Article
Medical Laboratory Technology
Juan Reyes-Barrera, Aida X. Medina-Urrutia, Esteban Jorge-Galarza, Horacio Osorio-Alonso, Abraham S. Arellano-Buendia, Gabriela Olvera-Mayorga, Nestor A. Sanchez-Ortiz, Margarita Torres-Tamayo, Armando R. Tovar Palacio, Ivan Torre-Villalvazo, Juan G. Juarez-Rojas
Summary: Results indicate that uric acid concentration is associated with dysfunctional adipose tissue. Despite the subjects being apparently healthy, the study demonstrates that uric acid is an early instigator of adipose tissue dysfunction.
CLINICA CHIMICA ACTA
(2022)
Article
Nutrition & Dietetics
Dalal Alkazemi, Noora Alsouri, Tasleem Zafar, Stan Kubow
Summary: Magnesium plays a key role in the development of metabolic disorders, and hypomagnesemia may be involved in the pathogenesis of metabolic syndrome (MetS) and its components. Hypomagnesemia is significantly associated with MetS and its components in adults living in Kuwait.
Article
Immunology
John R. Koethe, Carlee Moser, Todd T. Brown, James H. Stein, Theodoros Kelesidis, Michael Dube, Judith Currier, Grace A. McComsey
Summary: In persons with HIV initiating antiretroviral therapy, higher circulating leptin levels are associated with increased insulin resistance and systemic inflammation, independent of fat depot size. This suggests that adipocyte lipid content may contribute to impaired glucose tolerance and systemic inflammation in this population. Serum leptin level is a stronger determinant of insulin resistance and systemic inflammation compared to measurements of regional adiposity.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Hadas Ben-Assayag, Rafael Y. Brzezinski, Shlomo Berliner, David Zeltser, Itzhak Shapira, Ori Rogowski, Sharon Toker, Roy Eldor, Shani Shenhar-Tsarfaty
Summary: This study aimed to determine the prevalence of metabolically healthy individuals and characterize the transition from metabolic health to dysfunction. It found that roughly one-quarter of apparently healthy adults meet the current definitions of metabolic health. The transition from health to metabolic dysfunction is accompanied by inflammation and changes in several non-metabolic syndrome biomarkers. Aggressive screening for these biomarkers, blood pressure, and hsCRP might help identify apparently healthy individuals at increased risk of developing metabolic syndrome.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Health Care Sciences & Services
Syed Omair Adil, Md Asiful Islam, Kamarul Imran Musa, Kashif Shafique
Summary: A systematic review was conducted to determine the prevalence of metabolic syndrome (MetS) among apparently healthy adults in Pakistan. The pooled prevalence of MetS was found to be 28.8%, with the highest prevalence observed in a sub-urban village of Punjab (68%) and Sindh province (63.7%). Risk factors such as low high-density lipoprotein (HDL), central obesity, and high triglyceride were identified.
Article
Medicine, General & Internal
Shasha Yu, Xiaofan Guo, Guangxiao Li, Hongmei Yang, Yingxian Sun
Summary: In recent years, the incidence of metabolic syndrome (MetS) has been increasing in rural China. A community-based prospective cohort study was conducted to investigate the relationship between snoring and the incidence of MetS. The study found that snoring was significantly associated with a higher incidence of MetS, and severe snorers had double the risk of developing MetS compared to non-snorers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Cristina Tudoran, Mariana Tudoran, Talida Georgiana Cut, Voichita Elena Lazureanu, Felix Bende, Renata Fofiu, Alexandra Enache, Silvius Alexandru Pescariu, Dorin Novacescu
Summary: This study analyzed the evolution of diastolic dysfunction (DD) in individuals with post-COVID-19 syndrome. The results showed that DD was commonly diagnosed in patients with obesity and metabolic syndrome (MS), but there was also a significant prevalence in non-obese individuals. The severity of DD gradually decreased, especially in patients without MS.
Review
Pharmacology & Pharmacy
Maria Gonzalez-Rodriguez, Clara Ruiz-Fernandez, Alfonso Cordero-Barreal, Djedjiga Ait Eldjoudi, Jesus Pino, Yousof Farrag, Oreste Gualillo
Summary: Recent research has shown that adipokines play important roles not only in adipose signaling, but also in musculoskeletal diseases, potentially impacting disease progression and treatment response.
DRUG DISCOVERY TODAY
(2022)
Article
Nutrition & Dietetics
Noura B. Younes, Omnia Ahmed Mohamed, Nasser M. Rizk
Summary: This study demonstrates that DHA has the potential to mitigate obesity by reducing the secretion of inflammatory adipokines, oxidative stress, lipolysis, and apoptosis in adipocytes exposed to low O-2 tension-induced hypoxia.
Article
Immunology
Yuqiong Lu, Xiwen Zhang, Jiafang He, Zhanjing Dai, Penghua Shi, Yun Lu, Feng Chang
Summary: The meta-analysis demonstrated that berberine had a significant effect in decreasing inflammatory markers among patients with metabolic syndrome and related disorders. However, it did not affect the level of one specific marker.
INFLAMMOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Syed Omair Adil, Kamarul Imran Musa, Fareed Uddin, Kashif Shafique, Asima Khan, Md Asiful Islam
Summary: Anthropometric indices, including BMI, WC, WHtR, and VAI, were found to be the most accurate predictors of MetS in apparently healthy individuals in Karachi, Pakistan. Conversely, BSI was identified as the weakest indicator for predicting MetS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, Research & Experimental
Archana Arjunan, Juhyun Song
Summary: Dementia is a detrimental neuropathologic condition that has significant physical, mental, social, and financial impacts on patients and society. Patients with metabolic syndrome (MetS), a cluster of diseases that increase the risk of neurological diseases, have a higher likelihood of developing dementia. The synthesis and release of adipokines and myokines, hormones found in muscle and adipose tissue, may be implicated in various MetS conditions, but their precise role is still unclear. This review explores the involvement of adipokines and myokines in MetS-induced dementia through their regulation of glucose and insulin homeostasis, neuro-inflammation, vascular dysfunction, emotional changes, and cognitive function.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Yuting Duan, Weiguang Zhang, Zhe Li, Yue Niu, Yizhi Chen, Xiaomin Liu, Zheyi Dong, Ying Zheng, Xizhao Chen, Zhe Feng, Yong Wang, Delong Zhao, Qiu Liu, Hangtian Li, Huifang Peng, Xuefeng Sun, Guangyan Cai, Hongwei Jiang, Xiangmei Chen
Summary: This study evaluated the predictive value of eight obesity- and lipid-related indicators for MetS. The results showed that LAP, TYG, CVAI, and VAI, which are based on blood lipids, had higher predictive abilities for MetS compared to BMI, BRI, AVI, and BAI, which are based on anthropometry. Among these indicators, LAP had the best predictive ability.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Joy Manohar Sibi, Viswanathan Mohan, Mohan Deepa, Subash Babu, Vivekanandhan Aravindhan
Summary: Lymphatic filariasis might have limited short-term beneficial effects on metabolic syndrome by modulating incretin levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Karolina Bilska, Monika Dmitrzak-Weglarz, Przemyslaw Osip, Joanna Pawlak, Elzbieta Paszynska, Agnieszka Permoda-Pachuta
Summary: Metabolic syndrome is a growing health problem that coexists with nearly half of all patients with affective disorders. This study found that the adiponectin/leptin ratio is associated with metabolic syndrome in female patients with bipolar depression, and it has a negative correlation with certain biological parameters.
Article
Endocrinology & Metabolism
Xue Chen, Zhenzhen Wan, Tingting Geng, Kai Zhu, Rui Li, Qi Lu, Xiaoyu Lin, Sen Liu, Liangkai Chen, Yanjun Guo, Zhilei Shan, Liegang Liu, An Pan, JoAnn E. Manson, Gang Liu
Summary: This study investigated the associations between vitamin D status and microvascular complications in individuals with type 2 diabetes. The results showed that higher serum 25(OH)D concentrations were significantly associated with a lower risk of diabetic microvascular complications.
Article
Virology
Hao Wang, Mengze Gan, Bihao Wu, Rui Zeng, Zhen Wang, Jun Xu, Jia Li, Yandi Zhang, Jinge Cao, Li Chen, Dongsheng Di, Siyuan Peng, Jinfeng Lei, Yingying Zhao, Xuemei Song, Tingting Yuan, Tingting Zhou, Qian Liu, Jing Yi, Xi Wang, Hao Cai, Yanshou Lei, Yuying Wen, Wenhui Li, Qinlin Chen, Yufei Wang, Pinpin Long, Yu Yuan, Chaolong Wang, An Pan, Qi Wang, Rui Gong, Xionglin Fan, Tangchun Wu, Li Liu
Summary: Children are at high risk for COVID-19 and require vaccination. This study evaluates the humoral and cellular immune responses of COVID-19 vaccines in vaccinated children to establish a rational immunization strategy. The results show that the second dose of the inactivated COVID-19 vaccine significantly increases antibody titers and strengthens specific T cell responses compared to the first dose. Memory T cells specific to SARS-CoV-2 are also generated after the first vaccination. These findings provide scientific evidence for the vaccination strategy against COVID-19 in children.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Yan-Bo Zhang, Xiong-Fei Pan, Qi Lu, Yan-Xiu Wang, Ting-Ting Geng, Yan-Feng Zhou, Linda M. Liao, Zhou-Zheng Tu, Jun-Xiang Chen, Peng-Fei Xia, Yi Wang, Zhen-Zhen Wan, Kun-Quan Guo, Kun Yang, Han-Dong Yang, Shuo-Hua Chen, Guo-Dong Wang, Xu Han, Yi-Xin Wang, Danxia Yu, Mei-An He, Xiao-Min Zhang, Lie-Gang Liu, Tangchun Wu, Shou-Ling Wu, Gang Liu, An Pan
Summary: This study aims to examine the associations of combined lifestyle factors with incident cardiovascular disease (CVD) and mortality in patients with diabetes. The results demonstrate that adherence to multicomponent healthy lifestyles is associated with a lower risk of CVD and premature death in patients with diabetes.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Medicine, General & Internal
Tingting Geng, Kai Zhu, Qi Lu, Zhenzhen Wan, Xue Chen, Liegang Liu, An Pan, Gang Liu
Summary: This study aimed to examine the associations of overall lifestyle behaviors with risks of microvascular complications among patients with type 2 diabetes and explore the potential mediation effects of metabolic biomarkers. The study found that adherence to healthy lifestyle behaviors was associated with a significantly lower risk of microvascular complications, and these associations were mediated, in part, through improving metabolic biomarkers.
Article
Nutrition & Dietetics
Jing Ouyang, Yuwei Lai, Linjing Wu, Yi Wang, Ping Wu, Yi-Xiang Ye, Xue Yang, Yanyu Gao, Jiaying Yuan, Xingyue Song, Shijiao Yan, Chuanzhu Lv, Yi-Xin Wang, Gang Liu, Yayi Hu, An Pan, Xiong-Fei Pan
Summary: This study investigated the association between weight change from age 18 to pregnancy and gestational diabetes mellitus (GDM) among Chinese pregnant women. The results showed that weight change was linearly associated with a higher risk of GDM, and excessive weight gain increased the risk even more. Maintaining weight stability, especially preventing excessive weight gain from early adulthood to pregnancy, could be a potential strategy to reduce GDM risk.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Medicine, General & Internal
Ping Wu, Yi Wang, Yi Ye, Xue Yang, Yichao Huang, Yixiang Ye, Yuwei Lai, Jing Ouyang, Linjing Wu, Jianguo Xu, Jiaying Yuan, Yayi Hu, Yi-Xin Wang, Gang Liu, Da Chen, An Pan, Xiong-Fei Pan
Summary: This study aimed to investigate the associations of liver enzymes and hepatic steatosis index (HSI) in early pregnancy with gestational diabetes mellitus (GDM) risk, as well as the potential mediation effects of lipid metabolites. The results showed that elevated liver enzymes and HSI in early pregnancy, even within a normal range, were associated with higher risks of GDM among Chinese pregnant women, and this association was largely mediated by altered lipid metabolism.
Meeting Abstract
Cardiac & Cardiovascular Systems
Frank Qian, Kai Zhu, Qi Lu, Rui Liu, Zixin Qiu, Lin Li, An Pan, Gang Liu
Article
Cardiac & Cardiovascular Systems
Jun-Xiang Chen, Rui Li, Tingting Geng, Yuexuan Wang, Qi Lu, Zhou-Zheng Tu, Yue Li, Yun-Fei Liao, Kun Yang, Li-Rong Zhou, Wen-Wei Tong, Yan-Feng Zhou, Gang Liu, An Pan
Summary: This study found that there is a U-shaped association between high-density lipoprotein cholesterol (HDL-C) levels and mortality risk in individuals with hypertension, while individuals without hypertension show an L-shaped association. Compared to individuals with normal HDL-C levels (50-70 mg/dL), individuals with hypertension and very high HDL-C levels (>90 mg/dL) have a significantly higher risk of all-cause mortality. Additionally, larger size of HDL particles (HDL-P) is positively associated with mortality risk, whereas smaller size of HDL-P is inversely associated with mortality risk in individuals with hypertension.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Jiang-Shui Wang, Peng-Fei Xia, Meng-Nan Ma, Yue Li, Ting-Ting Geng, Yan-Bo Zhang, Zhou-Zheng Tu, Limiao Jiang, Li-Rong Zhou, Bing-Fei Zhang, Wen-Wei Tong, Zhilei Shan, Gang Liu, Kun Yang, An Pan
Summary: Understanding the trends in the prevalence of metabolically healthy obesity (MHO) among US adults from 1999 to 2018 can help with stratification and management of obesity and inform policy efforts.
Article
Chemistry, Analytical
Mengnan Ma, Xiong-Fei Pan, An Pan, Limiao Jiang
Summary: This study systematically investigated the effect of urine dilution on 1H NMR metabolic profiles and found that mild dilution can preserve high-abundance metabolites, reduce chemical shift variations, and increase signal separations. These findings are important for NMR-based metabolomics research and large-scale epidemiological studies with limited samples.
ANALYTICAL CHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Li Feng Tan, Huiqi Li, An Pan, Gim Gee Teng, Woon-Puay Koh
Summary: The relationship between gout and the risk of cognitive impairment or dementia is not well established. This study found that having gout at midlife is associated with a reduced risk of developing cognitive impairment later in life.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Endocrinology & Metabolism
Rui Li, Jun-Xiang Chen, Qi Lu, Ting-Ting Geng, Peng-Fei Xia, Yi Wang, Liang-Kai Chen, Zhi-Lei Shan, An Pan, Gang Liu
Summary: The study aimed to investigate the associations between lipoprotein subclasses categorized by particle sizes and the risk of all-cause and cardiovascular disease (CVD) mortality in individuals with type 2 diabetes. The findings showed that the associations between lipoprotein particles, particularly high-density lipoprotein (HDL) particles, and all-cause and CVD mortality varied significantly by particle sizes among patients with type 2 diabetes, highlighting the importance of particle size as a lipoprotein metric in mortality risk discrimination.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Ping Wu, Linjing Wu, Yi Wang, Yi Ye, Xue Yang, Jiaying Yuan, Jianguo Xu, Yi-Xin Wang, Xingyue Song, Shijiao Yan, Chuanzhu Lv, Gang Liu, An Pan, Xiong-Fei Pan
Summary: This study found that elevated serum FGF21 levels during pregnancy are associated with an increased risk of GDM, but this positive association is attenuated after adjusting for pre-pregnancy BMI. Additionally, the study found a modifying effect of overweight/obesity on the association between FGF21 and GDM risk, with the association being significant only in participants with a pre-pregnancy BMI of 24 kg/m(2).
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Nutrition & Dietetics
Yan-Feng Zhou, Xing-Yue Song, An Pan, Woon-Puay Koh
Summary: This study aimed to assess the impact of nutrition on healthy ageing in Asia by conducting a systematic review. The results showed that consuming healthy foods and adhering to healthy dietary patterns at midlife can increase the likelihood of healthy ageing.
Article
Medicine, General & Internal
Yi-Xiang Ye, Ting-Ting Geng, Yan-Feng Zhou, Pan He, Ji-Juan Zhang, Gang Liu, Walter Willett, An Pan, Woon-Puay Koh
Summary: This study investigated the association between a planetary health diet (PHD) score and environmental impacts and mortality outcomes in a Chinese cohort living in Singapore. The results showed that higher PHD scores were associated with lower greenhouse gas emissions and higher total water footprint and land use. In terms of mortality outcomes, higher adherence to PHD was linked to reduced risk of all-cause mortality, cardiovascular disease mortality, cancer mortality, and respiratory disease mortality.
