Review
Chemistry, Multidisciplinary
Shun Luo, Shuijie Qin, Gerile Oudeng, Li Zhang
Summary: Iron-based hollow nanoplatforms (Fe-HNPs) have gained increasing attention as safe and effective theranostic tools for cancer imaging and treatment. Fe-HNPs can serve as contrast agents for MRI and therapeutic agents for various therapies, while also allowing the loading of small molecules for multifunctional theranostics. This review summarizes the recent advancements in Fe-HNPs for cancer imaging and treatment, and discusses the potential clinical obstacles and implications for future research.
Review
Engineering, Biomedical
Shuang Liang, Guangfu Liao, Wenzhen Zhu, Li Zhang
Summary: This article introduces the theranostic nanoplatforms that integrate diagnostic and therapeutic functions, with a focus on hollow manganese (Mn)-based nanoplatforms. These platforms combine the advantages of hollow structures and theranostic features of Mn2+. The hollow cavity can encapsulate various small-molecule drugs for chemotherapy, photodynamic therapy, and photothermal therapy. After degradation in the tumor microenvironment, the released Mn2+ can serve as a magnetic resonance imaging contrast agent and a Fenton-like agent for chemodynamic therapy. Synergistic treatment outcomes can be achieved through reasonable design of the hollow nanosystems. Various Mn-based hollow nanoplatforms for MR imaging-guided cancer therapies are summarized, and potential obstacles and perspectives for translational applications are discussed.
BIOMATERIALS RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Shuren Wang, Yanglong Hou
Summary: Magnetic nanomaterials play a crucial role in the biomedical field and have various applications such as biosensors, drug delivery vehicles, and diagnostic agents. Researchers are continuously developing new types of magnetic nanomaterials, like iron carbide nanoparticles, to improve performance. Magnetic nanoparticles responsive to exogenous or endogenous stimuli have been developed, enhancing their applicability in more complex scenarios. These nanoparticles can respond to stimuli such as acidity, hydrogen peroxide, light, and magnetic fields.
Article
Engineering, Biomedical
Hui Wang, Ruxin Feng, Yan Wang, Qian Ma, Jie Wei, Suying Xu, Leyu Wang
Summary: Integrated theranostic nanoparticles with multi-modal imaging capabilities are developed, enabling accurate disease location and efficient treatment. These nanoparticles overcome the challenges of complicated biological environment and provide a promising strategy for personalized medicine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Xiuyu Jin, Quanhui Ye, Chien-Wei Wang, Ying Wu, Kangling Ma, Sihan Yu, Na Wei, Haifeng Gao
Summary: Protein immobilization on magnetic nanoparticles using the SpyTag-SpyCatcher chemistry is an effective method to enhance stability and facilitate separation. The SpyTag peptide incorporated into MNPs improves loading capacity and water dispersity, allowing for efficient and stable conjugation without the need for additional enzymes or cross-linkers. The platform offers protection and improved shelf life for immobilized proteins, with fast magnetophoresis for easy recovery under external magnetic fields.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Inorganic & Nuclear
Kingsley Poon, Abhishek Gupta, William S. Price, Hala Zreiqat, Gurvinder Singh
Summary: Progress in the development of manganese oxide nanoparticles (MONPs) has provided an alternative for early-stage diagnosis of life-threatening diseases and therapeutic delivery of drugs and genes. The synthesis and characterization of MONPs have enabled the production of multi-functional targeted nanoparticles in various sizes and shapes. The integration of diagnosis and therapeutic capabilities within a single entity, known as nanotheranostics, is promising for real-time monitoring of disease progression and evaluating therapeutic treatment efficacy.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Florence Franconi, Laurent Lemaire, Jean-Christophe Gimel, Samuel Bonnet, Patrick Saulnier
Summary: NMR-based diffusion methods are valuable tools for nanomedicine characterization and understanding interactions with the biological environment. They provide insights into diffusion phenomena and measurement of self-diffusion and mutual diffusion coefficients. NMR diffusometry spectroscopic and imaging methods have broad applications in nanomedicine, aiding in elucidating important issues.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Qiuhui Hu, Bo Zhang, Huiming Ren, Xiaoxuan Zhou, Chengbin He, Youqing Shen, Zhuxian Zhou, Hongjie Hu
Summary: This study introduces a facile and degradable self-assembly ss-cyclodextrin metal-organic framework (ss-CD-MOF) nanoplatform for customizable multifunctional imaging. The nanoparticles obtained with favorable morphology and size were functionalized with probes for multiple biomedical imaging. These ss-CD-MOF-based nanoparticles showed superior performance compared to small molecular probes, demonstrating their potential for developing safe and multifunctional imaging probes.
ACTA BIOMATERIALIA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefania Montemezzi, Giuseppe Cardano, Silvia Storer, Nicolo Cardobi, Carlo Cavedon, Lucia Camera
Summary: This study demonstrates the feasibility and efficacy of using DWI in MRI-guided breast biopsies for accurate lesion targeting and device positioning. DWI can effectively detect both mass and non-mass lesions with a minimum size of 5 mm.
EUROPEAN RADIOLOGY
(2021)
Review
Chemistry, Analytical
Dongxu Zhao, Jian Cao, Lei Zhang, Shaohua Zhang, Song Wu
Summary: This article summarizes the importance of early diagnosis of hepatocellular carcinoma (HCC) and the limitations of current diagnostic methods. It introduces the applications of molecular imaging and MRI in HCC diagnosis, and discusses the prospects of developing molecular imaging probes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jie Chen, Chunchao Xia, Ting Duan, Likun Cao, Hanyu Jiang, Xijiao Liu, Zhen Zhang, Zheng Ye, Zhenru Wu, Ronghui Gao, Yujun Shi, Bin Song
Summary: Necrosis or severe ischemia was found to be a sensitive imaging feature of MTM-HCC, with a high specificity. The combination of specific findings allowed for noninvasive prediction of this subtype with good accuracy and excellent specificity.
EUROPEAN RADIOLOGY
(2021)
Review
Environmental Sciences
B. H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Saad Ali Alshehri, Shadma Wahab, Lalitkumar K. Vora, Raghu Raj Singh Thakur, Prashant Kesharwani
Summary: Lyotropic liquid crystals, specifically cubosomes, are highly promising drug carriers due to their self-assembled, non-lamellar, and mesophase nanostructured properties. Cubosomes exhibit bicontinuous structures formed through the self-organization of amphiphilic lipids and stabilization using steric polymers. They have shown superior entrapment efficiency and stability for hydrophobic drugs compared to liposomes. Additionally, cubosomes have been extensively explored for their safe and effective delivery of therapeutic and contrast agents in cancer treatment and imaging.
ENVIRONMENTAL RESEARCH
(2023)
Review
Medicine, Research & Experimental
Beatriz Brito, Thomas W. Price, Juan Gallo, Manuel Banobre-Lopez, Graeme J. Stasiuk
Summary: This review introduces smart theranostics that integrate multiple functions, especially responsive agents for MRI, aiming to improve cancer therapy efficiency and diagnostic accuracy. The challenges and obstacles in the design and application are also discussed.
Article
Clinical Neurology
Feifei Zhang, Hongsheng Xie, Song Wang, Fei Li, Qiyong Gong, Zhiyun Jia
Summary: This study found that the volume of the right orbitofrontal cortex was negatively correlated with exercise addiction. The function of the right orbitofrontal cortex played an indirect role in exercise addiction and affected it through its volume. The volume of the right orbitofrontal cortex mediated the relationship between ability motivation and exercise addiction.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Environmental Sciences
Kathryn E. Anderssen, Geir Wing Gabrielsen, Mathias Kranz, France Collard
Summary: Monitoring plastic ingestion by marine wildlife is crucial for understanding the extent of plastic pollution and its impact on species and ecosystems. Current detection methods are slow and invasive, limiting the number of animals that can be screened. This study explores the use of MRI as a rapid and non-invasive method to detect plastic ingestion. The results show that MRI and NMR can directly or indirectly detect plastic in the digestive system of animals, with distinctive NMR signal characteristics for each type of plastic. While commercial MRI technology is not suitable for field use, existing single-sided MRI research systems could be adapted for monitoring wildlife outside the laboratory.
MARINE POLLUTION BULLETIN
(2022)
Article
Medicine, Research & Experimental
Bin Song, Young Cha, Sanghyeok Ko, Jeha Jeon, Nayeon Lee, Hyemyung Seo, Kyung-Joon Park, In-Hee Lee, Claudia Lopes, Melissa Feitosa, Maria Jose Luna, Jin Hyuk Jung, Jisun Kim, Dabin Hwang, Bruce M. Cohen, Martin H. Teicher, Pierre Leblanc, Bob S. Carter, Jeffrey H. Kordower, Vadim Y. Bolshakov, Sek Won Kong, Jeffrey S. Schweitzer, Kwang-Soo Kim
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Clinical Neurology
Diane Joss, Sara W. Lazar, Martin H. Teicher
PSYCHIATRY RESEARCH-NEUROIMAGING
(2020)
Article
Behavioral Sciences
Diane Joss, Alaptagin Khan, Sara W. Lazar, Martin H. Teicher
Summary: This pilot study examined bilateral amygdala volumetric changes among young adults with childhood maltreatment histories undergoing mindfulness intervention, finding significant variability in amygdala changes across individuals; changes in right amygdala volume correlated with baseline volumes, with larger amygdala showing volume increase and smaller amygdala decreasing; increasing right amygdala volume was associated with higher intervention compliance and greater self-compassion, while increasing left amygdala volume was linked to reduced perceived stress, rejection sensitivity, and interpersonal distress.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Psychiatry
Fredric Schiffer, Alaptagin Khan, Elizabeth Bolger, Edward Flynn, William P. P. Seltzer, Martin H. H. Teicher
Summary: The study evaluated unilateral transcranial photobiomodulation as a treatment for opioid use disorder in a randomized controlled trial involving 39 participants at 2 sites. The findings showed that the active treatment significantly reduced opioid cravings and use compared to the sham treatment, with improvements observed in both buprenorphine users and non-users. No adverse effects were reported in either group.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Martin H. Teicher, Jeoffry B. Gordon, Charles B. Nemeroff
Summary: Childhood maltreatment is the most important preventable risk factor for psychiatric disorders. Those who have been maltreated tend to develop psychiatric disorders earlier, have more severe symptoms, more comorbidities, and respond less favorably to treatment compared to non-maltreated individuals. Additionally, maltreated individuals show distinct alterations in stress-susceptible brain regions, hormonal responses, and inflammatory markers, highlighting the need for a more nuanced approach to diagnosis and treatment in psychiatric disorders.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Kyoko Ohashi, Carl M. Anderson, Alaptagin Khan, Michael L. Rohan, Elizabeth A. Bolger, Cynthia E. McGreenery, Martin H. Teicher
Summary: This study aimed to investigate the impact of maltreatment on CC microstructure and its relationship with sex. The results showed that the most significant alterations in males were found in axial diffusivity, while in females, alterations were observed in radial diffusivity and fractional anisotropy. Sex differences, as well as the effects of maltreatment, brain size, and sociodemographic factors, were limited.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Clinical
Stian Orm, Per Normann Andersen, Martin Hersch Teicher, Ingrid Nesdal Fossum, Merete Glenne Oie, Erik Winther Skogli
Summary: Deficits in executive functions, particularly cognitive flexibility, during childhood can predict psychopathology symptoms in emerging adulthood, beyond the influence of ADHD symptoms.
RESEARCH ON CHILD AND ADOLESCENT PSYCHOPATHOLOGY
(2023)
Article
Psychiatry
Martin H. Teicher, Elizabeth Bolger, Poopak Hafezi, Laura C. Hernandez Garcia, Cynthia E. McGreenery, Leslie Weiser, Kyoko Ohashi, Alaptagin Khan
Summary: The aim of this study was to assess the efficacy of Brain Balance@ exercises and Interactive Metronome@ training on ADHD symptoms in children, and to provide information for the design of a randomized control trial. Results showed significant reduction of ADHD symptoms with these interventions, but limited improvement on ADHD rating system. More research is needed with higher participant retention rate and multiple ratings during treatment course.
PSYCHIATRY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jianjun Zhu, Carl M. Anderson, Kyoko Ohashi, Alaptagin Khan, Martin H. Teicher
Summary: Childhood maltreatment is a common risk factor for both risk aversive and risk-taking disorders, but the reasons behind the different outcomes are unclear. This study aimed to determine if the type and timing of maltreatment experiences during childhood can impact the development of psychopathology. Retrospective data on severity of maltreatment were collected and analyzed using predictive analytics. The results showed that emotional maltreatment during teenage years was associated with heightened response to threat, while early childhood exposure to witnessing violence and peer physical bullying was associated with greater activation to neutral faces. These findings suggest that different sensitive periods exist in the development of corticolimbic regions and highlight the importance of considering the developmental perspective when studying the consequences of maltreatment.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Karlen Lyons-Ruth, Banu Ahtam, Frances Haofei Li, Sarah Dickerman, Jennifer E. Khoury, Michaela Sisitsky, Yangming Ou, Michelle Bosquet Enlow, Martin H. Teicher, P. Ellen Grant
Summary: This study found that maternal withdrawal is associated with lower infant gray matter volume (GMV), while negative/inappropriate interaction is associated with lower overall white matter volume (WMV). Maternal withdrawal is also associated with reduced right hippocampal volume at older ages.
HUMAN BRAIN MAPPING
(2023)
Article
Multidisciplinary Sciences
Martin H. Teicher, Elizabeth Bolger, Laura C. Hernandez Garcia, Poopak Hafezi, Leslie P. Weiser, Cynthia E. Mcgreenery, Alaptagin Khan, Kyoko Ohashi
Summary: This study assessed whether the morning use of an LED bright light device could increase alertness in adolescents. The results showed a significant association between the degree of device use and increased frontal EEG power, improved math performance, reduced errors of omission on attention tests, enhanced connectivity in the brain, and improved sleep cycle consistency.
Review
Pediatrics
Mariesa Cay, Joseph Gonzalez-Heydrich, Martin H. Teicher, Hanne van der Heijden, Dost Ongur, Ann K. Shinn, Jaymin Upadhyay
Summary: Childhood maltreatment can alter neurobiological properties and negatively impact neurodevelopment, leading to the emergence of psychopathology and pain syndromes. Compensatory mechanisms, potentially instilled by robust psychosocial support systems, can help preserve function and minimize symptoms in maltreated children.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Meeting Abstract
Neurosciences
Emily Belleau, Thomas Bolton, Roselinde Kaiser, Rachel Clegg, Emilia Cardenas, Franziska Goer, Pia Pechtel, Miranda Beltzer, Gordana Vitaliano, David Olson, Martin Teicher, Diego Pizzagalli
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Psychology, Clinical
Christy A. Denckla, Dante Cicchetti, Laura D. Kubzansky, Soraya Seedat, Martin H. Teicher, David R. Williams, Karestan C. Koenen
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2020)
Article
Psychology, Clinical
Diane Joss, Sara W. Lazar, Martin H. Teicher