Article
Medicine, Research & Experimental
Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin, Haifeng Zhang
Summary: The study reveals that CYP2E1 plays a role in hepatocarcinogenesis by manipulating the Wnt/Dvl2/beta-catenin pathway through inducing ROS accumulation, which leads to the inhibition of tumor growth and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Dan Fang, Mu-Ru Wang, Jia-Lun Guan, Ying-Ying Han, Jia-Qi Sheng, De-An Tian, Pei-Yuan Li
Summary: The study found that in HCC, high expression of BRD9 was closely related to malignancy, tumor stage, tumor size, and prognosis. BRD9 promoted cell proliferation and tumor growth, and mediated its effects by activating the Wnt/beta-catenin signaling pathway.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yuyuan Zi, Jie Gao, Chenglv Wang, Yidi Guan, Linzhao Li, Xinxin Ren, Lan Zhu, Yun Mu, Shuang-hui Chen, Zimei Zeng, Zhen Cao, Zhuoxian Rong, Pan Chen, Xiuping Zhang, Tao Chen, Haiguang Xin, Xuebing Li, Zhi Li, Lunquan Sun, Yuezhen Deng, Nan Li, Yingjie Nie
Summary: This study reveals that Pantothenate kinase 1 (PANK1) acts as a negative regulator of Wnt/beta-catenin signaling in hepatocellular carcinoma (HCC). Downregulation of PANK1 in HCC is associated with clinical features. Knockdown of PANK1 promotes HCC cell proliferation, growth, and invasion, while overexpression of PANK1 suppresses these processes. Mechanistically, PANK1 interacts with CK1 alpha and phosphorylates N-terminal residues in beta-catenin.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Zhi Li, Hai-Yan Yang, Xiao-Lan Zhang, Xu Zhang, Yu-Zhou Huang, Xin-Yuan Dai, Liang Shi, Guo-Ren Zhou, Ji-Fu Wei, Qiang Ding
Summary: This study revealed that KIF23 is up-regulated in TNBC and is associated with poor prognosis. KIF23 promotes TNBC proliferation, migration, and invasion by activating the Wnt/beta-catenin pathway and inducing epithelial-mesenchymal transition (EMT). The WDR5/FOXM1/KIF23/Wnt/beta-catenin axis may serve as a promising therapeutic target for TNBC treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Vikash Singh, Vonn Walter, Irina Elcheva, Yuka Imamura Kawasawa, Vladimir S. Spiegelman
Summary: In this study, the role of IGF2BP1 in the post-transcriptional regulation of Wnt/beta-catenin-induced genes in colorectal cancer (CRC) cells was investigated using iCLIP and RNA sequencing techniques. The study revealed that CRC cells exhibit a stronger dependency on IGF2BP1 expression for Wnt/beta-catenin-regulated genes compared to normal cells. iCLIP analysis showed significant changes in IGF2BP1-binding sites and enrichment of 6-mer motifs associated with IGF2BP1 binding in response to Wnt/beta-catenin signaling. Additionally, a signature of IGF2BP1-regulated genes significantly associated with colon cancer-free survival in humans was identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Jian Chen, Jia Liu, Shimin Chen, Ruijun Lai, Chuanchuan Zheng, Jialiang Lu, Xinshao Jiang, Feng He, Chengliang Yang, Kai Li, Kegong Xie, Yujin Tang, Liqiang Wang
Summary: Salinomycin may be a promising therapeutic drug for osteoarthritis (OA) as it has shown protective effects on cartilage cells, reduces disease-associated changes, and delays cartilage destruction and osteophyte formation. Its mechanism of action may involve regulating cell synthesis and inhibiting degradation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Senwen Feng, Junhao Liu, Hailiang Li, Jianfan Wen, Yujun Zhao, Xiaofeng Li, Guankun Lu, Peng Gao, Xiancheng Zeng
Summary: RAD54B is significantly upregulated in HCC and may serve as a potential prognostic marker and therapeutic target; RAD54B promotes HCC progression mainly through modulating the Wnt/β-catenin signaling pathway; Inhibition of the Wnt/β-catenin signaling pathway can counteract the activating effects of RAD54B on the motility of HCC cells.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Huamei Wei, Lizheng Huang, Qi Lu, Zheng Huang, Yanyan Huang, Zuoming Xu, Wenchuan Li, Jian Pu
Summary: m6A-modified LEAWBIH exerts oncogenic effects in hepatocellular carcinoma (HCC) by stabilizing LEAWBIH transcript and activating Wnt/β-catenin signaling pathway. This study provides a promising therapeutic target for HCC.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)
Article
Immunology
Runxiao Lv, Lili Du, Lunhao Bai
Summary: This study finds that RNF125 plays an important role in osteoarthritis (OA). Moderate physical exercise can protect cartilage, while the overexpression of RNF125 can inhibit the degradation of extracellular matrix in chondrocytes. RNF125 may be a novel biomarker for OA therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
David Buechel, Nami Sugiyama, Natalia Rubinstein, Meera Saxena, Ravi K. R. Kalathur, Fabiana Luond, Vida Vafaizadeh, Tomas Valenta, George Hausmann, Claudio Cantu, Konrad Basler, Gerhard Christofori
Summary: The transcriptional activity of beta-catenin plays a crucial role in the malignant progression of breast cancer, affecting tumor growth, invasion, and metastasis formation. This contrasts its adhesion function, highlighting the importance of Wnt/beta-catenin-dependent transcription in cancer progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Xinbing Yang, Yajing Du, Lulu Luo, Xinru Xu, Shizheng Xiong, Xueni Yang, Li Guo, Tingming Liang
Summary: Dysregulated expression of specific non-coding RNAs (ncRNAs) has been strongly linked to tumorigenesis, cancer progression, and therapeutic resistance. Recent evidence suggests that ncRNAs can interact with the Wnt/beta-catenin signaling pathway, influencing the expression of Wnt target genes in cancer cells. This review aims to unravel the complex associations between ncRNAs and the Wnt/beta-catenin signaling pathway and explore their potential implications for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Yinghui Liu, Jingjing Ma, Shimin Lu, Pengzhan He, Weiguo Dong
Summary: This study found that USP25 was overexpressed in hepatocellular carcinoma (HCC) and its high expression was closely associated with poor prognosis. USP25 promoted the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of HCC cells by interacting with TRIM21 to activate the beta-catenin signaling pathway.
CHINESE MEDICAL JOURNAL
(2023)
Article
Anatomy & Morphology
Chunyi Ji, Lijian Chen, Miaoxian Yuan, Weixin Xie, Xinyi Sheng, Qiang Yin
Summary: This study investigates the mechanism of KDM1A-regulated hepatoblastoma (HB) development. The expression levels of KDM1A and DKK3 were analyzed in HB patients, and experiments were conducted on cell lines and nude mice to study the effects of knockdown of KDM1A and DKK3. The results suggest that KDM1A stimulates HB development by activating the Wnt/beta-catenin pathway through inhibition of DKK3 transcription.
Review
Oncology
Molly L. Parrish, Russell R. Broaddus, Andrew B. Gladden
Summary: Endometrial carcinoma is the most diagnosed gynecological malignancy in Western countries, with rising incidence and mortality rates. Mutations in exon 3 of the CTNNB1 gene may lead to decreased progression-free survival in a subset of patients with endometrioid EC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Lei Ren, Hong Deng, Yu Jiang, Chunfeng Liu
Summary: This study investigates the dual regulation of EZH2 and KDM6A in the upstream modulation of SALL4, promoting GC cell progression via the Wnt/beta-catenin pathway. The results show that SALL4 is upregulated in GC cells and regulates the progression and invasion of GC cells through the Wnt/beta-catenin pathway, which can be separately upregulated or downregulated by KDM6A or EZH2.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Geochemistry & Geophysics
Lei Wang, Ping Qiao, Zhiqiang Li, Pan Zhang, Shaogui Deng, Yiren Fan
Summary: Compact and stable formulas are developed for the computation of triaxial electromagnetic logging responses in multilayered formations. The formulas are based on a new global amplitude propagator matrix (GAPM) algorithm and an efficient inverse Fourier transform technique. Numerical experiments demonstrate the suitability of these formulas for various geological conditions.
Article
Computer Science, Information Systems
Xiaogen Zhou, Zhiqiang Li, Yuyang Xue, Shun Chen, Meijuan Zheng, Cong Chen, Yue Yu, Xingqing Nie, Xingtao Lin, Luoyan Wang, Junlin Lan, Gang Chen, Min Du, Ensheng Xue, Tong Tong
Summary: In this paper, a cascaded unsupervised-based strategy (CUSS-Net) is proposed to improve the performance of the supervised CNN framework in white blood cell and skin lesion segmentation and classification. CUSS-Net consists of an unsupervised-based strategy (US) module, an enhanced segmentation network named E-SegNet, and a mask-guided classification network called MG-ClsNet. Experimental results show that CUSS-Net outperforms other state-of-the-art approaches.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Chemistry, Multidisciplinary
Zhiqiang Li, Jinpeng Zhao, Lulu Liu, Zhe Li
Summary: A physical model test was conducted on an alpine tunnel in Qinghai Province using the Osaka Mountain tunnel. By analyzing the data and utilizing the Surfer software, the temperature variation trends and vector graph of the tunnel were obtained. The freezing front characteristics of the tunnel under airflow conditions were systematically analyzed, and the governing equations for the freezing front in the tunnel model were proposed. The results showed that the ventilation significantly influenced the temperature distribution of the tunnel, with greater wind speeds resulting in stronger effects. The freezing front distance was largest in the inverted arch area, and the freezing front expansion in the wall foot area was higher than in the vault area. The freezing front demonstrated a parabolic attenuation, gradually easing and disappearing with increased tunnel depth.
APPLIED SCIENCES-BASEL
(2023)
Article
Agricultural Engineering
Meixin Wang, Yawei Zhan, Jiayue Zhao, Zhiqiang Li
Summary: In this research, p-toluenesulfonic acid was used to pretreat bamboo and investigate the extraction and depolymerization of hemicellulose. The maximum extraction yield of hemicellulose was found to be 95.16% under the conditions of 5% p-toluenesulfonic acid, 140 degrees C, and 30 minutes. The depolymerized components of hemicellulose in the filtrate were mainly xylose and xylooligosaccharide, with xylobiose accounting for 30.77%. This research provides a potential strategy for industrial production of xylose and xylooligosaccharide from bamboo and for future conversion and utilization.
BIORESOURCE TECHNOLOGY
(2023)
Article
Chemistry, Physical
Jie Wei, Ling Cao, Zhiqiang Li, Yanmei Wang, Bing Jin, Song Zhang
Summary: The ultrafast dynamics of 3,4-difluoroaniline is studied using time-resolved velocity map imaging and mass spectroscopy. After excitation to the S1 state at 299.6 or 291.8 nm, the relaxation process is characterized by three decay components. The hundreds-of-picosecond decay is attributed to intersystem crossing to triplet state and subsequent relaxation, while the dynamics in hundreds-of-femtoseconds for two excitations show differences, possibly due to molecules leaving the Franck-Condon region at 299.6 nm and intramolecular vibrational energy redistribution at 291.8 nm with highly vibrational excitation.
CHEMICAL PHYSICS LETTERS
(2023)
Article
Chemistry, Applied
Guizhen Yu, Qingyu Niu, Xiao Liu, Liang He, Jinxie Yu, Hang Han, Wenjing Wang, Ying Zhang, Zhiqiang Li, Qingqing Xiong
Summary: Hybrid anisotropic hydrogel is created by dispersing carbon quantum dots and ultrahigh magnetic nanoparticle-coated alumina (Fe/Al2O3) platelets in acrylamide aqueous solution with the assistance of a magnetic field, and then fixing the oriented structure through gelation. The aligned Fe/Al2O3 platelets lead to the formation of anisotropic structure, providing mechanical and fluorescent anisotropy to the hydrogels. White-light emission is achieved by adjusting the weight ratio of yellow-emitting ZnO QDs and blue-emitting N,S-CDs. This approach not only enriches the field of mechanical/fluorescent dual anisotropic soft materials, but also holds significant potential in organic light-emitting diodes, nonlinear optics, and field effect transistors.
Article
Energy & Fuels
Lin Li, Tiantian Liu, Zhiqiang Li, Xiangjun Chen, Lin Wang, Shuailong Feng
Summary: Spontaneous combustion of coal in coal mine goafs can lead to methane accumulation, increasing the risk of methane explosion disasters. This study investigates the impact of ventilation dilution on possible methane explosions during the spontaneous combustion of coal using a validated gas flow model. The research findings suggest that ventilation dilution can effectively dilute methane concentration and reduce the risk of methane explosions when coal combustion occurs on the air-inlet side, but it can increase the explosion risk if coal combustion takes place on the air-return side. This provides important insights for managing ventilation during spontaneous coal combustion disasters in coal mine goafs with methane.
Article
Environmental Sciences
Zongqiang Hu, Gang Chen, Chuntao Yan, Zhiqiang Li, Tao Wu, Li Li, Shengning Zhang
Summary: This study confirmed the role of autophagy in hepatic fibrosis and its effects on macrophage polarization and exosome secretion by establishing hepatic fibrosis model and co-culture model, providing evidence for treatment.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xinyao Xia, Qiuhe Wei, Chunxia Xiao, Yiping Ye, Zhiqiang Li, Cecile Marivingt-Mounir, Jean-Francois Chollet, Wende Liu, Hanxiang Wu
Summary: A total of 408 gene members were identified from 5 maize inbred lines, and the NRT genes of maize were classified into NRT1/PTR (NPF), NRT2 and NRT3 subfamilies. Divergence of the duplication patterns of NRT genes were identified, providing a basis for classification and identification of maize varieties. Maize NRT transporters may have both positive and negative roles in the disease resistance response. This study will contribute to further understanding of the potential roles of NRT gene families in plant-pathogen interactions.
Article
Computer Science, Software Engineering
Zhiqiang Li, Hongyu Zhang, Xiao-Yuan Jing, Juanying Xie, Min Guo, Jie Ren
Summary: Cross-project defect prediction aims to identify defective software modules in a target project using historical data from other projects. However, existing methods often overlook the selection of appropriate source data and suffer from class imbalance issues. This paper proposes a non-parametric data selection and sampling based domain programming predictor (DSSDPP) which overcomes these limitations. DSSDPP learns a discriminative transfer classifier by leveraging the structures of source and target data, achieving better prediction results compared to competing methods in single-source and multi-source scenarios.
IEEE TRANSACTIONS ON SOFTWARE ENGINEERING
(2023)
Article
Genetics & Heredity
Francesco Perini, Filippo Cendron, Zhou Wu, Natalia Sevane, Zhiqiang Li, Chunhua Huang, Jacqueline Smith, Emiliano Lasagna, Martino Cassandro, Mauro Penasa
Summary: This study characterized the sequence variations associated with the dwarf phenotype in three Italian chicken breeds and investigated the genes associated with their phenotype. The results showed significant SNPs associated with dwarfism in the MERI and MUG breeds, which shared a candidate genomic region on chromosome 1. However, the PPP breed did not show any association with this region.
Editorial Material
Energy & Fuels
Zhiqiang Li, Ning Qin, Zhouguang Lu
Article
Geosciences, Multidisciplinary
Jigen Xia, Zhiqiang Li, Yongli Ji, Hengrong Zhang, Fangong Li, Junyi Li, Xingmeng Dong
Summary: In this study, the finite element method was used to analyze the micro-cylindrically focused logging tool in a three-dimensional non-uniform medium model. The logging response characteristics of the tool at different detection depths, mudcake thicknesses, flush zones, and mudcake resistivity contrasts were investigated. The least-squares method was used to obtain the flush zone resistivity, mudcake resistivity, and mudcake thickness, and the micropotential and microgradient curves were synthesized. A digital focusing method was proposed to improve the focusing accuracy and flexibility of the instrument, enhancing its performance.
FRONTIERS IN EARTH SCIENCE
(2023)
Article
Chemistry, Physical
Zhiqiang Li, Shuai Gu, Kemeng Liao, Hongzhi Wang, Lihong Yin, Yulin Cao, Ning Qin, Qingmeng Gan, Yingzhi Li, Zhenyu Wang, Shu Yin, Zhouguang Lu
Summary: This study proposes a renewable lithium dextran sulfate (LDS) binder that can dynamically bind to current collectors and metallic Li, and regulate Li-ion diffusion. The full cells with LDS coated Cu foil as anode exhibit excellent cycling stability and Coulombic efficiency.
MATERIALS TODAY ENERGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lingli Wu, Bin Ma, Fei Yu, Zhongming Ma, Qingtao Meng, Zhiqiang Li, Haijing Zhou
Summary: This study aimed to investigate the diversity of oral microbiome in children with different caries status based on dmft scores. A total of 320 children aged 3-5 years were recruited, including 66 healthy children and 254 children affected by dental caries. Illumina MiSeq sequencing was used to analyze the salivary samples. The results showed that the salivary microbial diversity among the four groups was similar. The oral microbial profiles differed in children with different caries status based on dmft scores.
CLINICAL ORAL INVESTIGATIONS
(2023)