Article
Multidisciplinary Sciences
Anil Kamat, Condell Eastmond, Yuanyuan Gao, Arun Nemani, Erim Yanik, Lora Cavuoto, Matthew Hackett, Jack Norfleet, Steven Schwaitzberg, Suvranu De, Xavier Intes
Summary: This study presents a fNIRS dataset acquired on mobile subjects performing FLS tasks in a laboratory environment. Relevant information and FLS scores are provided to facilitate the use of this open-access dataset.
Article
Neurosciences
Milena Radoman, Natania A. Crane, Stephanie M. Gorka, Jessica Weafer, Scott A. Langenecker, Harriet de Wit, K. Luan Phan
Summary: The study found that measures of alcohol reward are related to neural indices of monetary reward in humans, supporting the linkage between individual differences in responses to drug and nondrug reward. These findings suggest a risk profile for drug use or abuse, particularly in young adults.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Stefano Cataldi, Clay Lacefield, N. Shashaank, Gautam Kumar, Siham Boumhaouad, David Sulzer
Summary: This study investigates the roles of the dorsomedial striatum (DMS) and dorsolateral striatum (DLS) in motor learning using a mouse Treadmill Training Task and photometry. The results show that as mice become more proficient at running, activity in the DMS direct pathway decreases, while direct pathway activity in the DLS remains similar throughout training. Additionally, the study demonstrates the importance of dopamine neurotransmission in efficient motor coordination learning.
Article
Biology
Kelly M. Martyniuk, Arturo Torres-Herraez, Daniel C. Lowes, Marcelo Rubinstein, Marie A. Labouesse, Christoph Kellendonk
Summary: In the striatum, the activity of acetylcholine neurons is regulated by dopamine release, and this regulation is mediated by dopamine D2 receptors. Through experiments on mice, it was found that D2 receptors affect the duration of acetylcholine level changes and regulate the temporal correlation between the two signals. These results suggest an important role of D2 receptors in motivation to initiate actions.
Article
Neurosciences
M. Thiele, K. S. L. Yuen, A. V. M. Gerlicher, R. Kalisch
Summary: Animal studies suggest that fear extinction learning involves prediction error signal encoded by dopamine neurons, similar to reward learning. However, the mechanisms in human fear extinction learning are still not fully understood, with previous findings indicating correlations with genetic variations related to dopamine.
Article
Neurosciences
Katrina P. Nguyen, Abhinav Sharma, Mauricio Gil-Silva, Aryn H. Gittis, Steven M. Chase
Summary: This study revealed that mouse locomotor learning is accompanied by specific paw kinematic progressions that change with different stages of performance. Mice refine interlimb coordination and stride length during learning, ultimately adopting a more variable locomotor strategy.
Article
Psychology, Multidisciplinary
Adam J. Toth, Fazilat Hojaji, Mark J. Campbell
Summary: This study aims to use existing kinematic data to investigate whether there are differences in specific phases of target acquisition movements between gamers of different expertise levels. The results show that gamers with higher expertise demonstrate superior motor planning and sensory-motor integration, which can be further improved through training.
COMPUTERS IN HUMAN BEHAVIOR
(2023)
Article
Sport Sciences
Sajjad Daneshgar, Taylor Tvrdy, Roger m. Enoka
Summary: The purpose of this study was to investigate the influence of practice on the pegboard times and peg-manipulation phases of older adults. The results showed that there were differences between groups in the phases of the peg-manipulation cycle that became faster with practice.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Biology
Tomas Mediavilla, Ozgun Ozalay, Hector M. Estevez-Silva, Barbara Frias, Greger Oradd, Fahad R. Sultan, Claudio Brozzoli, Benjamin Garzon, Martin Lovden, Daniel J. Marcellino
Summary: Observations in rodents suggest that learning-dependent changes may involve increased dendritic spine density, alterations in astrocyte volume, and adaptations within intracortical myelin. Using a motor skill learning paradigm, this study found nonlinear increases in intracortical myelin during learning, supporting the hypothesis that myelin is a component of structural changes observed by voxel-based morphometry.
Article
Neurosciences
Ashley C. Parr, Finnegan Calabro, Bart Larsen, Brenden Tervo-Clemmens, Samuel Elliot, Will Foran, Valur Olafsson, Beatriz Luna
Summary: Our study found that decreases in reward-state connectivity were associated with improvements in reward-guided decision-making and decreases in risk-taking. Additionally, NAcc tissue-iron mediated age-related changes and was associated with variability in connectivity, with developmental increases in NAcc R2? corresponding with developmental decreases in connectivity.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Suzuka Narukawa, Momoka Nishimura, Izumi Kuze, Ibuki Ohno, Masaki Fukunaga, Kohta I. Kobayasi, Shota A. Murai
Summary: This study investigated the neural correlates of rotating fidget spinners using functional magnetic resonance imaging. The results showed that several brain regions associated with motor control were activated during the rotation of spinners. Furthermore, easier-to-rotate spinners elicited stronger neural activity. The analysis also revealed increased functional connectivity between the cortex and striatum during spinner rotation.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Sukru B. Demiral, Peter Manza, Erin Biesecker, Corinde Wiers, Ehsan Shokri-Kojori, Katherine McPherson, Evan Dennis, Allison Johnson, Dardo Tomasi, Gene-Jack Wang, Nora D. Volkow
Summary: This study assessed the relationship between blink rates and the brain dopamine system, and found that eye blink measures obtained while stressing the dopamine system might provide a more sensitive behavioral biomarker of striatal D1R or D2R in healthy volunteers.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Dorsa Beroukhim-Kay, Bokkyu Kim, John Monterosso, Rebecca Lewthwaite, Carolee Winstein
Summary: During skill acquisition, improved practice performance and recall of a sensorimotor skill are correlated with distinct neural activity patterns, drawing on different motor learning mechanisms. Practice performance improvement is associated with activations in the frontal orbital cortex, putamen, amygdala, and insula, while recall performance is associated with activations in the primary motor cortex, superior frontal gyrus, somatosensory cortex, angular gyrus, and parietal gyrus.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Xiaopei Xu, Ling Hu, Peiyu Huang, Xiaojun Xu, Minming Zhang
Summary: This study found that current coffee consumption is associated with decreased striatal dopamine transporter availability in the caudate. However, the effects of caffeine on dopamine transporter may fade and disappear after quitting coffee consumption.
Article
Clinical Neurology
Pei-Pei Liu, Chih-Chang Chao, Ruey-Ming Liao
Summary: SKF83959 disrupts operant behaviors in rats in a dose-dependent manner by reducing response numbers, showing distinct behavioral profiles in different tasks. Changes in CaMKII-CREB signaling in various regions of the brain are associated with the altered behavior induced by the drug.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Sumiya Shibata, Tatsunori Watanabe, Yoshihiro Yukawa, Masatoshi Minakuchi, Ryota Shimomura, Sachimori Ichimura, Hikari Kirimoto, Tatsuya Mima
Summary: Transcranial static magnetic stimulation (tSMS) over the left primary motor cortex (M1) for 20 min modulates local cortical activity and interregional functional coupling in the theta band, suggesting its potential role in inducing neural oscillations and neurophysiological effects in the frontal cortex.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Tatsunori Watanabe, Nami Kubo, Xiaoxiao Chen, Keisuke Yunoki, Takuya Matsumoto, Takayuki Kuwabara, Toru Sunagawa, Shota Date, Tatsuya Mima, Hikari Kirimoto
Summary: This pilot study investigated the effects of transcranial static magnetic field stimulation (tSMS) on inhibitory control when applied over the dorsolateral prefrontal cortex (DLPFC). The results showed that tSMS did not affect reaction time, suggesting the possibility that it may not be capable of modulating inhibitory control or that the cognitive load in the study was insufficient to detect any effects.
Article
Neurosciences
Tatsunori Watanabe, Tatsuya Mima, Sumiya Shibata, Hikari Kirimoto
Summary: This study investigated how midfrontal theta and occipital gamma oscillations, associated with cognitive functions, are involved in visuomotor control during a precision force-matching task. The results showed that increasing visual feedback gain led to improved performance and changes in cortical oscillations, with increased theta synchronization in the midfrontal area and beta desynchronization in sensorimotor and posterior parietal areas. The findings suggest that cognitive control signaled by midfrontal theta modulates visuomotor processing to refine behavior.
Article
Neurosciences
Tomoya Gyoda, Ippei Nojima, Su-Chuan Lin, Satoko Koganemaru, Tatsuya Mima, Shigeo Tanabe, Ying-Zu Huang
Summary: This study aimed to investigate the effect of GABA activity strengthening through real-time neurofeedback training on subsequent motor learning. The results showed that the NFT intervention led to enhanced GABA activity and suppressed online learning but not offline learning.
Article
Behavioral Sciences
Akari Ogawa, Satoko Koganemaru, Toshimitsu Takahashi, Yuu Takemura, Hiroshi Irisawa, Masao Matsuhashi, Tatsuya Mima, Takashi Mizushima, Kenji Kansaku
Summary: This study investigated the brain activity during volitional swallowing in two ALS patients. The results showed individual differences in cortical motor outputs during swallowing, suggesting the need for a personalized therapeutic approach using ERD for ALS patients with dysphagia.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Editorial Material
Behavioral Sciences
Yuichi Takeuchi, Qun Li, Takeshi Kawano, Jun Nagai, Tatsuya Mima
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Editorial Material
Clinical Neurology
Sumiya Shibata, Tatsunori Watanabe, Naofumi Otsuru, Hideaki Onishi, Tatsuya Mima
Article
Neurosciences
Atsushi Shima, Tomoaki Miyake, Kazuki Tanaka, Akari Ogawa, Erika Omae, Yui Nagamori, Yusuke Miyata, Koji Ohata, Takakuni Maki, Yumie Ono, Tatsuya Mima, Ryosuke Takahashi, Satoko Koganemaru
Summary: Closed-loop brain stimulation combined with robot-assisted training targeting the swing phase of gait can enhance the recovery of gait function in post-stroke patients. Short-term and long-term interventions showed significant improvements in gait speed, the Timed Up and Go test result, and muscle strength. Further studies with a larger number of patients are needed.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Sumiya Shibata, Tatsunori Watanabe, Takuya Matsumoto, Keisuke Yunoki, Takayuki Horinouchi, Hikari Kirimoto, Jianxu Zhang, Hen Wang, Jinglong Wu, Hideaki Onishi, Tatsuya Mima
Summary: This study developed a novel transcranial static magnetic field stimulation (tSMS) system for non-invasive deep brain stimulation. The results showed that the system was able to generate a sufficient magnetic field for neuromodulation in deep brain areas. This stimulation method could potentially be used for brain function regulation therapy.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2022)
Letter
Clinical Neurology
Ryota Shimomura, Sumiya Shibata, Satoko Koganemaru, Masatoshi Minakuchi, Sachimori Ichimura, Akihiro Itoh, Katsumi Shimotake, Tatsuya Mima
Article
Neurosciences
Atsushi Shima, Kazuki Tanaka, Akari Ogawa, Erika Omae, Tomoaki Miyake, Yui Nagamori, Yusuke Miyata, Koji Ohata, Yumie Ono, Tatsuya Mima, Ryosuke Takahashi, Satoko Koganemaru
Summary: This article introduces a novel treatment approach for progressive supranuclear palsy (PSP) patients, which combines backward gait training with synchronized cerebellar transcranial alternating current stimulation (tACS). Through short-term and long-term interventions, it was found that synchronized stimulation significantly reduced postural instability and improved gait speed, balance function, and fall-related self-efficacy in daily life.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Ippei Nojima, Mitsuya Horiba, Kento Sahashi, Satoko Koganemaru, Satona Murakami, Kiminori Aoyama, Noriyuki Matsukawa, Yumie Ono, Tatsuya Mima, Yoshino Ueki
Summary: This study developed a closed-loop transcranial electrical stimulation (tES) intervention for Parkinsonian gait disturbances, which significantly improved gait speed, stride length, gait symmetry, and subjective feelings about freezing. This non-pharmacological and non-invasive treatment approach could be a breakthrough in restoring gait function in patients with Parkinson's disease and related disorders.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Tatsunori Watanabe, Xiaoxiao Chen, Keisuke Yunoki, Takuya Matsumoto, Takayuki Horinouchi, Kanami Ito, Haruki Ishida, Toru Sunagawa, Tatsuya Mima, Hikari Kirimoto
Summary: The effects of transcranial static magnetic stimulation (tSMS) on cognitive performance and brain activity were investigated in relation to left and right dorsolateral prefrontal cortex (DLPFC) stimulation. Both left and right DLPFC stimulation impaired working memory performance to a similar extent, but had different effects on brain oscillatory responses. Left DLPFC stimulation increased event-related synchronization in the beta band, while right DLPFC stimulation did not show this effect.
Article
Multidisciplinary Sciences
Yoshihiro Yukawa, Sumiya Shibata, Satoko Koganemaru, Masatoshi Minakuchi, Ryota Shimomura, Kazuhito Nakamura, Tatsuya Mima
Summary: This study aimed to investigate the effects of low-frequency rTMS combined with OT on the motor function recovery of the affected upper limb in chronic stroke patients with severe hemiparesis. The results showed that patients with severe hemiparesis exhibited increased upper limb use, improved movement quality, and reduced spasticity after receiving rTMS combined with OT. Patients with mild hemiparesis showed significant improvements in FMA scores and manual dexterity, increased upper limb use and MEP, and reduced spasticity after the treatment.
Review
Clinical Neurology
Ippei Nojima, Hisato Sugata, Hiroki Takeuchi, Tatsuya Mima
Summary: This meta-analysis evaluated the effect sizes of clinical studies investigating the use of BCI-based rehabilitation interventions in restoring upper extremity function in post-stroke patients. The results suggest that BCI-based training is superior to conventional interventions for motor recovery of the upper limbs, with a focus on the effectiveness of sensorimotor rhythm algorithm in detecting brain activity. Further studies involving larger cohorts are needed to confirm these results due to high risk of bias and heterogeneity among the studies.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)