Article
Behavioral Sciences
Bing-Xin Kang, Jie Ma, Jun Shen, Hui Xu, Hai-Qi Wang, Chi Zhao, Jun Xie, Sheng Zhong, Chen-Xin Gao, Xi-Rui Xu, Xin-Yu A, Xiao-Li Gu, Lianbo Xiao, Jianguang Xu
Summary: Structural remodeling and functional connectivity alterations may be one of the central brain mechanisms associated with end-stage KOA, as evidenced by decreased gray matter volumes in specific regions and weakened functional connectivity patterns in patients with KOA compared to healthy controls. Additionally, there is a negative correlation between gray matter volume in the left middle temporal gyrus and the Western Ontario and McMaster Universities Arthritis Index in patients with KOA.
BRAIN AND BEHAVIOR
(2022)
Article
Neuroimaging
Benjamin Mosch, Verena Hagena, Stephan Herpertz, Michaela Ruttorf, Martin Diers
Summary: The perceived lack of control over pain experience is a major contributor to agony and impaired quality of life in chronic pain patients, such as fibromyalgia (FM). This study used functional magnetic resonance imaging (fMRI) to investigate how perceived control affects pain perception and the underlying neural mechanisms. The results showed that FM patients failed to activate brain areas involved in pain modulation and reappraisal processes, and exhibited disrupted functional connectivity and decreased gray matter volumes compared to healthy controls. These findings provide evidence for extensive impairments in pain modulation in FM.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
S. A. Osimo, L. Piretti, S. Ionta, R. Rumiati, M. Aiello
Summary: Studies have shown that individuals with higher BMI exhibit slower subliminal processing of food images and lack specific inhibition towards food stimuli, which is associated with morphological alterations in key brain regions related to awareness and reward. Additionally, differences in gray matter density and resting-state connectivity patterns in reward brain regions are linked to variability in visual processing and inhibition performances in individuals, regardless of BMI.
Article
Neurosciences
Chunlian Chen, Bo Li, Shufen Zhang, Zhe Liu, Yu Wang, Minghe Xu, Yuqing Ji, Shuang Wang, Gang Sun, Kai Liu
Summary: In this study, brain structural alterations and relevant functional changes in patients with postpartum depression (PPD) were investigated. The findings revealed increased gray matter volume in the left dorsolateral prefrontal cortex, right precentral gyrus, and orbitofrontal cortex of PPD patients compared to healthy postnatal women. The functional connectivity between these regions also showed enhancement. Additionally, the increased gray matter volume in the left dorsolateral prefrontal cortex and the functional connectivity between the right precentral gyrus and right median cingulate gyrus were positively correlated with the severity of depression symptoms.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Vincent Huynh, Robin Luetolf, Jan Rosner, Roger Luechinger, Armin Curt, Spyros Kollias, Lars Michels, Michele Hubli
Summary: This study combined CPM testing, VBM, and rsFC to identify neural correlates of CPM in healthy subjects. Greater pain inhibition was related to specific brain regions' volume and functional connectivity strength, revealing structural and functional interactions related to CPM efficiency.
Article
Anesthesiology
Camila B. Pinto, Kevin Pacheco-Barrios, Faddi G. Saleh Velez, Muhammed E. Gunduz, Marionna Munger, Felipe Fregni
Summary: This study explores the association between brain gray matter volume and the severity of phantom limb manifestations, as well as the improvement of phantom limb pain after neuromodulatory treatments. The results show that alterations in cortical gray matter volume are correlated with the severity of phantom limb pain. Furthermore, patients who respond to neuromodulatory treatment have higher gray matter volume in somatosensory areas in the affected hemisphere at baseline.
Article
Behavioral Sciences
Jiabao Lin, Yajue Chen, Jiushu Xie, Qiuping Cheng, Mi Zou, Lei Mo
Summary: Studies have shown that episodic insight has been extensively studied in relation to neural correlates, but there is limited understanding of the neural mechanisms underlying dispositional insight. This study used voxel-based morphometry and resting-state functional connectivity analysis to investigate the neural mechanisms of dispositional insight. The findings revealed that dispositional insight is associated with regional gray matter volume in specific brain regions, as well as altered functional connectivity between these regions. Additionally, the personality trait of neuroticism was found to partially mediate the relationship between dispositional insight and a specific brain region.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Psychology, Clinical
Tina Meller, Simon Schmitt, Ulrich Ettinger, Phillip Grant, Frederike Stein, Katharina Brosch, Dominik Grotegerd, Katharina Dohm, Susanne Meinert, Katharina Foerster, Tim Hahn, Andreas Jansen, Udo Dannlowski, Axel Krug, Tilo Kircher, Igor Nenadic
Summary: This study found the association between subclinical psychotic-like experiences and brain structural changes, supporting a dimensional model of the neural correlates of symptoms of the psychotic spectrum.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Neuroimaging
Jing-Ting Sun, Bo Hu, Tian-Qi Chen, Zhu-Hong Chen, Yu-Xuan Shang, Yu-Ting Li, Rui Wang, Wen Wang
Summary: The systematic review and meta-analysis of neuroimaging studies in IA showed that IA patients have abnormal brain structure and function, including smaller gray matter volume and increased connectivity with other brain regions. These abnormalities may be related to the core symptoms of IA, such as emotional regulation disorder, distraction, and impaired executive control.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Neurosciences
Kanxin Gao, Rong Zhang, Ting Xu, Fan Zhou, Tingyong Feng
Summary: Procrastination is a prevalent issue that significantly impacts individual's health, wealth, and well-being. Studies have shown a negative correlation between conscientiousness and procrastination, with certain brain areas and functional connectivity associated with the impact of conscientiousness on procrastination. Self-control and motivation pathways are suggested to underlie this relationship.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Andrea Quattrone, Camilla Calomino, Alessia Sarica, Maria Eugenia Caligiuri, Maria Giovanna Bianco, Basilio Vescio, Pier Paolo Arcuri, Jolanda Buonocore, Marida De Maria, Maria Grazia Vaccaro, Aldo Quattrone
Summary: This study identified the bilateral inferior frontal gyrus (IFG) and superior temporal gyrus (STG) as regions associated with postural instability in Parkinson's disease (PD) patients. Voxel-based morphometry (VBM) analysis showed reduced grey matter volume in fronto-temporal areas in unsteady PD patients, and this reduction was selectively associated with the postural instability score.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Felix Brandl, Benedikt Weise, Satja Mulej Bratec, Nazia Jassim, Daniel Hoffmann Ayala, Teresa Bertram, Markus Ploner, Christian Sorg
Summary: Major depressive disorder, anxiety disorders, and chronic pain are closely related disorders with both shared and distinct changes in brain networks. The common changes suggest neural correlates for comorbidity, while the disorder-specific changes may underlie distinct phenotypes and mechanisms.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neuroimaging
Ikko Kimura, Gajanan S. Revankar, Kotaro Ogawa, Kaoru Amano, Yuta Kajiyama, Hideki Mochizuki
Summary: This study used structural and resting-state functional magnetic resonance imaging to identify the cortico-striatal network involved in impulsive compulsive behaviors (ICBs) and found differences in these networks between patients with impulse control disorder (ICD) and dopamine dysregulation syndrome (DDS).
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Jie Chen, Xinxin Gong, Letong Wang, Mengmeng Xu, Xiao Zhong, Ziyi Peng, Tao Song, Lin Xu, Jie Lian, Yongcong Shao, Xiechuan Weng
Summary: This study found that sleep deprivation leads to decreased risk perception and is associated with changes in communication between brain regions. Sleep deprivation increased regional homogeneity in the right postcentral gyrus and this increase was positively correlated with changes in risk perception. Furthermore, functional connectivity between the right postcentral gyrus, left medial temporal gyrus, and right inferior temporal gyrus was enhanced, and this enhanced connectivity was positively correlated with changes in risk perception.
Article
Clinical Neurology
Takashi Hanakawa, Fujiko Hotta, Tatsuhiro Nakamura, Keiichiro Shindo, Naoko Ushiba, Masaki Hirosawa, Yutaka Yamazaki, Yoshinao Moriyama, Syota Takagi, Katsuhiro Mizuno, Meigen Liu
Summary: This study investigates the relationship between macrostructural neuroplasticity and individual differences in motor recovery after stroke. The findings suggest that neuroplasticity in the cerebellum is correlated with motor recovery after stroke. These results provide important implications for the development of personalized rehabilitation strategies.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Review
Neurosciences
Sook-Lei Liew, Artemis Zavaliangos-Petropulu, Neda Jahanshad, Catherine E. Lang, Kathryn S. Hayward, Keith R. Lohse, Julia M. Juliano, Francesca Assogna, Lee A. Baugh, Anup K. Bhattacharya, Bavrina Bigjahan, Michael R. Borich, Lara A. Boyd, Amy Brodtmann, Cathrin M. Buetefisch, Winston D. Byblow, Jessica M. Cassidy, Adriana B. Conforto, R. Cameron Craddock, Michael A. Dimyan, Adrienne N. Dula, Elsa Ermer, Mark R. Etherton, Kelene A. Fercho, Chris M. Gregory, Shahram Hadidchi, Jess A. Holguin, Darryl H. Hwang, Simon Jung, Steven A. Kautz, Mohamed Salah Khlif, Nima Khoshab, Bokkyu Kim, Hosung Kim, Amy Kuceyeski, Martin Lotze, Bradley J. MacIntosh, John L. Margetis, Feroze B. Mohamed, Fabrizio Piras, Ander Ramos-Murguialday, Genevieve Richard, Pamela Roberts, Andrew D. Robertson, Jane M. Rondina, Natalia S. Rost, Nerses Sanossian, Nicolas Schweighofer, Na Jin Seo, Mark S. Shiroishi, Surjo R. Soekadar, Gianfranco Spalletta, Cathy M. Stinear, Anisha Suri, Wai Kwong W. Tang, Gregory T. Thielman, Daniela Vecchio, Arno Villringer, Nick S. Ward, Emilio Werden, Lars T. Westlye, Carolee Winstein, George F. Wittenberg, Kristin A. Wong, Chunshui Yu, Steven C. Cramer, Paul M. Thompson
Summary: The ENIGMA Stroke Recovery working group aims to understand the relationship between brain and behavior using meta- and mega-analytic approaches. They have developed neuroinformatics protocols and methods to manage large-scale data from over 2,100 stroke patients. The challenges and recommendations for data harmonization in stroke research are discussed.
HUMAN BRAIN MAPPING
(2022)
Article
Psychiatry
Yue Cui, Chao Li, Bing Liu, Jing Sui, Ming Song, Jun Chen, Yunchun Chen, Hua Guo, Peng Li, Lin Lu, Luxian Lv, Yuping Ning, Ping Wan, Huaning Wang, Huiling Wang, Huawang Wu, Hao Yan, Jun Yan, Yongfeng Yang, Hongxing Zhang, Dai Zhang, Tianzi Jiang
Summary: This study used deep-learning techniques to identify grey matter abnormalities associated with schizophrenia. By analyzing data from eight independent centers, researchers developed a deep-learning classifier that accurately distinguished schizophrenia patients from healthy controls.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Cell Biology
Keliang Pang, Richeng Jiang, Wei Zhang, Zhengyi Yang, Lin-Lin Li, Makoto Shimozawa, Simone Tambaro, Johanna Mayer, Baogui Zhang, Man Li, Jiesi Wang, Hang Liu, Ailing Yang, Xi Chen, Jiazheng Liu, Bengt Winblad, Hua Han, Tianzi Jiang, Weiwen Wang, Per Nilsson, Wei Guo, Bai Lu
Summary: The lack of predictive and translatable animal models has been a major obstacle in Alzheimer's disease (AD) research. While transgenic mice overexpressing App gene do not reflect disease progression accurately, the App knock-in rat model with humanized A beta sequence shows promise in mimicking AD pathologies and progression, including A beta plaques, tau pathology, neuronal death, and cognitive deficits. This rat model may provide valuable insights for AD research and drug development.
Article
Neurosciences
Jin Li, Dan Cao, Vasileios Dimakopoulos, Weiyang Shi, Shan Yu, Lingzhong Fan, Lennart Stieglitz, Lukas Imbach, Johannes Sarnthein, Tianzi Jiang
Summary: This study recorded intracranial EEG from the anterior and posterior hippocampi in humans to investigate the involvement and functional connections of these subregions in working memory (WM) processing. The results showed elevated low-frequency activity and increased theta/alpha band phase synchronization between anterior and posterior subregions during WM maintenance. Correct WM trials were associated with unidirectional influence from the posterior to the anterior hippocampus, while WM errors were associated with bidirectional interactions between the two subregions. These findings suggest that theta/alpha band synchrony within the hippocampus supports successful WM via a posterior to anterior influence.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Psychology, Biological
Jiayuan Xu, Xiaoxuan Liu, Qiaojun Li, Ran Goldblatt, Wen Qin, Feng Liu, Congying Chu, Qiang Luo, Alex Ing, Lining Guo, Nana Liu, Huaigui Liu, Conghong Huang, Jingliang Cheng, Meiyun Wang, Zuojun Geng, Wenzhen Zhu, Bing Zhang, Weihua Liao, Shijun Qiu, Hui Zhang, Xiaojun Xu, Yongqiang Yu, Bo Gao, Tong Han, Guangbin Cui, Feng Chen, Junfang Xian, Jiance Li, Jing Zhang, Xi-Nian Zuo, Dawei Wang, Wen Shen, Yanwei Miao, Fei Yuan, Su Lui, Xiaochu Zhang, Kai Xu, Longjiang Zhang, Zhaoxiang Ye, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Ruediger Bruehl, Jean-Luc Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomas Paus, Luise Poustka, Lauren Robinson, Sarah Hohmann, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Jeanne Winterer, Kevin Patrick, Vince Calhoun, Mulin Jun Li, Meng Liang, Peng Gong, Edward D. Barker, Nicholas Clinton, Andre Marquand, Le Yu, Chunshui Yu, Gunter Schumann
Summary: Research shows correlations between urbanization and brain function, neuropsychology, and mental illness symptoms, with the most pronounced effects on the cerebellum and prefrontal cortex. Urbanization impacts brain structure and function, perspective-taking, and depression symptoms, with neural variables acting as mediators.
NATURE HUMAN BEHAVIOUR
(2022)
Article
Biochemistry & Molecular Biology
Feng Liu, Jiayuan Xu, Lining Guo, Wen Qin, Meng Liang, Gunter Schumann, Chunshui Yu
Summary: Individual differences in human brain structure, function, and behavior can be explained by genetic variations, environmental exposures, and their interactions. While genetic variants associated with brain imaging phenotypes have been identified, the environmental exposures related to these phenotypes are largely unknown. This study proposes that research in environmental neuroscience should focus on understanding the associations between lifetime environmental exposures and brain imaging phenotypes, as well as identifying cumulative environmental effects and their vulnerable age windows.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Jingchun Liu, Caihong Wang, Wen Qin, Hao Ding, Yanmin Peng, Jun Guo, Tong Han, Jingliang Cheng, Chunshui Yu
Summary: Subcortical ischemic stroke can cause long-lasting changes in the cerebral cortex. This study investigated the relationship between cortical structural changes, motor recovery, lesion location, and early impairment of specific subsets of fibers in the corticospinal tract (CST) in patients with subcortical stroke. The findings revealed different patterns of cortical structural changes in patients with partial and complete recovery, which were associated with lesion location and impairment of specific CST fiber subsets.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Huaigui Liu, Wei Li, Nana Liu, Jie Tang, Lixin Sun, Jiayuan Xu, Yuan Ji, Yingying Xie, Hao Ding, Zhaoxiang Ye, Chunshui Yu, Wen Qin
Summary: Evidence suggests that dysregulation of the dopamine (DA) system and dysfunction of the prefrontal cortex (PFC) may contribute to the development of schizophrenia. However, the relationship between DA genes, PFC morphology, and schizophrenia is still not fully understood. In this study, we analyzed brain gene expression data and structural magnetic resonance imaging data to identify specific PFC subregions that are associated with the expression profiles of DA genes. We found that some PFC subregions showed abnormal increases in gray matter volume covariance with other brain regions in schizophrenia patients. Furthermore, our analysis of postmortem expression data revealed reduced coexpression of DA genes between the middle frontal gyrus and hippocampus in schizophrenia patients, with these genes being implicated in brain functions related to working memory, reward processing, speech production, and episodic memory.
Article
Neurosciences
Wenshuang Zhu, Feng Liu, Jilian Fu, Wen Qin, Kaizhong Xue, Jie Tang, Yong Zhang, Chunshui Yu
Summary: This study identified 903 clinically sensitive genes and 633 clinically insensitive genes associated with ALFF alterations in MDD. The sensitive genes were enriched for cell differentiation and development, while the insensitive genes were enriched for ion transport and synaptic signaling.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Jingchun Liu, Caihong Wang, Wen Qin, Jun Guo, Tong Han, Jingliang Cheng, Chunshui Yu
Summary: Subcortical stroke leads to structural changes in multiple areas of the cerebral cortex. The location of the lesion affects the pattern of cortical thickness changes. Motor outcomes and impairment of the corticospinal tract are correlated with cortical thickness in specific gyri. The longitudinal dataset shows gradual changes in cortical thickness and area in regions with structural reorganization.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Neuroimaging
Ling Wang, Yi Ji, Hao Ding, Qin Tian, Ke Fan, Dapeng Shi, Chunshui Yu, Wen Qin
Summary: The study used arterial spin labeling (ASL) to investigate abnormal cerebral blood flow (CBF) in patients with Leber's hereditary optic neuropathy (LHON) and its associations with disease duration and neuro-ophthalmological impairment. The results showed differences in brain regions of LHON patients, including the left sensorimotor and bilateral visual areas. LHON patients had lower CBF in the bilateral calcarine compared to healthy controls. Chronic LHON patients also showed lower CBF in the left middle frontal gyrus, sensorimotor cortex, and temporal-partial junction. Disease duration and neuro-ophthalmological impairments were found to affect the metabolism of non-visual areas.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Clinical Neurology
Kaori L. Ito, Bokkyu Kim, Jingchun Liu, Surjo R. Soekadar, Carolee Winstein, Chunshui Yu, Steven C. Cramer, Nicolas Schweighofer, Sook-Lei Liew
Summary: This retrospective study found that evaluating CST-LL from additional motor origins, such as the ventral premotor cortex, is more strongly associated with post-stroke motor severity than using CST-LL originating from primary motor cortex alone. This suggests that higher order motor regions add clinical relevance to motor impairment.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)