Pivotal Role of Inosine Triphosphate Pyrophosphatase in Maintaining Genome Stability and the Prevention of Apoptosis in Human Cells

DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis

(2011) Sugako Oka et al.   CANCER SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Translating pharmacogenetics into clinical practice: interleukin (IL)28B and inosine triphosphatase (ITPA) polymophisms in hepatitis C virus (HCV) infection

(2011) Elisabetta Cariani et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

The Effect ofITPAPolymorphisms on the Enzyme Kinetic Properties of Human Erythrocyte Inosine Triphosphatase Toward its Substrates ITP and 6-Thio-ITP

(2011) Jaap A. Bakker et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Perturbation of the Bcl-2 Network and an Induced Noxa/Bcl-xL Interaction Trigger Mitochondrial Dysfunction after DNA Damage

(2010) Hernando Lopez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells

(2010) Kunihiko Sakumi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase

(2010) Yusaku Nakabeppu et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals

(2010) Nona Abolhassani et al.   NUCLEIC ACIDS RESEARCH

DNA breakage and cell cycle checkpoint abrogation induced by a therapeutic thiopurine and UVA radiation

(2010) R Brem et al.   ONCOGENE

Mutator phenotype in cancer: Origin and consequences

(2010) Lawrence A. Loeb   SEMINARS IN CANCER BIOLOGY

ITPase-deficient mice show growth retardation and die before weaning

(2009) M Behmanesh et al.   CELL DEATH AND DIFFERENTIATION

Association between inosine triphosphate pyrophosphohydrolase deficiency and azathioprine-related adverse drug reactions in the Chinese kidney transplant recipients

(2009) Hui Xiong et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Functional Study of the P32T ITPA Variant Associated with Drug Sensitivity in Humans

(2009) Elena I. Stepchenkova et al.   JOURNAL OF MOLECULAR BIOLOGY

Production of clastogenic DNA precursors by the nucleotide metabolism inEscherichia coli

(2009) Brian Budke et al.   MOLECULAR MICROBIOLOGY

Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair

(2009) Bjørn Dalhus et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs

(2008) Sugako Oka et al.   EMBO JOURNAL

YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues

(2008) Stanislav G. Kozmin et al.   MOLECULAR MICROBIOLOGY