Article
Chemistry, Analytical
Chun Dai, Kun Wang, Ming Tan, Zhaolai Hua, Lin Xia, Lei Qin
Summary: In this study, a capillary pump-driven surface-enhanced Raman scattering (SERS) microfluidic chip (LoC-SERS) platform was developed for the sensitive detection of colorectal cancer-associated (CRC) microRNA (miRNA). The platform achieved ultra-low detection limits of miR-122 (4.26 aM) and miR-192 (4.71 aM) within a linear range of 10 aM-10 pM. The results of the platform for clinical samples are highly consistent with those measured by qRT-PCR methods.
ANALYTICAL METHODS
(2023)
Article
Biophysics
Asha P. Johnson, Chinnu Sabu, N. Kumara Swamy, Annstephy Anto, H. V. Gangadharappa, K. Pramod
Summary: Graphene nanoribbons (GNRs) are considered a promising platform for biomedical applications due to their unique properties. By altering the edge functionalities and geometry, their properties can be significantly reformed and controlled. GNRs are extensively explored in the field of biosensing.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Seyoung Koo, Miae Won, Hao Li, Won Young Kim, Mingle Li, Chenxu Yan, Amit Sharma, Zhiqian Guo, Wei-Hong Zhu, Jonathan L. Sessler, Jin Yong Lee, Jong Seung Kim
Summary: The study showed that QM-NH alpha fuc proved effective in detecting various types of cellular senescence, including replicative, ROS, UVA, and drug-induced senescence, as well as identifying senescent cells lacking beta-gal expression. Additionally, the non-invasive real-time senescence tracking provided by QM-NH alpha fuc was validated in an in vivo senescence model. The results suggest that QM-NH alpha fuc could emerge as a useful tool for investigating senescence processes in biological systems.
Article
Multidisciplinary Sciences
Lydia H. Bederka, Jamila R. Sanchez, Jennifer Rebeles, Patricia R. Araujo, Marcia H. Grayson, Shao-Chiang Lai, Louis R. DePalo, Sheila A. Habib, David G. Hill, Kathleen Lopez, Lara Patriquin, Robert Sussman, James Humphreys, Xavier T. Reveles, Vivienne Rebel
Summary: The feasibility of using a flow cytometry platform to analyze sputum for the diagnosis of lung cancer is demonstrated. The differences in cell characteristics, population size, and fluorescence intensity can be used to distinguish cancer samples from high-risk samples.
Article
Oncology
Shan Lin, Clement Larrue, Nastassja K. Scheidegger, Bo Kyung A. Seong, Neekesh Dharia, Miljan Kuljanin, Caroline S. Wechsler, Guillaume Kugener, Amanda L. Robichaud, Amy Saur Conway, Thelma Mashaka, Sarah Mouche, Biniam Adane, Jeremy A. Ryan, Joseph D. Mancias, Scott T. Younger, Federica Piccioni, Lynn H. Lee, Mark Wunderlich, Anthony Letai, Jerome Tamburini, Kimberly Stegmaier
Summary: This study utilized CRISPR screening to identify and validate AML-specific dependencies in vivo, including metabolic vulnerability and apoptosis regulator, providing an important strategy for discovering and prioritizing AML therapeutic targets.
Article
Environmental Sciences
Tomas Makaras, Julija Razumiene, Vidute Gureviciene, Gintare Sauliute, Milda Stankeviciute
Summary: This study investigates the reliability of glucose measurement as a biomarker for evaluating stress response in fish. The findings suggest that the amount of glucose released in fish-holding water significantly increases under stress, while the circulating levels of glucose in blood and gills decrease over time. The swimming activity of fish is also reduced when exposed to specific stressors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biology
Jieqiong Zhang, Tatsuya Tsukui, Xiumin Wu, Alyssa Brito, John Maxwell Trumble, Juan C. Caraballo, Greg M. Allen, Jose Zavala-Solorio, Chunlian Zhang, Jonathan Paw, Wendell A. Lim, Jiefei Geng, Yuliya Kutskova, Adam Freund, Ganesh Kolumam, Dean Sheppard, Robert L. Cohen
Summary: Immunological targeting of pathological cells has shown success in oncology and is expanding to other pathobiological contexts. A flexible platform has been presented that allows labeling cells of interest with a model antigen, ovalbumin (OVA), and can be eliminated by antigen-specific T cells or newly developed OVA antibodies. This platform facilitates the development of immune-based approaches to clear potential pathological cell types in vivo.
LIFE SCIENCE ALLIANCE
(2023)
Article
Biophysics
Yuxuan Qi, Yiwen Pan, Feng Gu, Shuai Wei, Chenglong Fei, Jingfen Han
Summary: RNA interference technology shows great potential in carcinoma therapy, but the efficiency and specificity of dsRNA delivery are crucial. A targeting delivery platform (CTL-PEG-FA) was constructed to efficiently and safely deliver dsRNA, which exhibited excellent gene binding capacity and reduced cytotoxicity. In vivo experiments showed that CTL-PEG-FA/Bcl-2 siRNA complex effectively accumulated at the tumor site, leading to tumor growth inhibition without obvious toxicity, suggesting its potential for clinical gene therapy applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Medicine, Research & Experimental
Sijia Li, Lihong Shao, Tiankai Xu, Xin Jiang, Guozi Yang, Lihua Dong
Summary: Radiotherapy is a significant treatment for tumors, but it can cause radiation damage to normal tissues. Exosomes, nanoscale vesicles containing complex miRNAs and proteins, have shown potential as biomarkers for diseases and in treatment of radiation damage by regulating inflammatory response and promoting tissue repair.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Samla Gauri Balakrishnan, Mohd Ridzuan Ahmad, Seyed Saeid Rahimian Koloor, Michal Petru
Summary: This study aims to simulate the extraction and separation of ctDNA from the blood plasma of cancer patients for early and effective cancer detection. The results showed efficient separation of ctDNA for early cancer management, with a high sensitivity and specificity in tracing ctDNA using a microfluidics platform and SPM bead particles.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Engineering, Biomedical
Shunxiang Gao, Qian Li, Shenghai Zhang, Xinghuai Sun, Hong Zhou, Zhongfeng Wang, Jihong Wu
Summary: Glaucoma is a major cause of blindness worldwide and early detection and intervention are crucial for its prognosis. Monitoring the biomarker GDF15 allows for precise diagnosis and assessment of glaucoma, and this study demonstrates that it can also aid in screening for glaucoma risk and early diagnosis.
Article
Chemistry, Analytical
Chunhua Wang, Yu Zhang, Wei Tang, Chao Wang, Yingkuan Han, Le Qiang, Jianwei Gao, Hong Liu, Lin Han
Summary: The developed universal biosensing platform combines the unique nanostructure and biochemistry properties of graphene oxide quantum dots with the high throughput and low cost of microfluidic chips, enabling reliable and simultaneous detection of multiple cancer biomarkers. This platform has a wide linear quantification range and ultra-low detection limits, allowing for simultaneous detection of multiple biomarkers from multiple individuals in a short time, significantly reducing detection costs and time.
ANALYTICA CHIMICA ACTA
(2021)
Review
Biochemistry & Molecular Biology
Yuanyuan Liang, Shun Li, Liling Tang
Summary: MicroRNAs, specifically the miR-320 family, play a crucial role in regulating gene expression and have been identified as tumor suppressors. Their functions in cancer research extend to inhibition of epithelial-mesenchymal transition, cell proliferation, and apoptosis, while also serving as potential biomarkers for cancer diagnosis and prognosis.
Article
Biochemistry & Molecular Biology
Refaat A. Eid, Mohamed A. Soltan, Muhammad Alaa Eldeen, Ayed A. Shati, Samy A. Dawood, Mohamed Eissa, Mohamed Samir A. Zaki, Mohammad Algahtani, Abdulrahman Theyab, Mohamed M. Abdel-Daim, Bonglee Kim
Summary: In this study, a comprehensive analysis of RACGAP1 gene expression and behavior in tumors was performed using bioinformatics tools. The results showed that RACGAP1 was highly expressed in several types of tumors and correlated with poor prognosis in various human cancers. Additionally, it was found that RACGAP1 influenced the tumor immune microenvironment by affecting the infiltration level of immune cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Valeria Morante, Martina Borghi, Iole Farina, Zuleika Michelini, Felicia Grasso, Alessandra Gallinaro, Serena Cecchetti, Antonio Di Virgilio, Andrea Canitano, Maria Franca Pirillo, Roberta Bona, Andrea Cara, Donatella Negri
Summary: The study validated the efficacy of the vaccine platform based on IDLVs for cancer immunotherapy in preclinical murine models, demonstrating the ability to eradicate and control tumor growth by delivering antigens such as OVA and TRP2.
Article
Oncology
Ellen D. Yorke, Andrew Jackson, Li Cheng Kuo, Anthonia Ojo, Kelly Panchoo, Prasad Adusumilli, Marjorie G. Zauderer, Valerie W. Rusch, Annemarie Shepherd, Andreas Rimner
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2017)
Article
Oncology
Takashi Eguchi, Sarina Bains, Ming-Ching Lee, Kay See Tan, Boris Hristov, Daniel H. Buitrago, Manjit S. Bains, Robert J. Downey, James Huang, James M. Isbell, Bernard J. Park, Valerie W. Rusch, David R. Jones, Prasad S. Adusumilli
JOURNAL OF CLINICAL ONCOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Neel P. Chudgar, Murray F. Brennan, Rodrigo R. Munhoz, Peter R. Bucciarelli, Kay See Tan, Sandra P. D'Angelo, Manjit S. Bains, Matthew Bott, James Huang, Bernard J. Park, Valerie W. Rusch, Prasad S. Adusumilli, William D. Tap, Samuel Singer, David R. Jones
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2017)
Meeting Abstract
Oncology
Boris Hristov, Takashi Eguchi, James Isbell, Bernard Park, Kay See Tan, Valerie Rusch, David Jones, Prasad Adusumilli
JOURNAL OF THORACIC ONCOLOGY
(2017)
Meeting Abstract
Oncology
Takashi Eguchi, Sarina Bains, Kay See Tan, Manjit Bains, Robert Downey, James Huang, James Isbell, Bernard Park, Valerie Rusch, David Jones, Prasad Adusumilli
JOURNAL OF THORACIC ONCOLOGY
(2017)
Article
Oncology
Yelena Y. Janjigian, Francisco Sanchez-Vega, Philip Jonsson, Walid K. Chatila, Jaclyn F. Hechtman, Geoffrey Y. Ku, Jamie C. Riches, Yaelle Tuvy, Ritika Kundra, Nancy Bouvier, Efsevia Vakiani, Jianjiong Gao, Zachary J. Heins, Benjamin E. Gross, David P. Kelsen, Liying Zhang, Vivian E. Strong, Mark Schattner, Hans Gerdes, Daniel G. Coit, Manjit Bains, Zsofia K. Stadler, Valerie W. Rusch, David R. Jones, Daniela Molena, Jinru Shia, Mark E. Robson, Marinela Capanu, Sumit Middha, Ahmet Zehir, David M. Hyman, Maurizio Scaltriti, Marc Ladanyi, Neal Rosen, David H. Ilson, Michael F. Berger, Laura Tang, Barry S. Taylor, David B. Solit, Nikolaus Schultz
Article
Hematology
Mansour Gergi, Andrew Goodwin, Kalev Freeman, Christos Colovos, Oksana Volod
Summary: COVID-19-associated coagulopathy is characterized by significant hypercoagulability and fibrinolysis shutdown, and viscoelastic hemostatic assays (VHA) may provide a useful tool in identifying this abnormal coagulation state. However, its application in sepsis patients and specifically in the context of COVID-19 is still not well-defined, with limited large randomized trials available.
BLOOD COAGULATION & FIBRINOLYSIS
(2021)
Article
Pharmacology & Pharmacy
Beth A. Bouchard, Christos Colovos, Michael A. Lawson, Zachary T. Osborn, Adrian M. Sackheim, Kara J. Mould, William J. Janssen, Mitchell J. Cohen, Devdoot Majumdar, Kalev Freeman
Summary: Coagulopathy in severe COVID-19 is characterized by elevated histone-DNA complexes, altered thrombin generation, and changes in fibrin structure. Endothelial cells play a crucial role in thrombin generation in COVID-19 patients. These findings contribute to our understanding of the underlying mechanisms of coagulopathy in COVID-19.
VASCULAR PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Michelle Sholzberg, Grace H. Tang, Hassan Rahhal, Musaad AlHamzah, Lisa Baumann Kreuziger, Fionnuala Ni Ainle, Faris Alomran, Khalid Alayed, Mohammed Alsheef, Fahad AlSumait, Carlos Eduardo Pompilio, Catherine Sperlich, Sabrena Tangri, Terence Tang, Peter Jaksa, Deepa Suryanarayan, Mozah Almarshoodi, Lana A. Castellucci, Paula D. James, David Lillicrap, Marc Carrier, Andrew Beckett, Christos Colovos, Jai Jayakar, Marie-Pier Arsenault, Cynthia Wu, Karine Doyon, E. Roseann Andreou, Vera Dounaevskaia, Eric K. Tseng, Gloria Lim, Michael Fralick, Saskia Middeldorp, Agnes Y. Y. Lee, Fei Zuo, Bruno R. da Costa, Kevin E. Thorpe, Elnara Marcia Negri, Mary Cushman, Peter Juni
Summary: This study aimed to evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. The results of the study may help guide the treatment options for similar patients in the future.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Surgery
Autumn Sacklow, Ajai K. Malhotra, Ethan Jones, Peter Callas, Mayo Fujii, Christos Colovos
Summary: This study aimed to identify factors associated with postoperative opioid use after common surgical procedures and develop an opioid risk score. The study found that factors such as early substance use, depression, anxiety, and asthma were associated with opioid use. A risk score based on these factors was calculated and showed good predictive ability for high opioid use.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Hematology
Debora Kamin Mukaz, Mansour Gergi, Insu Koh, Neil A. Zakai, Suzanne E. Judd, Michelle Sholzberg, Lisa Baumann Kreuziger, Kalev Freeman, Christos Colovos, Nels C. Olson, Mary Cushman
Summary: The study revealed that Black individuals have different correlations between D-dimer and thrombo-inflammatory biomarkers compared to White individuals, suggesting a potential link between D-dimer and racial disparities in cardiovascular diseases and venous thromboembolism. This indicates that D-dimer may serve as a marker of amplified thrombo-inflammatory response in Black people. Further investigation is needed to better understand the factors contributing to higher D-dimer levels in the general population.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Surgery
James M. Tatum, Navpreet K. Dhillon, Pratik A. Mehta, Christos Colovos, Eric J. Ley, Galinos Barmparas
Article
Surgery
Navpreet K. Dhillon, Nikhil T. Linaval, Kavita A. Patel, Christos Colovos, Ara Ko, Daniel R. Margulies, Eric J. Ley, Galinos Barmparas
Article
Oncology
Ramon Rami-Porta, Hisao Asamura, William D. Travis, Valerie W. Rusch
CA-A CANCER JOURNAL FOR CLINICIANS
(2017)
Article
Surgery
Hao-Xian Yang, Kaitlin M. Woo, Camelia S. Sima, Manjit S. Bains, Prasad S. Adusumilli, James Huang, David J. Finley, Nabil P. Rizk, Valerie W. Rusch, David R. Jones, Bernard J. Park
