Article
Immunology
Sang-Ho Choi, Jin Won Huh, Sang-Bum Hong, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Heungsup Sung, Eun Jin Chae, Kyung-Hyun Do, Sang-Oh Lee, Chae-Man Lim, Yang Soo Kim, Jun Hee Woo, Younsuck Koh
Summary: In Seoul, South Korea, severe human bocavirus-associated pneumonia cases were reported in adults, with a mortality rate of 54.5%. Higher death rates were observed in cases of co-infection (83.3%) and immunocompromise (80.0%).
EMERGING INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
David Polo, Alberto Lema, Enia Gandara, Jesus L. Romalde
Summary: Through a systematic review and meta-analysis of 35 studies in Europe, it was found that HBoV has a moderate prevalence among European countries, with no significant differences in prevalence by country. The study also analyzed the prevalence of HBoV as a single infection or co-infection with other viruses.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Immunology
Chikara Ogimi, Emily T. Martin, Hu Xie, Angela P. Campbell, Alpana Waghmare, Keith R. Jerome, Wendy M. Leisenring, Filippo Milano, Janet A. Englund, Michael Boeckh
Summary: BoV respiratory tract infections in transplant recipients are rare and associated with mild symptoms. Risk factors for acquisition include younger age and exposure to children.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Microbiology
Sandra Trapani, Alice Caporizzi, Silvia Ricci, Giuseppe Indolfi
Summary: Human bocavirus (HBoV) has emerged as an increasingly reported pathogen, primarily associated with respiratory tract infections in adults and children. It can act as a co-infectious agent or an isolated viral pathogen, and has also been found in asymptomatic individuals. This review provides an overview of HBoV's epidemiology, risk factors, transmission, pathogenicity, detection methods, and clinical features, including severe infections requiring hospitalization and rare fatal cases. Tissue viral persistence, reactivation, reinfection, and the burden of HBoV disease are also evaluated.
Article
Virology
Fang-Fei You, Min-Yi Zhang, Fei Wu, Qiu-Shuang Li, Qing Chen
Summary: The study found human bocavirus (HBoV) in Rattus norvegicus captured in China, indicating that R. norvegicus may be a carrier of HBoV. Phylogenetic analysis revealed that the virus is closely related to HBoV-2, which is of significant importance for public health.
ARCHIVES OF VIROLOGY
(2022)
Article
Medicine, Research & Experimental
Xingang Zhang, Jishan Zheng, Lihua Zhu, Huiqing Xu
Summary: This study investigated the prevalence and clinical characteristics of human bocavirus (HBoV) infection in infants with acute lower respiratory tract infection in China. The results showed that HBoV was frequently detected in infants, with the highest prevalence in winter. Co-infection was common, especially in infants requiring intensive care unit admission. Clinical symptoms included cough, fever, and respiratory distress.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Microbiology
Wenjing Wang, Renzheng Guan, Ziran Liu, Feng Zhang, Rui Sun, Sitong Liu, Xiaoyan Shi, Zhilei Su, Rongxiang Liang, Kangyu Hao, Zhaoguo Wang, Xianming Liu
Summary: Persistent infection and prolonged shedding of human bocavirus 1 (HBoV1) in children have been reported, but its role as a sole causative pathogen in acute respiratory infection (ARI) is yet to be established. This study aimed to explore the pathogenicity of HBoV in ARI patients and found that HBoV1 was detected in 28.1% of the samples, with a high rate of coinfection with bacteria. Clinical characterization suggested organ function impairment and the importance of disinfection and sterilization practices. Further investigation on the interactions between HBoV and other pathogens is needed.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemical Research Methods
Janet Ong, Stacy Soh, Soon Hoe Ho, Annabel Seah, Borame Sue Dickens, Ken Wei Tan, Joel Ruihan Koo, Alex R. Cook, Daniel R. Richards, Leon Yan-Feng Gaw, Lee Ching Ng, Jue Tao Lim
Summary: This study demonstrates the utility of the effective reproduction number R-t for real time dengue surveillance. Using data from Singapore, the study estimated R-t and identified environmental and anthropogenic factors that drive its transmission potential. Real time estimation of R-t can assist public health agencies in identifying high transmission risk areas and facilitating local outbreak preparedness and response.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Virology
Mengxiao Luo, Mario Mietzsch, Paul Chipman, Kangkang Song, Chen Xu, John Spear, Duncan Sousa, Robert McKenna, Maria Soderlund-Venermo, Mavis Agbandje-McKenna
Summary: Human bocaviruses (HBoVs) infect children and immunocompromised individuals, resulting in respiratory and gastrointestinal infections. This study compared the capsid structures of HBoV2 with previously determined HBoV1, HBoV3, and HBoV4, revealing strain and genus-specific features contributing to tissue tropism and antigenicity. Additionally, analyzing HBoV1 and HBoV2 structures under acidic conditions provided insights into capsid changes associated with endosomal and gastrointestinal acidification, unraveling the molecular mechanism of HBoV infection.
JOURNAL OF VIROLOGY
(2021)
Article
Pediatrics
Xifeng Tang, Ge Dai, Ting Wang, Huiming Sun, Wujun Jiang, Zhengrong Chen, Yongdong Yan
Summary: In this study, the clinical data of hospitalized children with lower respiratory tract infections caused by human bocavirus (HBoV) and human metapneumovirus (hMPV) were compared. The detection rate of HBoV was significantly higher than that of hMPV. Compared to hMPV, HBoV is more likely to cause severe infection and has a greater impact on children.
FRONTIERS IN PEDIATRICS
(2023)
Article
Microbiology
Rima Jeske, Larissa Dangel, Leander Sauerbrey, Dimitrios Frangoulidis, Lauren R. Teras, Silke F. Fischer, Tim Waterboer
Summary: The bacterium Coxiella burnetii (C. burnetii) is the causative agent of Q fever and has gained increasing interest due to outbreak events and its potential risk factor for lymphoma development. Multiplex serology using nine C. burnetii proteins showed promising results with specific antigens Com1 and GroEL achieving the highest sensitivity and specificity in detecting infections. This technology is valuable for investigating associations between C. burnetii infections and clinical manifestations in large-scale studies.
Review
Pediatrics
Jing Liao, Zhongying Yang, Yu He, Jianhua Wei, Luo Ren, Enmei Liu, Na Zang
Summary: This case report highlights a severe respiratory tract infection caused by HBoV1 in a child without other pathogen infections, leading to severe pneumonia and ARDS.
FRONTIERS IN PEDIATRICS
(2022)
Article
Virology
Kai Ji, Jinhan Sun, Yan Yan, Lei Han, Jianhui Guo, Anwen Ma, Xueqi Hao, Fang Li, Yuning Sun
Summary: HBoV was detected in 10.0% of children with CAP, with a peak incidence in children < 2 years old and predominantly in autumn and winter. Co-infection with bacteria and other respiratory viruses was common, and a higher incidence of severe pneumonia was found in HBoV-positive patients compared to HBoV-negative cases.
Article
Biotechnology & Applied Microbiology
Kattareeya Kumthip, Pattara Khamrin, Hiroshi Ushijima, Niwat Maneekarn
Summary: Human bocavirus is recognized as an important pathogen causing respiratory infection and acute gastroenteritis in young children worldwide and has been detected in various environmental samples. This study found evidence of HBoV in oysters in Thailand, emphasizing the need for further monitoring of the potential food- and waterborne transmission of this virus.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Review
Microbiology
Liting Shao, Weiran Shen, Shengqi Wang, Jianming Qiu
Summary: Human bocavirus 1 (HBoV1) is an autonomous human parvovirus that causes acute respiratory tract infections in children and infects human airway epithelial cells in vitro. It expresses multiple proteins and RNA, playing important roles in viral gene expression and replication, and serving as a helper virus for other viruses in human cells.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Orthopedics
Joshua W. Hustedt, Oren Goltzer, Daniel D. Bohl, James F. Fraser, Nina J. Lara, Mark J. Spangehl
JOURNAL OF ARTHROPLASTY
(2017)
Article
Orthopedics
Joshua W. Hustedt, Andrew Chung, Daniel D. Bohl, Neil Olmschied, Scott G. Edwards
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2017)
Article
Medicine, General & Internal
O. Olugbuyi, K. Swaby, P. Roberts, C. Christie, N. Kissoon
WEST INDIAN MEDICAL JOURNAL
(2018)
Article
Infectious Diseases
A. E. Ades, Claire Thorne, Antoni Soriano-Arandes, Catherine S. Peckham, David W. Brown, Daniel Lang, J. Glenn Morris, Celia D. C. Christie, Carlo Giaquinto
LANCET INFECTIOUS DISEASES
(2020)
Article
Medicine, General & Internal
A. E. Ades, Elizabeth B. Brickley, Neal Alexander, David Brown, Thomas Jaenisch, Democrito de Barros Miranda-Filho, Moritz Pohl, Kerstin D. Rosenberger, Antoni Soriano-Arandes, Claire Thorne, Ricardo Arraes de Alencar Ximenes, Thalia Velho Barreto de Araujo, Vivian Avelino-Silva, Sarah Esperanza Bethencourt Castillo, Victor Hugo Borja Aburto, Patricia Brasil, Celia D. C. Christie, Wayner Vieira de Souza, H. Jose Eduardo Gotuzzo, Bruno Hoen, Marion Koopmans, Celina Maria Turchi Martelli, Mauro Martins Teixeira, Ernesto T. A. Marques, Maria Consuelo Miranda, Ulisses Ramos Montarroyos, Maria Elisabeth Moreira, J. Glenn Morris, Barry Rockx, Paola Mariela Saba Villarroel, Carmen Soria Segarra, Adriana Tami, Marilia Dalva Turchi, Carlo Giaquinto, Xavier de Lamballerie, Annelies Wilder-Smith
Article
Infectious Diseases
Kadine Orrigio, Russell Bernard Pierre, Diahann Gordon-Harrison, Kaye Lewis-O'Connor, Georgiana Gordon-Strachan, Celia Dana Claire Christie
Summary: The study found a significant association between early sexual initiation and the risk factors for early sexual initiation and the complications associated with it. Prompt medical, legal, and psychosocial interventions are crucial for preventing the spread of HIV/AIDS among children and adolescents.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2021)
Article
Medicine, General & Internal
Aileen May Lue, Michelle-Ann Elizabeth Hue Richards-Dawson, Georgiana Marie Gordon-Strachan, Syed Matthew Kodilinye, Jacqueline Anne Theresa Dunkley-Thompson, Tracia Dahlia James-Powell, Curtis Alphonso Pryce, Chadwic De'sean Mears, Joshua James Anzinger, Karen Webster-Kerr, Celia Dana Claire Christie
Summary: In 2019, Jamaica experienced its largest dengue outbreak in 40 years, following previous epidemics of Zika virus and Chikungunya. The outbreak mainly affected children aged 1-10 years, and severe dengue resulted in a high mortality rate.
FRONTIERS IN MEDICINE
(2022)
Article
Orthopedics
Clayton H. Hui, Haroon Kisana, John R. Martin, Chad Steecher, Thomas Carter, Evan Lederman, Joshua W. Hustedt
Summary: This study aimed to examine the trends in physician professional fees and inpatient and outpatient facility fees in orthopaedic surgery in the United States. It was found that from 2008 to 2021, physician professional fees decreased by an average of 20%, while inpatient facility fees increased by 15% and outpatient facility fees increased by 72%.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2023)
Article
Pediatrics
Crista-Lee Shahine Berry, Roxanne Helene Melbourne-Chambers, Abigail Natalie Harrison, Joshua James Anzinger, Kelly-Ann Maxorinthia Gordon-Johnson, Varough Mohamed Deyde, Celia Dana Claire Christie
Summary: This study described pediatric COVID-19 situation in a developing country within the Caribbean. Most infected children had mild symptoms, while MIS-C patients showed more organ involvement and abnormal inflammatory biomarkers, with minimal critical care interventions and excellent outcomes.
FRONTIERS IN PEDIATRICS
(2022)
Article
Orthopedics
Joshua W. Hustedt, Sorka T. Deeyor, Clayton H. Hui, Arjun Vohra, Aaron C. Llanes, Briana L. Silvestri
Summary: This study compared the functional outcomes, pain reduction, and quality of life between denervation and suspension arthroplasty in patients treated for thumb carpometacarpal osteoarthritis. The results showed that denervation provided similar short-term outcomes and a quicker return to function, although the long-term outcomes remain unknown.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2023)
Review
Pediatrics
Celia D. C. Christie, Aileen M. Lue, Roxanne H. Melbourne-Chambers
Summary: This review discusses the impact of dengue, chikungunya, and zika on children in the Caribbean. Dengue is becoming more severe in the region and has increased morbidity and mortality in children. Chikungunya had an explosive epidemic in the Caribbean, with children under 5 years old being the most affected. Zika has a seroprevalence of 15% in pregnancy and causes various complications in children.
CURRENT OPINION IN PEDIATRICS
(2023)
Article
Orthopedics
Joshua W. Hustedt, Nicholas Chartrand, Dallin Merrell, Rachel Reichenbach, Eric Pinkston, Chad Stecher
Summary: Age has a moderating effect on the effectiveness of surgical treatment for intra-articular distal radius fractures in older adults. The older the age, the lower the effectiveness of surgical treatment. Patients aged <70 years may experience clinically meaningful improvement from surgery. Patients aged 70-80 years may still benefit from surgery but with decreasing effectiveness. Patients aged >80 years are unlikely to experience clinically significant improvement from surgical treatment.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2023)
Article
Health Care Sciences & Services
Elisa Ruiz-Burga, Patricia Bruijning-Verhagen, Paulette Palmer, Annalisa Sandcroft, Georgina Fernandes, Marieke de Hoog, Lenroy Bryan, Russell Pierre, Heather Bailey, Carlo Giaquinto, Claire Thorne, Celia D. C. Christie
Summary: This study evaluated the use of a smartphone app (ZIKApp) for self-reporting arbovirus symptoms and monitoring pregnancy complications in a cohort of pregnant women in an arbovirus-endemic region. The results showed that most women had good adherence to using the app and found it easy to understand and use.
JMIR FORMATIVE RESEARCH
(2022)
Letter
Immunology
Joshua J. Anzinger, Chadwic D. Mears, A. E. Ades, Keisha Francis, Yakima Phillips, Ynolde E. Leys, Moira J. Spyer, David Brown, Ana M. Bispo de Filippis, Eleni Nastouli, Thomas Byrne, Heather Bailey, Paulette Palmer, Lenroy Bryan, Karen Webster-Kerr, Carlo Giaquinto, Claire Thorne, Celia D. C. Christie, Brittiana Brown, Leroy Campbell, Carla Giaquinto, Georgiana Gordon-Strachan, Marlyn Grindley, Donna Kamicka, Clayton Kelly, John Lindo, Paul Mitchell, Orville Morgan, Alexander Onyonyor, Russell Pierre, Amanda Rousseau, Sofier Scott
Summary: To determine the extent of exposure to Zika virus (ZIKV) and chikungunya virus (CHIKV) in Jamaica, serum samples from 584 pregnant women were collected during 2017-2019. The results showed that 15.6% had antibodies against ZIKV and 83.6% against CHIKV. These findings suggest a potential recirculation of ZIKV in the near future, but not CHIKV.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Health Policy & Services
Flavia DeSouza, Elijah Paintsil, Teisha Brown, Russell Pierre, Danya Keene, Nancy Kim, Celia Christie
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2019)
