Sensitivity of Global Translation to mTOR Inhibition in REN Cells Depends on the Equilibrium between eIF4E and 4E-BP1

Cellular IRES-mediated translation

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The cancerous translation apparatus

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Malignant mesothelioma: Facts, Myths, and Hypotheses

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Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus

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MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

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Translational Regulation of Gene Expression during Conditions of Cell Stress

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The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTORC1 signaling: what we still don't know

(2010) X. Wang et al.   Journal of Molecular Cell Biology

Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin

(2009) S. Assouline et al.   BLOOD

Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma

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c-Myc and eIF4F Constitute a Feedforward Loop That Regulates Cell Growth: Implications for Anticancer Therapy

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Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Eukaryotic initiation factor 6 mediates a continuum between 60S ribosome biogenesis and translation

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Synthesis and function of ribosomal proteins - fading models and new perspectives

(2009) Sara Caldarola et al.   FEBS Journal

Spreading of mesothelioma cells is rapamycin-sensitive and requires continuing translation

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Canonical Initiation Factor Requirements of the Myc Family of Internal Ribosome Entry Segments

(2009) K. A. Spriggs et al.   MOLECULAR AND CELLULAR BIOLOGY

Blocking eukaryotic initiation factor 4F complex formation does not inhibit the mTORC1-dependent activation of protein synthesis in cardiomyocytes

(2008) Brandon P. H. Huang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

PKCβII modulates translation independently from mTOR and through RACK1

(2008) Stefano Grosso et al.   BIOCHEMICAL JOURNAL

Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells

(2008) Andrea Bianchini et al.   CARCINOGENESIS

Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation

(2008) Valentina Gandin et al.   NATURE

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

(2008) Beth Apsel et al.   Nature Chemical Biology

Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs

(2008) L. Rong et al.   RNA