Article
Virology
Maria Y. Valdespino-Vazquez, Cecilia A. Helguera-Repetto, Moises Leon-Juarez, Oscar Villavicencio-Carrisoza, Arturo Flores-Pliego, Elsa R. Moreno-Verduzco, Diana L. Diaz-Perez, Isabel Villegas-Mota, Elba Carrasco-Ramirez, Irma E. Lopez-Martinez, David M. Giraldo-Gomez, Rosalia Lira, Martha Yocupicio-Monroy, Mario Rodriguez-Bosch, Edgar E. Sevilla-Reyes, Manuel Cortes-Bonilla, Sandra Acevedo-Gallegos, Horacio Merchant-Larios, Jorge Arturo Cardona-Perez, Claudine Irles
Summary: The study found that congenital SARS-CoV-2 infection is possible during the first trimester of pregnancy, leading to damage in placenta and fetal organs, with organs like lungs and kidneys being specific targets for the coronavirus.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Obstetrics & Gynecology
Geyessar M. Abdalla, Motwalli A. Abdelfadeel, Mohamed A. Alfaraga, Yasir B. Elshambaty, Muhammad S. Masoud, Altahir A. Saeed, Khabab A. H. M. Ahmed, Mohammed A. Abdalla, Abdelrahman H. Abdelmoneim, Hiba A. O. Fadl
Summary: This case report presents the diagnosis and surgical management of a rare vesical ectopic pregnancy in a 36-year-old woman with a history of multiple cesarean sections. The patient presented with unusual symptoms and was diagnosed through ultrasound and cystoscopy.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Qin Li, Cuishan Chen, Jiaming Wu, Liona C. Poon, Chi Chiu Wang, Tin Chiu Li, Tao Zhang, Xianghao Guo, Liang Song, Xia Wang, Qian Zhang, Ziying Ye, Yongkang Yang, Jing Lu, Jianyu Yao, Dewei Ye, Yao Wang
Summary: Serum sPD-L1 levels are significantly decreased in missed miscarriage patients and may serve as a potential predictive biomarker for miscarriage. Downregulated gene expression levels related to PD-L1 were observed in placenta.
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Whitney Cowell, Elena Colicino, Talia Askowitz, Farida Nentin, Rosalind J. Wright
Summary: The study found that women pregnant with a male fetus had significantly greater odds of developing depressive symptoms during the postnatal period compared to women without depressive symptoms in either period. No significant associations were observed in either cohort among women with prenatal symptoms only or women with symptoms in both prenatal and postnatal periods.
BIOLOGY OF SEX DIFFERENCES
(2021)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Obstetrics & Gynecology
Mackenzie N. Naert, Hanaa Khadraoui, Alberto Muniz Rodriguez, Nathan S. Fox
Summary: In a retrospective cohort study, it was found that the risk of pregnancy loss in women with viable singleton pregnancies after confirmation of fetal heart activity is 5.4% before 20 weeks. The study also indicated that the risk of miscarriage in pregnant women can be stratified based on gestational age and number of previous miscarriages, ranging from 0.8% to 33.7%.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Jagadeesh Puvvula, Kathrine E. Manz, Joseph M. Braun, Kurt D. Pennell, Emily A. Defranco, Shuk-Mei Ho, Yuet-Kin Leung, Shouxiong Huang, Ann M. Vuong, Stephani S. Kim, Zana P. Percy, Priyanka Bhashyam, Raymund Lee, Dean P. Jones, Vilinh Tran, Dasom V. Kim, Aimin Chen
Summary: In this cross-sectional study, associations were found between urinary PAH concentrations during late pregnancy and metabolic features associated with several metabolic pathways among pregnant women and newborns. Further studies are needed to explore the mediating role of the metabolome in the relationship between PAHs and adverse pregnancy outcomes.
Article
Endocrinology & Metabolism
Victor J. J. Pop, Lianne P. P. Hulsbosch, Myrthe G. B. M. Boekhorst, Maarten A. C. Broeren, Johannes G. G. Krabbe, Wilmar M. M. Wiersinga
Summary: Pregnant women with overt hypothyroidism and hypothyroxinemia show higher levels of hypothyroid symptoms compared to euthyroid controls, with fT4 decrease towards end term associated with persistently high symptom levels. Properly defining euthyroid control groups and monitoring fT4 levels in subclinical hypothyroid women are crucial in managing hypothyroid symptoms during pregnancy.
Article
Obstetrics & Gynecology
Stefano Cosma, Andrea R. Carosso, Jessica Cusato, Fulvio Borella, Marco Carosso, Marialuisa Bovetti, Claudia Filippini, Antonio D'Avolio, Valeria Ghisetti, Giovanni Di Perri, Chiara Benedetto
Summary: This study evaluated the role of SARS-CoV-2 infection as a risk factor for early pregnancy loss in the first trimester, finding no significant difference in the cumulative incidence of COVID-19 between women with spontaneous abortion and those with ongoing pregnancy. COVID-19 appeared to have a favorable maternal course in the first trimester, similar to observations in the second and third trimesters.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Fausta Beneventi, Irene De Maggio, Chiara Cavagnoli, Camilla Bellingeri, Beatrice Ruspini, Greta Riceputi, Gianluca Viarengo, Veronique Ramoni, Arsenio Spinillo
Summary: This study evaluated EPC levels and sHLA-G concentrations in UCTD subjects compared to controls during pregnancy and in cord blood. The results showed higher counts of CD34(+) CD133(-) and CD34(+) CD133(+) and increased sHLA-G concentrations in UCTDs, indicating a distinctive response to systemic autoimmune disease in early UCTD.
REPRODUCTIVE SCIENCES
(2021)
Article
Obstetrics & Gynecology
Emmanuel Attali, Guy Kern, Yuval Fouks, Lee Reicher, Ariel Many, Ishai Levin, Yariv Yogev, Aviad Cohen
Summary: Objective: This study aimed to compare the efficacy of three different labor induction methods for nonviable third-trimester fetuses. Results showed that labor induction using transcervical foley catheter and concomitant oxytocin infusion was associated with higher rate of deliveries within 24 hours and shorter time to delivery compared to the use of vaginal Prostin(C) or Propess(C).
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Psychiatry
Hanna C. Gustafsson, Geoffrey A. Dunn, A. J. Mitchell, Kathleen F. Holton, Jennifer M. Loftis, Joel T. Nigg, Elinor L. Sullivan
Summary: This study found that individuals with heightened ADHD symptoms during pregnancy had higher plasma n-6:n-3 ratios and higher TNF-alpha concentrations compared to controls. However, there were no significant differences in dietary intake. This suggests that differences in plasma fatty acid concentrations associated with ADHD may be related to fatty acid metabolism.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Obstetrics & Gynecology
Jessica M. Turner, Rob Cincotta, Jacqueline Chua, Glenn Gardener, Scott Petersen, Joseph Thomas, Alison Lee-Tannock, Sailesh Kumar
Summary: Despite the widespread belief that decreased fetal movements are associated with an increased risk of stillbirth and poor obstetrical outcome, this study found no significant difference in ultrasound abnormalities between women with decreased fetal movements and controls.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Review
Developmental Biology
Charlotte A. Shilton, Anne Kahler, Jessica M. Roach, Terje Raudsepp, Amanda M. de Mestre
Summary: Embryonic and foetal loss is a major challenge in equine reproductive health. This review discusses key aspects of equine placental and foetal development, as well as incidence, risk factors, and causes of pregnancy loss, with a focus on genetic variants associated with reduced equine foetal viability.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2023)
Article
Obstetrics & Gynecology
Robert Para, Roberto Romero, Nardhy Gomez-Lopez, Adi L. Tarca, Bogdan Panaitescu, Bogdan Done, Richard Hsu, Percy Pacora, Chaur-Dong Hsu
Summary: This study investigated the combination of sFas and Elabela measurements in the maternal circulation as clinical biomarkers for preeclampsia. The results showed that patients with late-onset preeclampsia had higher concentrations of sFas and Elabela, and the combination of these two markers provided a stronger association with late-onset preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Developmental Biology
Sally Beard, Natasha Pritchard, Natalie Binder, Karen Schindler, Natasha De Alwis, Tu'uhevaha J. Kaitu'u-Lino, Stephen Tong, Natalie J. Hannan
Review
Developmental Biology
Natasha de Alwis, Natalie K. Binder, Sally Beard, Tu'uhevaha J. Kaitu'u-Lino, Stephen Tong, Fiona Brownfoot, Natalie J. Hannan
Article
Obstetrics & Gynecology
Natasha Pritchard, Tu'uhevaha Kaitu'u-Lino, Lynda Harris, Stephen Tong, Natalie Hannan
Summary: Nanomedicine technology in reproductive medicine and obstetrics holds promise for targeted therapeutic strategies that enhance efficacy and minimize off-target effects. Through nanoparticle delivery systems, interventions can effectively address various issues in reproductive medicine, providing new treatment options for women's health and reproductive capacity.
HUMAN REPRODUCTION UPDATE
(2021)
Article
Developmental Biology
Teresa M. MacDonald, Stephen Tong, Jenny Myers, Ping Cannon, Tuong-Vi Nguyen, Emerson Keenan, Elizabeth Murray, Alesia Harper, Natasha Pritchard, Natalie J. Hannan, Kirsten M. Dane, Anna L. Middleton, Valerie P. Kyritsis, Susan P. Walker, Tu'uhevaha J. Kaitu'u-Lino
Summary: The study found that circulating TFPI levels significantly increase prior to preeclampsia at 36 weeks, and are markedly elevated in preterm preeclampsia. TFPI may be beneficial for a multi-marker blood test to predict preeclampsia.
Editorial Material
Medicine, General & Internal
Stephen Tong, Tu'uhevaha Kaitu'u-Lino
Article
Developmental Biology
Tu'uhevaha J. Kaitu'u-Lino, Stephen Tong, Susan P. Walker, Teresa M. MacDonald, Ping Cannon, Tuong-Vi Nguyen, Suresh Anand Sadananthan, Mya-Thway Tint, Yi Ying Ong, Loy See Ling, Peter D. Gluckman, Yap-Seng Chong, Keith M. Godfrey, Shiao-Yng Chan, Kok Hian Tan, Yung Seng Lee, Navin Michael, Johan G. Eriksson, Mary E. Wlodek
Summary: Low maternal circulating SPINT1 concentrations are associated with poor fetal growth, as validated by a study in Singapore where pregnant women with lower SPINT1 levels were more likely to deliver small-for-gestational age infants.
Article
Developmental Biology
Lucy A. Bartho, Jessica L. O'Callaghan, Joshua J. Fisher, James S. M. Cuffe, Tu'uhevaha J. Kaitu'u-Lino, Natalie J. Hannan, Vicki L. Clifton, Anthony V. Perkins
Summary: This study highlighted the importance of mitochondrial regulators in placental aging and pathophysiology through analyzing gene and protein expression levels in placental samples from pregnancies with different complications. Significant changes were observed in key mitochondrial transcripts, with MFN1, MFN2, and TOMM20 showing alterations in expression levels in pregnancies with FGR and post-term placenta.
Article
Multidisciplinary Sciences
Damanpreet Garcha, Susan P. Walker, Teresa M. MacDonald, Jon Hyett, Jessica Jellins, Jenny Myers, Sebastian E. Illanes, Jhy K. Nien, Manuel Schepeler, Emerson Keenan, Carole-Anne Whigham, Ping Cannon, Elizabeth Murray, Tuong-Vi Nguyen, Manju Kandel, Joshua Masci, Ciara Murphy, Tess Cruickshank, Natasha Pritchard, Natalie J. Hannan, Fiona Brownfoot, Alexandra Roddy Mitchell, Anna Middleton, Gabrielle Pell, Georgia P. Wong, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: The study found that circulating maternal syndecan-1 is consistently reduced in women who are destined to deliver growth restricted infants or preterm infants due to disease. Reduced syndecan-1 secretion is caused by hypoxia, and its loss affects cell proliferation.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Catherine A. Cluver, Richard Hiscock, Eric H. Decloedt, David R. Hall, Sonja Schell, Ben W. Mol, Fiona Brownfoot, Tu'uhevaha J. Kaitu'u-Lino, Susan P. Walker, Stephen Tong
Summary: Extended release metformin can prolong gestation in women with preterm preeclampsia undergoing expectant management, with potential benefits on neonatal nursery stay. Further trials are needed to confirm these findings.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Obstetrics & Gynecology
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu'uhevaha J. Kaitu'u-Lino, Susan P. Walker, Owen Stock, Katie M. Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Natalie J. Hannan
Summary: LOX-1 expression is reduced in preeclamptic placentas and hypoxic cytotrophoblast, while treatment with esomeprazole or lansoprazole in vitro can increase placental LOX-1 expression. These findings contribute to a better understanding of maternal adaptations in pregnancy complications.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2021)
Article
Developmental Biology
Faith Andres, Georgia P. Wong, Susan P. Walker, Teresa M. MacDonald, Emerson Keenan, Ping Cannon, Tuong-Vi Nguyen, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: The circulating ADAM12 levels in the first trimester are reduced in fetal growth restriction and preeclampsia. This study validates ADAM12 as a biomarker for small for gestational age infants near term, but its predictive value for preeclampsia is inconsistent.
Article
Developmental Biology
Carole-Anne Whigham, Roxanne Hastie, Natalie J. Hannan, Fiona Brownfoot, Natasha Pritchard, Ping Cannon, Tuong Vi Nguyen, Manju Kandel, Joshua Masci, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: Inhibition of EGFR signaling and potentially mitochondrial respiration can alter PlGF secretion from primary trophoblast cells and HUVECs, coinciding with reduced sFlt-1 secretion. This suggests that common pathways regulate both pro- and anti-angiogenic molecules, providing insight into the pathogenesis of preeclampsia.
Review
Medicine, General & Internal
Teresa M. MacDonald, Susan P. Walker, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: Preeclampsia is a pregnancy-specific disease that has a significant impact on maternal and perinatal morbidity and mortality worldwide. Currently, there are limited options for predicting and diagnosing preeclampsia, and further research is needed to identify effective tests and biomarkers.
Article
Cardiac & Cardiovascular Systems
Roxanne Hastie, Lina Bergman, Susan P. Walker, Tu'uhevaha Kaitu'u-Lino, Natalie J. Hannan, Fiona Brownfoot, Sonja Schell, Alesia Harper, Ping Cannon, Catherine A. Cluver, Stephen Tong
Summary: The study shows that there is an association between circulating sFlt-1 and PlGF levels and severe adverse maternal outcomes among women with preeclampsia, with levels becoming more deranged with increasing disease severity. This suggests that further angiogenic imbalance may be a pathogenic disease driver responsible for the life-threatening maternal complications in preeclampsia.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Editorial Material
Biochemistry & Molecular Biology
Tu'uhevaha J. Kaitu'u-Lino, Lucy A. Bartho, Stephen Tong
Summary: A blood test measuring cell-free DNA methylation in early pregnancy may provide a novel method to predict the risk of preterm pre-eclampsia.