Article
Surgery
Eric Pittelkow, Will DeBrock, Laura Christopher, Raphael Mercho, Lily Ji-Yun Suh, Carla S. Fisher, Brett Hartman, Mary Lester, Aladdin H. Hassanein
Summary: This study evaluated patients who chose DIEP flap as the reconstructive method during initial consultation and compared characteristics of surgery in relation to their final reconstructive choice. Delayed-immediate DIEP reconstruction has advantages over immediate DIEP flap, including shorter free flap operative times. Patients commonly change their preference for second stage reconstruction.
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2022)
Review
Oncology
Andre S. Alves, Vincent Tan, Matteo Scampa, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: This study analyzed the optimal timing for deep inferior epigastric perforator flap (DIEP) breast reconstruction. The results showed that immediate breast reconstruction surgery has fewer delayed wound healing issues, while there were no significant differences in other complications.
Article
Neurosciences
Xiupeng Xu, Tongle Zhi, Lingyang Hua, Kuan Jiang, Chen Chen
Summary: This study revealed that activation of IRAK4 exacerbates secondary injury in TBI by regulating the TAK1 signaling pathway. Inhibition of IRAK4 can alleviate neuroinflammation, neuron apoptosis, brain edema, and dysfunction of the blood-brain barrier. The IRAK4 inhibitor PF-0665083 shows potential as a treatment strategy for TBI.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Critical Care Medicine
Chantal M. Sanchez, David J. Titus, Nicole M. Wilson, Julie E. Freund, Coleen M. Atkins
Summary: Early life stress may contribute to persistent cognitive deficits in individuals with mild traumatic brain injury, including impaired learning and memory function, as well as worsened cortical pathology.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Surgery
Jung-Ju Huang, Eva Yu-Hsuan Chuang, David Chon-Fok Cheong, Bong-Sung Kim, Frank Chun-Shin Chang, Wen-Ling Kuo
Summary: The study investigated the feasibility and aesthetic outcome of free perforator flap breast reconstruction via small lateral chest wall incision after R-NSM. Results showed that patients in the R-NSM group had smaller scars and better aesthetic outcomes in terms of breast symmetry and scar visibility, indicating potential benefits of this approach compared to C-NSM.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Article
Emergency Medicine
Gaku Fujiwara, Yohei Okada, Wataru Ishii, Ryoji Iizuka, Mamoru Murakami, Takehiko Sakakibara, Tarumi Yamaki, Naoya Hashimoto
Summary: The study found that skull fracture is associated with in-hospital mortality among patients with severe traumatic brain injury, and patients with both skull base and skull vault fractures have a higher mortality rate.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Neurosciences
Rodney M. Ritzel, Junyun He, Yun Li, Tuoxin Cao, Niaz Khan, Bosung Shim, Boris Sabirzhanov, Taryn Aubrecht, Bogdan A. Stoica, Alan I. Faden, Long-Jun Wu, Junfang Wu
Summary: The study reveals that microglia directly regulate acidosis after traumatic brain injury, exacerbating neural damage. Inhibiting microglia can reduce extracellular acidosis, ROS production, and inflammation, leading to neuroprotection and functional recovery. Additionally, the voltage-gated proton channel Hv1 in microglia plays a crucial role in integrating inflammation and acidosis during head injury.
Review
Surgery
Dany Y. Matar, Mengfan Wu, Valentin Haug, Dennis P. Orgill, Adriana C. Panayi
Summary: The study suggests that immediate breast reconstruction generally increases the risk of complications compared to delayed reconstruction. Further research is needed to determine the role of PMRT and reconstruction surgical technique in the incidence of complications between immediate and delayed reconstructions.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Surgery
Laura L. Barnes, Anne Patterson, Melinda Lem, Michael C. Holland, Rachel Lentz, Hani Sbitany, Merisa L. Piper
Summary: This study compared the outcomes of immediate autologous breast reconstruction and delayed-immediate reconstruction. The study found that the immediate reconstruction group had more complications such as mastectomy skin flap necrosis, while the delayed-immediate reconstruction group had more complications such as infection and readmission.
ANNALS OF PLASTIC SURGERY
(2023)
Article
Cell Biology
Wenqian Zhang, Jun Hong, Wencheng Zheng, Aijun Liu, Ying Yang
Summary: The study found that high glucose exacerbated neuroinflammation and apoptosis in the intermediate stage post-TBI by inhibiting the MEK5/ERK5 pathway.
Article
Critical Care Medicine
Allie M. Smith, Zyra J. Warfield, Seth L. Johnson, Alicia A. Hulitt, Daniela Ruedi-Bettschen, Christiano Dos Santos E Santos, Bernadette E. Grayson
Summary: Traumatic brain injury (TBI) is a leading cause of death among children in the United States, with juveniles being more prone to TBI and experiencing increased anxiety and stress behaviors as a result. The current study aimed to investigate the potential relationship between TBI and consumption of high-fat diets (HFD) on hypothalamic-pituitary-adrenal (HPA) axis function in juvenile rats. The findings suggest that the combination of TBI and high-fat diet consumption can lead to HPA axis dysfunction and increased anxiety-like behaviors.
JOURNAL OF NEUROTRAUMA
(2023)
Editorial Material
Clinical Neurology
Samuel N. Emerson, Antonio Aversa, Ossama Al-Mefty
Summary: Encephaloceles are pathological herniations of brain parenchyma through a bone defect. Surgical repair is necessary to eliminate the risk of complications. Endoscopic repairs have shown good results, but may require additional dissection and have associated risks. The ideal approach requires precise localization of the defect and repair with an inlay graft.
OPERATIVE NEUROSURGERY
(2022)
Article
Cell Biology
Flaubert Tchantchou, Molly Goodfellow, Fengying Li, Lyric Ramsue, Catriona Miller, Adam Puche, Gary Fiskum
Summary: The study showed that moderate HHCY exacerbates TBI outcomes by increasing oxidative stress, promoting inflammation and blood coagulation, increasing lesion size, and exacerbating anxiety-like behavior. This suggests that dysregulation of HCY catabolism may be a significant biological variable contributing to TBI pathophysiology heterogeneity.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Surgery
Jessica L. L. Marquez, Jack D. Sudduth, Keith Kuo, Ashraf A. A. Patel, Devin Eddington, Jayant P. P. Agarwal, Alvin C. C. Kwok
Summary: This study compared the postoperative complication rates between immediate (IBR), delayed immediate (DIBR), and delayed (DBR) breast reconstruction modalities. The results showed that DIBR and DBR were associated with lower overall complication rates compared to IBR. Physicians should consider patients' unique circumstances when deciding upon the appropriate timing modality.
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2023)
Article
Neurosciences
Jordi Pedragosa, Domenico Mercurio, Marco Oggioni, Leonardo Marquez-Kisinousky, Maria-Grazia de Simoni, Anna M. Planas
Summary: TBI triggers acute neutrophil infiltration followed by a persistent presence of neutrophils in the injured tissue. MBL plays a role in secondary neutrophil accumulation, blood-brain barrier breakdown, and axonal and white matter damage after TBI in mice. The absence of MBL leads to reduced neutrophil numbers, less accumulation of pentraxin-3 and fibrin(ogen), and better preservation of white matter integrity.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Cell Biology
Reed Berlet, Dorothy Anne Galang Cabantan, Daniel Gonzales-Portillo, Cesar V. Borlongan
Summary: Stem cell therapy is a potential treatment for stroke, Parkinson's disease, and Huntington's disease. Enriched environment and exercise can enhance the reconstruction of neural circuitry in stem cell transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Anna Gorsky, Molly Monsour, Hung Nguyen, Vanessa Castelli, Jea-Young Lee, Cesar Borlongan
Summary: This study found that transferring healthy mitochondria from mesenchymal stem cells to ischemic neurons can be an effective treatment for stroke. Cells grown under a metabolic switching paradigm displayed higher energy production and ATP production, as well as decreased proton leak. Co-culturing ischemic neurons with these cells resulted in improved cell viability, enhanced cell metabolism, and reduced mitochondrial reactive oxidative species mRNA.
NEUROMOLECULAR MEDICINE
(2023)
Article
Neurosciences
Molly Monsour, Anna Gorsky, Hung Nguyen, Vanessa Castelli, Jea-Young Lee, Cesar Borlongan
Summary: The study showed that switching energy source from glucose to galactose in cultured mesenchymal stem cells enhances oxidative phosphorylation, improving the cells' tolerance to ischemic insults.
Article
Clinical Neurology
Ying Zhang, Longhui Ma, Yi Yan, Li Zhao, Song Han, Di Wu, Cesar Borlongan, Junfa Li, Xunming Ji
Summary: This study demonstrates that cPKC gamma modulates autophagy via the mTOR-ULK1 pathway and plays a crucial role in neuroprotection during ischemic preconditioning.
TRANSLATIONAL STROKE RESEARCH
(2023)
Review
Neurosciences
Molly Monsour, Davide M. Croci, Siviero Agazzi, Cesar V. Borlongan
Summary: Interleukin-6 (IL-6) is a cytokine with dual signaling, playing a major role in neuroinflammation following stroke. The different signaling pathways of IL-6 may have distinct effects on stroke therapy, and the timing of IL-6 antagonists or agonists is crucial.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Gavin Miles Lockard, Adam Alayli, Molly Monsour, Jonah Gordon, Samantha Schimmel, Bassel Elsayed, Cesar V. Borlongan
Summary: Stem cell transplantation has potential in stroke treatment, reducing infarction size and improving neurobehavioral performance. Interleukin-6 (IL-6), typically considered proinflammatory, can also have beneficial effects on the nervous system when upregulated or when stem cells are preconditioned.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Molly Monsour, Cesar Borlongan
Summary: Stroke pathology and treatments usually focus on the brain, but inflammation in peripheral organs also plays a significant role. This review discusses the robust inflammatory response in peripheral organs to stroke and innovative stroke therapies that target peripheral inflammation.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Cell & Tissue Engineering
Satoru Yabuno, Takao Yasuhara, Takayuki Nagase, Satoshi Kawauchi, Chiaki Sugahara, Yosuke Okazaki, Kakeru Hosomoto, Susumu Sasada, Tatsuya Sasaki, Naoki Tajiri, Cesar V. Borlongan, Isao Date
Summary: This study aimed to investigate whether the combination therapy of intracerebral transplantation of human modified bone marrow-derived MSCs (SB623 cells) and voluntary exercise with running wheel could result in synergistic therapeutic effects on a rat model of ischemic stroke. The results showed that the SB623+exercise group achieved significant neurological recovery, decreased cerebral infarct area, and increased endogenous neurogenesis and angiogenesis.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Molly Monsour, Jonah Gordon, Gavin Lockard, Adam Alayli, Cesar V. Borlongan
Summary: Despite a good understanding of the pathophysiology of cell death after ischemic injury, there are few established treatments for stroke. Mitochondrial dysfunction plays a key role in secondary cell death, and recent advancements in stem cell therapies suggest that restoring mitochondrial integrity may be beneficial. This review discusses the role of mitochondria in the anti-oxidative effects of stem cell therapies for stroke.
Correction
Cell & Tissue Engineering
Satoru Yabuno, Takao Yasuhara, Takayuki Nagase, Satoshi Kawauchi, Chiaki Sugahara, Yosuke Okazaki, Kakeru Hosomoto, Susumu Sasada, Tatsuya Sasaki, Naoki Tajiri, Cesar V. Borlongan, Isao Date
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Alejandra Romo-Araiza, Rocio I. Picazo-Aguilar, Ernesto Griego, Luis A. Marquez, Emilio J. Galvan, Yolanda Cruz, Ana Maria Fernandez-Presas, Almudena Chavez-Guerra, Roxana Rodriguez-Barrera, Ana P. Azpiri-Cardos, Claudia Rosas-Quintero, Ricardo Jasso-Chavez, Cesar V. Borlongan, Antonio Ibarra
Summary: This study aimed to evaluate the effect of symbiotics supplementation on cognitive impairment induced by high fat and sugar diets. The results showed that symbiotic-supplemented rats had better memory, butyrate concentrations, neurogenesis, and synaptic plasticity enhancement.
CELL TRANSPLANTATION
(2023)
Meeting Abstract
Cell & Tissue Engineering
J-Y. Lee, J. Cho, C. Vignon, H. Streefkerk, M. de Kalbermatten, I. Garitaonandia, C. V. Borlongan
CELL TRANSPLANTATION
(2023)
Review
Cell & Tissue Engineering
Adam Alayli, Gavin Lockard, Jonah Gordon, Jacob Connolly, Molly Monsour, Samantha Schimmel, Ike Dela Pena, Cesar V. Borlongan
Summary: The field of stem cell therapy is rapidly developing and offering alternative solutions to diseases traditionally treated with medication or surgery. One area of focus is the treatment of medically refractory epilepsy, which has traditionally been approached through surgery or intervention. Research indicates that stem cell transplantation has the potential to significantly benefit epilepsy patients by reducing seizure frequency, intensity, and neurological deficits. This review examines recent advancements in stem cell research related to epilepsy, with a focus on animal models.
CELL TRANSPLANTATION
(2023)