Structure and Dynamics of the G121V Dihydrofolate Reductase Mutant: Lessons from a Transition-State Inhibitor Complex

Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

(2011) A. J. Adamczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics and dissipation in enzyme catalysis

(2011) N. Boekelheide et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis

(2011) G. Bhabha et al.   SCIENCE

Nuclear Magnetic Resonance Study of the Role of M42 in the Solution Dynamics ofEscherichia coliDihydrofolate Reductase

(2010) Randall V. Mauldin et al.   BIOCHEMISTRY

Coupled motions in enzyme catalysis

(2010) Vishal C Nashine et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Multi-Timescale Dynamics Study of FKBP12 Along the Rapamycin–mTOR Binding Coordinate

(2010) Paul J. Sapienza et al.   JOURNAL OF MOLECULAR BIOLOGY

Enzymatic transition states and dynamic motion in barrier crossing

(2009) Steven D Schwartz et al.   Nature Chemical Biology

Dynamic Dysfunction in Dihydrofolate Reductase Results from Antifolate Drug Binding: Modulation of Dynamics within a Structural State

(2009) Randall V. Mauldin et al.   STRUCTURE

Monitoring Aromatic Picosecond to Nanosecond Dynamics in Proteins via13C Relaxation: Expanding Perturbation Mapping of the Rigidifying Core Mutation, V54A, in Eglin c†

(2008) Joshua A. Boyer et al.   BIOCHEMISTRY

Hydrophobic Core Mutations in CI2 Globally Perturb Fast Side-Chain Dynamics Similarly without Regard to Position†

(2008) Matthew J. Whitley et al.   BIOCHEMISTRY

Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes

(2003) Michael J. Osborne et al.   PROTEIN SCIENCE