Article
Cardiac & Cardiovascular Systems
Zhaojie Meng, Shuya Zhang, Wei Li, Yunzhe Wang, Minjie Wang, Xin Liu, Cong-Lin Liu, Sha Liao, Tianxiao Liu, Chongzhe Yang, Jes S. Lindholt, Lars M. Rasmussen, Lasse M. Obel, Jane Stubbe, Axel C. Diederichsen, Yong Sun, Yabing Chen, Paul B. Yu, Peter Libby, Guo-Ping Shi, Junli Guo
Summary: In this study, it was found that blood eosinophil count and eosinophil cationic protein (ECP) concentration are risk factors for cardiovascular diseases. Eosinophils and ECP were shown to contribute to vascular calcification and atherogenesis through the BMPR-1A/1B-Smad-1/5/8-Runx2 signaling pathway.
EUROPEAN HEART JOURNAL
(2023)
Article
Medical Laboratory Technology
Ying-Ju Lai, Winston W-Y Kao, Yung-Hsin Yeh, Wei-Jan Chen, Pao-Hsien Chu
Summary: Lumican deficiency promotes pulmonary arterial remodeling. Administration of lumikine reverses the PAH pathogenesis caused by hypoxia-induced experimental PAH. Lumican is an antiproliferative target that functions to suppress pAKT activation during pathogenesis.
TRANSLATIONAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yu-qiang Pei, Yong-qiu Zheng, Yao-dong Ding, Qi-xiang Xu, Di Cao, Ya-ning Wu, Rui Wang, Jia-xin Yang, Jing Liang, Qian Ma, Hai-long Ge
Summary: Triptolide attenuated vascular calcification by inhibiting BMP2 and RUNX2 expression via upregulating miRNA-204 levels. Triptolide may be a potential new therapeutic option for treating vascular calcification.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Honghong Ma, Yang Yu, Lirong Mo, Qian Chen, Hui Dong, Yan Xu, Bing Zhuan
Summary: This study reveals the mechanism by which M1 macrophage-derived exosomal miR-663b contributes to dysfunctions in pulmonary artery smooth muscle cells (PASMCs) and the development of pulmonary hypertension (PH). It is found that miR-663b up-regulation enhances hypoxia-induced proliferation, inflammation, oxidative stress, and migration in PASMCs, while miR-663b down-regulation has the opposite effect. miR-663b promotes PASMC dysfunctions and PH development by inhibiting the AMPK/Sirt1 pathway. In an in vivo experiment, M1 macrophage exosomes with miR-663b down-regulation alleviate pulmonary vascular remodeling in pulmonary hypertension rats.
Article
Hematology
Yung-Chun Wang, Dunpeng Cai, Xiao-Bing Cui, Ya-Hui Chuang, William P. Fay, Shi-You Chen
Summary: JAK3 plays a crucial role in reendothelialization after vascular injury, with JAK3 deficiency attenuating intimal hyperplasia and enhancing the rate of reendothelialization. Knockdown of JAK3 restores smooth muscle cell expression and promotes endothelial cell proliferation in the injured area.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xunjia Li, Chengxuan Liu, Ying Li, Weijian Xiong, Deyu Zuo
Summary: The current study aimed to investigate the effects of erythropoietin (EPO) on vascular calcification under inflammatory conditions and the molecular regulator involved. The findings suggest that high-dose EPO and inflammation can exacerbate vascular calcification by activating p38 and increasing reactive oxygen species (ROS) levels.
Article
Biochemistry & Molecular Biology
Lena Kappert, Philipp Ruzicka, Anton Kutikhin, Carolina De la Torre, Andreas Fischer, Markus Hecker, Caroline Arnold, Thomas Korff
Summary: NFAT5 plays a crucial role in regulating cholesterol efflux in vascular smooth muscle cells (VSMCs) adjacent to arteriosclerotic plaques, and its loss may lead to cholesterol accumulation and inhibition of genes involved in lipid handling and oxidative stress management. The absence of Nfat5 in VSMCs contributes to the development of lipid-laden arterial lesions and promotes pro-atherogenic responses in the vasculature.
Article
Chemistry, Multidisciplinary
Lai-liu Luo, Jing-xuan Han, Shou-rong Wu, Vivi Kasim
Summary: This study suggests that SGLT2 inhibitor sotagliflozin may serve as a potential therapeutic angiogenesis agent for diabetic hindlimb ischemia (HLI). The results demonstrate that sotagliflozin can reverse the detrimental effects of high glucose and hypoxia on skeletal muscle cells, increase the expression and secretion of angiogenic factors, enhance the migration and proliferation capabilities of vascular endothelial and smooth muscle cells, and promote the formation of functional blood vessels. In vivo experiments show that intramuscular injection of sotagliflozin effectively restores blood perfusion in diabetic HLI mice.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Hematology
Ashish Misra, Rajan Rehan, Alexander Lin, Sanjay Patel, Edward A. Fisher
Summary: Clonal expansion plays a crucial role in atherosclerosis, particularly in smooth muscle cells and macrophages. Recent studies have revealed the contribution of clonal expansion to disease pathology and provided innovative directions for future therapies of atherosclerosis and associated cardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Trang Thi Doan Luong, Rashad Tuffaha, Mirjam Schuchardt, Barbara Moser, Nadeshda Schelski, Beate Boehme, Can Gollmann-Tepekoylu, Clara Schramm, Johannes Holfeld, Burkert Pieske, Erich Gulbins, Markus Toelle, Markus van der Giet, Florian Lang, Kai-Uwe Eckardt, Jakob Voelkl, Ioana Alesutan
Summary: The study found that acid sphingomyelinase (ASM)/ceramide is a critical regulator in promoting vascular smooth muscle cell (VSMC) calcification, partly through SGK1-dependent signaling. Inhibiting ASM may help reduce the progression of vascular calcification during chronic kidney disease (CKD).
Article
Chemistry, Medicinal
Ximena Volpini, Lautaro Natali, Maria Belen Brugo, Benjamin de la Cruz-Thea, Ruth Eliana Baigorri, Fabio Marcelo Cerban, Laura Fozzatti, Claudia Cristina Motran, Melina Mara Musri
Summary: Chagas disease is a neglected emerging global health problem. Trypanosoma cruzi infection promotes vascular remodeling and thickening of the aortic layers, potentially contributing to increased aortic stiffness. The expression of smooth muscle cell markers decreases while proliferative markers increase in infected mice. Cells coexpressing smooth muscle cell and macrophage markers are found in the media and adventitia layers of the aorta. Macrophage functional polarization is associated with M2-like phenotype in the adventitia.
ACS INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Mojtaba Parvizi, Zachary C. Ryan, Sanam Ebtehaj, Bonnie K. Arendt, Ian R. Lanza
Summary: Research has shown that senescent preadipocytes can induce an inflammatory phenotype, decrease cell viability, disrupt proliferation and migration, affecting the occurrence of vascular diseases by triggering phenotypic and functional changes in key cellular components of blood vessels.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Cell Biology
Lishan Zhang, Ziqi Fang, Guangdong Cheng, Mengting He, Yanliang Lin
Summary: A novel missense mutation (NM_000523: exon2: c.G917T: p.R306L) of Hoxd13 gene was identified in a Chinese family with synpolydactyly (SPD). Mice carrying the corresponding Hoxd13 mutation exhibited synpolydactyl phenotype. Further analysis revealed that this mutation promoted osteoclast differentiation and bone loss by regulating Smad5/p65/c-Fos/Rank axis, providing new insights into the development of SPD.
CELL DEATH & DISEASE
(2023)
Review
Pharmacology & Pharmacy
Tong Li, Baofu Wang, Hao Ding, Shiqi Chen, Weiting Cheng, Yang Li, Xiaoxiao Wu, Lei Wang, Yangyang Jiang, Ziwen Lu, Yu Teng, Sha Su, Xiaowan Han, Mingjing Zhao
Summary: Atherosclerosis (AS)-related diseases are the leading cause of death in clinical patients. Vascular smooth muscle cells (VSMCs) play a crucial role in AS, and intercellular communication through extracellular vesicles (EVs) is important in the pathophysiology of AS.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Zhaohui He, Gang Wang, Jianbo Wu, Zonghao Tang, Mao Luo
Summary: LRP1, a transmembrane receptor protein, plays multifunctional roles in maintaining vascular homeostasis by regulating vasoactive substances and specific intracellular signaling pathways. Recent advances in the discovery and mechanism of vascular homeostasis regulated by LRP1-dependent signaling pathways have expanded our understanding of vascular complications.
BIOMEDICINE & PHARMACOTHERAPY
(2021)