Article
Medicine, Research & Experimental
Alaa T. Abdelhafez, Asmaa M. S. Gomaa, Asmaa M. Ahmed, Manal M. Sayed, Marwa A. Ahmed
Summary: The study revealed that smoking induces a COPD model with endothelial dysfunction in mice, while Pio and Irb alone or in combination can provide protective effects against the disease, with better results in the combined group. There is a strong correlation between NO and H2S levels and the other measured parameters.
Article
Biochemistry & Molecular Biology
Alessandra Pulliero, Luca Mastracci, Letizia Tarantini, Zumama Khalid, Valentina Bollati, Alberto Izzotti
Summary: This study reveals the relationship between KRAS mutation and let-7a downregulation in cigarette smoke-induced lung carcinogenesis. Long-term exposure to cigarette smoke leads to a significant decrease in let-7a expression and an increase in KRAS mutation, resulting in a higher incidence of lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
Xiaofeng Mei, Ruilong Lu, Lili Cui, Yange Tian, Peng Zhao, Jiansheng Li
Summary: This study aimed to investigate the effects and mechanisms of Poly I:C on pathological changes in CS-induced COPD mice, such as airway inflammation and remodeling.
Article
Respiratory System
Jef Serre, Ajime Tom Tanjeko, Carolien Mathyssen, An-Sofie Vanherwegen, Tobias Heigl, Rob Janssen, Eric Verbeken, Karen Maes, Bart Vanaudenaerde, Wim Janssens, Ghislaine Gayan-Ramirez
Summary: In this study, a standardized CS exposure protocol resulted in higher serum cotinine levels and more severe inflammation in the whole-body exposure system compared to the nose-only system. Both exposure systems showed similar lung function impairment, but differences were observed in lung inflammation and remodeling, indicating potential sensitization to CS. Researchers should consider these differences when designing future studies for early intervention in COPD.
RESPIRATORY RESEARCH
(2021)
Article
Food Science & Technology
Lingyue Zhong, Lina Qin, Xinwen Ding, Long Ma, Yao Wang, Minghua Liu, Hui Chen, Hongli Yan, Lihua Song
Summary: This study investigated the protective effects of fermented black barley on cigarette smoke induced damage. The results showed that fermented black barley can alleviate lung and reproductive organ injury, improve sperm motility and antioxidative capacity of the lung. Furthermore, it can also regulate intestinal microbiome diversity and metabolic dysbiosis induced by cigarette smoking.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
So-Won Park, A. Yeong Lee, Je-Oh Lim, Se-Jin Lee, Woong-Il Kim, Yea-Gin Yang, Bohye Kim, Joong-Sun Kim, Sung-Wook Chae, Kun Na, Yun-Soo Seo, In-Sik Shin
Summary: The study found that Loranthus tanakae 70% ethanol extract (LTE) effectively alleviates pulmonary inflammation caused by exposure to cigarette smoke condensate and lipopolysaccharide by modulating the activity of Nrf2 and NF-κB, potentially making it a treatment option for pulmonary inflammatory diseases such as chronic obstructive pulmonary disease (COPD).
Article
Medicine, Research & Experimental
Tingting Wu, Keye Xu, Chaobo Liu, Yan Li, Mingcai Li
Summary: This study aimed to investigate the effect of interleukin-37 (IL-37) on cigarette smoke-induced lung inflammation. By administering IL-37-expressing lentivirus to mice, it was found that IL-37 can alleviate weight loss and pulmonary inflammation induced by cigarette smoke. IL-37 also significantly inhibited inflammatory cell recruitment, reduced inflammatory cell increase, and suppressed the production of pro-inflammatory cytokines.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Mays Mohammed Salih, Elektra Kantzari Robinson, Eric Malekos, Elizabeth Perez, Allyson Capili, Kihwan Kim, William Z. Zhang, Suzanne M. Cloonan, Susan Carpenter
Summary: Cigarette smoke exposure is a risk factor for chronic diseases, but the mechanism behind chronic inflammation caused by smoke is not well understood. This study reveals that smoke can activate lincRNA-Cox2, a long noncoding RNA that regulates inflammatory gene expression. It also demonstrates dysregulated gene transcription and splicing in the bone marrow niche after smoke exposure. This work provides insights into the immune signaling alterations caused by cigarette smoke and highlights the important role of lincRNA-Cox2 in regulating immune genes after smoke exposure.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Pediatrics
Scott T. Kelley, William Liu, Penelope J. E. Quintana, Eunha Hoh, Nathan G. Dodder, E. Melinda Mahabee-Gittens, Samuel Padilla, Shawn Ogden, Sia Frenzel, Laura Sisk-Hackworth, Georg E. Matt
Summary: Despite smoking bans, children can be exposed to tobacco smoke residue (i.e., thirdhand smoke) that lingers on surfaces and in settled house dust. Thirdhand smoke exposure is associated with changes in the microbiomes of the home environment and of the children living in these homes. Thirdhand smoke is associated with increased phylogenetic diversity of the home environment and changes in the abundances of several genera of the child microbiome known to be affected by active smoking and secondhand smoke. Thirdhand smoke exposure by itself may induce alterations in the microbiome that play a role in childhood pathologies.
PEDIATRIC RESEARCH
(2021)
Article
Immunology
Tiantian Cen, Yifeng Mai, Jie Jin, Minxuan Huang, Mingcai Li, Shanshan Wang, Hongying Ma
Summary: Our study aimed to investigate the ability of IL-41 to protect against CS-induced lung inflammation in vivo. The results showed that IL-41 pre-treatment alleviated pulmonary inflammatory infiltration and lung tissue lesions, limited CS-induced weight loss, and promoted the polarization of M2 macrophages. IL-41 also increased the levels of IL-10 and reduced the production of TNF-α, IL-6, and IL-1β.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Magdiel Perez-Cruz, Bachirou Kone, Remi Porte, Christophe Carnoy, Julien Tabareau, Pierre Gosset, Francois Trottein, Jean-Claude Sirard, Muriel Pichavant, Philippe Gosset
Summary: This study demonstrates that stimulating innate immunity with a TLR5 ligand is an effective antibacterial treatment in COPD-exposed mice, suggesting innovative therapeutic strategies against acute exacerbations in COPD.
Article
Biochemistry & Molecular Biology
Xinjing Wang, Priya Murugesan, Pan Zhang, Shiqing Xu, Liang Peng, Chen Wang, Hua Cai
Summary: This study investigated the expression of NOX isoforms in the lungs of COPD patients and their role in oxidative stress and inflammatory responses to acute cigarette smoke. It was found that NOX1 and NOX4 mediate these responses and targeting them may provide a potential treatment for COPD.
Article
Genetics & Heredity
Feng Wang, Stefan Hadzic, Elsa T. Roxlau, Baerbel Fuehler, Annabella Janise-Libawski, Tobias Wimmer, Bo Lei, Shao-Wei Li, Norbert Weissmann, Knut Stieger
Summary: Exposure to electronic cigarette vapor, with or without nicotine, in mouse models was found to lead to inflammatory and pro-angiogenic reactions in the retina, retinal pigmented epithelium, and choroid. These reactions became more pronounced with longer exposure time.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Immunology
Deqing Yang, Dan Xu, Tao Wang, Zhicheng Yuan, Lian Liu, Yongchun Shen, Fuqiang Wen
Summary: Pre-treatment with MitoQ significantly attenuated cigarette smoke-induced airway inflammation and mucus hypersecretion in mice, potentially by modulating mitochondrial function and the NF-kappa B signal pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Simone N. De Luca, Kurt Brassington, Stanley M. H. Chan, Aleksandar Dobric, Kevin Mou, Huei Jiunn Seow, Ross Vlahos
Summary: The study revealed that smoking can impair pulmonary and neurocognitive functions, leading to memory deficits and microglial activation. While smoking cessation can reduce lung inflammation, its effectiveness in improving memory deficits and microglial activation remains uncertain. Antioxidant therapy may help prevent smoking-induced memory impairment.
JOURNAL OF NEUROINFLAMMATION
(2022)