. Hernandez, L. Saludas, G. Abizanda, B. Pelacho, C. Roncal, B. Sanchez, I Palacios, F. Prosper, M. J. Blanco-Prieto
Summary: This study demonstrates the potential of a biomimetic and biodegradable micro-platform in enhancing cardiovascular progenitor therapy. In a rat model of chronic myocardial infarction, biomimetic microcarriers improved cardiac function, reduced chronic cardiac remodeling, and increased vasculogenesis through the paracrine signaling of CPCs. These findings suggest that biomimetic microcarriers offer a promising and effective strategy for biomaterial-assisted CPC delivery to the heart.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Rui Duan, Haotian Pan, DongCheng Li, Shengen Liao, Bing Han
Summary: This study aims to investigate the mechanism by which ERG protects the heart after myocardial infarction (MI). The results indicate that ERG improves cardiac function, reduces the size of the damaged area, prevents heart remodeling, fibrosis, and cardiomyocyte death. Through experiments, it is confirmed that ERG protects the heart by reducing s-glutathionylation through the NF-κB-dependent Wnt5a-sFlt-1 pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Kurt D. D. Marshall, Paula J. J. Klutho, Lihui Song, Rajika Roy, Maike Krenz, Christopher P. P. Baines
Summary: This study demonstrates that cardiac-specific overexpression of FASTKD1 in mice provides protection against myocardial infarction-induced cardiac rupture and modulates inflammatory, extracellular matrix, and antioxidant responses following myocardial infarction. These effects are associated with enhanced activation of the integrated stress response.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Rachel Rosenzweig, Vinay Kumar, Sahil Gupta, Oscar Bermeo-Blanco, Matthew S. Stratton, Richard J. Gumina, Shyam S. Bansal
Summary: The study identified the activation of ER-alpha signaling in CD4(+) T cells during ischemic heart failure and demonstrated the potential of using ER beta agonist OSU-ERb-012 to inhibit T cells and reduce left ventricular remodeling. Treatment with OSU-ERb-012 effectively inhibited proliferation and proinflammatory cytokine expression in T cells, leading to improved cardiac outcomes in a mouse model.
CIRCULATION-HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Go Hashimoto, Maurice Enriquez-Sarano, Larissa Stanberry, Felix Oh, Matthew Wang, Keith Acosta, Hirotomo Sato, Bernardo B. C. Lopes, Miho Fukui, Santiago Garcia, Mario Goessl, Paul Sorajja, Vinayak N. Bapat, John Lesser, Joao L. Cavalcante
Summary: In patients with chronic moderate or severe aortic regurgitation (AR), those with heart failure symptoms have greater left ventricular end-systolic volume index (LVESVi) measured by cardiac magnetic resonance (CMR). In patients with no or minimal symptoms, CMR quantification of LVESVi and severity of aortic regurgitation may identify those at risk of death or incident heart failure and should be considered in the clinical evaluation and decision-making of these patients.
Article
Plant Sciences
Mingming Yang, Haiyan Wu, Hang Qian, Dongfeng Li, Hao Xu, Jishun Chen, Jixin Zhong, Wenwen Wu, Handong Yang, Xinlong Chen, Xinwen Min, Jun Chen
Summary: This study investigated the effect of Linggui Zhugan decoction on the Wnt/beta-catenin signaling pathway in rat myocardium, and examined the mechanism by which it improves ventricular remodeling in rats with heart failure. The results showed that Linggui Zhugan decoction inhibits the expression of key proteins in the Wnt/beta-catenin signaling pathway, delays cardiomyocyte hypertrophy and fibrosis, and improves cardiac function.
Article
Biochemistry & Molecular Biology
Jianzhou Shi, Jiateng Sun, Liu Liu, Tiankai Shan, Haoyu Meng, Tongtong Yang, Sibo Wang, Tianwen Wei, Bingrui Chen, Yao Ma, Qiming Wang, Hao Wang, Jiabao Liu, Liansheng Wang
Summary: Overexpression of p16ink4a in cardiac fibroblasts can ameliorate cardiac dysfunction and attenuate pathological cardiac remodeling in mice after myocardial infarction (MI) by regulating the p16ink4a/CDK4/pRb pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Nanoscience & Nanotechnology
Jiacheng Fang, Yuxuan Zhang, Delong Chen, Yiyue Zheng, Jun Jiang
Summary: This article summarizes the pathological mechanisms of ventricular remodeling following myocardial infarction and the role of exosomes in these processes, with a focus on the importance of exosomal cargos such as proteins and ncRNAs. It also highlights the potential diagnostic and therapeutic strategies in this field.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Pharmacology & Pharmacy
Weihua Bian, Wangping Chen, Thanh Nguyen, Yang Zhou, Jianyi Zhang
Summary: The study demonstrates that miR-199a-overexpressing hiPSC-CMs can increase cell proliferation in a heart infarction model, improving cardiac function and fibrosis. While the treatment may lead to lethal arrhythmia, there was no evidence of sudden death in the mouse model. Future investigations on miR-199a-overexpressing hiPSC-CMs in larger animals are supported by these results.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wineke Bakker, Calinda K. E. Dingenouts, Kirsten Lodder, Karien C. Wiesmeijer, Alwin de Jong, Kondababu Kurakula, Hans-Jurgen J. Mager, Anke M. Smits, Margreet R. de Vries, Paul H. A. Quax, Marie Jose T. H. Goumans
Summary: In HHT1, deficiency of endoglin leads to immune cell imbalance, particularly an excessive increase in inflammatory macrophages, which hinders tissue repair. Inhibiting BMP signaling restores macrophage balance and improves tissue repair after ischemic injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Henning Guthoff, Alexander Hof, Anna Klinke, Martina Maass, Juergen Konradi, Dennis Mehrkens, Simon Geissen, Felix S. Nettersheim, Simon Braumann, Erik Michaelsson, Richard J. Nies, Samuel Lee, Marie-Christin Redzinski, Vera B. M. Peters, Harshal N. Nemade, Philipp von Stein, Holger Winkels, Volker Rudolph, Stephan Baldus, Matti Adam, Martin Mollenhauer
Summary: Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide, and ischemic cardiomyopathy is becoming a leading reason for hospitalization in the western world. Neutrophils (PMN) play a key role in the inflammatory response of the ischemic myocardium, and the enzyme myeloperoxidase (MPO) expressed in PMN is an important mediator of their inflammatory capacities. Reducing PMN count and inhibiting MPO showed positive effects on scar formation and cardiac function in murine models of MI, suggesting that MPO could be a promising pharmacological target for preventing long-term morbidity after MI.
Article
Cardiac & Cardiovascular Systems
Juan A. Sanchez, Francis D. Ferdinand, James I. Fann
ANNALS OF THORACIC SURGERY
(2016)
Article
Cardiac & Cardiovascular Systems
James I. Fann, Susan D. Moffatt-Bruce, J. Michael DiMaio, Juan A. Sanchez
ANNALS OF THORACIC SURGERY
(2016)
Article
Cardiac & Cardiovascular Systems
Kevin W. Lobdell, James I. Fann, Juan A. Sanchez
ANNALS OF THORACIC SURGERY
(2016)
Article
Surgery
Todd C. Crawford, John V. Conte, Juan A. Sanchez
SURGICAL CLINICS OF NORTH AMERICA
(2017)
Article
Cardiac & Cardiovascular Systems
Vaithinathan Selvaraju, Sumanth C. Suresh, Mahesh Thirunavukkarasu, Jayakanthan Mannu, Jocelyn L. C. Foye, Premendu P. Mathur, J. Alexander Palesty, Juan A. Sanchez, David W. McFadden, Nilanjana Maulik
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2017)
Article
Nursing
Paula R. Graling, Juan A. Sanchez
Article
Cardiac & Cardiovascular Systems
Kevin W. Lobdell, Geoffrey A. Rose, Aneil K. Mishra, Juan A. Sanchez, James I. Fann
ANNALS OF THORACIC SURGERY
(2018)
Article
Gastroenterology & Hepatology
Artem Shmelev, Anne M. Sill, Gopal C. Kowdley, Juan A. Sanchez, Steven C. Cunningham
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2018)
Article
Cardiac & Cardiovascular Systems
Mahesh Thirunavukkarasu, Vaithinathan Selvaraju, Mandip Joshi, Vladimir Coca-Soliz, Leonidas Tapias, IbnalWalid Saad, Craig Fournier, Aaftab Husain, Jacob Campbell, Siu-Pok Yee, Juan A. Sanchez, J. Alexander Palesty, David W. McFadden, Nilanjana Maulik
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2018)
Meeting Abstract
Surgery
Xun Zhou, Charles D. Fraser, Alejandro Suarez-Pierre, Cecillia Lui, Juan A. Sanchez, Bradley S. Taylor, John V. Conte, Robert S. D. Higgins
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2018)
Review
Surgery
Rodrigo F. Alban, Emily C. Anania, Tara N. Cohen, Peter J. Fabri, Bruce L. Gewertz, Monica Jain, Jeffrey K. Jopling, Paul M. Maggio, Juan A. Sanchez, Harry C. Sax
CURRENT PROBLEMS IN SURGERY
(2019)
Editorial Material
Surgery
Rodrigo F. Alban, Emily C. Anania, Tara N. Cohen, Peter J. Fabri, Bruce L. Gewertz, Monica Jain, Jeffrey K. Jopling, Paul M. Maggio, Juan A. Sanchez, Harry C. Sax
CURRENT PROBLEMS IN SURGERY
(2019)
Article
Cardiac & Cardiovascular Systems
Juan A. Sanchez, Kevin W. Lobdell, Susan D. Moffatt-Bruce, James I. Fann
ANNALS OF THORACIC SURGERY
(2017)
Meeting Abstract
Cardiac & Cardiovascular Systems
Mahesh Thirunavukkarasu, Babatunde Oriowo, Vaithinathan Selvaraju, Mandip Joshi, Leonidas Tapias, Vladimir Coca-Soliz, Ibnalwalid Saad, Juan A. Sanchez, J. Alexander Palestey, Siu-Pok Yee, Nilanjana Maulik
Meeting Abstract
Cardiac & Cardiovascular Systems
Mahesh Thirunavukkarasu, Babatunde Oriowo, Vaithinathan Selvaraju, Mandip Joshi, Leonidas Tapias, Vladimir Coca-Soliz, Ibnalwalid Saad, Juan A. Sanchez, J. Alexander Palestey, Siu-Pok Yee, Nilanjana Maulik