Article
Public, Environmental & Occupational Health
Lars Louis Andersen, Jonas Vinstrup, Joaquin Calatayud, Ruben Lopez-Bueno, Thomas Clausen, Claus Manniche
Summary: This study examines the association between the use of analgesics and anxiolytic/sedative/hypnotic (ASH) medication and the risk of disability pension and mortality. The results show that frequent use of these medications increases the risk of disability pension and early death among workers. Better management of musculoskeletal and mental health conditions, without excessive medication use, is necessary.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Felicity Bishop, Miznah Al-Abbadey, Lisa Roberts, Hugh MacPherson, Beth Stuart, Dawn Carnes, Carol Fawkes, Lucy Yardley, Katherine Bradbury
Summary: This study aimed to identify significant predictors of patient outcomes, test psychological mediators, and compare effects across three treatment approaches. Results showed that stronger therapeutic alliance and higher patient satisfaction can significantly reduce back-related disability, while self-efficacy, pain perceptions, and psychosocial distress partially mediated these relationships.
Article
Medicine, General & Internal
Trond Roed Pettersen, Jan Schjott, Heather G. Allore, Bjorn Bendz, Britt Borregaard, Bengt Fridlund, Alf Inge Larsen, Jan Erik Nordrehaug, Svein Rotevatn, Tore Wentzel-Larsen, Tone Merete Norekval
Summary: After percutaneous coronary intervention (PCI), some patients still have concerns and uncertainties about the safety and efficacy of generic medicines. This mistrust and uncertainty are particularly prevalent among patients with lower socioeconomic status, older age, female sex, immigrants, and poorer mental health. However, this study demonstrates a shift towards more positive perceptions of generic medicines in the longer term.
Article
Orthopedics
Christina Lyngso Udby, Allan Riis, Janus Laust Thomsen, Nanna Rolving
Summary: Research found that using telephone reminders in a study of low back pain patients did not impact outcome estimates, and there were no differences in baseline characteristics between patients who responded before or after receiving the reminder call.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Anesthesiology
Wendelien H. van der Gaag, Alessandro Chiarotto, Martijn W. Heymans, Wendy T. M. Enthoven, Jantine Van Rijckevorsel-Scheele, Sita M. A. Bierma-Zeinstra, Arthur M. Bohnen, Bart W. Koes
Summary: This study aimed to develop and internally validate clinical prediction models for poor long-term outcomes in older patients with back pain. The results showed good overall performance of all 3 models, with the model predicting persistent disability performing the best. Common predictors in all models include age, chronic duration, disability, a recent back pain episode, and patients' recovery expectations.
Article
Anesthesiology
Monika Mueller, Lukas Buetikofer, Ole K. Andersen, Paul Heini, Lars Arendt-Nielsen, Peter Juni, Michele Curatolo
Summary: Trajectory analysis revealed that cold pain hypersensitivity is a strong predictor of worse recovery after spine surgery. Factors such as cold pain hypersensitivity, marital status, and duration of pain independently predicted recovery outcomes.
Article
Medicine, General & Internal
Jing Tian, Graeme Jones, Xin Lin, Yuan Zhou, Anna King, James Vickers, Feng Pan
Summary: This study investigates the association between the number of chronic pain sites and the risk of dementia and its subtypes. The findings suggest that a greater number of chronic pain sites is associated with an increased risk of all-cause dementia and Alzheimer's disease, but not vascular and frontotemporal dementia.
Article
Medicine, General & Internal
Pablo Hernandez-Lucas, Juan Lopez-Barreiro, Jose Luis Garcia-Soidan, Vicente Romo-Perez
Summary: The study indicates that implementing a theoretical-practical program based on the Back School has beneficial effects on low back functionality and reduces the number of medical visits due to low back pain in adult population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Purva Khare, James F. Conway, Devika S. Manickam
Summary: Lipidoid nanoparticles (LNPs) are successful carriers for nucleic acid delivery, but their ability to deliver small molecule drugs has not been reported. This study showed that delivering adenosine triphosphate (ATP) to brain endothelial cells (BECs) can increase cellular energetics. By utilizing the helper lipid PEG-DMG, the stability of ATP-loaded LNPs was maintained, resulting in increased uptake of ATP in BECs.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Public, Environmental & Occupational Health
C. Blumenberg, F. C. Wehrmeister, F. C. Barros, B. D. Flesch, F. Guimaraes, I Valerio, L. Z. Ferreira, M. Echeverria, S. A. Karam, H. Goncalves, A. M. B. Menezes
Summary: The study found that excessive use of mobile devices is associated with neck and low back pains, while excessive use of computers is only associated with neck pain. Therefore, guidelines should be developed to recommend the appropriate length of time for using computers and mobile devices to prevent back pain.
Article
Rehabilitation
Joannes M. Hallegraeff, Emiel van Trijffel, Ronald W. Kan, Martijn S. Stenneberg, Michiel F. Reneman
Summary: This study aimed to investigate the predictive role of illness perceptions in chronic low back pain and pain-related disability. It found that illness perceptions independently predicted chronic low back pain, but had a relatively low predictive value for pain-related disability.
Article
Anesthesiology
Christopher Eccleston, Emma Fisher, Sammeli Liikkanen, Toni Sarapohja, Carina Stenfors, Satu K. Jaaskelainen, Andrew S. C. Rice, Leena Mattila, Taru Blom, J. Raymond Bratty
Summary: Adults with chronic low back pain were recruited for a trial of a novel digital therapeutic intervention called DTxP. The study found that participants in the DTxP group reported greater reductions in fear of movement and better global impression of change when compared with sham placebo and standard care post treatment. No other significant group differences were noted at posttreatment or follow-up.
Article
Medicine, General & Internal
Indiara Soares Oliveira, Shaiane Silva Tomazoni, Adriane Aver Vanin, Amanda Costa Araujo, Flavia Cordeiro de Medeiros, Renan Kendy Ananias Oshima, Leonardo Oliveira Pena Costa, Luciola da Cunha Menezes Costa
Summary: This study describes the management strategies used in public emergency departments in a middle-income country for patients with acute non-specific low back pain. The results show that there is an acceptable rate of prescription for diagnostic imaging tests, but high medication prescriptions and low rates of referrals to other healthcare services.
Article
Multidisciplinary Sciences
Ruth Choe, Yu Fan Sim, Catherine H. L. Hong, Sameema Mohideen, Ranjani Nadarajan, Fabian Yap, Lynette P. -C. Shek, Chin-Ying Stephen Hsu, Birit F. P. Broekman, Joao N. Ferreira
Summary: In the Asian GUSTO birth cohort, this study found a relationship between early childhood socioemotional factors and oral health-related quality of life (OHRQoL), as well as an impact of orofacial pain (OFP) and early childhood caries (ECC) on OHRQoL. Additionally, internalizing behaviors and orofacial pain were identified as potential factors negatively affecting OHRQoL in early childhood. Further investigations in clinically relevant populations are warranted to better understand this complex relationship.
Article
Cardiac & Cardiovascular Systems
Hoa T. T. Vu, Richard Norman, Ngoc M. Pham, Hoai T. T. Nguyen, Hung M. Pham, Quang N. Nguyen, Loi D. Do, Hieu B. Tran, Rachel R. Huxley, Crystal M. Y. Lee, Tu M. Hoang, Christopher M. Reid
Summary: Patients undergoing PCI in Vietnam have relatively low adverse outcomes, with key factors including age over 75, male gender, acute myocardial infarction, left ventricular ejection fraction <= 40%, prior cerebral vascular disease, and unsuccessful PCI.
Review
Anesthesiology
Nick Christelis, Brian Simpson, Marc Russo, Michael Stanton-Hicks, Giancarlo Barolat, Simon Thomson, Stephan Schug, Ralf Baron, Eric Buchser, Daniel B. Carr, Timothy R. Deer, Ivano Dones, Sam Eldabe, Rollin Gallagher, Frank Huygen, David Kloth, Robert Levy, Richard North, Christophe Perruchoud, Erika Petersen, Philippe Rigoard, Konstantin Slavin, Dennis Turk, Todd Wetzel, John Loeser
Summary: The term "Failed back surgery syndrome (FBSS)" is considered inadequate and misleading for describing patients with persistent pain following spine surgery. The International Association for the Study of Pain (IASP) proposed "Chronic pain after spinal surgery (CPSS)" as a replacement term, which is now accepted by the World Health Organization (WHO). Through a structured workshop and Delphi process, "Persistent spinal pain syndrome" was selected as a preferred option and suggested for adoption to strengthen the new ICD-11 classification.
Article
Pharmacology & Pharmacy
Chui C. Chong, Stephan A. Schug
Summary: This study compared the clinical efficacy and tolerability of oral versus sublingual ketamine lozenges in adult patients with moderate-to-severe breakthrough pain. The sublingual administration of ketamine led to a faster onset of pain relief but also had a higher rate of adverse events. Overall, both sublingual and oral administration of ketamine produced similar analgesic effects.
CLINICAL DRUG INVESTIGATION
(2021)
Article
Anesthesiology
Jane Nikles, Gerben Keijzers, Geoffrey Mitchell, Scott F. Farrell, Siegfried Perez, Stephan Schug, Robert S. Ware, Samuel A. McLean, Luke B. Connelly, Michele Sterling
Summary: A double blind, placebo-controlled trial examined the potential effectiveness of pregabalin for acute whiplash-associated disorders (WADs). The results suggest that pregabalin may be more effective than placebo in reducing neck pain intensity, although feasibility issues need to be addressed.
Review
Rheumatology
Andrew M. Briggs, Helen Slater, Sharon Van Doornum, Lauren Pearson, Eliza C. Tassone, Lorena Romero, Jason Chua, Ilana N. Ackerman
Summary: Objective evidence has shown that chronic musculoskeletal pain conditions have an impact on sexual function, particularly in noninflammatory conditions. Poorer sexual function outcomes are consistently observed in cohorts with pain compared to comparison groups. Qualitative studies have identified impaired sexual function, compromised intimate relationships, and the effects of pain on sexual identity, body image, and self-worth. Consideration of these associations is important for providing holistic, person-centered musculoskeletal pain care.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Anesthesiology
Adrien Lemoine, Annemijn Witdouck, Helene Beloeil, Francis Bonnet, E. Albrecht, H. Beloeil, F. Bonnet, A. Delbos, S. Freys, A. Hill, G. P. Joshi, H. Kehlet, P. Lavand'homme, P. Lirk, D. Lobo, E. Pogatzki-Zahn, N. Rawal, J. Raeder, A. R. Sauter, S. Schug, M. Van de Velde
Summary: This review aimed to update optimal pain management recommendations after prostatectomy, highlighting the impact of different surgical approaches on postoperative pain levels. NSAIDs, COX-2 inhibitors, and continuous intravenous lidocaine were effective in reducing postoperative pain scores. TAP block was recommended as the first-choice regional analgesic technique for laparoscopic/robotic procedures, while intravenous lidocaine should be considered for open surgeries.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2021)
Review
Medicine, General & Internal
Stephan A. Schug
Summary: NSAIDs are an important non-opioid component of multimodal perioperative analgesia, but their potential harmful effects on healing after surgery and trauma remain controversial. Current animal data suggest potential harm, but are contradictory, while human data are limited and of poor quality. Well-designed and large randomized controlled trials are needed to provide definitive answers on the use of NSAIDs postoperatively.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Anesthesiology
S. Feray, J. Lubach, G. P. Joshi, F. Bonnet, M. Van de Velde
Summary: Video-assisted thoracoscopic surgery has become popular for its faster recovery and reduced postoperative pain. This systematic review analyzed 71 studies and recommended pre-intra-operative administration of basic analgesia, intra-operative dexmedetomidine infusion, and regional analgesic techniques for optimal pain management. Opioids should be used as rescue analgesics in the postoperative period.
Article
Health Care Sciences & Services
Margaret-Ann Tait, Daniel S. J. Costa, Rachel Campbell, Richard Norman, Stephan Schug, Claudia Rutherford
Summary: This study aims to collect real-world data to evaluate health-related quality of life in patients prescribed medicinal cannabis oil and describe any differences over time. The findings are expected to provide insights into whether patient-reported outcomes improve in patients accessing prescribed medicinal cannabis.
JMIR RESEARCH PROTOCOLS
(2021)
Article
Anesthesiology
Helen Slater, Joanne E. Jordan, Peter B. O'Sullivan, Robert Schutze, Roger Goucke, Jason Chua, Allyson Browne, Ben Horgan, Simone De Morgan, Andrew M. Briggs
Summary: This study identified the care-seeking priorities of people living with chronic pain and carers using the eDelphi method. The results revealed that important care-seeking priorities included validation, communication, multidisciplinary approaches, holistic care, partnerships, practitioner knowledge, self-management, medicines, and diagnosis. Cross-discipline health professionals agreed on the importance of these priorities and expressed confidence in their ability to support them.
Review
Rehabilitation
Aidan O'Shea, Jonathan Drennan, Chris Littlewood, Helen Slater, Julius Sim, Joseph G. McVeigh
Summary: This review aims to identify barriers and facilitators to self-management from the perspectives of people with shoulder pain and clinicians involved in their care. The findings highlight the importance of patient-centered support, patient and clinician beliefs, pain, and therapeutic response in influencing self-management. The included studies mostly focused on exercise-based rehabilitation, and further research is needed to explore barriers and facilitators to broader self-management.
CLINICAL REHABILITATION
(2022)
Article
Clinical Neurology
Gerardo A. Arwi, Penelope H. R. Tuffin, Stephan A. Schug
Summary: Compliance with discharge analgesia prescribing guidelines in a tertiary Australian hospital has increased but still needs improvement. The study reveals high rates of unused opioids and improper storage and disposal of pain medication.
JOURNAL OF PAIN RESEARCH
(2022)
Article
Emergency Medicine
Hideo Tohira, Deon Brink, Lauren Davids, Rudolph Brits, Stephen Ball, Stephan Schug, Paul Bailey, Judith Finn
Summary: This retrospective cohort study describes the use of sublingual ketamine wafers by volunteer emergency medical technicians (EMTs) for pain management in rural Western Australia. The study findings suggest that the administration of ketamine wafers by volunteer EMTs was a useful additional pain management option without any evidence of major adverse events, especially when long transport to hospital was required.
EMERGENCY MEDICINE AUSTRALASIA
(2023)
Article
Anesthesiology
Andrew J. Toner, Martin A. Bailey, Stephan A. Schug, Michael Phillips, Jacobus P. J. Ungerer, Andrew A. Somogyi, Tomas B. Corcoran
Summary: This study investigated the determinants of systemic lidocaine concentrations during prolonged administration in breast cancer surgery patients. The results showed that lidocaine concentrations increased non-linearly during the early intravenous phase but reached a pseudo steady-state during the later subcutaneous phase. Higher dose rates based on lean body weight were associated with higher steady-state concentrations.
ANAESTHESIA AND INTENSIVE CARE
(2023)
Article
Multidisciplinary Sciences
Margaret-Ann Tait, Daniel S. J. Costa, Rachel Campbell, Richard Norman, Leon N. Warne, Stephan Schug, Claudia Rutherford
Summary: This study aimed to assess the overall health-related quality of life and other health indicators in patients accessing prescribed medicinal cannabis in Australia, and the results showed significant improvements in the first three months.
Article
Clinical Neurology
Darren Beales, Yi Ki Ho, James Lewin, Bianca Wen-Qi Loh, Amirah Binte Yusof, Sharon Grieve, Sonia Ranelli, David Holthouse, Tim Mitchell, Helen Slater
Summary: This study aimed to co-create a trustworthy infographic to share information about the lived experience of complex regional pain syndrome (CRPS). The infographic was completed using participatory design and rated highly for understandability. Participants indicated a significant willingness to share this infographic with others.
BRITISH JOURNAL OF PAIN
(2023)