Review
Biochemistry & Molecular Biology
Yi-Fen Lai, Ting-Yi Lin, Pin-Kuan Ho, Yi-Hao Chen, Yu-Chuan Huang, Da-Wen Lu
Summary: In this review, the neuroprotective function of erythropoietin (EPO) in extra-hematopoietic tissues, especially the retina, is highlighted. The available pre-clinical studies of EPO in treating various optic neuropathies are summarized. Furthermore, future strategies for optic nerve protection and repair using EPO and its derivatives are explored.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Junji Ikeda, Yasuhiro Shimojima, Akira Yamada, Yoshiki Sekijima
Summary: This study found that in patients with immune-mediated HP, the volume of contrast-enhanced dura mater was higher, particularly in the convexity, cranial fossa, and tentorium cerebelli regions; patients with cranial nerve VIII neuropathy had significantly higher volume of contrast-enhanced dura mater in the cranial fossa; the volume of contrast-enhanced dura mater in the tentorium cerebelli was positively correlated with CSF protein levels.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Mei-Xue Dong, Qing Wang, Jun-Feng Xu, Ling Hu, Ying Yu, Tao Li
Summary: Abusing laughing gas can lead to peripheral neuropathy, resulting in symptoms such as wheelchair dependence and nerve damage. The patient experienced significant improvement in symptoms after appropriate treatment.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Ying Gong, Roel G. J. Klein Wolterink, Valeriia Gulaia, Silvie Cloosen, Femke A. I. Ehlers, Lotte Wieten, Yvo F. Graus, Gerard M. J. Bos, Wilfred T. V. Germeraad
Summary: The study describes a novel fully humanized anti-MUC1 antibody, which, especially after defucosylation, is a promising therapeutic candidate for cellular immunotherapy.
Review
Biochemistry & Molecular Biology
Abhishek Shastri, Ahmad Al Aiyan, Uday Kishore, Maria Elena Farrugia
Summary: Dysfunction of the immune system can lead to peripheral nervous system damage. The immune mechanisms involve inflammation and proliferation of Schwann cells and result in demyelination and axonal degeneration. Animal models have contributed to understanding the pathophysiology of inflammatory polyradiculoneuropathies. Detection of specific antibodies aids in diagnosis. Paraneoplastic neuropathies are immune-mediated reactions to tumor cells. This review discusses the immunological and pathophysiological mechanisms, as well as the electrophysiological characteristics, laboratory features, and treatment options of dysimmune neuropathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Gastroenterology & Hepatology
Laurence P. Diggs, Benjamin Ruf, Chi Ma, Bernd Heinrich, Linda Cui, Qianfei Zhang, John C. McVey, Simon Wabitsch, Sophia Heinrich, Umberto Rosato, Walter Lai, Varun Subramanyam, Thomas Longerich, Sven H. Loosen, Tom Luedde, Ulf Peter Neumann, Sabina Desar, David Kleiner, Gregory Gores, Xin Wei Wang, Tim F. Greten
Summary: Stimulating antigen-presenting cells such as macrophages and dendritic cells through CD40 agonist significantly enhances the response to anti-PD-1 therapy in intrahepatic cholangiocarcinoma (iCCA) models, leading to a greater reduction in tumor burden. The combination of CD40 agonist and PD-1 inhibitor, along with chemotherapy, shows promising results in improving therapeutic efficacy and overall survival.
JOURNAL OF HEPATOLOGY
(2021)
Article
Clinical Neurology
Susan K. Halstead, Mark Jackson, Ezio Bianchi, Stefan Rupp, Nicolas Granger, Marika Menchetti, Greta Galli, Paul Freeman, Adriana Kaczmarska, Sofie F. M. Bhatti, Josep Brocal, Roberto Jose-Lopez, Andrea Tipold, Rodrigo Gutierrez Quintana, Edward J. Ives, Theofanis Liatis, Jasmin Nessler, Clare Rusbridge, Hugh J. Willison, Angie Rupp
Summary: Recent research has found that anti-GM2 and anti-GalNAc-GD1a IgG ganglioside antibodies can serve as biomarkers for acute canine polyradiculoneuritis, a canine equivalent of Guillain-Barre syndrome. This study aimed to investigate the presence of similar antibodies in cats diagnosed with immune-mediated polyneuropathies. The presence of IgG antibodies against various glycolipids was examined in the sera of cats with immune-mediated polyneuropathies, as well as cats with other neurological disorders and neurologically normal cats. Results showed that anti-GM2 IgG antibodies were a better marker for identifying immune-mediated polyneuropathies in cats, compared to anti-GalNAc-GD1a antibodies, and these antibodies may serve as serum biomarkers for this condition in cats.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Yangchun Li, Man Tang, Lu Yu, Ying He, Lisong Liang, Hao Qu, Wei Si, Xiao Hu
Summary: We report a case of a 57-year-old female patient diagnosed with aquaporin 4 (AQP4)-IgG positive neuromyelitis optica spectrum disorders (NMOSD) with undifferentiated connective tissue disease and multiple peripheral neuropathy. The patient tested positive for multiple anti-ganglioside antibodies and anti-sulfatide antibodies. After treatment with methylprednisolone, gamma globulin, plasma exchange, and rituximab, the patient's condition improved and she was discharged from the hospital.
Article
Clinical Neurology
Jiting Zhu, Yuanyuan Zhang, Runyun Li, Yi Lin, Ying Fu, Yaping Yan, Wenli Zhu, Ning Wang, Zaiqiang Zhang, Guorong Xu
Summary: This study investigated the diagnostic efficiency of a novel immunoblotting detection assay for anti-ganglioside antibodies (AGAs) in Guillain-Barre syndrome (GBS). The results showed a high detection rate of AGAs in GBS patients, with specific assistance in diagnosing the AMAN subtype.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Sonja Koerner, Markus Maximilian Koch, Lars Hendrik Mueschen, Tabea Seeliger, Olivia Schreiber-Katz, Stefan Gingele, Martin Stangel, Reinhard Dengler, Susanne Petri, Thomas Skripuletz, Alma Osmanovic
Summary: This study assessed cranial nerve involvement in immune-mediated neuropathy patients undergoing immunoglobulin treatment by measuring blink reflex R1 latency prolongation. It identified prolonged R1 latencies in 23 out of 104 patients, who had more severe functional impairments and limited clinical presentation. The study highlights the potential of blink reflex studies to detect subclinical cranial nerve involvement and calls for further research on the clinical utility of measuring R1 latency.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Giuseppe Liberatore, Alberto De Lorenzo, Claudia Giannotta, Fiore Manganelli, Massimiliano Filosto, Giuseppe Cosentino, Dario Cocito, Chiara Briani, Andrea Cortese, Raffaella Fazio, Giuseppe Lauria, Angelo Maurizio Clerici, Tiziana Rosso, Girolama Alessandra Marfia, Giovanni Antonini, Guido Cavaletti, Marinella Carpo, Pietro Emiliano Doneddu, Emanuele Spina, Stefano Cotti Piccinelli, Erdita Peci, Luis Querol, Eduardo Nobile-Orazio
Summary: This study investigated the occurrence and clinical features of anti-nerve autoantibodies in Italian patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The results showed that anti-neurofascin155 and anti-contactin1 antibodies were associated with specific clinical symptoms, while anti-ganglioside antibodies were related to a progressive course.
NEUROLOGICAL SCIENCES
(2022)
Article
Immunology
Haider S. Mahdi, Mary Woodall-Jappe, Preeti Singh, Myron S. Czuczman
Summary: This study evaluated the efficacy of adding E7777 to anti-PD-1 antibody therapy. Results showed that combination therapy with E7777 and anti-PD-1 led to increased anti-tumor activity and improved overall survival compared to monotherapy. Additionally, the combination therapy was able to counterbalance Treg cell infiltration induced by anti-PD-1 treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Correction
Hematology
Ke Wan, Yafei Yin, Zimian Luo, Jianzhao Cheng
Summary: This article describes a remarkable therapeutic response to roxadustat in a case of anti-erythropoietin antibody-mediated pure red cell aplasia.
ANNALS OF HEMATOLOGY
(2021)
Article
Medicine, General & Internal
Limei Zhang, Linqing Ma, Lihua Zhou, Lu Sun, Chunru Han, Qi Fang
Summary: We present a case of Miller-Fisher syndrome (MFS) in a 48-year-old male patient with positive anti-GD1b and anti-GM1 antibodies combined with multiple autoimmune antibodies. The patient experienced symptoms of dizziness, visual rotation, nausea, and vomiting accompanied by unsteady gait and diplopia. Treatment with immunoglobulins and hormones led to symptom improvement.
Article
Multidisciplinary Sciences
Dan Wu, Linda J. Richards, Zhiyong Zhao, Zuozhen Cao, Wanrong Luo, Wei Shao, Song-Hai Shi, Michael Miller, Susumu Mori, Seth Blackshaw, Jiangyang Zhang
Summary: The study reconstructed a four-dimensional continuum of the embryonic mouse brain from E10.5 to E15.5, revealing morphological and microscopic changes in the developing brain and correlating gene expression data with neuroanatomical changes. By identifying developmental modes and regional clusters, it demonstrates how this method can be used to analyze interactions between upstream genetic events and anatomical changes in brain development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Zifei Liang, Choong H. Lee, Tanzil M. Arefin, Zijun Dong, Piotr Walczak, Song-Hai Shi, Florian Knoll, Yulin Ge, Leslie Ying, Jiangyang Zhang
Summary: This study demonstrates the use of deep convolutional neural networks to estimate histological staining intensity directly from MRI signals, providing three-dimensional images that closely mimic target histology and enhanced sensitivity and specificity compared to conventional MRI markers. Additionally, the relative contribution of each MRI contrast within the networks can be used to optimize multi-contrast MRI acquisition, serving as a resource for validating novel MRI techniques.
Article
Radiology, Nuclear Medicine & Medical Imaging
Choong Heon Lee, Piotr Walczak, Jiangyang Zhang
Summary: In this study, we investigated the ability of ihMT MRI to detect white matter structures in the hypomyelinated shiverer mouse brain. Our results showed that ihMT can provide clear visualization of the hypomyelinated corpus callosum, with higher myelin contrast compared to conventional MT. These findings suggest the potential use of ihMT as a marker for early myelination or myelin repair.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zuozhen Cao, Huijia Lin, Fusheng Gao, Xiaoxia Shen, Hongxi Zhang, Jiangyang Zhang, Lizhong Du, Can Lai, Xiaolu Ma, Dan Wu
Summary: This study systematically characterized the microstructural alterations in neonates with hypoxic-ischemic encephalopathy (HIE) using advanced diffusion MRI. The results showed extensive microstructural injury in severe HIE, and association fiber injury with rightward lateralization in moderate and mild HIE.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Alina Sprenger-Svacina, Johannes Haensch, Kilian Weiss, Nils Grosse Hokamp, David Maintz, Marc Schlamann, Gereon R. Fink, Natalie Schloss, Kai Laukamp, Gilbert Wunderlich, Helmar C. Lehmann, Thorsten Lichtenstein
Summary: This study evaluated the utility of a multi-parametric MRI protocol to detect loss of spinal motor neurons and subsequent muscle damage in adult SMA patients. The results showed that water T-2 mapping and Dixon-based PDFF estimation can distinguish between SMA patients and controls.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Anna Lena Fisse, Jeremias Motte, Thomas Grueter, Felix Kohle, Cornelius Kronlage, Jan-Hendrik Stahl, Natalie Winter, Tabea Seeliger, Stefan Gingele, Frauke Stascheit, Benjamin Hotter, Juliane Klehmet, Karsten Kummer, Elena K. Enax-Krumova, Dietrich Sturm, Thomas Skripuletz, Jens Schmidt, Min-Suk Yoon, Kalliopi Pitarokoili, Helmar C. Lehmann, Alexander Grimm
Summary: This study investigates the current care of patients with immune-mediated polyneuropathies in specialized centers in Germany and provides important epidemiological insights. The findings suggest that the development of specific treatment and follow-up recommendations is necessary to ensure a uniform standard of patient care.
Article
Clinical Neurology
Sonja E. Leonhard, Annemiek A. van der Eijk, Henning Andersen, Giovanni Antonini, Samuel Arends, Shahram Attarian, Fabio A. Barroso, Kathleen J. Bateman, Manou R. Batstra, Luana Benedetti, Bianca van den Berg, Peter Van den Bergh, Jan Burmann, Mark Busby, Carlos Casasnovas, David R. Cornblath, Amy Davidson, Alex Y. Doets, Pieter A. van Doorn, Charlotte Dornonville de la Cour, Thomas E. Feasby, Janev Fehmi, Tania Garcia-Sobrino, Jonathan M. Goldstein, Kenneth C. Gorson, Volkan Granit, Robert D. M. Hadden, Thomas Harbo, Hans-Peter Hartung, Imran Hasan, Jakob Holbech, James K. L. Holt, Israt Jahan, Zhahirul Islam, Summer Karafiath, Hans D. Katzberg, Ruud P. Kleyweg, Noah Kolb, Krista Kuitwaard, Motoi Kuwahara, Susumu Kusunoki, Linda W. G. Luijten, Satoshi Kuwabara, Edward Lee Pan, Helmar C. Lehmann, Marijke Maas, Lorena Martin-Aguilar, James Al Miller, Quazi Deen Mohammad, Soledad Monges, Velina Nedkova-Hristova, Eduardo Nobile-Orazio, Julio Pardo, Yann Pereon, Luis Querol, Ricardo Reisin, Wouter Van Rijs, Simon Rinaldi, Rhys C. Roberts, Joyce Roodbol, Nortina Shahrizaila, Soren Hein Sindrup, Beth Stein, Tan Cheng-Yin, Hatice Tankisi, Anne P. Tio-Gillen, Maria J. Sedano Tous, Christine Verboon, Frederique H. Vermeij, Leo H. Visser, Ruth Huizinga, Hugh J. Willison, Bart C. Jacobs
Summary: This study analyzed the role of infections in Guillain-Barre syndrome (GBS) and their association with clinical features and disease severity. The distribution of infections varied across geographical regions, but the association between infection and clinical phenotype differed. Coinfections were common, highlighting the importance of broad serologic testing. Infections were also found to have prognostic value for GBS outcome.
Article
Pharmacology & Pharmacy
Ines Klein, Janne Boenert, Felix Lange, Britt Christensen, Meike K. Wassermann, Martin H. J. Wiesen, Daniel Navin Olschewski, Monika Rabenstein, Carsten Mueller, Helmar C. Lehmann, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger, Sabine Ulrike Vay
Summary: Glia cells play a critical role in mediating the side effects of paclitaxel, influencing their (neuro-) inflammatory and (neuro-) regenerative properties and their interaction with other glia cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Martin K. R. Svacina, Alina Sprenger-Svacina, Anastasia Tsakmaklis, Alina M. Rueb, Ines Klein, Hauke Wuestenberg, Gereon R. Fink, Helmar C. Lehmann, Maria J. G. T. Vehreschild, Fedja Farowski
Summary: This study found that the gut microbiome of CIDP patients has increased diversity and enrichment of Firmicutes, which produce short-chain fatty acids. However, intravenous immunoglobulin (IVIg) administration did not have a short-term impact on the gut microbiome in CIDP patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chenyang Li, Els Fieremans, Dmitry S. S. Novikov, Yulin Ge, Jiangyang Zhang
Summary: FEXI and DKI(t) show similar sensitivity to exchange processes in white matter but are affected by tissue microstructure in gray matter.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Neurosciences
Martin K. R. Svacina, Anika Meissner, Finja Schweitzer, Alina Sprenger-Svacina, Ines Klein, Hauke Wuestenberg, Felix Kohle, Helene L. Walter, Michael Schroeter, Helmar C. Lehmann
Summary: This exploratory study analyzed the impact of COVID-19 mRNA vaccine on disease activity and IVIg-immunomodulation in CIDP patients. The results showed that except for a significantly lower expression of CD32b on naive B cells after vaccination, there were no significant alterations in immunomarkers for CIDP or IVIg-mediated immunomodulation. This study suggests that COVID-19 mRNA vaccine does not affect immune activity in CIDP and does not alter the immunomodulatory effects of IVIg.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2023)
Article
Neurosciences
Zifei Liang, Tanzil Mahmud Arefin, Choong H. Lee, Jiangyang Zhang
Summary: Diffusion MRI (dMRI) tractography is the only non-invasive tool for mapping macroscopic structural connectivity. This study demonstrated that a deep learning network trained on mesoscopic tract-tracing data can improve the estimation of fiber orientation distributions (FODs) in mouse brain dMRI data, leading to enhanced specificity in tractography results without compromising sensitivity.
Article
Neurosciences
Tanzil Mahmud Arefin, Choong Heon Lee, Zifei Liang, Harikrishna Rallapalli, Youssef Z. Wadghiri, Daniel H. Turnbull, Jiangyang Zhang
Summary: In this study, we aimed to optimize the imaging and computational pipeline to achieve the best possible spatial overlaps between dMRI tractography and tracer-based axonal projection maps in the mouse brain corticothalamic network. We developed a dMRI-based atlas of the mouse forebrain and reconstructed detailed corticothalamic structural connectivity matrices using different imaging and tractography parameters. Our results suggest that these parameters significantly affect tractography outcomes and our atlas can be used to investigate macroscopic structural connectivity in the mouse brain.
Article
Cell Biology
Ines Klein, Jorg Isensee, Martin H. J. Wiesen, Thomas Imhof, Meike K. Wassermann, Carsten Mueller, Tim Hucho, Manuel Koch, Helmar C. Lehmann
Summary: Peripheral neuropathy is a common side effect of cancer treatment with paclitaxel, but the mechanisms of paclitaxel transport into neurons are not well understood. This study identified OATP1A1 and OATP1B2 as the primary neuronal transporters for paclitaxel and suggested that inhibiting these transporters may prevent paclitaxel-induced neuropathy.
Review
Clinical Neurology
Felix Kohle, Marinos C. C. Dalakas, Helmar C. C. Lehmann
Summary: Despite advances in the treatment of CIDP and other AN, many patients remain unsatisfied with available treatments. Repurposing DMTs from other autoimmune conditions, particularly MS and NMOSD, is a promising strategy for establishing new treatment options for AN. B cell-directed and complement-targeting strategies, such as anti-CD20/anti-CD19 agents, Bruton's tyrosine kinase inhibitors, and anti-C5 agents, show promise as therapeutic approaches for AN.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)